Research Output

Reproducibility of CRISPR-Cas9 methods for generation of conditional mouse alleles: A multi-center evaluation

Gurumurthy, C. B., O'Brien, A. R., Quadros, R. M., Adams, J., Alcaide, P., Ayabe, S., Ballard, J., Batra, S. K., Beauchamp, M. C., Becker, K. A., Bernas, G., Brough, D., Carrillo-Salinas, F., Chan, W., Chen, H., Dawson, R., Demambro, V., D'Hont, J., Dibb, K. M., Eudy, J. D. & 93 others, Gan, L., Gao, J., Gonzales, A., Guntur, A. R., Guo, H., Harms, D. W., Harrington, A., Hentges, K. E., Humphreys, N., Imai, S., Ishii, H., Iwama, M., Jonasch, E., Karolak, M., Keavney, B., Khin, N. C., Konno, M., Kotani, Y., Kunihiro, Y., Lakshmanan, I., Larochelle, C., Lawrence, C. B., Li, L., Lindner, V., Liu, X. D., Lopez-Castejon, G., Loudon, A., Lowe, J., Jerome-Majewska, L. A., Matsusaka, T., Miura, H., Miyasaka, Y., Morpurgo, B., Motyl, K., Nabeshima, Y. I., Nakade, K., Nakashiba, T., Nakashima, K., Obata, Y., Ogiwara, S., Ouellet, M., Oxburgh, L., Piltz, S., Pinz, I., Ponnusamy, M. P., Ray, D., Redder, R. J., Rosen, C. J., Ross, N., Ruhe, M. T., Ryzhova, L., Salvador, A. M., Alam, S. S., Sedlacek, R., Sharma, K., Smith, C., Staes, K., Starrs, L., Sugiyama, F., Takahashi, S., Tanaka, T., Trafford, A. W., Uno, Y., Vanhoutte, L., Vanrockeghem, F., Willis, B. J., Wright, C. S., Yamauchi, Y., Yi, X., Yoshimi, K., Zhang, X., Zhang, Y., Ohtsuka, M., Das, S., Garry, D. J., Hochepied, T., Thomas, P., Parker-Thornburg, J., Adamson, A. D., Yoshiki, A., Schmouth, J. F., Golovko, A., Thompson, W. R., Lloyd, K. C. K., Wood, J. A., Cowan, M., Mashimo, T., Mizuno, S., Zhu, H., Kasparek, P., Liaw, L., Miano, J. M. & Burgio, G., Aug 26 2019, In : Genome biology. 20, 1, 171.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Reshaping the critical role of surgeons in oncology research

Jones, R. P., Are, C., Hugh, T. J., Grünhagen, D. J., Xu, J., Balch, C. M. & Poston, G. J., May 1 2019, In : Nature Reviews Clinical Oncology. 16, 5, p. 327-332 6 p.

Research output: Contribution to journalReview article

1 Scopus citations

Responsibility and Sustainability in Brain Science, Technology, and Neuroethics in China—a Culture-Oriented Perspective

Wang, Y., Yin, J., Wang, G., Li, P., Bi, G., Li, S., Xia, X., Song, J., Pei, G. & Zheng, J. C., Feb 6 2019, In : Neuron. 101, 3, p. 375-379 5 p.

Research output: Contribution to journalShort survey

1 Scopus citations

Retromer facilitates the localization of Bcl-xL to the mitochondrial outer membrane

Farmer, T., O'Neill, K. L., Naslavsky, N., Luo, X. & Caplan, S., Jan 1 2019, In : Molecular biology of the cell. 30, 10, p. 1138-1146 9 p.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Risk factors for anastomotic leak after esophagectomy for cancer: A NSQIP procedure-targeted analysis

Hall, B. R., Flores, L. E., Parshall, Z. S., Shostrom, V. K., Are, C. & Reames, B. N., Jan 1 2019, In : Journal of Surgical Oncology. 120, 4, p. 661-669 9 p.

Research output: Contribution to journalArticle

2 Scopus citations

RNA-binding protein hur regulates both mutant and wild-type IDH1 in IDH1-mutated cancer

Zarei, M., Lal, S., Vaziri-Gohar, A., O'Hayer, K., Gunda, V., Singh, P. K., Brody, J. R. & Winter, J. M., Feb 2019, In : Molecular Cancer Research. 17, 2, p. 508-520 13 p.

Research output: Contribution to journalArticle

2 Scopus citations

Role of keratan sulfate expression in human pancreatic cancer malignancy

Leiphrakpam, P. D., Patil, P. P., Remmers, N., Swanson, B., Grandgenett, P. M., Qiu, F., Yu, F. & Radhakrishnan, P., Dec 1 2019, In : Scientific reports. 9, 1, 9665.

Research output: Contribution to journalArticle

Open Access

Role of protein arginine methyltransferase 5 in group 3 (MYC-driven) Medulloblastoma

Chaturvedi, N. K., Mahapatra, S., Kesherwani, V., Kling, M. J., Shukla, M., Ray, S., Kanchan, R., Perumal, N., McGuire, T. R., Graham Sharp, J., Joshi, S. S. & Coulter, D. W., Nov 6 2019, In : BMC cancer. 19, 1, 1056.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Secreted Metabolome of Human Macrophages Exposed to Methamphetamine

Pawlak, K., Lech, K., Vei, A., Burch, S., Zieschang, S., Jaquet, S., Yu, F., Harwood, E., Morsey, B., Fox, H. S. & Ciborowski, P., Jun 20 2019, In : Analytical chemistry. 91, 14, p. 9190-9197 8 p.

Research output: Contribution to journalArticle

Selective inhibition of histone deacetylases 1/2/6 in combination with gemcitabine: A promising combination for pancreatic cancer therapy

Laschanzky, R. S., Humphrey, L. E., Ma, J., Smith, L. M., Enke, T. J., Shukla, S. K., Dasgupta, A., Singh, P. K., Howell, G. M., Brattain, M. G., Ly, Q. P., Black, A. R. & Black, J. D., Sep 2019, In : Cancers. 11, 9, 1327.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Silencing of Neuropilins and GIPC1 in pancreatic ductal adenocarcinoma exerts multiple cellular and molecular antitumor effects

Borchardt, H., Schulz, A., Datta, K., Muders, M. H. & Aigner, A., Dec 1 2019, In : Scientific reports. 9, 1, 15471.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Smad4 loss in colorectal cancer patients correlates with recurrence, loss of immune infiltrate, and chemoresistance

Wasserman, I., Lee, L. H., Ogino, S., Marco, M. R., Wu, C., Chen, X., Datta, J., Sadot, E., Szeglin, B., Guillem, J. G., Paty, P. B., Weiser, M. R., Nash, G. M., Saltz, L., Barlas, A., Manova-Todorova, K., Uppada, S. P. B., Elghouayel, A. E., Ntiamoah, P., Glickman, J. N. & 15 others, Hamada, T., Kosumi, K., Inamura, K., Chan, A. T., Nishihara, R., Cercek, A., Ganesh, K., Kemeny, N. E., Dhawan, P., Yaeger, R., Sawyers, C. L., Garcia-Aguilar, J., Giannakis, M., Shia, J. & Joshua Smith, J., Jan 1 2019, In : Clinical Cancer Research. 25, 6, p. 1948-1956 9 p.

Research output: Contribution to journalArticle

11 Scopus citations

Small molecule ONC201 inhibits HIV-1 replication in macrophages via FOXO3a and TRAIL

Zhao, R., Li, Y., Gorantla, S., Poluektova, L. Y., Lin, H., Gao, F., Wang, H., Zhao, J., Zheng, J. C. & Huang, Y., Aug 2019, In : Antiviral Research. 168, p. 134-145 12 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Sox2 dosage: A critical determinant in the functions of Sox2 in both normal and tumor cells

Metz, E. P. & Rizzino, A., Nov 2019, In : Journal of Cellular Physiology. 234, 11, p. 19298-19306 9 p.

Research output: Contribution to journalReview article

2 Scopus citations
Open Access
3 Scopus citations

Supercell refinement: A cautionary tale

Lovelace, J., Petrícek, V., Murshudov, G. & Borgstahl, G. E. O., Sep 1 2019, In : Acta Crystallographica Section D: Structural Biology. 75, p. 852-860 9 p.

Research output: Contribution to journalArticle

Open Access

Surgical imaging of pancreatic cancer using polysaccharide-delivered near infrared fluorophores

Qi, B., Crawford, A. J., Wojtynek, N. E., Hollingsworth, M. A., Ly, Q. P. & Mohs, A. M., Jan 1 2019, Molecular-Guided Surgery: Molecules, Devices, and Applications V. Pogue, B. W. & Gioux, S. (eds.). SPIE, 108620O. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; vol. 10862).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Survival analysis of multi-omics data identifies potential prognostic markers of pancreatic ductal adenocarcinoma

Mishra, N. K., Southekal, S. & Guda, C., Jan 1 2019, In : Frontiers in Genetics. 10, JUN, 624.

Research output: Contribution to journalComment/debate

Open Access
5 Scopus citations

Synthesis and biological characterization of clicked chloroquine copolymers as macromolecular inhibitors of cancer cell migration

Yu, F., Wang, Y., Hang, Y., Tang, W., Zhao, Z. & Oupický, D., Nov 15 2019, In : Journal of Polymer Science, Part A: Polymer Chemistry. 57, 22, p. 2235-2242 8 p.

Research output: Contribution to journalArticle

1 Scopus citations

Synthesis of bioreducible polycations with controlled topologies

You, Y. Z., Yan, J. J., Yu, F., Yu, Z. Q. & Oupicky, D., Jan 1 2019, Methods in Molecular Biology. Humana Press Inc., p. 27-38 12 p. (Methods in Molecular Biology; vol. 1943).

Research output: Chapter in Book/Report/Conference proceedingChapter

Systems Biology Approach to Identify Novel Genomic Determinants for Pancreatic Cancer Pathogenesis

Khatri, I., Ganguly, K., Sharma, S., Carmicheal, J., Kaur, S., Batra, S. K. & Bhasin, M. K., Dec 1 2019, In : Scientific reports. 9, 1, 123.

Research output: Contribution to journalArticle

2 Scopus citations

Targeted drug delivery and image-guided therapy of heterogeneous ovarian cancer using HER2-targeted theranostic nanoparticles

Satpathy, M., Wang, L., Zielinski, R. J., Qian, W., Wang, Y. A., Mohs, A. M., Kairdolf, B. A., Ji, X., Capala, J., Lipowska, M., Nie, S., Mao, H. & Yang, L., Jan 1 2019, In : Theranostics. 9, 3, p. 778-795 18 p.

Research output: Contribution to journalArticle

Open Access
12 Scopus citations

Targeting fatty acid synthase to inhibit tumor growth and overcome taxane resistance

Souchek, J. J., Muraskin, L., Houser, L., Vu, Q. & Mohs, A. M., Jan 1 2019, Visualizing and Quantifying Drug Distribution in Tissue III. Chan, K. F. & Evans, C. L. (eds.). SPIE, 1085909. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; vol. 10859).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Targeting IκappaB kinases for cancer therapy

Awasthee, N., Rai, V., Chava, S., Nallasamy, P., Kunnumakkara, A. B., Bishayee, A., Chauhan, S. C., Challagundla, K. B. & Gupta, S. C., Jun 2019, In : Seminars in Cancer Biology. 56, p. 12-24 13 p.

Research output: Contribution to journalReview article

13 Scopus citations

Targeting LIF-mediated paracrine interaction for pancreatic cancer therapy and monitoring

Shi, Y., Gao, W., Lytle, N. K., Huang, P., Yuan, X., Dann, A. M., Ridinger-Saison, M., DelGiorno, K. E., Antal, C. E., Liang, G., Atkins, A. R., Erikson, G., Sun, H., Meisenhelder, J., Terenziani, E., Woo, G., Fang, L., Santisakultarm, T. P., Manor, U., Xu, R. & 18 others, Becerra, C. R., Borazanci, E., Von Hoff, D. D., Grandgenett, P. M., Hollingsworth, M. A., Leblanc, M., Umetsu, S. E., Collisson, E. A., Scadeng, M., Lowy, A. M., Donahue, T. R., Reya, T., Downes, M., Evans, R. M., Wahl, G. M., Pawson, T., Tian, R. & Hunter, T., May 2 2019, In : Nature. 569, 7754, p. 131-135 5 p.

Research output: Contribution to journalArticle

27 Scopus citations

The Best Approach to Esophagectomy: Do We Know Yet?

Yanala, U. R., Are, C. & Dhir, M., Jul 15 2019, In : Annals of Surgical Oncology. 26, 7, p. 1976-1978 3 p.

Research output: Contribution to journalEditorial

Open Access

The cell biology of the hepatocyte: A membrane trafficking machine

Schulze, R. J., Schott, M. B., Casey, C. A., Tuma, P. L. & McNiven, M. A., Jan 1 2019, In : Journal of Cell Biology. 218, 7, p. 2096-2112 17 p.

Research output: Contribution to journalReview article

Open Access
4 Scopus citations

The effect of gender on operative autonomy in general surgery residents

Procedural Learning and Safety Collaborative, Nov 2019, In : Surgery (United States). 166, 5, p. 738-743 6 p.

Research output: Contribution to journalArticle

3 Scopus citations

The glycan CA19-9 promotes pancreatitis and pancreatic cancer in mice

Engle, D. D., Tiriac, H., Rivera, K. D., Pommier, A., Whalen, S., Oni, T. E., Alagesan, B., Lee, E. J., Yao, M. A., Lucito, M. S., Spielman, B., Silva, B. D., Schoepfer, C., Wright, K., Creighton, B., Afinowicz, L., Yu, K. H., Grützmann, R., Aust, D., Gimotty, P. A. & 8 others, Pollard, K. S., Hruban, R. H., Goggins, M. G., Pilarsky, C., Park, Y., Pappin, D. J., Hollingsworth, M. A. & Tuveson, D. A., Jan 1 2019, In : Science. 364, 6446, p. 1156-1162 7 p.

Research output: Contribution to journalArticle

19 Scopus citations

The glycoprotein mucin-1 negatively regulates GalNAc transferase 5 expression in pancreatic cancer

Caffrey, T., Sagar, S., Thomas, D., Lewallen, M. E., Hollingsworth, M. A. & Radhakrishnan, P., Oct 1 2019, In : FEBS Letters. 593, 19, p. 2751-2761 11 p.

Research output: Contribution to journalArticle

The integrated National NeuroAIDS Tissue Consortium database: A rich platform for neuroHIV research

Heithoff, A. J., Totusek, S. A., Le, D., Barwick, L., Gensler, G., Franklin, D. R., Dye, A. C., Pandey, S., Sherman, S., Guda, C. & Fox, H. S., Jan 8 2019, In : Database. 2019, bay134.

Research output: Contribution to journalArticle

2 Scopus citations

The ion channel, TRPM2, contributes to the pathogenesis of radiodermatitis

Perraud, A. L., Rao, D. M., Kosmacek, E. A., Dagunts, A., Oberley-Deegan, R. E. & Gally, F., Mar 8 2019, In : Radiation and Environmental Biophysics. 58, 1, p. 89-98 10 p.

Research output: Contribution to journalArticle

The Journey of HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs) from Lab to Clinic

Namasivayam, V., Vanangamudi, M., Kramer, V. G., Kurup, S., Zhan, P., Liu, X., Kongsted, J. & Byrareddy, S. N., May 23 2019, In : Journal of Medicinal Chemistry. 62, 10, p. 4851-4883 33 p.

Research output: Contribution to journalReview article

23 Scopus citations

The miR-17~92 cluster activates mTORC1 in mantle cell lymphoma by targeting multiple regulators in the STK11/AMPK/TSC/mTOR pathway

Jiang, C., Bi, C., Jiang, X., Tian, T., Huang, X., Wang, C., Fernandez, M. R., Iqbal, J., Chan, W. C., McKeithan, T. W., Lewis, R. E. & Fu, K., May 2019, In : British Journal of Haematology. 185, 3, p. 616-620 5 p.

Research output: Contribution to journalLetter

1 Scopus citations

The mitochondrial deoxyguanosine kinase is required for cancer cell stemness in lung adenocarcinoma

Lin, S., Huang, C., Sun, J., Bollt, O., Wang, X., Martine, E., Kang, J., Taylor, M. D., Fang, B., Singh, P. K., Koomen, J., Hao, J. & Yang, S., Dec 1 2019, In : EMBO Molecular Medicine. 11, 12, e10849.

Research output: Contribution to journalArticle

Open Access

The neuroprotection of KIBRA in promoting neuron survival and against amyloid β-induced apoptosis

Song, L., Tang, S., Dong, L., Han, X., Cong, L., Dong, J., Han, X., Zhang, Q., Wang, Y. & Du, Y., Apr 12 2019, In : Frontiers in Cellular Neuroscience. 13, 137.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Thermodynamic contributions for the inclusion of bulges and mismatches in dna hairpin loops

Shikiya, R. & Marky, L. A., Jun 5 2019, A Closer Look at Calorimetry. Nova Science Publishers, Inc., p. 31-60 30 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Thermodynamic investigation of kissing-loop interactions

Carr, C. E. & Marky, L. A., Feb 2019, In : Biochimie. 157, p. 177-183 7 p.

Research output: Contribution to journalArticle

The role of alcohol-induced Golgi fragmentation for androgen receptor signaling in prostate cancer

Manca, S., Frisbie, C. P., LaGrange, C. A., Casey, C. A., Riethoven, J. J. M. & Petrosyan, A., Jan 1 2019, In : Molecular Cancer Research. 17, 1, p. 225-237 13 p.

Research output: Contribution to journalArticle

3 Scopus citations

The role of exosomes and MYC in therapy resistance of acute myeloid leukemia: Challenges and opportunities

Mudgapalli, N., Nallasamy, P., Chava, H., Chava, S., Pathania, A. S., Gunda, V., Gorantla, S., Pandey, M. K., Gupta, S. C. & Challagundla, K. B., Dec 2019, In : Molecular Aspects of Medicine. 70, p. 21-32 12 p.

Research output: Contribution to journalReview article

1 Scopus citations

The Transcribed-Ultra Conserved Regions: Novel non-coding RNA players in neuroblastoma progression

Mudgapalli, N., Shaw, B. P., Chava, S. & Challagundla, K. B., Jan 1 2019, In : Non-coding RNA. 5, 2, 39.

Research output: Contribution to journalReview article

Open Access

The Value of Commission on Cancer Accreditation: Improving Survival Outcomes by Enhancing Compliance with Quality Measures

Misra, S., Fan, J., Yanala, U. & Are, C., Jan 1 2019, In : Annals of Surgical Oncology.

Research output: Contribution to journalEditorial

Tight junction proteins in gastrointestinal and liver disease

Zeisel, M. B., Dhawan, P. & Baumert, T. F., Mar 1 2019, In : Gut. 68, 3, p. 547-561 15 p.

Research output: Contribution to journalReview article

18 Scopus citations

Timely expression and activation of YAP1 in granulosa cells is essential for ovarian follicle development

Lv, X., He, C., Huang, C., Wang, H., Hua, G., Wang, Z., Zhou, J., Chen, X., Ma, B., Timm, B. K., Maclin, V., Dong, J., Rueda, B. R., Davis, J. S. & Wang, C., Sep 1 2019, In : FASEB Journal. 33, 9, p. 10049-10064 16 p.

Research output: Contribution to journalArticle

5 Scopus citations

Treatment of acute lung injury and early- and late-stage pulmonary fibrosis with combination emulsion siRNA polyplexes

Wang, Y., Ding, L., Li, Z., Chen, G., Sun, M. & Oupicky, D., Nov 28 2019, In : Journal of Controlled Release. 314, p. 12-24 13 p.

Research output: Contribution to journalArticle

2 Scopus citations

Trefoil factor(s) and CA19.9: A promising panel for early detection of pancreatic cancer

Jahan, R., Ganguly, K., Smith, L. M., Atri, P., Carmicheal, J., Sheinin, Y., Rachagani, S., Natarajan, G., Brand, R. E., Macha, M. A., Grandgenett, P. M., Kaur, S. & Batra, S. K., Apr 2019, In : EBioMedicine. 42, p. 375-385 11 p.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Truncated O-glycans promote epithelial-to-mesenchymal transition and stemness properties of pancreatic cancer cells

Thomas, D., Sagar, S., Caffrey, T., Grandgenett, P. M. & Radhakrishnan, P., Oct 1 2019, In : Journal of cellular and molecular medicine. 23, 10, p. 6885-6896 12 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Tumor‐associated neutrophils in cancer: Going pro

Wu, L., Saxena, S., Awaji, M. & Singh, R. K., Apr 2019, In : Cancers. 11, 4, 564.

Research output: Contribution to journalArticle

Open Access
24 Scopus citations

Tumor-stromal crosstalk in pancreatic cancer and tissue fibrosis

Thomas, D. & Radhakrishnan, P., Jan 21 2019, In : Molecular cancer. 18, 1, 14.

Research output: Contribution to journalReview article

30 Scopus citations