Computational Chemistry & Innovative Therapeutics

Research Output

Research Output per year

1979 2020

• 77 Article
• 5 Review article
• 3 Comment/debate
• 1 Chapter

Research Output per year

Research Output per year

Search results

• 2020

  Amino acids regulate cisplatin insensitivity in neuroblastoma

  Gunda, V., Pathania, A. S., Chava, S., Prathipati, P., Chaturvedi, N. K., Coulter, D. W., Pandey, M. K., Durden, D. L. & Challagundla, K. B., Sep 2020, In: Cancers. 12, 9, p. 1-17 17 p., 2576.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Neuroblastoma
  • Cisplatin
  • Amino Acids
  • Hydroxychloroquine
  • Autophagy
  1 Scopus citations

• COVID-19 and cancer comorbidity: Therapeutic opportunities and challenges

  Pathania, A. S., Prathipati, P., Abdul, B. A. A., Chava, S., Katta, S. S., Gupta, S. C., Gangula, P. R., Pandey, M. K., Durden, D. L., Byrareddy, S. N. & Challagundla, K. B., 2020, In: Theranostics. 11, 2, p. 731-753 23 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Coronavirus
  • Comorbidity
  • Neoplasms
  • Pandemics
  • Severe Acute Respiratory Syndrome
• 2019

  Combinatorial Approach to Improve Cancer Immunotherapy: Rational Drug Design Strategy to Simultaneously Hit Multiple Targets to Kill Tumor Cells and to Activate the Immune System

  Joshi, S. & Durden, D. L., 2019, In: Journal of Oncology. 2019, 5245034.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Drug Design
  • Immunotherapy
  • Immune System
  • Neoplasms
  • Myeloid-Derived Suppressor Cells
  34 Scopus citations

• Erratum: Vascular permeability and remodelling coincide with inflammatory and reparative processes after joint bleeding in factor VIII-deficient mice (Thrombosis and Haemostasis (2018) 118:6 DOI: 10.1055/s-0038-1641755)

  Cooke, E. J., Zhou, J. Y., Wyseure, T., Joshi, S., Bhat, V., Durden, D. L., Mosnier, L. O. & Von Drygalski, A., 2019, In: Thrombosis and Haemostasis. 119, 9, p. 1546 1 p.

  Research output: Contribution to journal › Comment/debate › peer-review

  Open Access

  • Vascular Remodeling
  • Factor VIII
  • Capillary Permeability
  • Hemostasis
  • Names

• Nilotinib, an approved leukemia drug, inhibits smoothened signaling in Hedgehog-dependent medulloblastoma

  Chahal, K. K., Li, J., Kufareva, I., Parle, M., Durden, D. L., Wechsler-Reya, R. J., Chen, C. C. & Abagyan, R., Sep 1 2019, In: PloS one. 14, 9, e0214901.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • 4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide
  • Hedgehogs
  • Erinaceidae
  • Medulloblastoma
  • leukemia
  1 Scopus citations

• SF2523: Dual PI3K/BRD4 inhibitor blocks tumor immunosuppression and promotes adaptive immune responses in cancer

  Joshi, S., Singh, A. R., Liu, K. X., Pham, T. V., Zulcic, M., Skola, D., Chun, H. B., Glass, C. K., Morales, G. A., Garlich, J. R. & Durden, D. L., 2019, In: Molecular cancer therapeutics. 18, 6, p. 1036-1044 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Adaptive Immunity
  • Phosphatidylinositol 3-Kinases
  • Immunosuppression
  • Tumor Microenvironment
  • Immunosuppressive Agents
  10 Scopus citations
• 2018

  Induction of autophagy by PI3K/MTOR and PI3K/MTOR/BRD4 inhibitors suppresses HIV-1 replication

  Campbell, G. R., Bruckman, R. S., Herns, S. D., Joshi, S., Durden, D. L. & Spector, S. A., Apr 20 2018, In: Journal of Biological Chemistry. 293, 16, p. 5808-5820 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Macrophages
  • dactolisib
  • Phosphatidylinositol 3-Kinases
  • Autophagy
  • HIV-1
  18 Scopus citations

• Vascular Permeability and Remodelling Coincide with Inflammatory and Reparative Processes after Joint Bleeding in Factor VIII-Deficient Mice

  Cooke, E. J., Zhou, J. Y., Wyseure, T., Joshi, S., Bhat, V., Durden, D. L., Mosnier, L. O. & Drygalski, A. V., Jun 1 2018, In: Thrombosis and Haemostasis. 118, 6, p. 1036-1047 12 p., 170891.

  Research output: Contribution to journal › Article › peer-review

  • Hemarthrosis
  • Vascular Remodeling
  • Factor VIII
  • Capillary Permeability
  • Joints
  14 Scopus citations
• 2017

  Dual-activity PI3K-BRD4 inhibitor for the orthogonal inhibition of MYC to block tumor growth and metastasis

  Andrews, F. H., Singh, A. R., Joshi, S., Smith, C. A., Morales, G. A., Garlich, J. R., Durden, D. L. & Kutateladze, T. G., Feb 14 2017, In: Proceedings of the National Academy of Sciences of the United States of America. 114, 7, p. E1072-E1080

  Research output: Contribution to journal › Article › peer-review

  • Phosphatidylinositol 3-Kinases
  • Neoplasm Metastasis
  • Growth
  • Neoplasms
  • Lead
  51 Scopus citations

• Rac2 is required for alternative macrophage activation and bleomycin induced pulmonary fibrosis; a macrophage autonomous phenotype

  Joshi, S., Singh, A. R., Wong, S. S., Zulcic, M., Jiang, M., Pardo, A., Selman, M., Hagood, J. S. & Durden, D. L., Aug 2017, In: PloS one. 12, 8, e0182851.

  Research output: Contribution to journal › Article › peer-review

  • Macrophages
  • macrophage activation
  • fibrosis
  • Pulmonary Fibrosis
  • Macrophage Activation
  12 Scopus citations

• The differential ability of asparagine and glutamine in promoting the closed/active enzyme conformation rationalizes the Wolinella succinogenes L-asparaginase substrate specificity

  Nguyen, H. A., Durden, D. L. & Lavie, A., Jan 31 2017, In: Scientific reports. 7, 41643.

  Research output: Contribution to journal › Article › peer-review

  • Wolinella
  • Glutaminase
  • Asparaginase
  • Asparagine
  • Substrate Specificity
  11 Scopus citations
• 2016

  PI-3K inhibitors preferentially target CD15+ cancer stem cell population in SHH driven medulloblastoma

  Singh, A. R., Joshi, S., Zulcic, M., Alcaraz, M., Garlich, J. R., Morales, G. A., Cho, Y. J., Bao, L., Levy, M. L., Newbury, R., Malicki, D., Messer, K., Crawford, J. & Durden, D. L., Mar 2016, In: PloS one. 11, 3, e0150836.

  Research output: Contribution to journal › Article › peer-review

  • Stem cells
  • phosphatidylinositol 3-kinase
  • Hedgehog Proteins
  • Erinaceidae
  • Medulloblastoma
  11 Scopus citations

• Single agent and synergistic activity of the "first-in-class" dual PI3K/BRD4 inhibitor SF1126 with sorafenib in hepatocellular carcinoma

  Singh, A. R., Joshi, S., Burgoyne, A. M., Sicklick, J. K., Ikeda, S., Kono, Y., Garlich, J. R., Morales, G. A. & Durden, D. L., Nov 2016, In: Molecular cancer therapeutics. 15, 11, p. 2553-2562 10 p.

  Research output: Contribution to journal › Article › peer-review

  • SF 1126
  • Sorafenib
  • Phosphatidylinositol 3-Kinases
  • Hepatocellular Carcinoma
  • Phase II Clinical Trials
  27 Scopus citations
• 2015

  Knockout serum replacement promotes cell survival by preventing BIM from inducing mitochondrial cytochrome c release

  Ishii, Y., Nhiayi, M. K., Tse, E., Cheng, J., Massimino, M., Durden, D. L., Vigneri, P. & Wang, J. Y. J., Oct 16 2015, In: PloS one. 10, 10, e0140585.

  Research output: Contribution to journal › Article › peer-review

  • Phosphorylation
  • cytochrome c
  • Cytochromes c
  • Cells
  • cell viability
  10 Scopus citations

• Pan-PI-3 kinase inhibitor SF1126 shows antitumor and antiangiogenic activity in renal cell carcinoma

  Joshi, S., Singh, A. R. & Durden, D. L., Mar 2015, In: Cancer Chemotherapy and Pharmacology. 75, 3, p. 595-608 14 p.

  Research output: Contribution to journal › Article › peer-review

  • SF 1126
  • Phosphatidylinositol 3-Kinases
  • Cells
  • Renal Cell Carcinoma
  • Tumors
  14 Scopus citations

• Vascular remodeling underlies rebleeding in hemophilic arthropathy

  Bhat, V., Olmer, M., Joshi, S., Durden, D. L., Cramer, T. J., Barnes, R. F. W., Ball, S. T., Hughes, T. H., Silva, M., Luck, J. V., Moore, R. E., Mosnier, L. O. & von Drygalski, A., Nov 2015, In: American Journal of Hematology. 90, 11, p. 1027-1035 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Vascular Remodeling
  • Joint Diseases
  • Joints
  • Hemophilia A
  • Blood Vessels
  41 Scopus citations
• 2014

  A macrophage-dominant PI3K isoform controls hypoxia-induced HIF1α and HIF2α stability and tumor growth, angiogenesis, and metastasis

  Joshi, S., Singh, A. R., Zulcic, M. & Durden, D. L., Oct 1 2014, In: Molecular Cancer Research. 12, 10, p. 1520-1531 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Phosphatidylinositol 3-Kinases
  • Protein Isoforms
  • Hypoxia
  • Macrophages
  • Neoplasm Metastasis
  64 Scopus citations

• Anti-tumor effect of a novel PI3-kinase inhibitor, SF1126, in ¹² V-Ha-Ras transgenic mouse glioma model

  Singh, A. R., Joshi, S., George, E. & Durden, D. L., 2014, In: Cancer Cell International. 14, 1, 105.

  Research output: Contribution to journal › Article › peer-review

  • SF 1126
  • Phosphatidylinositol 3-Kinases
  • Glioma
  • Transgenic Mice
  • Vitronectin
  12 Scopus citations

• A PKC-SHP1 signaling axis desensitizes Fcγ receptor signaling by reducing the tyrosine phosphorylation of CBL and regulates FcγR mediated phagocytosis

  Joshi, S., Singh, A. R., Zulcic, M. & Durden, D. L., May 7 2014, In: BMC Immunology. 15, 1, 18.

  Research output: Contribution to journal › Article › peer-review

  • Fc Receptors
  • Phagocytosis
  • Tyrosine
  • Phosphorylation
  • Guanosine Triphosphate
  5 Scopus citations

• MDM2 regulates hypoxic hypoxia-inducible factor 1α stability in an E3 ligase, proteasome, and PTEN-phosphatidylinositol 3-kinase-AKT-dependent manner

  Joshi, S., Singh, A. R. & Durden, D. L., Aug 15 2014, In: Journal of Biological Chemistry. 289, 33, p. 22785-22797 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Hypoxia-Inducible Factor 1
  • Ubiquitin-Protein Ligases
  • Proteasome Endopeptidase Complex
  • Phosphatidylinositol 3-Kinase
  • Phosphatidylinositol 3-Kinases
  49 Scopus citations

• Pediatric phase II trials of poly-ICLC in the management of newly diagnosed and recurrent brain tumors

  Hartman, L. L. R., Crawford, J. R., Makale, M. T., Milburn, M., Joshi, S., Salazar, A. M., Hasenauer, B., Vandenberg, S. R., Macdonald, T. J. & Durden, D. L., Aug 2014, In: Journal of Pediatric Hematology/Oncology. 36, 6, p. 451-457 7 p.

  Research output: Contribution to journal › Article › peer-review

  • poly ICLC
  • Brain Neoplasms
  • Glioma
  • Pediatrics
  • Child
  23 Scopus citations

• PTEN and PI-3 kinase inhibitors control LPS signaling and the lymphoproliferative response in the CD19+ B cell compartment

  Singh, A. R., Peirce, S. K., Joshi, S. & Durden, D. L., Sep 10 2014, In: Experimental Cell Research. 327, 1, p. 78-90 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Phosphatidylinositol 3-Kinases
  • B-Lymphocytes
  • Pattern Recognition Receptors
  • Splenomegaly
  • SF 1126
  9 Scopus citations

• PTEN status mediates 2ME2 anti-tumor efficacy in preclinical glioblastoma models: Role of HIF1α suppression

  Muh, C. R., Joshi, S., Singh, A. R., Kesari, S., Durden, D. L. & Makale, M. T., Jan 2014, In: Journal of Neuro-Oncology. 116, 1, p. 89-97 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Glioblastoma
  • Glioma
  • Phosphatidylinositol 3-Kinases
  • Brain Neoplasms
  • Neoplasms
  12 Scopus citations

• Rac2 controls tumor growth, metastasis and M1-M2 macrophage differentiation in vivo

  Joshi, S., Singh, A. R., Zulcic, M., Bao, L., Messer, K., Ideker, T., Dutkowski, J. & Durden, D. L., Apr 25 2014, In: PloS one. 9, 4, e95893.

  Research output: Contribution to journal › Article › peer-review

  • Macrophages
  • metastasis
  • Tumors
  • macrophages
  • neoplasms
  64 Scopus citations
• 2013

  An integrin-targeted, pan-isoform, phosphoinositide-3 kinase inhibitor, SF1126, has activity against multiple myeloma in vivo

  De, P., Dey, N., Terakedis, B., Bergsagel, P. L., Li, Z. H., Mahadevan, D., Garlich, J. R., Trudel, S., Makale, M. T. & Durden, D. L., Apr 2013, In: Cancer Chemotherapy and Pharmacology. 71, 4, p. 867-881 15 p.

  Research output: Contribution to journal › Article › peer-review

  • SF 1126
  • Phosphatidylinositol 3-Kinase
  • Multiple Myeloma
  • Integrins
  • Protein Isoforms
  19 Scopus citations

• Distinct roles for fibroblast growth factor signaling in cerebellar development and medulloblastoma

  Emmenegger, B. A., Hwang, E. I., Moore, C., Markant, S. L., Brun, S. N., Dutton, J. W., Read, T. A., Fogarty, M. P., Singh, A. R., Durden, D. L., Yang, C., McKeehan, W. L. & Wechsler-Reya, R. J., Aug 29 2013, In: Oncogene. 32, 35, p. 4181-4188 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Medulloblastoma
  • Fibroblast Growth Factors
  • Hedgehog Proteins
  • Neurons
  • Fibroblast Growth Factor 2
  23 Scopus citations

• Synthesis and cancer stem cell-based activity of substituted 5-morpholino-7H-thieno[3,2-b]pyran-7-ones designed as next generation PI3K inhibitors

  Morales, G. A., Garlich, J. R., Su, J., Peng, X., Newblom, J., Weber, K. & Durden, D. L., Mar 14 2013, In: Journal of Medicinal Chemistry. 56, 5, p. 1922-1939 18 p.

  Research output: Contribution to journal › Article › peer-review

  • Pyrans
  • Morpholinos
  • Neoplastic Stem Cells
  • Phosphatidylinositol 3-Kinase
  • SF 1126
  31 Scopus citations
• 2012

  Phase i pharmacokinetic and pharmacodynamic study of the pan-PI3K/mTORC vascular targeted pro-drug SF1126 in patients with advanced solid tumours and B-cell malignancies

  Mahadevan, D., Chiorean, E. G., Harris, W. B., Von Hoff, D. D., Stejskal-Barnett, A., Qi, W., Anthony, S. P., Younger, A. E., Rensvold, D. M., Cordova, F., Shelton, C. F., Becker, M. D., Garlich, J. R., Durden, D. L. & Ramanathan, R. K., Dec 2012, In: European Journal of Cancer. 48, 18, p. 3319-3327 9 p.

  Research output: Contribution to journal › Article › peer-review

  • SF 1126
  • Prodrugs
  • Phosphatidylinositol 3-Kinases
  • B-Lymphocytes
  • Pharmacokinetics
  76 Scopus citations

• SF1126, a Pan-PI3K inhibitor has potent pre-clinical activity in aggressive B-cell non-Hodgkin lymphomas by inducing cell cycle arrest and apoptosis

  Qi, W., Stejskal, A., Morales, C., Cooke, L. S., Garlich, J. R., Durden, D. & Mahadevan, D., 2012, In: Journal of Cancer Science and Therapy. 4, 7, p. 207-213 7 p.

  Research output: Contribution to journal › Article › peer-review

  • SF 1126
  • B-Cell Lymphoma
  • Phosphatidylinositol 3-Kinases
  • Cell Cycle Checkpoints
  • Non-Hodgkin's Lymphoma
  4 Scopus citations
• 2011

  The PI-3 kinase-Akt-MDM2-survivin signaling axis in high-risk neuroblastoma: A target for PI-3 kinase inhibitor intervention

  Peirce, S. K., Findley, H. W., Prince, C., Dasgupta, A., Cooper, T. & Durden, D. L., Aug 2011, In: Cancer Chemotherapy and Pharmacology. 68, 2, p. 325-335 11 p.

  Research output: Contribution to journal › Article › peer-review

  • SF 1126
  • Survivin
  • Phosphatidylinositol 3-Kinases
  • Neuroblastoma
  • Tumors
  19 Scopus citations
• 2010

  Heterozygosity for Ptenpromotes Tumorigenesis in a Mouse Model of Medulloblastoma

  Castellino, R. C., Barwick, B. G., Schniederjan, M., Buss, M. C., Becher, O., Hambardzumyan, D., Macdonald, T. J., Brat, D. J. & Durden, D. L., 2010, In: PloS one. 5, 5, e10849.

  Research output: Contribution to journal › Article › peer-review

  • Medulloblastoma
  • carcinogenesis
  • Tumors
  • phosphatidylinositol 3-kinase
  • Genes
  34 Scopus citations

• In vitro evaluation of pan-PI3-kinase inhibitor SF1126 in trastuzumab-sensitive and trastuzumab-resistant HER2-over-expressing breast cancer cells

  Ozbay, T., Durden, D. L., Liu, T., O'Regan, R. M. & Nahta, R., Mar 2010, In: Cancer Chemotherapy and Pharmacology. 65, 4, p. 697-706 10 p.

  Research output: Contribution to journal › Article › peer-review

  • SF 1126
  • Trastuzumab
  • Phosphatidylinositol 3-Kinases
  • Cells
  • Breast Neoplasms
  35 Scopus citations
• 2009

  Epidermal growth factor receptor and PTEN modulate tissue factor expression in glioblastoma through JunD/activator protein-1 transcriptional activity

  Rong, Y., Belozerov, V. E., Tucker-Burden, C., Chen, G., Durden, D. L., Olson, J. J., Van Meir, E. G., Mackinan, N. & Brat, D. J., Mar 15 2009, In: Cancer Research. 69, 6, p. 2540-2549 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Thromboplastin
  • Transcription Factor AP-1
  • Glioblastoma
  • ErbB Receptors
  • Astrocytoma
  91 Scopus citations

• Erratum to "Expression of RAC2 in endothelial cells is required for the postnatal neovascular response" [Exp. Cell Res. 315 (2009) 248-263] (DOI:10.1016/j.yexcr.2008.10.003)

  De, P., Peng, Q., Traktuev, D. O., Li, W., Yoder, M. C., March, K. L. & Durden, D. L., Oct 1 2009, In: Experimental Cell Research. 315, 16, p. 2869 1 p.

  Research output: Contribution to journal › Comment/debate › peer-review

• Expression of RAC2 in endothelial cells is required for the postnatal neovascular response

  De, P., Peng, Q., Traktuevc, D. O., Li, W., Yoder, M. C., March, K. L. & Durden, D. L., Jan 15 2009, In: Experimental Cell Research. 315, 2, p. 248-263 16 p.

  Research output: Contribution to journal › Article › peer-review

  • Integrins
  • Endothelial Cells
  • Vitronectin
  • matrigel
  • GTP Phosphohydrolases
  13 Scopus citations

• PHA665752, a small-molecule inhibitor of c-Met, inhibits hepatocyte growth factor-stimulated migration and proliferation of c-Met-positive neuroblastoma cells

  Crosswell, H. E., Dasgupta, A., Alvarado, C. S., Watt, T., Christensen, J. G., De, P., Durden, D. L. & Findley, H. W., Nov 25 2009, In: BMC cancer. 9, 411.

  Research output: Contribution to journal › Article › peer-review

  • 5-((2,6-dichlorobenzyl)sulfonyl)-3-((3,5-dimethyl-4-((2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-1,3-dihydro-2H-indol-2-one
  • Hepatocyte Growth Factor
  • Neuroblastoma
  • Cell Proliferation
  • Rosiglitazone
  34 Scopus citations

• PI-3 Kinase-PTEN signaling node: An intercept point for the control of angiogenesis

  Castellino, R. C., Muh, C. R. & Durden, D. L., 2009, In: Current Pharmaceutical Design. 15, 4, p. 380-388 9 p.

  Research output: Contribution to journal › Review article › peer-review

  • Cell Surface Receptors
  • Phosphatidylinositol 3-Kinases
  • Bevacizumab
  • Growth
  • Cell Cycle Checkpoints
  16 Scopus citations

• Regulation of XIAP Translation and Induction by MDM2 following Irradiation

  Gu, L., Zhu, N., Zhang, H., Durden, D. L., Feng, Y. & Zhou, M., May 5 2009, In: Cancer Cell. 15, 5, p. 363-375 13 p.

  Research output: Contribution to journal › Article › peer-review

  • X-Linked Inhibitor of Apoptosis Protein
  • Up-Regulation
  • Apoptosis
  • 5' Untranslated Regions
  • DNA Damage
  121 Scopus citations
• 2008

  A vascular targeted pan phosphoinositide 3-kinase inhibitor prodrug, SF1126, with antitumor and antiangiogenic activity

  Garlich, J. R., De, P., Dey, N., Jing, D. S., Peng, X., Miller, A., Murali, R., Lu, Y., Mills, G. B., Kundra, V., Shu, H. K., Peng, Q. & Durden, D. L., Jan 1 2008, In: Cancer Research. 68, 1, p. 206-215 10 p.

  Research output: Contribution to journal › Article › peer-review

  • SF 1126
  • Prodrugs
  • Phosphatidylinositol 3-Kinase
  • Blood Vessels
  • 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one
  240 Scopus citations

• Rap1a null mice have altered myeloid cell functions suggesting distinct roles for the closely related Rap1a and 1b proteins (Journal of Immunology (2007) 179 (8322-8331))

  Li, Y., Yan, J., De, P., Chang, H. C., Yamauchi, A., Christopherson, K. W., Paranavitana, N. C., Peng, X., Kim, C., Munugulavadla, V., Kapur, R., Chen, H., Shou, W., Stone, J. C., Kaplan, M. H., Dinauer, M. C., Durden, D. L. & Quilliam, L. A., Mar 1 2008, In: Journal of Immunology. 180, 5, p. 3612 1 p.

  Research output: Contribution to journal › Comment/debate › peer-review
  1 Scopus citations

• The protein phosphatase activity of PTEN regulates Src family kinases and controls glioma migration

  Dey, N., Crosswell, H. E., Pradip, D., Parsons, R., Peng, Q., Jing, D. S. & Durden, D. L., Mar 15 2008, In: Cancer Research. 68, 6, p. 1862-1871 10 p.

  Research output: Contribution to journal › Article › peer-review

  • PTEN Phosphohydrolase
  • src-Family Kinases
  • Glioma
  • Phosphotransferases
  • Phosphatidylinositol 3-Kinase
  124 Scopus citations
• 2007

  A short N-terminal sequence of PTEN controls cytoplasmic localization and is required for suppression of cell growth

  Denning, G., Jean-Joseph, B., Prince, C., Durden, D. L. & Vogt, P. K., Jun 7 2007, In: Oncogene. 26, 27, p. 3930-3940 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Nuclear Localization Signals
  • Phosphoric Monoester Hydrolases
  • Growth
  • Nuclear Export Signals
  • phosphatidylinositol 3,4,5-triphosphate
  80 Scopus citations

• CSK controls Retinoic Acid Receptor (RAR) signaling: A RAR-c-SRC signaling axis is required for neuritogenic differentiation

  Dey, N., De, P. K., Wang, M., Zhang, H., Dobrota, E. A., Robertson, K. A. & Durden, D. L., Jun 2007, In: Molecular and cellular biology. 27, 11, p. 4179-4197 19 p.

  Research output: Contribution to journal › Article › peer-review

  • Retinoic Acid Receptors
  • Tretinoin
  • Neuronal Outgrowth
  • Surface Plasmon Resonance
  • Proline
  49 Scopus citations

• Mechanisms of Disease: The PI3K-Akt-PTEN signaling node - An intercept point for the control of angiogenesis in brain tumors

  Castellino, R. C. & Durden, D. L., Dec 2007, In: Nature Clinical Practice Neurology. 3, 12, p. 682-693 12 p.

  Research output: Contribution to journal › Review article › peer-review

  • Tensins
  • Phosphoric Monoester Hydrolases
  • Phosphatidylinositol 3-Kinase
  • Brain Neoplasms
  • Cell Surface Receptors
  92 Scopus citations

• Rap1a null mice have altered myeloid cell functions suggesting distinct roles for the closely related Rap1a and 1b proteins

  Li, Y., Yan, J., De, P., Chang, H. C., Yamauchi, A., Christopherson, K. W., Paranavitana, N. C., Peng, X., Kim, C., Munugulavadla, V., Kapur, R., Chen, H., Shou, W., Stone, J. C., Kaplan, M. H., Dinauer, M. C., Durden, D. L. & Quilliam, L. A., Dec 15 2007, In: Journal of Immunology. 179, 12, p. 8322-8331 10 p.

  Research output: Contribution to journal › Article › peer-review

  • rap1 GTP-Binding Proteins
  • Myeloid Cells
  • Chemotaxis
  • Superoxides
  • Neutrophils
  83 Scopus citations
• 2006

  Early growth response gene-1 regulates hypoxia-induced expression of tissue factor in glioblastoma multiforme through hypoxia-inducible factor-1-independent mechanisms

  Rong, Y., Hu, F., Huang, R. P., Mackman, N., Horowitz, J. M., Jensen, R. L., Durden, D. L., Van Meir, E. G. & Brat, D. J., Jul 15 2006, In: Cancer Research. 66, 14, p. 7067-7074 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Hypoxia-Inducible Factor 1
  • Thromboplastin
  • Glioblastoma
  • Hypoxia
  • Growth
  79 Scopus citations

• 'Pseudopalisading' necrosis in glioblastoma: A familiar morphologic feature that links vascular pathology, hypoxia, and angiogenesis

  Rong, Y., Durden, D. L., Van Meir, E. G. & Brat, D. J., Jun 2006, In: Journal of Neuropathology and Experimental Neurology. 65, 6, p. 529-539 11 p.

  Research output: Contribution to journal › Review article › peer-review

  • Glioblastoma
  • Hypoxia
  • Necrosis
  • Pathology
  • Blood Vessels
  337 Scopus citations

• Role of glutamine depletion in directing tissue-specific nutrient stress responses to L-asparaginase

  Reinert, R. B., Oberle, L. M., Wek, S. A., Bunpo, P., Xue, P. W., Mileva, I., Goodwin, L. O., Aldrich, C. J., Durden, D. L., McNurlan, M. A., Wek, R. C. & Anthony, T. G., Oct 20 2006, In: Journal of Biological Chemistry. 281, 42, p. 31222-31233 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Asparaginase
  • Phosphorylation
  • Nutrients
  • Wolinella
  • Escherichia coli
  71 Scopus citations
• 2005

  CSK negatively regulates nerve growth factor induced neural differentiation and augments AKT kinase activity

  Dey, N., Howell, B. W., De, P. K. & Durden, D. L., Jul 1 2005, In: Experimental Cell Research. 307, 1, p. 1-14 14 p.

  Research output: Contribution to journal › Article › peer-review

  • src-Family Kinases
  • Nerve Growth Factor
  • Phosphotransferases
  • Neuronal Outgrowth
  • PC12 Cells
  28 Scopus citations

• Cytokine expression and signaling in brain tumors

  Dey, N., Durden, D. L. & Van Meir, E. G., Jan 1 2005, Cytokines and the CNS. CRC Press, p. 194-242 49 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • Tumors
  • Brain Neoplasms
  • Brain
  • Central Nervous System Neoplasms
  • Cytokines
  1 Scopus citations