Research Output

2020

Solvent tuning of photochemistry upon excited-state symmetry breaking

Dereka, B., Svechkarev, D., Rosspeintner, A., Aster, A., Lunzer, M., Liska, R., Mohs, A. M. & Vauthey, E., Dec 1 2020, In : Nature communications. 11, 1, 1925.

Research output: Contribution to journalArticle

Open Access

Sorting nexin 17 (SNX17) links endosomal sorting to Eps15 homology domain protein 1 (EHD1)-mediated fission machinery

Dhawan, K., Naslavsky, N., Caplan, S. & Hanson, P. I., Mar 20 2020, In : Journal of Biological Chemistry. 295, 12, p. 3837-3850 14 p.

Research output: Contribution to journalArticle

1 Scopus citations

Squamous trans-differentiation of pancreatic cancer cells promotes stromal inflammation

Somerville, T. D. D., Biffi, G., Daßler-Plenker, J., Hur, S. K., He, X. Y., Vance, K. E., Miyabayashi, K., Xu, Y., Maia-Silva, D., Klingbeil, O., Demerdash, O. E., Preall, J. B., Hollingsworth, M. A., Egeblad, M., Tuveson, D. A. & Vakoc, C. R., Apr 2020, In : eLife. 9, e53381.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Stromal Modulation and Treatment of Metastatic Pancreatic Cancer with Local Intraperitoneal Triple miRNA/siRNA Nanotherapy

Xie, Y., Hang, Y., Wang, Y., Sleightholm, R., Prajapati, D. R., Bader, J., Yu, A., Tang, W., Jaramillo, L., Li, J., Singh, R. K. & Oupický, D., Jan 28 2020, In : ACS Nano. 14, 1, p. 255-271 17 p.

Research output: Contribution to journalArticle

2 Scopus citations

Targeting pulmonary tumor microenvironment with CXCR4-inhibiting nanocomplex to enhance anti–PD-L1 immunotherapy

Li, Z., Wang, Y., Shen, Y., Qian, C., Oupicky, D. & Sun, M., May 2020, In : Science Advances. 6, 20, eaaz9240.

Research output: Contribution to journalArticle

Open Access

Targeting the IκB Kinase Enhancer and Its Feedback Circuit in Pancreatic Cancer

Challa, S., Husain, K., Kim, R., Coppola, D., Batra, S. K., Cheng, J. Q. & Malafa, M. P., Feb 2020, In : Translational Oncology. 13, 2, p. 481-489 9 p.

Research output: Contribution to journalArticle

Open Access

The epidemiology and pathogenesis of coronavirus disease (COVID-19) outbreak

Rothan, H. A. & Byrareddy, S. N., May 2020, In : Journal of Autoimmunity. 109, 102433.

Research output: Contribution to journalReview article

Open Access
158 Scopus citations

The proteomic landscape of pancreatic ductal adenocarcinoma liver metastases identifies molecular subtypes and associations with clinical response A C

Law, H. C. H., Lagundzin, D., Clement, E. J., Qiao, F., Wagner, Z. S., Krieger, K. L., Costanzo-Garvey, D., Caffrey, T. C., Grem, J. L., DiMaio, D. J., Grandgenett, P. M., Cook, L. M., Fisher, K. W., Yu, F., Hollingsworth, M. A. & Woods, N. T., Mar 1 2020, In : Clinical Cancer Research. 26, 5, p. 1065-1076 12 p.

Research output: Contribution to journalArticle

Open Access

Tuned near infrared fluorescent hyaluronic acid conjugates for delivery to pancreatic cancer for intraoperative imaging

Qi, B., Crawford, A. J., Wojtynek, N. E., Talmon, G. A., Hollingsworth, M. A., Ly, Q. P. & Mohs, A. M., Jan 1 2020, In : Theranostics. 10, 8, p. 3413-3429 17 p.

Research output: Contribution to journalArticle

Open Access

Unraveling mucin domains in cancer and metastasis: when protectors become predators

Ganguly, K., Rauth, S., Marimuthu, S., Kumar, S. & Batra, S. K., Jan 1 2020, (Accepted/In press) In : Cancer and Metastasis Reviews.

Research output: Contribution to journalReview article

Upregulation of ZIP14 and altered zinc homeostasis in muscles in pancreatic cancer cachexia

Shakri, A. R., Zhong, T. J., Ma, W., Coker, C., Kim, S., Calluori, S., Scholze, H., Szabolcs, M., Caffrey, T., Grandgenett, P. M., Hollingsworth, M. A., Tanji, K., Kluger, M. D., Miller, G., Biswas, A. K. & Acharyya, S., Jan 2020, In : Cancers. 12, 1, 3.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Urban airborne PM2.5-activated microglia mediate neurotoxicity through glutaminase-containing extracellular vesicles in olfactory bulb

Chen, X., Guo, J., Huang, Y., Liu, S., Huang, Y., Zhang, Z., Zhang, F., Lu, Z., Li, F., Zheng, J. C. & Ding, W., Sep 2020, In : Environmental Pollution. 264, 114716.

Research output: Contribution to journalArticle

Open Access

Urban American Indian Community Health Beliefs Associated with Addressing Cancer in the Northern Plains Region

Idoate, R., Gilbert, M., King, K. M., Spellman, L., McWilliams, B., Strong, B., Bronner, L., Siahpush, M., Ramos, A. K., Clarke, M., Michaud, T., Godfrey, M. & Solheim, J., Jan 1 2020, (Accepted/In press) In : Journal of Cancer Education.

Research output: Contribution to journalArticle

Use of polymeric CXCR4 inhibitors as siRNA delivery vehicles for the treatment of acute myeloid leukemia

Wang, Y., Xie, Y., Williams, J., Hang, Y., Richter, L., Becker, M., Amador, C., Oupický, D. & Hyde, R. K., Feb 1 2020, In : Cancer Gene Therapy. 27, 1-2, p. 45-55 11 p.

Research output: Contribution to journalArticle

3 Scopus citations
2019

Acetaldehyde suppresses the display of HBV-MHC class I complexes on HBV-expressing hepatocytes

Ganesan, M., Krutik, V. M., Makarov, E., Mathews, S., Kharbanda, K. K., Poluektova, L. Y., Casey, C. A. & Osna, N. A., Aug 2019, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 317, 2, p. G127-G140

Research output: Contribution to journalArticle

3 Scopus citations

Adaptation of an R5 simian-human immunodeficiency virus encoding an HIV clade a envelope with or without ablation of adaptive host immunity: Differential selection of viral mutants

Zhou, M., Humbert, M., Mukhtar, M. M., Scinto, H. B., Vyas, H. K., Lakhashe, S. K., Byrareddy, S. N., Maurer, G., Thorat, S., Owuor, J., Lai, Z., Chen, Y., Griffiths, A., Chenine, A. L., Gumber, S., Villinger, F., Montefiori, D. & Ruprecht, R. M., May 1 2019, In : Journal of virology. 93, 9, e02267-18.

Research output: Contribution to journalArticle

Afatinib and Temozolomide combination inhibits tumorigenesis by targeting EGFRvIII-cMet signaling in glioblastoma cells

Vengoji, R., Macha, M. A., Nimmakayala, R. K., Rachagani, S., Siddiqui, J. A., Mallya, K., Gorantla, S., Jain, M., Ponnusamy, M. P., Batra, S. K. & Shonka, N., Jun 18 2019, In : Journal of Experimental and Clinical Cancer Research. 38, 1, 266.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

A Genome-wide Functional Signature Ontology Map and Applications to Natural Product Mechanism of Action Discovery

McMillan, E. A., Kwon, G., Clemenceau, J. R., Fisher, K. W., Vaden, R. M., Shaikh, A. F., Neilsen, B. K., Kelly, D., Potts, M. B., Sung, Y. J., Mendiratta, S., Hight, S. K., Lee, Y., MacMillan, J. B., Lewis, R. E., Kim, H. S. & White, M. A., Oct 17 2019, In : Cell Chemical Biology. 26, 10, p. 1380-1392.e6

Research output: Contribution to journalArticle

2 Scopus citations

A Human Papillomavirus-Independent Cervical Cancer Animal Model Reveals Unconventional Mechanisms of Cervical Carcinogenesis

He, C., Lv, X., Huang, C., Angeletti, P. C., Hua, G., Dong, J., Zhou, J., Wang, Z., Ma, B., Chen, X., Lambert, P. F., Rueda, B. R., Davis, J. S. & Wang, C., Mar 5 2019, In : Cell Reports. 26, 10, p. 2636-2650.e5

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

Alcohol metabolism potentiates HIV-induced hepatotoxicity: Contribution to end-stage liver disease

Ganesan, M., New-Aaron, M., Dagur, R. S., Makarov, E., Wang, W., Kharbanda, K. K., Kidambi, S., Poluektova, L. Y. & Osna, N. A., Dec 2019, In : Biomolecules. 9, 12, 851.

Research output: Contribution to journalArticle

Open Access

Alendronate-Modified Polymeric Micelles for the Treatment of Breast Cancer Bone Metastasis

Liu, T., Romanova, S., Wang, S., Hyun, M. A., Zhang, C., Cohen, S. M., Singh, R. K. & Bronich, T. K., Jan 1 2019, In : Molecular Pharmaceutics.

Research output: Contribution to journalArticle

Amphiphilic polyanhydride-based recombinant MUC4β-nanovaccine activates dendritic cells

Banerjee, K., Gautam, S. K., Kshirsagar, P., Ross, K. A., Spagnol, G., Sorgen, P., Wannemuehler, M. J., Narasimhan, B., Solheim, J. C., Kumar, S., Batra, S. K. & Jain, M., Jan 1 2019, In : Genes and Cancer. 10, 3-4, p. 52-62 11 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Animal models of cancer-associated cachexia

Shukla, S. K. & Singh, P. K., Apr 17 2019, Animal Models in Cancer Drug Discovery. Elsevier, p. 59-74 16 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Anti-Claudin-1 Conjugated to a Near-Infrared Fluorophore Targets Colon Cancer in PDOX Mouse Models

Hollandsworth, H. M., Lwin, T. M., Amirfakhri, S., Filemoni, F., Batra, S. K., Hoffman, R. M., Dhawan, P. & Bouvet, M., Oct 2019, In : Journal of Surgical Research. 242, p. 145-150 6 p.

Research output: Contribution to journalArticle

4 Scopus citations

A Panel of Protein Kinase Chemosensors Distinguishes Different Types of Fatty Liver Disease

Beck, J. R., Cabral, F., Rasineni, K., Casey, C. A., Harris, E. N. & Stains, C. I., Sep 17 2019, In : Biochemistry. 58, 37, p. 3911-3917 7 p.

Research output: Contribution to journalArticle

1 Scopus citations

Aperiodic order coming of age: From inorganic materials to dynamic protein superstructures

Borgstahl, G., Goldman, A. I. & Thiel, P. A., Jan 1 2019, In : Acta Crystallographica Section A: Foundations and Advances. 75, p. 212-213 2 p.

Research output: Contribution to journalEditorial

Open Access
1 Scopus citations

A polymeric nanogel-based treatment regimen for enhanced efficacy and sequential administration of synergistic drug combination in pancreatic cancer

Soni, K. S., Thomas, D., Caffrey, T., Mehla, K., Lei, F., O'Connell, K. A., Sagar, S., Lele, S. M., Hollingsworth, M. A., Radhakrishnan, P. & Bronich, T. K., Jan 1 2019, In : Journal of Pharmacology and Experimental Therapeutics. 370, 3, p. 894-901 8 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Artificial intelligence analysis of newborn leucocyte epigenomic markers for the prediction of autism

Bahado-Singh, R. O., Vishweswaraiah, S., Aydas, B., Mishra, N. K., Yilmaz, A., Guda, C. & Radhakrishna, U., Dec 1 2019, In : Brain Research. 1724, 146457.

Research output: Contribution to journalArticle

1 Scopus citations

A simple fluorescent assay for the discovery of protein-protein interaction inhibitors

Al-Mugotir, M., Kolar, C., Vance, K., Kelly, D. L., Natarajan, A. & Borgstahl, G. E. O., Mar 15 2019, In : Analytical Biochemistry. 569, p. 46-52 7 p.

Research output: Contribution to journalArticle

A Tat/Rev Induced Limiting Dilution Assay to Measure Viral Reservoirs in Non-Human Primate Models of HIV Infection

Frank, I., Acharya, A., Routhu, N. K., Aravantinou, M., Harper, J. L., Maldonado, S., Sole Cigoli, M., Semova, S., Mazel, S., Paiardini, M., Derby, N., Byrareddy, S. N. & Martinelli, E., Dec 1 2019, In : Scientific reports. 9, 1, 12078.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Beta 2-microglobulin regulates amyloid precursor-like protein 2 expression and the migration of pancreatic cancer cells

Sliker, B. H., Goetz, B. T., Peters, H. L., Poelaert, B. J., Borgstahl, G. E. O. & Solheim, J. C., Jun 3 2019, In : Cancer Biology and Therapy. 20, 6, p. 931-940 10 p.

Research output: Contribution to journalArticle

1 Scopus citations

Betaglycan drives the mesenchymal stromal cell osteogenic program and prostate cancer-induced osteogenesis

Cook, L. M., Frieling, J. S., Nerlakanti, N., McGuire, J. J., Stewart, P. A., Burger, K. L., Cleveland, J. L. & Lynch, C. C., Oct 31 2019, In : Oncogene. 38, 44, p. 6959-6969 11 p.

Research output: Contribution to journalArticle

2 Scopus citations

BH3-only proteins target BCL-xL/MCL-1, not BAX/BAK, to initiate apoptosis

Huang, K., O’Neill, K. L., Li, J., Zhou, W., Han, N., Pang, X., Wu, W., Struble, L., Borgstahl, G., Liu, Z., Zhang, L. & Luo, X., Nov 1 2019, In : Cell Research. 29, 11, p. 942-952 11 p.

Research output: Contribution to journalArticle

8 Scopus citations

Brain changes in a maternal immune activation model of neurodevelopmental brain disorders

Bergdolt, L. & Dunaevsky, A., Apr 2019, In : Progress in Neurobiology. 175, p. 1-19 19 p.

Research output: Contribution to journalReview article

14 Scopus citations

Cancer-Associated Fibroblasts Enhance Survival and Progression of the Aggressive Pancreatic Tumor Via FGF-2 and CXCL8

Awaji, M., Futakuchi, M., Heavican, T., Iqbal, J. & Singh, R. K., Apr 1 2019, In : Cancer Microenvironment. 12, 1, p. 37-46 10 p.

Research output: Contribution to journalArticle

4 Scopus citations

Cancer-associated fibroblasts’ functional heterogeneity in pancreatic ductal adenocarcinoma

Awaji, M. & Singh, R. K., Mar 2019, In : Cancers. 11, 3, 290.

Research output: Contribution to journalReview article

Open Access
9 Scopus citations

Cancer-associated mucins: role in immune modulation and metastasis

Bhatia, R., Gautam, S. K., Cannon, A., Thompson, C., Hall, B. R., Aithal, A., Banerjee, K., Jain, M., Solheim, J. C., Kumar, S. & Batra, S. K., Jun 15 2019, In : Cancer and Metastasis Reviews. 38, 1-2, p. 223-236 14 p.

Research output: Contribution to journalReview article

18 Scopus citations

Cancer surgery on the global stage: Much to be done

Are, C. & Balch, C. M., Jan 1 2019, In : Gaceta Mexicana de Oncologia. 18, 3, p. 118-120 3 p.

Research output: Contribution to journalReview article

Open Access

Cannabinoid attenuation of intestinal inflammation in chronic SIV-infected rhesus macaques involves T cell modulation and differential expression of micro-RNAs and pro-inflammatory genes

Kumar, V., Torben, W., Mansfield, J., Alvarez, X., Vande Stouwe, C., Li, J., Byrareddy, S. N., Didier, P. J., Pahar, B., Molina, P. E. & Mohan, M., Jan 1 2019, In : Frontiers in immunology. 10, APR, 914.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

CDK5 inhibitor downregulates Mcl-1 and sensitizes pancreatic cancer cell lines to navitoclax

Kour, S., Rana, S., Contreras, J. I., King, H. M., Robb, C. M., Sonawane, Y. A., Bendjennat, M., Crawford, A. J., Barger, C. J., Kizhake, S., Luo, X., Hollingsworth, M. A. & Natarajan, A., Oct 2019, In : Molecular pharmacology. 96, 4, p. 419-429 11 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations
4 Scopus citations

Cocaine Induces Inflammatory Gut Milieu by Compromising the Mucosal Barrier Integrity and Altering the Gut Microbiota Colonization

Chivero, E. T., Ahmad, R., Thangaraj, A., Periyasamy, P., Kumar, B., Kroeger, E., Feng, D., Guo, M. L., Roy, S., Dhawan, P., Singh, A. B. & Buch, S., Dec 1 2019, In : Scientific reports. 9, 1, 12187.

Research output: Contribution to journalArticle

Open Access

Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer

Bryant, K. L., Stalnecker, C. A., Zeitouni, D., Klomp, J. E., Peng, S., Tikunov, A. P., Gunda, V., Pierobon, M., Waters, A. M., George, S. D., Tomar, G., Papke, B., Hobbs, G. A., Yan, L., Hayes, T. K., Diehl, J. N., Goode, G. D., Chaika, N. V., Wang, Y., Zhang, G. F. & 11 others, Witkiewicz, A. K., Knudsen, E. S., Petricoin, E. F., Singh, P. K., Macdonald, J. M., Tran, N. L., Lyssiotis, C. A., Ying, H., Kimmelman, A. C., Cox, A. D. & Der, C. J., Apr 1 2019, In : Nature Medicine. 25, 4, p. 628-640 13 p.

Research output: Contribution to journalArticle

64 Scopus citations

Combination therapies and drug delivery platforms in combating pancreatic cancer

Lei, F., Xi, X., Batra, S. K. & Bronich, T. K., Jan 1 2019, In : Journal of Pharmacology and Experimental Therapeutics. 370, 3, p. 682-694 13 p.

Research output: Contribution to journalReview article

Open Access
Open Access
1 Scopus citations

Correction to: Zika Virus and the Metabolism of Neuronal Cells (Molecular Neurobiology, (2019), 56, 4, (2551-2557), 10.1007/s12035-018-1263-x)

Rothan, H. A., Fang, S., Mohan, M. & Byrareddy, S. N., Apr 1 2019, In : Molecular Neurobiology. 56, 4, 1 p.

Research output: Contribution to journalComment/debate

Correction to: Tumor-Penetrating Nanoparticles for Enhanced Anticancer Activity of Combined Photodynamic and Hypoxia-Activated Therapy (ACS Nano (2017) 11:2 (2227-2238) DOI: 10.1021/acsnano.6b08731)

Wang, Y., Xie, Y., Li, J., Peng, Z. H., Sheinin, Y., Zhou, J. & Oupický, D., Apr 23 2019, In : ACS Nano. 13, 4, 1 p.

Research output: Contribution to journalComment/debate

1 Scopus citations

Corrigendum: Discovery of Novel and Clinically Relevant Markers in Formalin-Fixed Paraffin-Embedded Esophageal Cancer Specimen (Front. Oncol (2018) 8 (157) DOI: 10.3389/fonc.2018.00157)

Abdo, J., Wichman, C. S., Dietz, N. E., Ciborowski, P., Fleegel, J., Mittal, S. K. & Agrawal, D. K., Jan 1 2019, In : Frontiers in Oncology. 9, APR, 273.

Research output: Contribution to journalComment/debate

Open Access

CTDP1 regulates breast cancer survival and DNA repair through BRCT-specific interactions with FANCI

Hu, W. F., Krieger, K. L., Lagundžin, D., Li, X., Cheung, R. S., Taniguchi, T., Johnson, K. R., Bessho, T., Monteiro, A. N. A. & Woods, N. T., Dec 1 2019, In : Cell Death Discovery. 5, 1, 105.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations