Center for Molecular Target Discovery & Development

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Review article
2020

CAR T-Cell Therapy in Hematologic Malignancies: A Voyage in Progress

Holstein, S. A. & Lunning, M. A., Jan 1 2020, In : Clinical Pharmacology and Therapeutics. 107, 1, p. 112-122 11 p.

Research output: Contribution to journalReview article

4 Scopus citations

Characterizing pathological imperfections in macromolecular crystals: lattice disorders and modulations

Lovelace, J. J. & Borgstahl, G. E. O., Jan 2 2020, In : Crystallography Reviews. 26, 1, p. 3-50 48 p.

Research output: Contribution to journalReview article

1 Scopus citations

Developments in continuous therapy and maintenance treatment approaches for patients with newly diagnosed multiple myeloma

Dimopoulos, M. A., Jakubowiak, A. J., McCarthy, P. L., Orlowski, R. Z., Attal, M., Bladé, J., Goldschmidt, H., Weisel, K. C., Ramasamy, K., Zweegman, S., Spencer, A., Huang, J. S. Y., Lu, J., Sunami, K., Iida, S., Chng, W. J., Holstein, S. A., Rocci, A., Skacel, T., Labotka, R. & 2 others, Palumbo, A. & Anderson, K. C., Feb 1 2020, In : Blood Cancer Journal. 10, 2, 17.

Research output: Contribution to journalReview article

Open Access
7 Scopus citations

Image-guided tumor surgery: The emerging role of nanotechnology

Wojtynek, N. E. & Mohs, A. M., Jul 1 2020, In : Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology. 12, 4, e1624.

Research output: Contribution to journalReview article

3 Scopus citations

International harmonization in performing and reporting minimal residual disease assessment in multiple myeloma trials

Costa, L. J., Derman, B. A., Bal, S., Sidana, S., Chhabra, S., Silbermann, R., Ye, J. C., Cook, G., Cornell, R. F., Holstein, S. A., Shi, Q., Omel, J., Callander, N. S., Chng, W. J., Hungria, V., Maiolino, A., Stadtmauer, E., Giralt, S., Pasquini, M., Jakubowiak, A. J. & 16 others, Morgan, G. J., Krishnan, A., Jackson, G. H., Mohty, M., Mateos, M. V., Dimopoulos, M. A., Facon, T., Spencer, A., Miguel, J. S., Hari, P., Usmani, S. Z., Manier, S., McCarthy, P., Kumar, S., Gay, F. & Paiva, B., 2020, (Accepted/In press) In : Leukemia.

Research output: Contribution to journalReview article

Repair and regeneration of small intestine: A review of current engineering approaches

Qi, D., Shi, W., Black, A. R., Kuss, M. A., Pang, X., He, Y., Liu, B. & Duan, B., May 2020, In : Biomaterials. 240, 119832.

Research output: Contribution to journalReview article

1 Scopus citations

Selective α7 nicotinic receptor agonists and positive allosteric modulators for the treatment of schizophrenia–a review

Antonio-Tolentino, K. & Hopkins, C. R., Jun 2 2020, In : Expert Opinion on Investigational Drugs. 29, 6, p. 603-610 8 p.

Research output: Contribution to journalReview article

Summary of the 2019 Blood and Marrow Transplant Clinical Trials Network Myeloma Intergroup Workshop on Minimal Residual Disease and Immune Profiling

Holstein, S. A., Howard, A., Avigan, D., Bhutani, M., Cohen, A. D., Costa, L. J., Dhodapkar, M. V., Gay, F., Gormley, N., Green, D. J., Hillengass, J., Korde, N., Li, Z., Mailankody, S., Neri, P., Parekh, S., Pasquini, M. C., Puig, N., Roodman, G. D., Samur, M. K. & 7 others, Shah, N., Shah, U. A., Shi, Q., Spencer, A., Suman, V. J., Usmani, S. Z. & McCarthy, P. L., 2020, (Accepted/In press) In : Biology of Blood and Marrow Transplantation.

Research output: Contribution to journalReview article

Summary of the Third Annual Blood and Marrow Transplant Clinical Trials Network Myeloma Intergroup Workshop on Minimal Residual Disease and Immune Profiling

Holstein, S. A., Al-Kadhimi, Z., Costa, L. J., Hahn, T., Hari, P., Hillengass, J., Jacob, A., Munshi, N. C., Oliva, S., Pasquini, M. C., Shi, Q., Stadtmauer, E. A., Waldvogel, S. L. & McCarthy, P. L., Jan 2020, In : Biology of Blood and Marrow Transplantation. 26, 1, p. e7-e15

Research output: Contribution to journalReview article

4 Scopus citations

The third model of Bax/Bak activation: A Bcl-2 family feud finally resolved?

Luo, X., O'Neill, K. L. & Huang, K., 2020, In : F1000Research. 9, 935.

Research output: Contribution to journalReview article

Open Access

Visual Pathway Degeneration in Chemotherapy-Related Neurotoxicity: A Review and Directions for Future Research

Anderson, D. E., Holstein, S. A. & Kedar, S., May 3 2020, In : Neuro-Ophthalmology. 44, 3, p. 139-147 9 p.

Research output: Contribution to journalReview article

2019

A review of the molecular design and biological activities of RXR agonists

de Almeida, N. R. & Conda-Sheridan, M., Jul 2019, In : Medicinal Research Reviews. 39, 4, p. 1372-1397 26 p.

Research output: Contribution to journalReview article

2 Scopus citations

Fluorescence Guidance in Surgical Oncology: Challenges, Opportunities, and Translation

Olson, M. T., Ly, Q. P. & Mohs, A. M., Apr 15 2019, In : Molecular Imaging and Biology. 21, 2, p. 200-218 19 p.

Research output: Contribution to journalReview article

10 Scopus citations

Methods to prevent and treat relapse after hematopoietic stem cell transplantation with tyrosine kinase inhibitors, immunomodulating drugs, deacetylase inhibitors, and hypomethylating agents

Chen, Y. B., McCarthy, P. L., Hahn, T., Holstein, S. A., Ueda, M., Kröger, N., Bishop, M. & de Lima, M., Apr 1 2019, In : Bone marrow transplantation. 54, 4, p. 497-507 11 p.

Research output: Contribution to journalReview article

2 Scopus citations

Organic fluorescent dye-based nanomaterials: Advances in the rational design for imaging and sensing applications

Svechkarev, D. & Mohs, A. M., 2019, In : Current medicinal chemistry. 26, 21, p. 4042-4064 23 p.

Research output: Contribution to journalReview article

5 Scopus citations

Recent Advances in EPAC-Targeted Therapies: A Biophysical Perspective

Ahmed, A., Boulton, S., Shao, H., Akimoto, M., Natarajan, A., Cheng, X. & Melacini, G., Nov 19 2019, In : Cells. 8, 11

Research output: Contribution to journalReview article

Open Access
2 Scopus citations

Review of Transient Receptor Potential Canonical (TRPC5) Channel Modulators and Diseases

Sharma, S. & Hopkins, C. R., Sep 12 2019, In : Journal of Medicinal Chemistry. 62, 17, p. 7589-7602 14 p.

Research output: Contribution to journalReview article

5 Scopus citations

The evolving role of maintenance therapy following autologous stem cell transplantation in multiple myeloma

Merz, A. M. A., Merz, M., Hillengass, J., Holstein, S. A. & McCarthy, P., Oct 3 2019, In : Expert review of anticancer therapy. 19, 10, p. 889-898 10 p.

Research output: Contribution to journalReview article

1 Scopus citations
2018

Mechanisms of erythrocyte development and regeneration: Implications for regenerative medicine and beyond

Bresnick, E. H., Hewitt, K. J., Mehta, C., Keles, S., Paulson, R. F. & Johnson, K. D., Jan 2018, In : Development (Cambridge). 145, 1, dev151423.

Research output: Contribution to journalReview article

11 Scopus citations
2015

American Society of Blood and Marrow Transplantation, European Society of Blood and Marrow Transplantation, Blood and Marrow Transplant Clinical Trials Network, and International Myeloma Working Group Consensus Conference on Salvage Hematopoietic Cell Transplantation in Patients with Relapsed Multiple Myeloma

Giralt, S., Garderet, L., Durie, B., Cook, G., Gahrton, G., Bruno, B., Hari, P., Lokhorst, H., McCarthy, P., Krishnan, A., Sonneveld, P., Goldschmidt, H., Jagannath, S., Barlogie, B., Mateos, M., Gimsing, P., Sezer, O., Mikhael, J., Lu, J., Dimopoulos, M. & 45 others, Mazumder, A., Palumbo, A., Abonour, R., Anderson, K., Attal, M., Blade, J., Bird, J., Cavo, M., Comenzo, R., de la Rubia, J., Einsele, H., Garcia-Sanz, R., Hillengass, J., Holstein, S., Johnsen, H. E., Joshua, D., Koehne, G., Kumar, S., Kyle, R., Leleu, X., Lonial, S., Ludwig, H., Nahi, H., Nooka, A., Orlowski, R., Rajkumar, V., Reiman, A., Richardson, P., Riva, E., San Miguel, J., Turreson, I., Usmani, S., Vesole, D., Bensinger, W., Qazilbash, M., Efebera, Y., Mohty, M., Gasparreto, C., Gajewski, J., LeMaistre, C. F., Bredeson, C., Moreau, P., Pasquini, M., Kroeger, N. & Stadtmauer, E., Dec 2015, In : Biology of Blood and Marrow Transplantation. 21, 12, p. 2039-2051 13 p.

Research output: Contribution to journalReview article

95 Scopus citations

Management of relapsed multiple myeloma after autologous stem cell transplant

Holstein, S. A., Richardson, P. G., Laubach, J. P. & McCarthy, P. L., May 1 2015, In : Biology of Blood and Marrow Transplantation. 21, 5, p. 793-798 6 p.

Research output: Contribution to journalReview article

15 Scopus citations
2014

Epigenetic and genetic mechanisms in red cell biology

Hewitt, K. J., Sanalkumar, R., Johnson, K. D., Keles, S. & Bresnick, E. H., May 2014, In : Current Opinion in Hematology. 21, 3, p. 155-164 10 p.

Research output: Contribution to journalReview article

4 Scopus citations

Multiple myeloma

Holstein, S. A., Liu, H. & McCarthy, P. L., Dec 1 2014, In : Hematology/Oncology Clinics of North America. 28, 6, p. 1113-1129 17 p.

Research output: Contribution to journalReview article

6 Scopus citations
2013

Cellular reprogramming to reset epigenetic signatures

Hewitt, K. J. & Garlick, J. A., Jul 2013, In : Molecular Aspects of Medicine. 34, 4, p. 841-848 8 p.

Research output: Contribution to journalReview article

13 Scopus citations

DNA damage tolerance: A double-edged sword guarding the genome

Ghosal, G. & Chen, J., Jun 1 2013, In : Translational Cancer Research. 2, 3, p. 107-129 23 p.

Research output: Contribution to journalReview article

113 Scopus citations
2012

ACS chemical neuroscience molecule spotlight on begacestat (GSI-953)

Hopkins, C. R., Jan 18 2012, In : ACS Chemical Neuroscience. 3, 1, p. 3-4 2 p.

Research output: Contribution to journalReview article

25 Scopus citations

ACS chemical neuroscience molecule spotlight on BMS-708163

Hopkins, C. R., Mar 21 2012, In : ACS Chemical Neuroscience. 3, 3, p. 149-150 2 p.

Research output: Contribution to journalReview article

5 Scopus citations

ACS chemical neuroscience molecule spotlight on potiga (Ezogabine)

Hopkins, C. R., Aug 15 2012, In : ACS Chemical Neuroscience. 3, 8, p. 632 1 p.

Research output: Contribution to journalReview article

4 Scopus citations

ACS chemical neuroscience molecule spotlight on suvorexant

Hopkins, C. R., Sep 19 2012, In : ACS Chemical Neuroscience. 3, 9, p. 647-648 2 p.

Research output: Contribution to journalReview article

10 Scopus citations

Allosteric modulation of seven transmembrane spanning receptors: Theory, practice, and opportunities for central nervous system drug discovery

Melancon, B. J., Hopkins, C. R., Wood, M. R., Emmitte, K. A., Niswender, C. M., Christopoulos, A., Conn, P. J. & Lindsley, C. W., Feb 23 2012, In : Journal of Medicinal Chemistry. 55, 4, p. 1445-1464 20 p.

Research output: Contribution to journalReview article

169 Scopus citations

BRCT domains: A little more than kin, and less than kind

Gerloff, D. L., Woods, N. T., Farago, A. A. & Monteiro, A. N. A., Aug 14 2012, In : FEBS Letters. 586, 17, p. 2711-2716 6 p.

Research output: Contribution to journalReview article

25 Scopus citations

Is there a future for prenyltransferase inhibitors in cancer therapy?

Holstein, S. A. & Hohl, R. J., Dec 2012, In : Current Opinion in Pharmacology. 12, 6, p. 704-709 6 p.

Research output: Contribution to journalReview article

24 Scopus citations
27 Scopus citations

Protein kinase C signaling and cell cycle regulation

Black, A. R. & Black, J. D., 2012, In : Frontiers in immunology. 3, JAN, Article 423.

Research output: Contribution to journalReview article

34 Scopus citations

Therapeutic additions and possible deletions in oncology in 2011

Holstein, S. A. & Hohl, R. J., Jan 2012, In : Clinical Pharmacology and Therapeutics. 91, 1, p. 15-17 3 p.

Research output: Contribution to journalReview article

9 Scopus citations
2011

ACS chemical neuroscience molecule spotlight on ELND006: Another γ-secretase inhibitor fails in the clinic

Hopkins, C. R., Jun 15 2011, In : ACS Chemical Neuroscience. 2, 6, p. 279-280 2 p.

Research output: Contribution to journalReview article

34 Scopus citations

ACS chemical neuroscience molecule spotlight on STX209 (Arbaclofen)

Hopkins, C. R., Aug 17 2011, In : ACS Chemical Neuroscience. 2, 8, p. 381 1 p.

Research output: Contribution to journalReview article

3 Scopus citations

ACS chemical neuroscience molecule spotlight on telcagepant (MK-0974)

Hopkins, C. R., Jul 20 2011, In : ACS Chemical Neuroscience. 2, 7, p. 334-335 2 p.

Research output: Contribution to journalReview article

2 Scopus citations

Recent progress on the identification of metabotropic glutamate 4 receptor ligands and their potential utility as CNS therapeutics

Robichaud, A. J., Engers, D. W., Lindsley, C. W. & Hopkins, C. R., Aug 17 2011, In : ACS Chemical Neuroscience. 2, 8, p. 433-449 17 p.

Research output: Contribution to journalReview article

31 Scopus citations
2010

Applications of nanotechnology to imaging and therapy of brain tumors

Mohs, A. M. & Provenzale, J. M., Aug 2010, In : Neuroimaging Clinics of North America. 20, 3, p. 283-292 10 p.

Research output: Contribution to journalReview article

13 Scopus citations

DNA polymerases at the eukaryotic fork-20 years later

Pavlov, Y. I. & Shcherbakova, P. V., Mar 1 2010, In : Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 685, 1-2, p. 45-53 9 p.

Research output: Contribution to journalReview article

70 Scopus citations

The antipsychotic potential of muscarinic allosteric modulation

Bridges, T. M., LeBois, E. P., Hopkins, C. R., Wood, M. R., Jones, C. K., Conn, P. J. & Lindsley, C. W., May 2010, In : Drug News and Perspectives. 23, 4, p. 229-240 12 p.

Research output: Contribution to journalReview article

48 Scopus citations
2009

MGluR4-positive allosteric modulation as potential treatment for Parkinson's disease

Hopkins, C. R., Lindsley, C. W. & Niswender, C. M., Jun 2009, In : Future Medicinal Chemistry. 1, 3, p. 501-513 13 p.

Research output: Contribution to journalReview article

52 Scopus citations

Recent progress in the development of mGluR4 positive allosteric modulators for the treatment of Parkinson's disease

Lindsley, C. W., Niswender, C. M., Engers, D. W. & Hopkins, C. R., 2009, In : Current Topics in Medicinal Chemistry. 9, 10, p. 949-963 15 p.

Research output: Contribution to journalReview article

35 Scopus citations
2008

Bioconjugated quantum dots for in vivo molecular and cellular imaging

Smith, A. M., Duan, H., Mohs, A. M. & Nie, S., Aug 17 2008, In : Advanced Drug Delivery Reviews. 60, 11, p. 1226-1240 15 p.

Research output: Contribution to journalReview article

905 Scopus citations

Epidermal growth factor receptor-directed therapy in esophageal cancer

Pande, A. U., Iyer, R. V., Rani, A., Maddipatla, S., Yang, G. Y., Nwogu, C. E., Black, J. D., Levea, C. M. & Javle, M. M., Jun 2008, In : ONCOLOGY. 73, 5-6, p. 281-289 9 p.

Research output: Contribution to journalReview article

27 Scopus citations

Molecule of the month

Hopkins, C. R., 2008, In : Current Topics in Medicinal Chemistry. 8, 18, p. 1710-1711 2 p.

Research output: Contribution to journalReview article

2007

Gadolinium(III)-based blood-pool contrast agents for magnetic resonance imaging: Status and clinical potential

Mohs, A. M. & Lu, Z. R., Mar 2007, In : Expert Opinion on Drug Delivery. 4, 2, p. 149-164 16 p.

Research output: Contribution to journalReview article

42 Scopus citations

Yeast DNA polymerase ζ: Beyond translesion DNA synthesis

Shcherbakova, P. V., Mar 2007, In : Chemtracts. 19, 3, p. 100-110 11 p.

Research output: Contribution to journalReview article

1 Scopus citations
2006

Polydisulfide Gd(III) chelates as biodegradable macromolecular magnetic resonance imaging contrast agents

Lu, Z. R., Mohs, A. M., Zong, Y. & Feng, Y., 2006, In : International journal of nanomedicine. 1, 1, p. 31-40 10 p.

Research output: Contribution to journalReview article

48 Scopus citations