Center for Molecular Target Discovery & Development

Holstein, S. A., Heckman, C. A., Davies, F. E., Morgan, G. J., Gelius, S. S. & Lehmann, F., Jan 2023, In: Current Cancer Drug Targets. 23, 1, p. 25-46 22 p.

Research output: Contribution to journal › Review article › peer-review

8 Scopus citations

Chimeric Antigen Receptor T-Cell and Bispecific Antibody Therapy in Multiple Myeloma: Moving Into the Future

Holstein, S. A., Grant, S. J. & Wildes, T. M., Sep 20 2023, In: Journal of Clinical Oncology. 41, 27, p. 4416-4429 14 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

48 Scopus citations

Mucins as contrast agent targets for fluorescence-guided surgery of pancreatic cancer

Muilenburg, K. M., Isder, C. C., Radhakrishnan, P., Batra, S. K., Ly, Q. P., Carlson, M. A., Bouvet, M., Hollingsworth, M. A. & Mohs, A. M., May 1 2023, In: Cancer Letters. 561, 216150.

Research output: Contribution to journal › Review article › peer-review

Open Access

8 Scopus citations

Sticky, Adaptable, and Many-sided: SAM protein versatility in normal and pathological hematopoietic states

Ray, S. & Hewitt, K., Aug 2023, In: BioEssays. 45, 8, 2300022.

Research output: Contribution to journal › Review article › peer-review

Open Access

4 Scopus citations

Targeting the Isoprenoid Biosynthetic Pathway in Multiple Myeloma

Haney, S. L. & Holstein, S. A., Jan 2023, In: International journal of molecular sciences. 24, 1, 111.

Research output: Contribution to journal › Review article › peer-review

Open Access

7 Scopus citations

2022

A plain language summary of daratumumab plus lenalidomide/bortezomib/dexamethasone in transplant-eligible Black patients with newly diagnosed multiple myeloma in the GRIFFIN study

Nooka, A. K., Kaufman, J. L., Rodriguez, C., Jakubowiak, A., Efebera, Y., Reeves, B., Wildes, T., Holstein, S. A., Anderson, L. D., Badros, A., Shune, L., Chari, A., Pei, H., Cortoos, A., Patel, S., Lin, T. S., Richardson, P. G. & Voorhees, P., Dec 1 2022, In: Future Oncology. 18, 40, p. 4443-4456 14 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

Current Frontline Treatment of Multiple Myeloma

Holstein, S. A., Jul 2022, In: Oncology (United States). 36, 7, p. 430-441 12 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

7 Scopus citations

Mechanisms and Regulation of DNA-Protein Crosslink Repair During DNA Replication by SPRTN Protease

Perry, M. & Ghosal, G., Jun 15 2022, In: Frontiers in Molecular Biosciences. 9, 916697.

Research output: Contribution to journal › Review article › peer-review

Open Access

12 Scopus citations

New answers to the old RIDDLE: RNF168 and the DNA damage response pathway

Kelliher, J., Ghosal, G. & Leung, J. W. C., May 2022, In: FEBS Journal. 289, 9, p. 2467-2480 14 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

17 Scopus citations

PKCα and PKCδ: Friends and Rivals

Black, J. D., Affandi, T., Black, A. R. & Reyland, M. E., Aug 2022, In: Journal of Biological Chemistry. 298, 8, 102194.

Research output: Contribution to journal › Review article › peer-review

Open Access

16 Scopus citations

Selective CDK9 degradation using a proteolysis-targeting chimera (PROTAC) strategy

Mallareddy, J. R., Singh, S., Boghean, L. & Natarajan, A., Jan 2022, In: Future Medicinal Chemistry. 14, 3, p. 131-134 4 p.

Research output: Contribution to journal › Review article › peer-review

7 Scopus citations

The era of lenalidomide maintenance therapy in multiple myeloma: settings for achieving best outcomes

Kesireddy, M. & Holstein, S. A., 2022, In: Expert Review of Clinical Pharmacology. 15, 1, p. 19-31 13 p.

Research output: Contribution to journal › Review article › peer-review

3 Scopus citations

Urea-Modified Self-Assembling Peptide Amphiphiles That Form Well-Defined Nanostructures and Hydrogels for Biomedical Applications

Xing, H., Rodger, A., Comer, J., Picco, A. S., Huck-Iriart, C., Ezell, E. L. & Conda-Sheridan, M., Oct 17 2022, In: ACS Applied Bio Materials. 5, 10, p. 4599-4610 12 p.

Research output: Contribution to journal › Review article › peer-review

14 Scopus citations

2021

Evolution of Treatment Paradigms in Newly Diagnosed Multiple Myeloma

Elnair, R. A. & Holstein, S. A., May 2021, In: Drugs. 81, 7, p. 825-840 16 p.

Research output: Contribution to journal › Review article › peer-review

8 Scopus citations

Future directions in maintenance therapy in multiple myeloma

Holstein, S. A., Suman, V. J., Hillengass, J. & McCarthy, P. L., Jun 1 2021, In: Journal of Clinical Medicine. 10, 11, 2261.

Research output: Contribution to journal › Review article › peer-review

Open Access

7 Scopus citations

Inhibitors, protacs and molecular glues as diverse therapeutic modalities to target cyclin-dependent kinase

Rana, S., Mallareddy, J. R., Singh, S., Boghean, L. & Natarajan, A., Nov 1 2021, In: Cancers. 13, 21, 5506.

Research output: Contribution to journal › Review article › peer-review

Open Access

21 Scopus citations

International harmonization in performing and reporting minimal residual disease assessment in multiple myeloma trials

Costa, L. J., Derman, B. A., Bal, S., Sidana, S., Chhabra, S., Silbermann, R., Ye, J. C., Cook, G., Cornell, R. F., Holstein, S. A., Shi, Q., Omel, J., Callander, N. S., Chng, W. J., Hungria, V., Maiolino, A., Stadtmauer, E., Giralt, S., Pasquini, M. & Jakubowiak, A. J. & 16 others, Morgan, G. J., Krishnan, A., Jackson, G. H., Mohty, M., Mateos, M. V., Dimopoulos, M. A., Facon, T., Spencer, A., Miguel, J. S., Hari, P., Usmani, S. Z., Manier, S., McCarthy, P., Kumar, S., Gay, F. & Paiva, B., Jan 2021, In: Leukemia. 35, 1, p. 18-30 13 p.

Research output: Contribution to journal › Review article › peer-review

91 Scopus citations

Mass spectrometry based untargeted metabolomics for plant systems biology

Alvarez, S. & Naldrett, M. J., May 2021, In: Emerging topics in life sciences. 5, 2, p. 189-201 13 p.

Research output: Contribution to journal › Review article › peer-review

14 Scopus citations

Novel inhibitors of the renal inward rectifier potassium channel of the mosquito vector Aedes aegypti

Mashinson, V. & Hopkins, C. R., Nov 2021, In: Future Medicinal Chemistry. 13, 22, p. 2015-2025 11 p.

Research output: Contribution to journal › Review article › peer-review

3 Scopus citations

The 2020 BMT CTN Myeloma Intergroup Workshop on Immune Profiling and Minimal Residual Disease Testing in Multiple Myeloma

Holstein, S. A., Bahlis, N., Bergsagel, P. L., Bhutani, M., Bolli, N., Brownstein, C., Demolis, P., Foureau, D., Gay, F., Ghobrial, I. M., Gormley, N., Hillengass, J., Kaiser, M., Maus, M. V., Melenhorst, J. J., Merz, M., Dwyer, M. O., Paiva, B., Pasquini, M. C. & Shah, N. & 3 others, Wong, S. W., Usmani, S. Z. & McCarthy, P. L., Oct 2021, In: Transplantation and Cellular Therapy. 27, 10, p. 807-816 10 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

3 Scopus citations

Treatment Considerations for Transplant-Ineligible Multiple Myeloma

Elnair, R. A. & Holstein, S. A., Apr 2021, In: Oncology (United States). 35, 4, p. 170-189 20 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

2 Scopus citations

Treatment of relapsed and refractory multiple myeloma: recommendations from the International Myeloma Working Group

Moreau, P., Kumar, S. K., San Miguel, J., Davies, F., Zamagni, E., Bahlis, N., Ludwig, H., Mikhael, J., Terpos, E., Schjesvold, F., Martin, T., Yong, K., Durie, B. G. M., Facon, T., Jurczyszyn, A., Sidana, S., Raje, N., van de Donk, N., Lonial, S. & Cavo, M. & 50 others, Kristinsson, S. Y., Lentzsch, S., Hajek, R., Anderson, K. C., João, C., Einsele, H., Sonneveld, P., Engelhardt, M., Fonseca, R., Vangsted, A., Weisel, K., Baz, R., Hungria, V., Berdeja, J. G., Leal da Costa, F., Maiolino, A., Waage, A., Vesole, D. H., Ocio, E. M., Quach, H., Driessen, C., Bladé, J., Leleu, X., Riva, E., Bergsagel, P. L., Hou, J., Chng, W. J., Mellqvist, U. H., Dytfeld, D., Harousseau, J. L., Goldschmidt, H., Laubach, J., Munshi, N. C., Gay, F., Beksac, M., Costa, L. J., Kaiser, M., Hari, P., Boccadoro, M., Usmani, S. Z., Zweegman, S., Holstein, S., Sezer, O., Harrison, S., Nahi, H., Cook, G., Mateos, M. V., Rajkumar, S. V., Dimopoulos, M. A. & Richardson, P. G., Mar 2021, In: The Lancet Oncology. 22, 3, p. e105-e118

Research output: Contribution to journal › Review article › peer-review

Open Access

196 Scopus citations

2020

A gene expression high-throughput screen (GE-HTS) for coordinated detection of functionally similar effectors in cancer

Rao, C., Huisman, D. H., Vieira, H. M., Frodyma, D. E., Neilsen, B. K., Chakraborty, B., Hight, S. K., White, M. A., Fisher, K. W. & Lewis, R. E., Nov 2020, In: Cancers. 12, 11, p. 1-16 16 p., 3143.

Research output: Contribution to journal › Review article › peer-review

Open Access

7 Scopus citations

CAR T-Cell Therapy in Hematologic Malignancies: A Voyage in Progress

Holstein, S. A. & Lunning, M. A., Jan 1 2020, In: Clinical Pharmacology and Therapeutics. 107, 1, p. 112-122 11 p.

Research output: Contribution to journal › Review article › peer-review

135 Scopus citations

Characterizing pathological imperfections in macromolecular crystals: lattice disorders and modulations

Lovelace, J. J. & Borgstahl, G. E. O., Jan 2 2020, In: Crystallography Reviews. 26, 1, p. 3-50 48 p.

Research output: Contribution to journal › Review article › peer-review

9 Scopus citations

Developments in continuous therapy and maintenance treatment approaches for patients with newly diagnosed multiple myeloma

Dimopoulos, M. A., Jakubowiak, A. J., McCarthy, P. L., Orlowski, R. Z., Attal, M., Bladé, J., Goldschmidt, H., Weisel, K. C., Ramasamy, K., Zweegman, S., Spencer, A., Huang, J. S. Y., Lu, J., Sunami, K., Iida, S., Chng, W. J., Holstein, S. A., Rocci, A., Skacel, T. & Labotka, R. & 2 others, Palumbo, A. & Anderson, K. C., Feb 1 2020, In: Blood Cancer Journal. 10, 2, 17.

Research output: Contribution to journal › Review article › peer-review

Open Access

88 Scopus citations

Image-guided tumor surgery: The emerging role of nanotechnology

Wojtynek, N. E. & Mohs, A. M., Jul 1 2020, In: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology. 12, 4, e1624.

Research output: Contribution to journal › Review article › peer-review

51 Scopus citations

Regulation of Normal and Malignant Hematopoiesis by FBOX Ubiquitin E3 Ligases

Hynes-Smith, R. W., Wittorf, K. J. & Buckley, S. M., Dec 2020, In: Trends in Immunology. 41, 12, p. 1128-1140 13 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

8 Scopus citations

Repair and regeneration of small intestine: A review of current engineering approaches

Qi, D., Shi, W., Black, A. R., Kuss, M. A., Pang, X., He, Y., Liu, B. & Duan, B., May 2020, In: Biomaterials. 240, 119832.

Research output: Contribution to journal › Review article › peer-review

33 Scopus citations

Selective α7 nicotinic receptor agonists and positive allosteric modulators for the treatment of schizophrenia–a review

Antonio-Tolentino, K. & Hopkins, C. R., Jun 2 2020, In: Expert Opinion on Investigational Drugs. 29, 6, p. 603-610 8 p.

Research output: Contribution to journal › Review article › peer-review

19 Scopus citations

Summary of the 2019 Blood and Marrow Transplant Clinical Trials Network Myeloma Intergroup Workshop on Minimal Residual Disease and Immune Profiling

Holstein, S. A., Howard, A., Avigan, D., Bhutani, M., Cohen, A. D., Costa, L. J., Dhodapkar, M. V., Gay, F., Gormley, N., Green, D. J., Hillengass, J., Korde, N., Li, Z., Mailankody, S., Neri, P., Parekh, S., Pasquini, M. C., Puig, N., Roodman, G. D. & Samur, M. K. & 7 others, Shah, N., Shah, U. A., Shi, Q., Spencer, A., Suman, V. J., Usmani, S. Z. & McCarthy, P. L., Oct 2020, In: Biology of Blood and Marrow Transplantation. 26, 10, p. e247-e255

Research output: Contribution to journal › Review article › peer-review

Open Access

5 Scopus citations

Summary of the Third Annual Blood and Marrow Transplant Clinical Trials Network Myeloma Intergroup Workshop on Minimal Residual Disease and Immune Profiling

Holstein, S. A., Al-Kadhimi, Z., Costa, L. J., Hahn, T., Hari, P., Hillengass, J., Jacob, A., Munshi, N. C., Oliva, S., Pasquini, M. C., Shi, Q., Stadtmauer, E. A., Waldvogel, S. L. & McCarthy, P. L., Jan 2020, In: Biology of Blood and Marrow Transplantation. 26, 1, p. e7-e15

Research output: Contribution to journal › Review article › peer-review

Open Access

14 Scopus citations

The third model of Bax/Bak activation: A Bcl-2 family feud finally resolved?

Luo, X., O'Neill, K. L. & Huang, K., 2020, In: F1000Research. 9, 935.

Research output: Contribution to journal › Review article › peer-review

Open Access

64 Scopus citations

Variable Molecular Weight Nanoparticles for Near-Infrared Fluorescence Imaging and Photothermal Ablation

Sarkar, S., Graham-Gurysh, E. G., Macneill, C. M., Kelkar, S., Mccarthy, B. D., Mohs, A. & Levi-Polyachenko, N., Oct 9 2020, In: ACS Applied Polymer Materials. 2, 10, p. 4162-4170 9 p.

Research output: Contribution to journal › Review article › peer-review

6 Scopus citations

Visual Pathway Degeneration in Chemotherapy-Related Neurotoxicity: A Review and Directions for Future Research

Anderson, D. E., Holstein, S. A. & Kedar, S., May 3 2020, In: Neuro-Ophthalmology. 44, 3, p. 139-147 9 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

2 Scopus citations

2019

A review of the molecular design and biological activities of RXR agonists

de Almeida, N. R. & Conda-Sheridan, M., Jul 2019, In: Medicinal Research Reviews. 39, 4, p. 1372-1397 26 p.

Research output: Contribution to journal › Review article › peer-review

56 Scopus citations

Fluorescence Guidance in Surgical Oncology: Challenges, Opportunities, and Translation

Olson, M. T., Ly, Q. P. & Mohs, A. M., Apr 15 2019, In: Molecular Imaging and Biology. 21, 2, p. 200-218 19 p.

Research output: Contribution to journal › Review article › peer-review

64 Scopus citations

Methods to prevent and treat relapse after hematopoietic stem cell transplantation with tyrosine kinase inhibitors, immunomodulating drugs, deacetylase inhibitors, and hypomethylating agents

Chen, Y. B., McCarthy, P. L., Hahn, T., Holstein, S. A., Ueda, M., Kröger, N., Bishop, M. & de Lima, M., Apr 1 2019, In: Bone marrow transplantation. 54, 4, p. 497-507 11 p.

Research output: Contribution to journal › Review article › peer-review

11 Scopus citations

Organic fluorescent dye-based nanomaterials: Advances in the rational design for imaging and sensing applications

Svechkarev, D. & Mohs, A. M., 2019, In: Current medicinal chemistry. 26, 21, p. 4042-4064 23 p.

Research output: Contribution to journal › Review article › peer-review

71 Scopus citations

Organic Fluorescent Dye-based Nanomaterials: Advances in the Rational Design for Imaging and Sensing Applications

Svechkarev, D. & Mohs, A. M., 2019, In: Current medicinal chemistry. 26, 21, p. 4042-4064 23 p.

Research output: Contribution to journal › Review article › peer-review

Review of Transient Receptor Potential Canonical (TRPC5) Channel Modulators and Diseases

Sharma, S. & Hopkins, C. R., Sep 12 2019, In: Journal of Medicinal Chemistry. 62, 17, p. 7589-7602 14 p.

Research output: Contribution to journal › Review article › peer-review

34 Scopus citations

The evolving role of maintenance therapy following autologous stem cell transplantation in multiple myeloma

Merz, A. M. A., Merz, M., Hillengass, J., Holstein, S. A. & McCarthy, P., Oct 3 2019, In: Expert review of anticancer therapy. 19, 10, p. 889-898 10 p.

Research output: Contribution to journal › Review article › peer-review