Research Output

2020

Mechanisms, biomarkers and targets for therapy in alcohol-associated liver injury: From Genetics to nutrition: Summary of the ISBRA 2018 symposium

Kirpich, I. A., Warner, D. R., Feng, W., Joshi-Barve, S., McClain, C. J., Seth, D., Zhong, W., Zhou, Z., Osna, N. A. & Kharbanda, K. K., Mar 2020, In : Alcohol. 83, p. 105-114 10 p.

Research output: Contribution to journalReview article

1 Scopus citations

Mechanistic and functional shades of mucins and associated glycans in colon cancer

Pothuraju, R., Krishn, S. R., Gautam, S. K., Pai, P., Ganguly, K., Chaudhary, S., Rachagani, S., Kaur, S. & Batra, S. K., Mar 2020, In : Cancers. 12, 3, 649.

Research output: Contribution to journalReview article

Open Access
1 Scopus citations

Metabolic alterations in pancreatic cancer progression

Vernucci, E., Abrego, J., Gunda, V., Shukla, S. K., Dasgupta, A., Rai, V., Chaika, N., Buettner, K., Illies, A., Yu, F., Lazenby, A. J., Swanson, B. J. & Singh, P. K., Jan 2020, In : Cancers. 12, 1, 2.

Research output: Contribution to journalArticle

Open Access

Metabolic subtyping for novel personalized therapies against pancreatic cancer

Mehla, K. & Singh, P. K., Jan 1 2020, In : Clinical Cancer Research. 26, 1, p. 6-8 3 p.

Research output: Contribution to journalArticle

1 Scopus citations

MicroRNAs Orchestrate Pathophysiology of Breast Cancer Brain Metastasis: Advances in Therapy

Kanchan, R. K., Siddiqui, J. A., Mahapatra, S., Batra, S. K. & Nasser, M. W., Feb 15 2020, In : Molecular cancer. 19, 1, 29.

Research output: Contribution to journalReview article

Open Access
1 Scopus citations

MiR-1253 exerts tumor-suppressive effects in medulloblastoma via inhibition of CDK6 and CD276 (B7-H3)

Kanchan, R. K., Perumal, N., Atri, P., Chirravuri Venkata, R., Thapa, I., Klinkebiel, D. L., Donson, A. M., Perry, D., Punsoni, M., Talmon, G. A., Coulter, D. W., Boue’, D. R., Snuderl, M., Nasser, M. W., Batra, S. K., Vibhakar, R. & Mahapatra, S., Jul 1 2020, In : Brain Pathology. 30, 4, p. 732-745 14 p.

Research output: Contribution to journalArticle

1 Scopus citations

miR-15a-5p, miR-15b-5p, and miR-16-5p inhibit tumor progression by directly targeting MYCN in neuroblastoma

Chava, S., Reynolds, C. P., Pathania, A. S., Gorantla, S., Poluektova, L. Y., Coulter, D. W., Gupta, S. C., Pandey, M. K. & Challagundla, K. B., Jan 1 2020, In : Molecular Oncology. 14, 1, p. 180-196 17 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

MnTE-2-PyP, a manganese porphyrin, reduces cytotoxicity caused by irradiation in a diabetic environment through the induction of endogenous antioxidant defenses

Chatterjee, A., Kosmacek, E. A., Shrishrimal, S., McDonald, J. T. & Oberley-Deegan, R. E., Jul 2020, In : Redox Biology. 34, 101542.

Research output: Contribution to journalArticle

Open Access

MnTnBuOE-2-PyP treatment protects from radioactive iodine (I-131) treatment-related side effects in thyroid cancer

Patel, A., Kosmacek, E. A., Fisher, K. W., Goldner, W. & Oberley-Deegan, R. E., Mar 1 2020, In : Radiation and Environmental Biophysics. 59, 1, p. 99-109 11 p.

Research output: Contribution to journalArticle

Open Access

Molecular implications of MUC5AC-CD44 axis in colorectal cancer progression and chemoresistance

Pothuraju, R., Rachagani, S., Krishn, S. R., Chaudhary, S., Nimmakayala, R. K., Siddiqui, J. A., Ganguly, K., Lakshmanan, I., Cox, J. L., Mallya, K., Kaur, S. & Batra, S. K., Feb 25 2020, In : Molecular cancer. 19, 1, 37.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Molecular targeting of renal cell carcinoma by an oral combination

Jordan, A. R., Wang, J., Yates, T. J., Hasanali, S. L., Lokeshwar, S. D., Morera, D. S., Shamaladevi, N., Li, C. S., Klaassen, Z., Terris, M. K., Thangaraju, M., Singh, A. B., Soloway, M. S. & Lokeshwar, V. B., May 1 2020, In : Oncogenesis. 9, 5, 52.

Research output: Contribution to journalArticle

Open Access

Monocyte metabolic reprogramming promotes pro-inflammatory activity and Staphylococcus aureus biofilm clearance

Yamada, K. J., Heim, C. E., Xi, X., Attri, K. S., Wang, D., Zhang, W., Singh, P. K., Bronich, T. K. & Kielian, T., Jan 1 2020, In : PLoS pathogens. 16, 3, e1008354.

Research output: Contribution to journalArticle

Open Access

MUC16 as a potential target for the surgical detection of pancreatic cancer

Olson, M. T., Wojtynek, N. E., Caffrey, T. C., Radhakrishnan, P., Ly, Q. P., Talmon, G. A., Hollingsworth, M. A. & Mohs, A. M., Jan 1 2020, Molecular-Guided Surgery: Molecules, Devices, and Applications VI. Gioux, S., Gibbs, S. L. & Pogue, B. W. (eds.). SPIE, 112220M. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; vol. 11222).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

MUC1 oncoprotein mitigates ER stress via CDA-mediated reprogramming of pyrimidine metabolism

Olou, A. A., King, R. J., Yu, F. & Singh, P. K., Apr 16 2020, In : Oncogene. 39, 16, p. 3381-3395 15 p.

Research output: Contribution to journalArticle

MUCIN-4 (MUC4) is a novel tumor antigen in pancreatic cancer immunotherapy

Gautam, S. K., Kumar, S., Dam, V., Ghersi, D., Jain, M. & Batra, S. K., Feb 2020, In : Seminars in Immunology. 47, 101391.

Research output: Contribution to journalReview article

MyD88 regulates a prolonged adaptation response to environmental dust exposure-induced lung disease

Johnson, A. N., Harkema, J. R., Nelson, A. J., Dickinson, J. D., Kalil, J., Duryee, M. J., Thiele, G. M., Kumar, B., Singh, A. B., Gaurav, R., Glover, S. C., Tang, Y., Romberger, D. J., Kielian, T. & Poole, J. A., Apr 22 2020, In : Respiratory Research. 21, 1, 97.

Research output: Contribution to journalArticle

Open Access

Neuropilin-2 is an independent prognostic factor for shorter cancer-specific survival in patients with acinar adenocarcinoma of the prostate

Borkowetz, A., Froehner, M., Rauner, M., Conrad, S., Erdmann, K., Mayr, T., Datta, K., Hofbauer, L. C., Baretton, G. B., Wirth, M., Fuessel, S., Toma, M. & Muders, M. H., May 1 2020, In : International Journal of Cancer. 146, 9, p. 2619-2627 9 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Neutrophils are mediators of metastatic prostate cancer progression in bone

Costanzo-Garvey, D. L., Keeley, T., Case, A. J., Watson, G. F., Alsamraae, M., Yu, Y., Su, K., Heim, C. E., Kielian, T., Morrissey, C., Frieling, J. S. & Cook, L. M., Jun 1 2020, In : Cancer Immunology, Immunotherapy. 69, 6, p. 1113-1130 18 p.

Research output: Contribution to journalArticle

Open Access

Neutrophils in the Tumor Microenvironment

Wu, L., Saxena, S. & Singh, R. K., Jan 1 2020, Advances in Experimental Medicine and Biology. Springer, p. 1-20 20 p. (Advances in Experimental Medicine and Biology; vol. 1224).

Research output: Chapter in Book/Report/Conference proceedingChapter

NF-κB Duplications in the Promoter-Variant HIV-1C LTR Impact Inflammation Without Altering Viral Replication in the Context of Simian Human Immunodeficiency Viruses and Opioid-Exposure

Dave, R. S., Ali, H., Sil, S., Knight, L. A., Pandey, K., Madduri, L. S. V., Qiu, F., Ranga, U., Buch, S. & Byrareddy, S. N., Jan 31 2020, In : Frontiers in immunology. 11, 95.

Research output: Contribution to journalArticle

Open Access

Odyssey of trefoil factors in cancer: Diagnostic and therapeutic implications

Jahan, R., Shah, A., Kisling, S. G., Macha, M. A., Thayer, S., Batra, S. K. & Kaur, S., Apr 2020, In : Biochimica et Biophysica Acta - Reviews on Cancer. 1873, 2, 188362.

Research output: Contribution to journalReview article

Pan-cancer analysis of whole genomes

The ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium, Feb 6 2020, In : Nature. 578, 7793, p. 82-93 12 p.

Research output: Contribution to journalArticle

Open Access
53 Scopus citations

Pan-Cancer Analysis Reveals the Diverse Landscape of Novel Sense and Antisense Fusion Transcripts

Vellichirammal, N. N., Albahrani, A., Banwait, J. K., Mishra, N. K., Li, Y., Roychoudhury, S., Kling, M. J., Mirza, S., Bhakat, K. K., Band, V., Joshi, S. S. & Guda, C., Mar 6 2020, In : Molecular Therapy - Nucleic Acids. 19, p. 1379-1398 20 p.

Research output: Contribution to journalArticle

Open Access

Pancreatic Stellate Cells: The Key Orchestrator of The Pancreatic Tumor Microenvironment

Thomas, D. & Radhakrishnan, P., Jan 1 2020, Advances in Experimental Medicine and Biology. Springer, p. 57-70 14 p. (Advances in Experimental Medicine and Biology; vol. 1234).

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Placental DNA methylation changes in detection of tetralogy of Fallot

Bahado-Singh, R., Vishweswaraiah, S., Mishra, N. K., Guda, C. & Radhakrishna, U., Jun 1 2020, In : Ultrasound in Obstetrics and Gynecology. 55, 6, p. 768-775 8 p.

Research output: Contribution to journalArticle

Precision cardiovascular medicine: artificial intelligence and epigenetics for the pathogenesis and prediction of coarctation in neonates

Bahado-Singh, R. O., Vishweswaraiah, S., Aydas, B., Yilmaz, A., Saiyed, N. M., Mishra, N. K., Guda, C. & Radhakrishna, U., Jan 1 2020, (Accepted/In press) In : Journal of Maternal-Fetal and Neonatal Medicine.

Research output: Contribution to journalArticle

1 Scopus citations

Precision medicine and actionable alterations in lung cancer: A single institution experience

Mambetsariev, I., Wang, Y., Chen, C., Nadaf, S., Pharaon, R., Fricke, J., Amanam, I., Amini, A., Bild, A., Chu, P., Erhunmwunsee, L., Kim, J., Munu, J., Pillai, R., Raz, D., Sampath, S., Vora, L., Qiu, F., Smith, L., Batra, S. K. & 4 others, Massarelli, E., Koczywas, M., Reckamp, K. & Salgia, R., Jan 1 2020, In : PloS one. 15, 2, e0228188.

Research output: Contribution to journalArticle

Open Access

Predicted Prognosis of Patients with Pancreatic Cancer by Machine Learning

Yokoyama, S., Hamada, T., Higashi, M., Matsuo, K., Maemura, K., Kurahara, H., Horinouchi, M., Hiraki, T., Sugimoto, T., Akahane, T., Yonezawa, S., Kornmann, M., Batra, S. K., Hollingsworth, M. A. & Tanimoto, A., May 15 2020, In : Clinical cancer research : an official journal of the American Association for Cancer Research. 26, 10, p. 2411-2421 11 p.

Research output: Contribution to journalArticle

Presence and structure-activity relationship of intrinsically disordered regions across mucins

Carmicheal, J., Atri, P., Sharma, S., Kumar, S., Chirravuri Venkata, R., Kulkarni, P., Salgia, R., Ghersi, D., Kaur, S. & Batra, S. K., Feb 1 2020, In : FASEB Journal. 34, 2, p. 1939-1957 19 p.

Research output: Contribution to journalArticle

Open Access

Prognostic and therapeutic implications of NHERF1 expression and regulation in colorectal cancer

Leiphrakpam, P. D., Lazenby, A. J., Chowdhury, S., Smith, L. M., Mathiesen, M., Brattain, M. G., Wang, J., Black, J. D. & Are, C., Mar 1 2020, In : Journal of Surgical Oncology. 121, 3, p. 547-560 14 p.

Research output: Contribution to journalArticle

Prognostic relevance and inter-observer reliability of chest-imaging in pediatric ARDS: a pediatric acute respiratory distress incidence and epidemiology (PARDIE) study

the Pediatric Acute Respiratory Distress Syndrome Incidence and Epidemiology (PARDIE) V3 Investigators and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network, Jan 1 2020, (Accepted/In press) In : Intensive Care Medicine.

Research output: Contribution to journalArticle

Open Access

Proximal tubule cyclophilin D regulates fatty acid oxidation in cisplatin-induced acute kidney injury

Jang, H. S., Noh, M. R., Jung, E. M., Kim, W. Y., Southekal, S., Guda, C., Foster, K. W., Oupicky, D., Ferrer, F. A. & Padanilam, B. J., Feb 2020, In : Kidney International. 97, 2, p. 327-339 13 p.

Research output: Contribution to journalArticle

2 Scopus citations

Radiomics-based outcome prediction for pancreatic cancer following stereotactic body radiotherapy

Parr, E., Du, Q., Zhang, C., Lin, C., Kamal, A., McAlister, J., Liang, X., Bavitz, K., Rux, G., Hollingsworth, M., Baine, M. & Zheng, D., Apr 2020, In : Cancers. 12, 4, 1051.

Research output: Contribution to journalArticle

Open Access

Radiomics in stratification of pancreatic cystic lesions: Machine learning in action

Dalal, V., Carmicheal, J., Dhaliwal, A., Jain, M., Kaur, S. & Batra, S. K., Jan 28 2020, In : Cancer Letters. 469, p. 228-237 10 p.

Research output: Contribution to journalShort survey

Recent Advances in the Development of Integrase Inhibitors for HIV Treatment

Trivedi, J., Mahajan, D., Jaffe, R. J., Acharya, A., Mitra, D. & Byrareddy, S. N., Feb 1 2020, In : Current HIV/AIDS Reports. 17, 1, p. 63-75 13 p.

Research output: Contribution to journalReview article

Recent advances in understanding the complexity of alcohol-induced pancreatic dysfunction and pancreatitis development

Rasineni, K., Srinivasan, M. P., Balamurugan, A. N., Kaphalia, B. S., Wang, S., Ding, W. X., Pandol, S. J., Lugea, A., Simon, L., Molina, P. E., Gao, P., Casey, C. A., Osna, N. A. & Kharbanda, K. K., May 2020, In : Biomolecules. 10, 5, 669.

Research output: Contribution to journalReview article

Open Access

Reprogrammed astrocytes display higher neurogenic competence, migration ability and cell death resistance than reprogrammed fibroblasts

Xia, X., Li, C., Wang, Y., Deng, X., Ma, Y., Ding, L. & Zheng, J., Feb 8 2020, In : Translational Neurodegeneration. 9, 1, 6.

Research output: Contribution to journalArticle

Open Access

Reprogramming of ovarian granulosa cells by YAP1 leads to development of high-grade cancer with mesenchymal lineage and serous features

Lv, X., He, C., Huang, C., Hua, G., Chen, X., Timm, B. K., Maclin, V. M., Haggerty, A. A., Aust, S. K., Golden, D. M., Dave, B. J., Tseng, Y. A., Chen, L., Wang, H., Chen, P., Klinkebiel, D. L., Karpf, A. R., Dong, J., Drapkin, R. I., Rueda, B. R. & 2 others, Davis, J. S. & Wang, C., Jan 1 2020, (Accepted/In press) In : Science Bulletin.

Research output: Contribution to journalArticle

RIG-I and TLR4 responses and adverse outcomes in pediatric influenza-related critical illness

PALISI Pediatric Intensive Care Influenza (PICFLU) Network Investigators, Jan 1 2020, (Accepted/In press) In : Journal of Allergy and Clinical Immunology.

Research output: Contribution to journalArticle

Rilpivirine-associated aggregation-induced emission enables cell-based nanoparticle tracking

Mukadam, I. Z., Machhi, J., Herskovitz, J., Hasan, M., Oleynikov, M. D., Blomberg, W. R., Svechkarev, D., Mohs, A. M., Zhou, Y., Dash, P., McMillan, J. E., Gorantla, S., Garrison, J., Gendelman, H. E. & Kevadiya, B. D., Feb 2020, In : Biomaterials. 231, 119669.

Research output: Contribution to journalArticle

Role of alcohol in pathogenesis of hepatitis B virus infection

Ganesan, M., Eikenberry, A., Poluektova, L. Y., Kharbanda, K. K. & Osna, N. A., Mar 7 2020, In : World Journal of Gastroenterology. 26, 9, p. 883-903 21 p.

Research output: Contribution to journalReview article

Open Access
Open Access
1 Scopus citations

Role of Small Intestine and Gut Microbiome in Plant-Based Oral Tolerance for Hemophilia

Kumar, S. R. P., Wang, X., Avuthu, N., Bertolini, T. B., Terhorst, C., Guda, C., Daniell, H. & Herzog, R. W., May 20 2020, In : Frontiers in immunology. 11, 844.

Research output: Contribution to journalArticle

Open Access

Role of tumor and stroma-derived IGF/IGFBPS in pancreatic cancer

Thomas, D. & Radhakrishnan, P., May 2020, In : Cancers. 12, 5, 1228.

Research output: Contribution to journalReview article

Open Access

SARS-CoV-2 Infection Leads to Neurological Dysfunction

Acharya, A., Kevadiya, B. D., Gendelman, H. E. & Byrareddy, S. N., Jun 1 2020, In : Journal of Neuroimmune Pharmacology. 15, 2, p. 167-173 7 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
4 Scopus citations

Short-term stable isotope probing of proteins reveals taxa incorporating inorganic carbon in a hot spring microbial mat

Steinke, L., Slysz, G. W., Lipton, M. S., Klatt, C., Moran, J. J., Romine, M. F., Wood, J. M., Anderson, G., Bryant, D. A. & Ward, D. M., Mar 1 2020, In : Applied and environmental microbiology. 86, 7, 1829.

Research output: Contribution to journalArticle

1 Scopus citations

SIRT1-NOX4 signaling axis regulates cancer cachexia

Dasgupta, A., Shukla, S. K., Vernucci, E., King, R. J., Abrego, J., Mulder, S. E., Mullen, N. J., Graves, G., Buettner, K., Thakur, R., Murthy, D., Attri, K. S., Wang, D., Chaika, N. V., Pacheco, C. G., Rai, I., Engle, D. D., Grandgenett, P. M., Punsoni, M., Reames, B. N. & 10 others, Teoh-Fitzgerald, M., Oberley-Deegan, R., Yu, F., Klute, K. A., Hollingsworth, M. A., Zimmerman, M. C., Mehla, K., Sadoshima, J., Tuveson, D. A. & Singh, P. K., Jul 6 2020, In : The Journal of experimental medicine. 217, 7

Research output: Contribution to journalArticle