Research Output

2019

Vitamin e δ-tocotrienol sensitizes human pancreatic cancer cells to TRAIL-induced apoptosis through proteasome-mediated down-regulation of c-FLIPs

Francois, R. A., Zhang, A., Husain, K., Wang, C., Hutchinson, S., Kongnyuy, M., Batra, S. K., Coppola, D., Sebti, S. M. & Malafa, M. P., Jul 22 2019, In : Cancer Cell International. 19, 1, 189.

Research output: Contribution to journalArticle

Open Access

YAP1-LATS2 feedback loop dictates senescent or malignant cell fate to maintain tissue homeostasis

He, C., Lv, X., Huang, C., Hua, G., Ma, B., Chen, X., Angeletti, P. C., Dong, J., Zhou, J., Wang, Z., Rueda, B. R., Davis, J. S. & Wang, C., Mar 2019, In : EMBO Reports. 20, 3, e44948.

Research output: Contribution to journalArticle

3 Scopus citations

Zika Virus and the Metabolism of Neuronal Cells

Rothan, H. A., Fang, S., Mahesh, M. & Byrareddy, S. N., Apr 1 2019, In : Molecular Neurobiology. 56, 4, p. 2551-2557 7 p.

Research output: Contribution to journalReview article

10 Scopus citations

ω-Hydroxy isoprenoid bisphosphonates as linkable GGDPS inhibitors

Bhuiyan, N. H., Varney, M. L., Bhattacharya, D. S., Payne, W. M., Mohs, A. M., Holstein, S. A. & Wiemer, D. F., Oct 1 2019, In : Bioorganic and Medicinal Chemistry Letters. 29, 19, 126633.

Research output: Contribution to journalArticle

2018

3D Bioprinting of Breast Cancer Models for Drug Resistance Study

Wang, Y., Shi, W., Kuss, M., Mirza, S., Qi, D., Krasnoslobodtsev, A. V., Zeng, J., Band, H., Band, V. & Duan, B., Dec 10 2018, In : ACS Biomaterials Science and Engineering. 4, 12, p. 4401-4411 11 p.

Research output: Contribution to journalArticle

11 Scopus citations

3D hydrogel breast cancer models for studying the effects of hypoxia on epithelial to mesenchymal transition

Wang, Y., Mirza, S., Wu, S., Zeng, J., Shi, W., Band, H., Band, V. & Duan, B., Aug 14 2018, In : Oncotarget. 9, 63, p. 32191-32203 13 p.

Research output: Contribution to journalArticle

10 Scopus citations

Advanced pancreatic cancer: A meta-analysis of clinical trials over thirty years

Hall, B. R., Cannon, A., Atri, P., Wichman, C. S., Smith, L. M., Ganti, A. K., Are, C., Sasson, A. R., Kumar, S. & Batra, S. K., Apr 10 2018, In : Oncotarget. 9, 27, p. 19396-19405 10 p.

Research output: Contribution to journalArticle

11 Scopus citations

Advances in Stimulus-Responsive Polymeric Materials for Systemic Delivery of Nucleic Acids

Sun, M., Wang, K. & Oupický, D., Feb 21 2018, In : Advanced Healthcare Materials. 7, 4, 1701070.

Research output: Contribution to journalArticle

15 Scopus citations

A Functional Signature Ontology (FUSION) screen detects an AMPK inhibitor with selective toxicity toward human colon tumor cells

Das, B., Neilsen, B. K., Fisher, K. W., Gehring, D., Hu, Y., Volle, D. J., Kim, H. S., McCall, J. L., Kelly, D. L., MacMillan, J. B., White, M. A. & Lewis, R. E., Dec 1 2018, In : Scientific reports. 8, 1, 3770.

Research output: Contribution to journalArticle

7 Scopus citations

Analysis of sulfates on low molecular weight heparin using mass spectrometry: structural characterization of enoxaparin

Gupta, R. & Ponnusamy, M. P., Jun 3 2018, In : Expert Review of Proteomics. 15, 6, p. 503-513 11 p.

Research output: Contribution to journalReview article

1 Scopus citations

A networked swellable dextrin nanogels loading Bcl2 siRNA for melanoma tumor therapy

Li, H., Zhou, Z., Zhang, F., Guo, Y., Yang, X., Jiang, H., Tan, F., Oupicky, D. & Sun, M., Sep 1 2018, In : Nano Research. 11, 9, p. 4627-4642 16 p.

Research output: Contribution to journalArticle

5 Scopus citations

An Mtb-Human Protein-Protein Interaction Map Identifies a Switch between Host Antiviral and Antibacterial Responses

Penn, B. H., Netter, Z., Johnson, J. R., Von Dollen, J., Jang, G. M., Johnson, T., Ohol, Y. M., Maher, C., Bell, S. L., Geiger, K., Golovkine, G., Du, X., Choi, A., Parry, T., Mohapatra, B. C., Storck, M. D., Band, H., Chen, C., Jäger, S., Shales, M. & 5 others, Portnoy, D. A., Hernandez, R., Coscoy, L., Cox, J. S. & Krogan, N. J., Aug 16 2018, In : Molecular Cell. 71, 4, p. 637-648.e5

Research output: Contribution to journalArticle

18 Scopus citations

An update on minding the gap in cancer

Mesnil, M., Aasen, T., Boucher, J., Chépied, A., Cronier, L., Defamie, N., Kameritsch, P., Laird, D. W., Lampe, P. D., Lathia, J. D., Leithe, E., Mehta, P. P., Monvoisin, A., Pogoda, K., Sin, W. C., Tabernero, A., Yamasaki, H., Yeh, E. S., Dagli, M. L. Z. & Naus, C. C., Jan 2018, In : Biochimica et Biophysica Acta - Biomembranes. 1860, 1, p. 237-243 7 p.

Research output: Contribution to journalReview article

9 Scopus citations

A review of the catalytic mechanism of human manganese superoxide dismutase

Azadmanesh, J. & Borgstahl, G. E. O., Feb 2018, In : Antioxidants. 7, 2, 25.

Research output: Contribution to journalReview article

29 Scopus citations

ATP-activated decrosslinking and charge-reversal vectors for siRNA delivery and cancer therapy

Zhou, Z., Zhang, Q., Zhang, M., Li, H., Chen, G., Qian, C., Oupicky, D. & Sun, M., Jan 1 2018, In : Theranostics. 8, 17, p. 4604-4619 16 p.

Research output: Contribution to journalArticle

10 Scopus citations

Axed MUC4 (MUC4/X) aggravates pancreatic malignant phenotype by activating integrin-β1/FAK/ERK pathway

Jahan, R., Macha, M. A., Rachagani, S., Das, S., Smith, L. M., Kaur, S. & Batra, S. K., Aug 2018, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1864, 8, p. 2538-2549 12 p.

Research output: Contribution to journalArticle

7 Scopus citations

Bioreduction-ruptured nanogel for switch on/off release of Bcl2 siRNA in breast tumor therapy

Li, H., Yang, X., Gao, F., Qian, C., Li, C., Oupicky, D. & Sun, M., Dec 28 2018, In : Journal of Controlled Release. 292, p. 78-90 13 p.

Research output: Contribution to journalArticle

9 Scopus citations

Biphasic changes in airway epithelial cell EGF receptor binding and phosphorylation induced by components of hogbarn dust

Dodmane, P. R., Schulte, N. A., Heires, A. J., Band, H., Romberger, D. J. & Toews, M. L., Nov 26 2018, In : Experimental Lung Research. 44, 10, p. 443-454 12 p.

Research output: Contribution to journalArticle

Burnout, substance abuse, and suicide: A surgical perspective

Are, C., Caniglia, A. J., Sharma, A. & Gold, J. P., Jan 1 2018, Practical Ethics for the Surgeon. Wolters Kluwer Health Adis (ESP), p. 229-262 34 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Carbamoylated erythropoietin modulates cognitive outcomes of social defeat and differentially regulates gene expression in the dorsal and ventral hippocampus

Sathyanesan, M., Watt, M. J., Haiar, J. M., Scholl, J. L., Davies, S. R., Paulsen, R. T., Wiederin, J., Ciborowski, P. & Newton, S. S., Dec 1 2018, In : Translational Psychiatry. 8, 1, 113.

Research output: Contribution to journalArticle

4 Scopus citations

Cathelicidin-derived antimicrobial peptides inhibit Zika virus through direct inactivation and interferon pathway

He, M., Zhang, H., Li, Y., Wang, G., Tang, B., Zhao, J., Huang, Y. & Zheng, J., Apr 12 2018, In : Frontiers in immunology. 9, APR, 722.

Research output: Contribution to journalArticle

19 Scopus citations

Characterization of CDK(5) inhibitor, 20-223 (aka CP668863) for colorectal cancer therapy

Robb, C. M., Kour, S., Contreras, J. I., Agarwal, E., Barger, C. J., Rana, S., Sonawane, Y., Neilsen, B. K., Taylor, M., Kizhake, S., Thakare, R. N., Chowdhury, S., Wang, J., Black, J. D., Hollingsworth, M. A., Brattain, M. G. & Natarajan, A., Jan 1 2018, In : Oncotarget. 9, 4, p. 5216-5232 17 p.

Research output: Contribution to journalArticle

8 Scopus citations

Characterization of stem cell and cancer stem cell populations in ovary and ovarian tumors

Parte, S. C., Batra, S. K. & Kakar, S. S., Aug 18 2018, In : Journal of Ovarian Research. 11, 1, 69.

Research output: Contribution to journalArticle

14 Scopus citations

Charge and Assembly Reversible Micelles Fueled by Intracellular ATP for Improved siRNA Transfection

Zhou, Z., Li, C., Zhang, M., Zhang, Q., Qian, C., Oupicky, D. & Sun, M., Sep 26 2018, In : ACS Applied Materials and Interfaces. 10, 38, p. 32026-32037 12 p.

Research output: Contribution to journalArticle

9 Scopus citations

Chemical Genetic Screens Identify Kinase Inhibitor Combinations that Target Anti-Apoptotic Proteins for Cancer Therapy

Contreras, J. I., Robb, C. M., King, H. M., Baxter, J., Crawford, A. J., Kour, S., Kizhake, S., Sonawane, Y. A., Rana, S., Hollingsworth, M. A., Luo, X. & Natarajan, A., May 18 2018, In : ACS chemical biology. 13, 5, p. 1148-1152 5 p.

Research output: Contribution to journalArticle

4 Scopus citations

Cholangiocarcinoma therapy with nanoparticles that combine downregulation of MicroRNA-210 with inhibition of cancer cell invasiveness

Xie, Y., Wang, Y., Li, J., Hang, Y., Jaramillo, L., Wehrkamp, C. J., Phillippi, M. A., Mohr, A. M., Chen, Y., Talmon, G. A., Mott, J. L. & Oupicky, D., Jan 1 2018, In : Theranostics. 8, 16, p. 4305-4320 16 p.

Research output: Contribution to journalArticle

8 Scopus citations

Cholesterol Modification Enhances Antimetastatic Activity and siRNA Delivery Efficacy of Poly(ethylenimine)-Based CXCR4 Antagonists

Wu, P., Luo, X., Wu, H., Yu, F., Wang, K., Sun, M. & Oupicky, D., Nov 2018, In : Macromolecular Bioscience. 18, 11, 1800234.

Research output: Contribution to journalArticle

3 Scopus citations

Cigarette smoke and HIV synergistically affect lung pathology in cynomolgus macaques

Chand, H. S., Vazquez-Guillamet, R., Royer, C., Rudolph, K., Mishra, N., Singh, S. P., Hussain, S. S., Barrett, E., Callen, S., Byrareddy, S. N., Vazquez Guillamet, M. C., Abukhalaf, J., Sheybani, A., Exil, V., Raizada, V., Agarwal, H., Nair, M., Villinger, F., Buch, S. & Sopori, M., Dec 3 2018, In : Journal of Clinical Investigation. 128, 12, p. 5428-5433 6 p.

Research output: Contribution to journalArticle

5 Scopus citations

Cigarette Smoke Induces Stem Cell Features of Pancreatic Cancer Cells via PAF1

Nimmakayala, R. K., Seshacharyulu, P., Lakshmanan, I., Rachagani, S., Chugh, S., Karmakar, S., Rauth, S., Vengoji, R., Atri, P., Talmon, G. A., Lele, S. M., Smith, L. M., Thapa, I., Bastola, D., Ouellette, M. M., Batra, S. K. & Ponnusamy, M. P., Sep 2018, In : Gastroenterology. 155, 3, p. 892-908.e6

Research output: Contribution to journalArticle

19 Scopus citations

Combination of mAb-AR20.5, anti-PD-L1 and PolyICLC inhibits tumor progression and prolongs survival of MUC1.Tg mice challenged with pancreatic tumors

Mehla, K., Tremayne, J., Grunkemeyer, J. A., O’Connell, K. A., Steele, M. M., Caffrey, T. C., Zhu, X., Yu, F., Singh, P. K., Schultes, B. C., Madiyalakan, R., Nicodemus, C. F. & Hollingsworth, M. A., Mar 1 2018, In : Cancer Immunology, Immunotherapy. 67, 3, p. 445-457 13 p.

Research output: Contribution to journalArticle

8 Scopus citations

Comparative molecular characterization of typical and exceptional responders in glioblastoma

Wipfler, K., Cornish, A. S. & Guda, C., Jun 19 2018, In : Oncotarget. 9, 47, p. 28421-28433 13 p.

Research output: Contribution to journalArticle

5 Scopus citations

Concise Review: Current Status of Three-Dimensional Organoids as Preclinical Models

Kaushik, G., Ponnusamy, M. P. & Batra, S. K., Sep 2018, In : STEM CELLS. 36, 9, p. 1329-1340 12 p.

Research output: Contribution to journalReview article

21 Scopus citations

Conjugate Polyplexes with Anti-Invasive Properties and Improved siRNA Delivery in Vivo

Chen, Y., Li, J. & Oupický, D., Feb 21 2018, In : Bioconjugate Chemistry. 29, 2, p. 296-305 10 p.

Research output: Contribution to journalArticle

2 Scopus citations

Connexin43 carboxyl-terminal domain directly interacts with β-catenin

Spagnol, G., Trease, A. J., Zheng, L., Gutierrez, M., Basu, I., Sarmiento, C., Moore, G., Cervantes, M. & Sorgen, P. L., Jun 2018, In : International journal of molecular sciences. 19, 6, 1562.

Research output: Contribution to journalArticle

11 Scopus citations

Coordination-driven assembly of catechol-modified chitosan for the kidney-specific delivery of salvianolic acid B to treat renal fibrosis

Li, J., Zhang, C., He, W., Qiao, H., Chen, J., Wang, K., Oupický, D. & Sun, M., Jan 2018, In : Biomaterials Science. 6, 1, p. 179-188 10 p.

Research output: Contribution to journalArticle

12 Scopus citations

Correction: An essential role of cbl and cbl-b ubiquitin ligases in mammary stem cell maintenance (doi: 10.1242/dev.138164)

Mohapatra, B., Zutshi, N., An, W., Goetz, B., Arya, P., Bielecki, T. A., Mushtaq, I., Storck, M. D., Meza, J. L., Band, V. & Band, H., Jan 1 2018, In : Development (Cambridge). 145, 21, dev172650.

Research output: Contribution to journalComment/debate

1 Scopus citations

Correction: KSR1 is required for cell cycle reinitiation following DNA damage.(Journal of Biological Chemistry (2018)284 (6705– 6715))

Razidlo, G. L., Johnson, H. J., Stoeger, S. M., Cowan, K. H., Bessho, T. & Lewis, R. E., Dec 7 2018, In : Journal of Biological Chemistry. 293, 49, 1 p.

Research output: Contribution to journalComment/debate

Current concerns and perspectives on Zika virus co-infection with arboviruses and HIV

Rothan, H. A., Bidokhti, M. R. M. & Byrareddy, S. N., May 2018, In : Journal of Autoimmunity. 89, p. 11-20 10 p.

Research output: Contribution to journalReview article

24 Scopus citations

Current Status and Future Directions in Colorectal Cancer

Meyer, B. & Are, C., Dec 1 2018, In : Indian Journal of Surgical Oncology. 9, 4, p. 440-441 2 p.

Research output: Contribution to journalEditorial

Cyclam-Modified PEI for Combined VEGF siRNA Silencing and CXCR4 Inhibition to Treat Metastatic Breast Cancer

Zhou, Y., Yu, F., Zhang, F., Chen, G., Wang, K., Sun, M., Li, J. & Oupický, D., Feb 12 2018, In : Biomacromolecules. 19, 2, p. 392-401 10 p.

Research output: Contribution to journalArticle

14 Scopus citations

Cyclin-dependent kinase 1-mediated phosphorylation of YES links mitotic arrest and apoptosis during antitubulin chemotherapy

Wang, Z., Chen, X., Zhong, M. Z., Yang, S., Zhou, J., Klinkebiel, D. L., Karpf, A. R., Chen, Y. & Dong, J., Dec 2018, In : Cellular Signalling. 52, p. 137-146 10 p.

Research output: Contribution to journalArticle

3 Scopus citations

Demethylase JMJD6 as a New Regulator of Interferon Signaling: Effects of HCV and Ethanol Metabolism

Ganesan, M., Tikhanovich, I., Vangimalla, S. S., Dagur, R. S., Wang, W., Poluektova, L. I., Sun, Y., Mercer, D. F., Tuma, D., Weinman, S. A., Kharbanda, K. K. & Osna, N. A., 2018, In : CMGH. 5, 2, p. 101-112 12 p.

Research output: Contribution to journalArticle

8 Scopus citations

Desmoplasia in pancreatic ductal adenocarcinoma: Insight into pathological function and therapeutic potential

Cannon, A., Thompson, C., Hall, B. R., Jain, M., Kumar, S. & Batra, S. K., Mar 2018, In : Genes and Cancer. 9, 3-4, p. 78-86 9 p.

Research output: Contribution to journalArticle

9 Scopus citations

Development and characterization of carboxy-terminus specific monoclonal antibodies for understanding MUC16 cleavage in human ovarian cancer

Aithal, A., Junker, W. M., Kshirsagar, P., Das, S., Kaur, S., Orzechowski, C., Gautam, S. K., Jahan, R., Sheinin, Y. M., Lakshmanan, I., Ponnusamy, M. P., Batra, S. K. & Jain, M., Apr 2018, In : PloS one. 13, 4, e0193907.

Research output: Contribution to journalArticle

3 Scopus citations

Development of colloidally stable carbazole-based fluorescent nanoaggregates

Svechkarev, D., Kyrychenko, A., Payne, W. M. & Mohs, A. M., Feb 1 2018, In : Journal of Photochemistry and Photobiology A: Chemistry. 352, p. 55-64 10 p.

Research output: Contribution to journalArticle

3 Scopus citations

Development of fluorinated polyplex nanoemulsions for improved small interfering RNA delivery and cancer therapy

Chen, G., Wang, K., Wu, P., Wang, Y., Zhou, Z., Yin, L., Sun, M. & Oupický, D., Jul 1 2018, In : Nano Research. 11, 7, p. 3746-3761 16 p.

Research output: Contribution to journalArticle

10 Scopus citations

Dileucine-like motifs in the C-terminal tail of connexin32 control its endocytosis and assembly into gap junctions

Ray, A., Katoch, P., Jain, N. & Mehta, P. P., Mar 1 2018, In : Journal of cell science. 131, 5, jcs207340.

Research output: Contribution to journalArticle

2 Scopus citations

Direct conversion of mouse astrocytes into neural progenitor cells and specific lineages of neurons

Ma, K., Deng, X., Xia, X., Fan, Z., Qi, X., Wang, Y., Li, Y., Ma, Y., Chen, Q., Peng, H., Ding, J., Li, C., Huang, Y., Tian, C. & Zheng, J. C., Nov 5 2018, In : Translational Neurodegeneration. 7, 1, 29.

Research output: Contribution to journalArticle

9 Scopus citations

Discovery of novel and clinically relevant markers in formalin-fixed paraffin-embedded esophageal cancer specimen

Abdo, J., Wichman, C. S., Dietz, N. E., Ciborowski, P., Fleegel, J., Mittal, S. K. & Agrawal, D. K., May 9 2018, In : Frontiers in Oncology. 8, MAY, 157.

Research output: Contribution to journalArticle

1 Scopus citations