Center for Molecular Target Discovery & Development

Research Output

Filter
Article
2020

Amides as bioisosteres of triazole-based geranylgeranyl diphosphate synthase inhibitors

Goetz, D. B., Varney, M. L., Wiemer, D. F. & Holstein, S. A., Aug 15 2020, In : Bioorganic and Medicinal Chemistry. 28, 16, 115604.

Research output: Contribution to journalArticle

BAX-dependent mitochondrial pathway mediates the crosstalk between ferroptosis and apoptosis

Lee, Y. S., Kalimuthu, K., Park, Y. S., Luo, X., Choudry, M. H. A., Bartlett, D. L. & Lee, Y. J., 2020, (Accepted/In press) In : Apoptosis.

Research output: Contribution to journalArticle

Daratumumab, lenalidomide, bortezomib, and dexamethasone for transplant-eligible newly diagnosed multiple myeloma: the GRIFFIN trial

Voorhees, P. M., Kaufman, J. L., Laubach, J., Sborov, D. W., Reeves, B., Rodriguez, C., Chari, A., Silbermann, R., Costa, L. J., Anderson, L. D., Nathwani, N., Shah, N., Efebera, Y. A., Holstein, S. A., Costello, C., Jakubowiak, A., Wildes, T. M., Orlowski, R. Z., Shain, K. H., Cowan, A. J. & 9 others, Murphy, S., Lutska, Y., Pei, H., Ukropec, J., Vermeulen, J., de Boer, C., Hoehn, D., Lin, T. S. & Richardson, P. G., Aug 20 2020, In : Blood. 136, 8, p. 936-945 10 p.

Research output: Contribution to journalArticle

Open Access

Development of a MUC16-Targeted Near-Infrared Fluorescent Antibody Conjugate for Intraoperative Imaging of Pancreatic Cancer

Olson, M. T., Wojtynek, N. E., Talmon, G. A., Caffrey, T. C., Radhakrishnan, P., Ly, Q. P., Hollingsworth, M. A. & Mohs, A. M., Aug 1 2020, In : Molecular cancer therapeutics. 19, 8, p. 1670-1681 12 p.

Research output: Contribution to journalArticle

Discovery, synthesis and characterization of a series of 7-aryl-imidazo[1,2-a]pyridine-3-ylquinolines as activin-like kinase (ALK) inhibitors

Engers, D. W., Bollinger, S. R., Felts, A. S., Vadukoot, A. K., Williams, C. H., Blobaum, A. L., Lindsley, C. W., Hong, C. C. & Hopkins, C. R., Sep 15 2020, In : Bioorganic and Medicinal Chemistry Letters. 30, 18, 127418.

Research output: Contribution to journalArticle

DNA polymerase δ proofreads errors made by DNA polymerase e

Bulock, C. R., Xing, X. & Shcherbakova, P. V., Mar 17 2020, In : Proceedings of the National Academy of Sciences of the United States of America. 117, 11, p. 6035-6041 7 p.

Research output: Contribution to journalArticle

Open Access

EHD1 and RUSC2 control basal epidermal growth factor receptor cell surface expression and recycling

Tom, E. C., Mushtaq, I., Mohapatra, B. C., Luan, H., Bhat, A. M., Zutshi, N., Chakraborty, S., Islam, N., Arya, P., Bielecki, T. A., Iseka, F. M., Bhattacharyya, S., Cypher, L. R., Goetz, B. T., Negi, S. K., Storck, M. D., Rana, S., Barnekow, A., Singh, P. K., Ying, G. & 4 others, Guda, C., Natarajan, A., Band, V. & Banda, H., Apr 1 2020, In : Molecular and cellular biology. 40, 7, e00434.

Research output: Contribution to journalArticle

1 Scopus citations

Endohyphal bacteria associated with virulence, increased expression of fumonisin biosynthetic genes, and production of fumonisin and macroconidia in Fusarium fujikuroi W343

Obasa, K., Adesemoye, A., Obasa, R., Moraga-Amador, D., Shinogle, H., Alvarez, S. & Kelley, K., Jan 1 2020, In : Plant Pathology. 69, 1, p. 87-100 14 p.

Research output: Contribution to journalArticle

Fluorescent Sensor Arrays Can Predict and Quantify the Composition of Multicomponent Bacterial Samples

Svechkarev, D., Sadykov, M. R., Houser, L. J., Bayles, K. W. & Mohs, A. M., Jan 15 2020, In : Frontiers in Chemistry. 7, 916.

Research output: Contribution to journalArticle

Open Access

High-throughput identification of protein functional similarities using a gene-expression-based siRNA screen

Neilsen, B. K., Kelly, D. L., Chakraborty, B., Kim, H. S., White, M. A., Lewis, R. E. & Fisher, K. W., Dec 1 2020, In : Scientific Data. 7, 1, 27.

Research output: Contribution to journalArticle

Open Access

Homologous Recombination Repair Truncations Predict Hypermutation in Microsatellite Stable Colorectal and Endometrial Tumors

Lee, M., Eng, G., Barbari, S. R., Deshpande, V., Shcherbakova, P. V. & Gala, M. K., Mar 1 2020, In : Clinical and translational gastroenterology. 11, 3, p. e00149

Research output: Contribution to journalArticle

Open Access

Kilbournase, a protease-associated domain subtilase secreted by the fungal corn pathogen Stenocarpella maydis

Naumann, T. A., Naldrett, M. J. & Price, N. P. J., Aug 2020, In : Fungal Genetics and Biology. 141, 103399.

Research output: Contribution to journalArticle

KVA-D-88, a Novel Preferable Phosphodiesterase 4B Inhibitor, Decreases Cocaine-Mediated Reward Properties in Vivo

Burkovetskaya, M. E., Liu, Q., Vadukoot, A. K., Gautam, N., Alnouti, Y., Kumar, S., Miczek, K., Buch, S., Hopkins, C. R. & Guo, M., Aug 5 2020, In : ACS Chemical Neuroscience. 11, 15, p. 2231-2242 12 p.

Research output: Contribution to journalArticle

Long-Term Follow-up of CALGB (Alliance) 100001: Autologous Followed by Nonmyeloablative Allogeneic Transplant for Multiple Myeloma

Holstein, S. A., Suman, V. J., Owzar, K., Santo, K., Benson, D. M., Shea, T. C., Martin, T., Silverman, M., Isola, L., Vij, R., Cheson, B. D., Linker, C., Anderson, K. C., Richardson, P. G. & McCarthy, P. L., Aug 2020, In : Biology of Blood and Marrow Transplantation. 26, 8, p. 1414-1424 11 p.

Research output: Contribution to journalArticle

MARCH5-dependent degradation of MCL1/NOXA complexes defines susceptibility to antimitotic drug treatment

Haschka, M. D., Karbon, G., Soratroi, C., O’Neill, K. L., Luo, X. & Villunger, A., Aug 1 2020, In : Cell Death and Differentiation. 27, 8, p. 2297-2312 16 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Nanoformulation of CCL21 greatly increases its effectiveness as an immunotherapy for neuroblastoma

Poelaert, B. J., Romanova, S., Knoche, S. M., Olson, M. T., Sliker, B. H., Smits, K., Dickey, B. L., Moffitt-Holida, A. E. J., Goetz, B. T., Khan, N., Smith, L., Band, H., Mohs, A. M., Coulter, D. W., Bronich, T. K. & Solheim, J. C., Nov 10 2020, In : Journal of Controlled Release. 327, p. 266-283 18 p.

Research output: Contribution to journalArticle

Nanoparticle Formulation of Indocyanine Green Improves Image-Guided Surgery in a Murine Model of Breast Cancer

Wojtynek, N. E., Olson, M. T., Bielecki, T. A., An, W., Bhat, A. M., Band, H., Lauer, S. R., Silva-Lopez, E. & Mohs, A. M., Aug 1 2020, In : Molecular Imaging and Biology. 22, 4, p. 891-903 13 p.

Research output: Contribution to journalArticle

1 Scopus citations

Nonsynonymous mutations in linker-2 of the PDR5 multidrug transporter identify a new RNA stability element

Rahman, H., Rudrow, A., Carneglia, J., Patrick Joly, S. S., Nicotera, D., Naldrett, M., Choy, J., Ambudkar, S. V. & Golin, J., Jan 1 2020, In : G3: Genes, Genomes, Genetics. 10, 1, p. 357-369 13 p.

Research output: Contribution to journalArticle

Open Access

Potent, specific MEPicides for treatment of zoonotic staphylococci

Edwards, R. L., Heueck, I., Lee, S. G., Shah, I. T., Miller, J. J., Jezewski, A. J., Mikati, M. O., Wang, X., Brothers, R. C., Heidel, K. M., Osbourn, D. M., Burnham, C. A. D., Alvarez, S., Fritz, S. A., Dowd, C. S., Jez, J. M. & Odom John, A. R., Jun 2020, In : PLoS pathogens. 16, 6, e1007806.

Research output: Contribution to journalArticle

Open Access

Prognostic and therapeutic implications of NHERF1 expression and regulation in colorectal cancer

Leiphrakpam, P. D., Lazenby, A. J., Chowdhury, S., Smith, L. M., Mathiesen, M., Brattain, M. G., Wang, J., Black, J. D. & Are, C., Mar 1 2020, In : Journal of Surgical Oncology. 121, 3, p. 547-560 14 p.

Research output: Contribution to journalArticle

Rilpivirine-associated aggregation-induced emission enables cell-based nanoparticle tracking

Mukadam, I. Z., Machhi, J., Herskovitz, J., Hasan, M., Oleynikov, M. D., Blomberg, W. R., Svechkarev, D., Mohs, A. M., Zhou, Y., Dash, P., McMillan, J. E., Gorantla, S., Garrison, J., Gendelman, H. E. & Kevadiya, B. D., Feb 2020, In : Biomaterials. 231, 119669.

Research output: Contribution to journalArticle

Solvent tuning of photochemistry upon excited-state symmetry breaking

Dereka, B., Svechkarev, D., Rosspeintner, A., Aster, A., Lunzer, M., Liska, R., Mohs, A. M. & Vauthey, E., Dec 1 2020, In : Nature communications. 11, 1, 1925.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Sterile α-motif domain requirement for cellular signaling and survival

Ray, S., Chee, L., Matson, D. R., Palermo, N. Y., Bresnick, E. H. & Hewitt, K. J., May 15 2020, In : Journal of Biological Chemistry. 295, 20, p. 7113-7125 13 p.

Research output: Contribution to journalArticle

Open Access

Sulfation Modulates the Targeting Properties of Hyaluronic Acid to P-Selectin and CD44

Bhattacharya, D. S., Svechkarev, D., Bapat, A., Patil, P., Hollingsworth, M. A. & Mohs, A. M., Jun 8 2020, In : ACS Biomaterials Science and Engineering. 6, 6, p. 3585-3598 14 p.

Research output: Contribution to journalArticle

Symbiotic prodrugs (SymProDs) dual targeting of NFkappaB and CDK

Rana, S., Kour, S., Sonawane, Y. A., Robb, C. M., Contreras, J. I., Kizhake, S., Zahid, M., Karpf, A. R. & Natarajan, A., Aug 1 2020, In : Chemical Biology and Drug Design. 96, 2, p. 773-784 12 p.

Research output: Contribution to journalArticle

Synthesis and Antichlamydial Activity of Molecules Based on Dysregulators of Cylindrical Proteases

Seleem, M. A., Rodrigues De Almeida, N., Chhonker, Y. S., Murry, D. J., Guterres, Z. D. R., Blocker, A. M., Kuwabara, S., Fisher, D. J., Leal, E. S., Martinefski, M. R., Bollini, M., Monge, M. E., Ouellette, S. P. & Conda-Sheridan, M., Apr 23 2020, In : Journal of Medicinal Chemistry. 63, 8, p. 4370-4387 18 p.

Research output: Contribution to journalArticle

The proteomic landscape of pancreatic ductal adenocarcinoma liver metastases identifies molecular subtypes and associations with clinical response A C

Law, H. C. H., Lagundzin, D., Clement, E. J., Qiao, F., Wagner, Z. S., Krieger, K. L., Costanzo-Garvey, D., Caffrey, T. C., Grem, J. L., DiMaio, D. J., Grandgenett, P. M., Cook, L. M., Fisher, K. W., Yu, F., Hollingsworth, M. A. & Woods, N. T., Mar 1 2020, In : Clinical Cancer Research. 26, 5, p. 1065-1076 12 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Tuned near infrared fluorescent hyaluronic acid conjugates for delivery to pancreatic cancer for intraoperative imaging

Qi, B., Crawford, A. J., Wojtynek, N. E., Talmon, G. A., Hollingsworth, M. A., Ly, Q. P. & Mohs, A. M., 2020, In : Theranostics. 10, 8, p. 3413-3429 17 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Twisting of Charged Nanoribbons to Helicoids Driven by Electrostatics

Zaldivar, G., Conda-Sheridan, M. & Tagliazucchi, M., Apr 16 2020, In : Journal of Physical Chemistry B. 124, 15, p. 3221-3227 7 p.

Research output: Contribution to journalArticle

U000328, a novel ALK2/3 kinase inhibitor, represses hepcidin and significantly improves the phenotype of IRIDA

Belot, A., Gourbeyre, O., Fay, A., Palin, A., Besson-Fournier, C., Latour, C., Hopkins, C. R., Tidmarsh, G. F., Coppin, H., Roth, M. P., Ritter, M. R., Hong, C. C. & Meynard, D., Mar 1 2020, In : Haematologica. 105, 3

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

UBR5 HECT domain mutations identified in mantle cell lymphoma control maturation of B cells

Swenson, S. A., Gilbreath, T. J., Vahle, H., Hynes-Smith, R. W., Graham, J. H., Law, H. C. H., Amador, C., Woods, N. T., Green, M. R. & Buckley, S. M., Jul 2020, In : Blood. 9, 3, p. 299-312 14 p.

Research output: Contribution to journalArticle

Open Access

Venetoclax causes metabolic reprogramming independent of BCL-2 inhibition

Roca-Portoles, A., Rodriguez-Blanco, G., Sumpton, D., Cloix, C., Mullin, M., Mackay, G. M., O’Neill, K., Lemgruber, L., Luo, X. & Tait, S. W. G., Aug 1 2020, In : Cell Death and Disease. 11, 8, 616.

Research output: Contribution to journalArticle

Open Access
2019

A Genome-wide Functional Signature Ontology Map and Applications to Natural Product Mechanism of Action Discovery

McMillan, E. A., Kwon, G., Clemenceau, J. R., Fisher, K. W., Vaden, R. M., Shaikh, A. F., Neilsen, B. K., Kelly, D., Potts, M. B., Sung, Y. J., Mendiratta, S., Hight, S. K., Lee, Y., MacMillan, J. B., Lewis, R. E., Kim, H. S. & White, M. A., Oct 17 2019, In : Cell Chemical Biology. 26, 10, p. 1380-1392.e6

Research output: Contribution to journalArticle

2 Scopus citations

A mitotic CDK5-PP4 phospho-signaling cascade primes 53BP1 for DNA repair in G1

Zheng, X. F., Acharya, S. S., Choe, K. N., Nikhil, K., Adelmant, G., Satapathy, S. R., Sharma, S., Viccaro, K., Rana, S., Natarajan, A., Sicinski, P., Marto, J. A., Shah, K. & Chowdhury, D., Dec 1 2019, In : Nature communications. 10, 1, 4252.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Analgesic Effects of the GIRK Activator, VU0466551, Alone and in Combination with Morphine in Acute and Persistent Pain Models

Abney, K. K., Bubser, M., Du, Y., Kozek, K. A., Bridges, T. M., Linsdley, C. W., Daniels, J. S., Morrison, R. D., Wickman, K., Hopkins, C. R., Jones, C. K. & Weaver, C. D., Mar 20 2019, In : ACS Chemical Neuroscience. 10, 3, p. 1294-1299 6 p.

Research output: Contribution to journalArticle

2 Scopus citations

A patent review of bisphosphonates in treating bone disease

Holstein, S. A., May 4 2019, In : Expert Opinion on Therapeutic Patents. 29, 5, p. 315-325 11 p.

Research output: Contribution to journalArticle

6 Scopus citations

A recurrent cancer-associated substitution in DNA polymerase ε produces a hyperactive enzyme

Xing, X., Kane, D. P., Bulock, C. R., Moore, E. A., Sharma, S., Chabes, A. & Shcherbakova, P. V., Dec 1 2019, In : Nature communications. 10, 1, 374.

Research output: Contribution to journalArticle

7 Scopus citations

A simple fluorescent assay for the discovery of protein-protein interaction inhibitors

Al-Mugotir, M., Kolar, C., Vance, K., Kelly, D. L., Natarajan, A. & Borgstahl, G. E. O., Mar 15 2019, In : Analytical Biochemistry. 569, p. 46-52 7 p.

Research output: Contribution to journalArticle

1 Scopus citations

Beta 2-microglobulin regulates amyloid precursor-like protein 2 expression and the migration of pancreatic cancer cells

Sliker, B. H., Goetz, B. T., Peters, H. L., Poelaert, B. J., Borgstahl, G. E. O. & Solheim, J. C., Jun 3 2019, In : Cancer Biology and Therapy. 20, 6, p. 931-940 10 p.

Research output: Contribution to journalArticle

1 Scopus citations

BH3-only proteins are dispensable for apoptosis induced by pharmacological inhibition of both MCL-1 and BCL-XL

Greaves, G., Milani, M., Butterworth, M., Carter, R. J., Byrne, D. P., Eyers, P. A., Luo, X., Cohen, G. M. & Varadarajan, S., Jun 1 2019, In : Cell Death and Differentiation. 26, 6, p. 1037-1047 11 p.

Research output: Contribution to journalArticle

18 Scopus citations

BH3-only proteins target BCL-xL/MCL-1, not BAX/BAK, to initiate apoptosis

Huang, K., O’Neill, K. L., Li, J., Zhou, W., Han, N., Pang, X., Wu, W., Struble, L., Borgstahl, G., Liu, Z., Zhang, L. & Luo, X., Nov 1 2019, In : Cell Research. 29, 11, p. 942-952 11 p.

Research output: Contribution to journalArticle

9 Scopus citations

Brassicaceae-specific Gretchen Hagen 3 acyl acid amido synthetases conjugate amino acids to chorismate, a precursor of aromatic amino acids and salicylic acid

Holland, C. K., Westfall, C. S., Schaffer, J. E., De Santiago, A., Zubieta, C., Alvarez, S. & Jez, J. M., Nov 8 2019, In : Journal of Biological Chemistry. 294, 45, p. 16855-16864 10 p.

Research output: Contribution to journalArticle

2 Scopus citations

Catalytically inactive Dnmt3b rescues mouse embryonic development by accessory and repressive functions

Nowialis, P., Lopusna, K., Opavska, J., Haney, S. L., Abraham, A., Sheng, P., Riva, A., Natarajan, A., Guryanova, O., Simpson, M., Hlady, R., Xie, M. & Opavsky, R., Dec 1 2019, In : Nature communications. 10, 1, 4374.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

CDK5 inhibitor downregulates Mcl-1 and sensitizes pancreatic cancer cell lines to navitoclax

Kour, S., Rana, S., Contreras, J. I., King, H. M., Robb, C. M., Sonawane, Y. A., Bendjennat, M., Crawford, A. J., Barger, C. J., Kizhake, S., Luo, X., Hollingsworth, M. A. & Natarajan, A., Oct 2019, In : Molecular pharmacology. 96, 4, p. 419-429 11 p.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

CTDP1 regulates breast cancer survival and DNA repair through BRCT-specific interactions with FANCI

Hu, W. F., Krieger, K. L., Lagundžin, D., Li, X., Cheung, R. S., Taniguchi, T., Johnson, K. R., Bessho, T., Monteiro, A. N. A. & Woods, N. T., Dec 1 2019, In : Cell Death Discovery. 5, 1, 105.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Delineating the role of FANCA in glucose-stimulated insulin secretion in β cells through its protein interactome

Lagundžin, D., Hu, W. F., Law, H. C. H., Krieger, K. L., Qiao, F., Clement, E. J., Drincic, A. T., Nedić, O., Naldrett, M. J., Alvarez, S. & Woods, N. T., Aug 1 2019, In : PloS one. 14, 8, e0220568.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Discovery, Structure-Activity Relationship, and Biological Characterization of a Novel Series of 6-((1 H-Pyrazolo[4,3- b]pyridin-3-yl)amino)-benzo[ d]isothiazole-3-carboxamides as Positive Allosteric Modulators of the Metabotropic Glutamate Receptor 4 (mGlu 4 )

Bollinger, S. R., Engers, D. W., Panarese, J. D., West, M., Engers, J. L., Loch, M. T., Rodriguez, A. L., Blobaum, A. L., Jones, C. K., Thompson Gray, A., Conn, P. J., Lindsley, C. W., Niswender, C. M. & Hopkins, C. R., Oct 1 2019, In : Journal of Medicinal Chemistry. 62, 1, p. 342-358 17 p.

Research output: Contribution to journalArticle

6 Scopus citations

Discovery, synthesis and characterization of a series of (1-alkyl-3-methyl-1H-pyrazol-5-yl)-2-(5-aryl-2H-tetrazol-2-yl)acetamides as novel GIRK1/2 potassium channel activators

Sharma, S., Kozek, K. A., Abney, K. K., Kumar, S., Gautam, N., Alnouti, Y., David Weaver, C. & Hopkins, C. R., Mar 15 2019, In : Bioorganic and Medicinal Chemistry Letters. 29, 6, p. 791-796 6 p.

Research output: Contribution to journalArticle