Research Output

2019

Less is more: creation and validation of a novel, affordable suturing simulator for anorectal surgery

Langenfeld, S. J., Fuglestad, M. A., Cologne, K. G., Thompson, J. S., Are, C. & Steele, S. R., Nov 1 2019, In : Techniques in Coloproctology. 23, 11, p. 1057-1064 8 p.

Research output: Contribution to journalArticle

LIMD1 phosphorylation in mitosis is required for mitotic progression and its tumor-suppressing activity

Zhou, J., Zhang, L., Zhou, W., Chen, Y., Cheng, Y. & Dong, J., Mar 2019, In : FEBS Journal. 286, 5, p. 963-974 12 p.

Research output: Contribution to journalArticle

Lipid droplet size directs lipolysis and lipophagy catabolism in hepatocytes

Schott, M. B., Weller, S. G., Schulze, R. J., Krueger, E. W., Drizyte-Miller, K., Casey, C. A. & McNiven, M. A., Oct 7 2019, In : Journal of Cell Biology. 218, 10, p. 3320-3335 16 p.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations

Lipophagy and alcohol-induced fatty liver

Yang, L., Yang, C., Thomes, P. G., Kharbanda, K. K., Casey, C. A., McNiven, M. A. & Donohue, T. M., Jan 1 2019, In : Frontiers in Pharmacology. 10, MAY, 495.

Research output: Contribution to journalReview article

Open Access
5 Scopus citations

Long non-coding RNAs are emerging targets of phytochemicals for cancer and other chronic diseases

Mishra, S., Verma, S. S., Rai, V., Awasthee, N., Chava, S., Hui, K. M., Kumar, A. P., Challagundla, K. B., Sethi, G. & Gupta, S. C., Jan 1 2019, In : Cellular and Molecular Life Sciences.

Research output: Contribution to journalReview article

25 Scopus citations

Loss of FBXO9 enhances proteasome activity and promotes aggressiveness in acute myeloid leukemia

Willow Hynes-Smith, R., Swenson, S. A., Vahle, H., Wittorf, K. J., Caplan, M., Amador, C., Katherine Hyde, R. & Buckley, S. M., Nov 2019, In : Cancers. 11, 11, 1717.

Research output: Contribution to journalArticle

Open Access

Lysosome and proteasome dysfunction in alcohol-induced liver injury

Donohue, T. M., Osna, N. A., Kharbanda, K. K. & Thomes, P. G., Dec 2019, In : Liver Research. 3, 3-4, p. 191-205 15 p.

Research output: Contribution to journalReview article

Open Access
1 Scopus citations

Management of Locally Advanced Pancreatic Cancer: Results of an International Survey of Current Practice

Reames, B. N., Blair, A. B., Krell, R. W., Groot, V. P., Gemenetzis, G., Padussis, J. C., Thayer, S. P., Falconi, M., Wolfgang, C. L., Weiss, M. J., Are, C. & He, J., Jan 1 2019, (Accepted/In press) In : Annals of surgery.

Research output: Contribution to journalArticle

5 Scopus citations

Managing Squamous Cell Esophageal Cancer

Batra, R., Malhotra, G. K., Singh, S. & Are, C., Jun 2019, In : Surgical Clinics of North America. 99, 3, p. 529-541 13 p.

Research output: Contribution to journalReview article

2 Scopus citations

Meningeal lymphatics in aging and Alzheimer's disease

Jaffe, R. J., Dave, R. S. & Byrareddy, S. N., Mar 1 2019, In : Journal of Threatened Taxa. 7, S2.

Research output: Contribution to journalEditorial

Metabolic Regulation of Macrophage Polarization in Cancer

Mehla, K. & Singh, P. K., Dec 2019, In : Trends in Cancer. 5, 12, p. 822-834 13 p.

Research output: Contribution to journalReview article

2 Scopus citations

MICAL-L1 coordinates ciliogenesis by recruiting EHD1 to the primary cilium

Xie, S., Farmer, T., Naslavsky, N. & Caplan, S., Jan 1 2019, In : Journal of cell science. 132, 22, jcs233973.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

MicroRNA regulation of K-Ras in pancreatic cancer and opportunities for therapeutic intervention

Karmakar, S., Kaushik, G., Nimmakayala, R., Rachagani, S., Ponnusamy, M. P. & Batra, S. K., Feb 2019, In : Seminars in Cancer Biology. 54, p. 63-71 9 p.

Research output: Contribution to journalReview article

14 Scopus citations

MiR-106b regulates the proliferation and differentiation of neural stem/progenitor cells through Tp53inp1-Tp53-Cdkn1a axis

Xia, X., Lu, H., Li, C., Huang, Y., Wang, Y., Yang, X. & Zheng, J. C., Sep 23 2019, In : Stem Cell Research and Therapy. 10, 1, 282.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Mitochondrial superoxide disrupts the metabolic and epigenetic landscape of CD4+ and CD8+ T-lymphocytes

Moshfegh, C. M., Collins, C. W., Gunda, V., Vasanthakumar, A., Cao, J. Z., Singh, P. K., Godley, L. A. & Case, A. J., Oct 2019, In : Redox Biology. 27, 101141.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

MnTE-2-PyP attenuates TGF-β-induced epithelial-mesenchymal transition of colorectal cancer cells by inhibiting the Smad2/3 signaling pathway

Yang, Y., Zhang, P., Yan, R., Wang, Q., Fang, E., Wu, H., Li, S., Tan, H., Zhou, X., Ma, X., Tang, Y., Huang, Y., Deng, R., Liu, Y., Tong, S., Wang, Z., Oberley-Deegan, R. E. & Tong, Q., Jan 1 2019, In : Oxidative medicine and cellular longevity. 2019, 8639791.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Molecular and physiological evaluation of pancreatic cancer-induced cachexia

Shukla, S. K., Dasgupta, A., Mulder, S. E. & Singh, P. K., Jan 1 2019, Methods in Molecular Biology. Humana Press Inc., p. 321-333 13 p. (Methods in Molecular Biology; vol. 1882).

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Mouse models of pancreatic cancer: An ever-emerging arm of cancer drug discovery

Ganguly, K., Batra, S. K. & Kaur, S., Apr 17 2019, Animal Models in Cancer Drug Discovery. Elsevier, p. 249-266 18 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Mucin-1 is required for Coxsackie Virus B3-induced inflammation in pancreatitis

Liu, X., Clemens, D. L., Grunkemeyer, J. A., Price, J. D., O’Connell, K., Chapman, N. M., Storz, P., Wen, H., Cox, J. L., Reid, W. L., Hollingsworth, M. A. & Thayer, S., Dec 1 2019, In : Scientific reports. 9, 1, 10656.

Research output: Contribution to journalArticle

Open Access

Mutant p53 R175H promotes cancer initiation in the pancreas by stabilizing HSP70

Polireddy, K., Singh, K., Pruski, M., Jones, N. C., Manisundaram, N. V., Ponnela, P., Ouellette, M., Van Buren, G., Younes, M., Bynon, J. S., Dar, W. A. & Bailey, J. M., Jul 1 2019, In : Cancer Letters. 453, p. 122-130 9 p.

Research output: Contribution to journalArticle

2 Scopus citations

Nanoparticle Formulation of Indocyanine Green Improves Image-Guided Surgery in a Murine Model of Breast Cancer

Wojtynek, N. E., Olson, M. T., Bielecki, T. A., An, W., Bhat, A. M., Band, H., Lauer, S. R., Silva-Lopez, E. & Mohs, A. M., Jan 1 2019, (Accepted/In press) In : Molecular Imaging and Biology.

Research output: Contribution to journalArticle

1 Scopus citations

Neuropeptide Y receptor interactions regulate its mitogenic activity

Czarnecka, M., Lu, C., Pons, J., Maheswaran, I., Ciborowski, P., Zhang, L., Cheema, A. & Kitlinska, J., Feb 2019, In : Neuropeptides. 73, p. 11-24 14 p.

Research output: Contribution to journalArticle

1 Scopus citations

Novel intra-operative peripheral nerve agent for fluorescence guided imaging

Liu, X., Lovell, P., Cruz, D. R., Houser, L., Lagrange, C. A. & Mohs, A. M., Jan 1 2019, Clinical and Translational Neurophotonics 2020. Madsen, S. J., Yang, V. X. D. & Thakor, N. V. (eds.). SPIE, 112250J. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; vol. 11225).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Novel therapies hijack the blood-brain barrier to eradicate glioblastoma cancer stem cells

Vengoji, R., Ponnusamy, M. P., Rachagani, S., Mahapatra, S., Batra, S. K., Shonka, N. & Macha, M. A., Mar 12 2019, In : Carcinogenesis. 40, 1, p. 2-14 13 p.

Research output: Contribution to journalReview article

3 Scopus citations

O-GlcNAc Transferase Suppresses Inflammation and Necroptosis by Targeting Receptor-Interacting Serine/Threonine-Protein Kinase 3

Li, X., Gong, W., Wang, H., Li, T., Attri, K. S., Lewis, R. E., Kalil, A. C., Bhinderwala, F., Powers, R., Yin, G., Herring, L. E., Asara, J. M., Lei, Y. L., Yang, X., Rodriguez, D. A., Yang, M., Green, D. R., Singh, P. K. & Wen, H., Mar 19 2019, In : Immunity. 50, 3, p. 576-590.e6

Research output: Contribution to journalArticle

11 Scopus citations

Optimizing intracellular signaling domains for CAR NK cells in HIV immunotherapy: a comprehensive review

Zenere, G., Olwenyi, O. A., Byrareddy, S. N. & Braun, S. E., Apr 2019, In : Drug Discovery Today. 24, 4, p. 983-991 9 p.

Research output: Contribution to journalReview article

1 Scopus citations

Organic fluorescent dye-based nanomaterials: Advances in the rational design for imaging and sensing applications

Svechkarev, D. & Mohs, A. M., Jan 1 2019, In : Current medicinal chemistry. 26, 21, p. 4042-4064 23 p.

Research output: Contribution to journalReview article

4 Scopus citations

p63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas

Hsieh, M. H., Choe, J. H., Gadhvi, J., Kim, Y. J., Arguez, M. A., Palmer, M., Gerold, H., Nowak, C., Do, H., Mazambani, S., Knighton, J. K., Cha, M., Goodwin, J., Kang, M. K., Jeong, J. Y., Lee, S. Y., Faubert, B., Xuan, Z., Abel, E. D., Scafoglio, C. & 11 others, Shackelford, D. B., Minna, J. D., Singh, P. K., Shulaev, V., Bleris, L., Hoyt, K., Kim, J., Inoue, M., DeBerardinis, R. J., Kim, T. H. & Kim, J. W., Aug 13 2019, In : Cell Reports. 28, 7, p. 1860-1878.e9

Research output: Contribution to journalArticle

Open Access
10 Scopus citations

p66Shc protein through a redox mechanism enhances the progression of prostate cancer cells towards castration-resistance

Miller, D. R., Ingersoll, M. A., Chatterjee, A., Baker, B., Shrishrimal, S., Kosmacek, E. A., Zhu, Y., Cheng, P. W., Oberley-Deegan, R. E. & Lin, M. F., Aug 1 2019, In : Free Radical Biology and Medicine. 139, p. 24-34 11 p.

Research output: Contribution to journalArticle

3 Scopus citations

Paediatric acute respiratory distress syndrome incidence and epidemiology (PARDIE): an international, observational study

Pediatric Acute Respiratory Distress syndrome Incidence and Epidemiology (PARDIE) Investigators & Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network, Feb 2019, In : The Lancet Respiratory Medicine. 7, 2, p. 115-128 14 p.

Research output: Contribution to journalArticle

28 Scopus citations
2 Scopus citations

Phosphorylation of Cx43 residue Y313 by Src contributes to blocking the interaction with Drebrin and disassembling gap junctions

Zheng, L., Li, H., Cannon, A., Trease, A. J., Spagnol, G., Zheng, H., Radio, S., Patel, K., Batra, S. & Sorgen, P. L., Jan 2019, In : Journal of Molecular and Cellular Cardiology. 126, p. 36-49 14 p.

Research output: Contribution to journalArticle

1 Scopus citations

Placental epigenetics for evaluation of fetal congenital heart defects: Ventricular septal defect (VSD)

Radhakrishna, U., Albayrak, S., Zafra, R., Baraa, A., Vishweswaraiah, S., Veerappa, A. M., Mahishi, D., Saiyed, N., Mishra, N. K., Guda, C., Ali-Fehmi, R. & Bahado-Singh, R. O., Mar 2019, In : PloS one. 14, 3, e0200229.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Pluripotent Stem Cell-Derived Cerebral Organoids Reveal Human Oligodendrogenesis with Dorsal and Ventral Origins

Kim, H., Xu, R., Padmashri, R., Dunaevsky, A., Liu, Y., Dreyfus, C. F. & Jiang, P., May 14 2019, In : Stem Cell Reports. 12, 5, p. 890-905 16 p.

Research output: Contribution to journalArticle

8 Scopus citations

Pluronic block copolymers enhance the anti-myeloma activity of proteasome inhibitors

Hu, H., Petrosyan, A., Osna, N. A., Liu, T., Olou, A. A., Alakhova, D. Y., Singh, P. K., Kabanov, A. V., Faber, E. A. & Bronich, T. K., Jul 28 2019, In : Journal of Controlled Release. 306, p. 149-164 16 p.

Research output: Contribution to journalArticle

2 Scopus citations

PR55α regulatory subunit of PP2A inhibits the MOB1/LATS cascade and activates YAP in pancreatic cancer cells

Hein, A. L., Brandquist, N. D., Ouellette, C. Y., Seshacharyulu, P., Enke, C. A., Ouellette, M. M., Batra, S. K. & Yan, Y., Nov 1 2019, In : Oncogenesis. 8, 11, 63.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Promise of chemokine network-targeted nanoparticles in combination nucleic acid therapies of metastatic cancer

Xie, Y., Wang, Y., Li, J., Hang, Y. & Oupický, D., Mar 1 2019, In : Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology. 11, 2, e1528.

Research output: Contribution to journalReview article

5 Scopus citations

Prostate tumor cell exosomes containing hyaluronidase Hyal1 stimulate prostate stromal cell motility by engagement of FAK-mediated integrin signaling

McAtee, C. O., Booth, C., Elowsky, C., Zhao, L., Payne, J., Fangman, T., Caplan, S., Henry, M. D. & Simpson, M. A., May 2019, In : Matrix Biology. 78-79, p. 165-179 15 p.

Research output: Contribution to journalArticle

11 Scopus citations

PTTG1: a Unique Regulator of Stem/Cancer Stem Cells in the Ovary and Ovarian Cancer

Parte, S., Virant-Klun, I., Patankar, M., Batra, S. K., Straughn, A. & Kakar, S. S., Dec 1 2019, In : Stem Cell Reviews and Reports. 15, 6, p. 866-879 14 p.

Research output: Contribution to journalArticle

2 Scopus citations

Radiotherapy as an Adjunct to Surgery for Pancreatic Cancer: Where Are We After More Than 30 Years of Research and Trials?

Ferrantella, A., Dudeja, V. & Are, C., Dec 1 2019, In : Annals of Surgical Oncology. 26, 13, p. 4166-4167 2 p.

Research output: Contribution to journalEditorial

Open Access

Reactive oxygen species drive epigenetic changes in radiation-induced fibrosis

Shrishrimal, S., Kosmacek, E. A. & Oberley-Deegan, R. E., Jan 1 2019, In : Oxidative medicine and cellular longevity. 2019, 4278658.

Research output: Contribution to journalReview article

Open Access
13 Scopus citations

Regulation of Connexin32 by ephrin receptors and T-cell protein-tyrosine phosphatase

Trease, A. J., Li, H., Spagnol, G., Zheng, L., Stauch, K. L. & Sorgen, P. L., Jan 4 2019, In : Journal of Biological Chemistry. 294, 1, p. 341-350 10 p.

Research output: Contribution to journalArticle

Relaxin and extracellular matrix remodeling: Mechanisms and signaling pathways

Ng, H. H., Shen, M., Samuel, C. S., Schlossmann, J. & Bennett, R. G., May 1 2019, In : Molecular and Cellular Endocrinology. 487, p. 59-65 7 p.

Research output: Contribution to journalReview article

3 Scopus citations

Relaxin and fibrosis: Emerging targets, challenges, and future directions

Kanai, A. J., Konieczko, E. M., Bennett, R. G., Samuel, C. S. & Royce, S. G., May 1 2019, In : Molecular and Cellular Endocrinology. 487, p. 66-74 9 p.

Research output: Contribution to journalReview article

1 Scopus citations

Reproducibility of CRISPR-Cas9 methods for generation of conditional mouse alleles: A multi-center evaluation

Gurumurthy, C. B., O'Brien, A. R., Quadros, R. M., Adams, J., Alcaide, P., Ayabe, S., Ballard, J., Batra, S. K., Beauchamp, M. C., Becker, K. A., Bernas, G., Brough, D., Carrillo-Salinas, F., Chan, W., Chen, H., Dawson, R., Demambro, V., D'Hont, J., Dibb, K. M., Eudy, J. D. & 93 others, Gan, L., Gao, J., Gonzales, A., Guntur, A. R., Guo, H., Harms, D. W., Harrington, A., Hentges, K. E., Humphreys, N., Imai, S., Ishii, H., Iwama, M., Jonasch, E., Karolak, M., Keavney, B., Khin, N. C., Konno, M., Kotani, Y., Kunihiro, Y., Lakshmanan, I., Larochelle, C., Lawrence, C. B., Li, L., Lindner, V., Liu, X. D., Lopez-Castejon, G., Loudon, A., Lowe, J., Jerome-Majewska, L. A., Matsusaka, T., Miura, H., Miyasaka, Y., Morpurgo, B., Motyl, K., Nabeshima, Y. I., Nakade, K., Nakashiba, T., Nakashima, K., Obata, Y., Ogiwara, S., Ouellet, M., Oxburgh, L., Piltz, S., Pinz, I., Ponnusamy, M. P., Ray, D., Redder, R. J., Rosen, C. J., Ross, N., Ruhe, M. T., Ryzhova, L., Salvador, A. M., Alam, S. S., Sedlacek, R., Sharma, K., Smith, C., Staes, K., Starrs, L., Sugiyama, F., Takahashi, S., Tanaka, T., Trafford, A. W., Uno, Y., Vanhoutte, L., Vanrockeghem, F., Willis, B. J., Wright, C. S., Yamauchi, Y., Yi, X., Yoshimi, K., Zhang, X., Zhang, Y., Ohtsuka, M., Das, S., Garry, D. J., Hochepied, T., Thomas, P., Parker-Thornburg, J., Adamson, A. D., Yoshiki, A., Schmouth, J. F., Golovko, A., Thompson, W. R., Lloyd, K. C. K., Wood, J. A., Cowan, M., Mashimo, T., Mizuno, S., Zhu, H., Kasparek, P., Liaw, L., Miano, J. M. & Burgio, G., Aug 26 2019, In : Genome biology. 20, 1, 171.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Reshaping the critical role of surgeons in oncology research

Jones, R. P., Are, C., Hugh, T. J., Grünhagen, D. J., Xu, J., Balch, C. M. & Poston, G. J., May 1 2019, In : Nature Reviews Clinical Oncology. 16, 5, p. 327-332 6 p.

Research output: Contribution to journalReview article

1 Scopus citations