Eppley Institute for Cancer Research

Research Output

2020

High-speed atomic force microscopy directly visualizes conformational dynamics of the HIV Vif protein in complex with three host proteins

Pan, Y., Shlyakhtenko, L. S. & Lyubchenko, Y. L., Aug 21 2020, In : The Journal of biological chemistry. 295, 34, p. 11995-12001 7 p.

Research output: Contribution to journalArticle

Open Access

High-throughput identification of protein functional similarities using a gene-expression-based siRNA screen

Neilsen, B. K., Kelly, D. L., Chakraborty, B., Kim, H. S., White, M. A., Lewis, R. E. & Fisher, K. W., Dec 1 2020, In : Scientific Data. 7, 1, 27.

Research output: Contribution to journalArticle

Open Access

HLA-B influences integrin beta-1 expression and pancreatic cancer cell migration

Sliker, B. H., Goetz, B. T., Barnes, R., King, H., Maurer, H. C., Olive, K. P. & Solheim, J. C., May 15 2020, In : Experimental Cell Research. 390, 2, 111960.

Research output: Contribution to journalArticle

Homologous Recombination Repair Truncations Predict Hypermutation in Microsatellite Stable Colorectal and Endometrial Tumors

Lee, M., Eng, G., Barbari, S. R., Deshpande, V., Shcherbakova, P. V. & Gala, M. K., Mar 1 2020, In : Clinical and translational gastroenterology. 11, 3, p. e00149

Research output: Contribution to journalArticle

Open Access

How does fascin promote cancer metastasis?

Lin, S., Taylor, M. D., Singh, P. K. & Yang, S., 2020, (Accepted/In press) In : FEBS Journal.

Research output: Contribution to journalReview article

Open Access

IL-17–CXC Chemokine Receptor 2 Axis Facilitates Breast Cancer Progression by Up-Regulating Neutrophil Recruitment

Wu, L., Awaji, M., Saxena, S., Varney, M. L., Sharma, B. & Singh, R. K., Jan 2020, In : American Journal of Pathology. 190, 1, p. 222-233 12 p.

Research output: Contribution to journalArticle

4 Scopus citations

Image-guided tumor surgery: The emerging role of nanotechnology

Wojtynek, N. E. & Mohs, A. M., Jul 1 2020, In : Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology. 12, 4, e1624.

Research output: Contribution to journalReview article

3 Scopus citations

Inhibitory activity of salivary glycoproteins on phytohemagglutins (PHA): Possible molecules to enhance nutritional quality of red kidney beans

Chachadi, V. B., Nayanegali, T. R., Pujari, B. G., Umarji, L. V., Budyhalamath, V., Inamdar, S. R. & Cheng, P. W., Jun 2020, In : Legume Research. 43, 3, p. 337-344 8 p., LR-4034.

Research output: Contribution to journalArticle

Open Access

Interaction of aβ42 with membranes triggers the self-assembly into oligomers

Banerjee, S., Hashemi, M., Zagorski, K. & Lyubchenko, Y. L., Feb 1 2020, In : International journal of molecular sciences. 21, 3, 1129.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

International harmonization in performing and reporting minimal residual disease assessment in multiple myeloma trials

Costa, L. J., Derman, B. A., Bal, S., Sidana, S., Chhabra, S., Silbermann, R., Ye, J. C., Cook, G., Cornell, R. F., Holstein, S. A., Shi, Q., Omel, J., Callander, N. S., Chng, W. J., Hungria, V., Maiolino, A., Stadtmauer, E., Giralt, S., Pasquini, M., Jakubowiak, A. J. & 16 others, Morgan, G. J., Krishnan, A., Jackson, G. H., Mohty, M., Mateos, M. V., Dimopoulos, M. A., Facon, T., Spencer, A., Miguel, J. S., Hari, P., Usmani, S. Z., Manier, S., McCarthy, P., Kumar, S., Gay, F. & Paiva, B., 2020, (Accepted/In press) In : Leukemia.

Research output: Contribution to journalReview article

2 Scopus citations

In vivo modeling of metastatic human highgrade serous ovarian cancer in mice

Kim, O., Park, E. Y., Klinkebie, D. L., Pack, S. D., Shin, Y. H., Abdullaev, Z., Emerson, R. E., Coffey, D. M., Kwon, S. Y., Creighton, C. J., Kwon, S., Chang, E. C., Chiang, T., Yatsenko, A. N., Chien, J., Cheon, D. J., Yang-Hartwich, Y., Nakshatri, H., Nephew, K. P., Behringer, R. R. & 8 others, Fernandez, F. M., Cho, C. H., Vanderhyden, B., Drapkin, R., Bast, R. C., Miller, K. D., Karpf, A. R. & Kim, J., Jun 2020, In : PLoS genetics. 16, 6, e1008808.

Research output: Contribution to journalArticle

Open Access

JNK signaling contributes to skeletal muscle wasting and protein turnover in pancreatic cancer cachexia

Mulder, S. E., Dasgupta, A., King, R. J., Abrego, J., Attri, K. S., Murthy, D., Shukla, S. K. & Singh, P. K., Oct 28 2020, In : Cancer Letters. 491, p. 70-77 8 p.

Research output: Contribution to journalArticle

Kilbournase, a protease-associated domain subtilase secreted by the fungal corn pathogen Stenocarpella maydis

Naumann, T. A., Naldrett, M. J. & Price, N. P. J., Aug 2020, In : Fungal Genetics and Biology. 141, 103399.

Research output: Contribution to journalArticle

Kinesin Kif2C in regulation of DNA double strand break dynamics and repair

Zhu, S., Paydar, M., Wang, F., Li, Y., Wang, L., Barrette, B., Bessho, T., Kwok, B. H. & Peng, A., Jan 2020, In : eLife. 9, e53402.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

KVA-D-88, a Novel Preferable Phosphodiesterase 4B Inhibitor, Decreases Cocaine-Mediated Reward Properties in Vivo

Burkovetskaya, M. E., Liu, Q., Vadukoot, A. K., Gautam, N., Alnouti, Y., Kumar, S., Miczek, K., Buch, S., Hopkins, C. R. & Guo, M., Aug 5 2020, In : ACS Chemical Neuroscience. 11, 15, p. 2231-2242 12 p.

Research output: Contribution to journalArticle

Lactate production by Staphylococcus aureus biofilm inhibits HDAC11 to reprogramme the host immune response during persistent infection

Heim, C. E., Bosch, M. E., Yamada, K. J., Aldrich, A. L., Chaudhari, S. S., Klinkebiel, D., Gries, C. M., Alqarzaee, A. A., Li, Y., Thomas, V. C., Seto, E., Karpf, A. R. & Kielian, T., Oct 1 2020, In : Nature Microbiology. 5, 10, p. 1271-1284 14 p.

Research output: Contribution to journalArticle

3 Scopus citations

Linking NRP2 With EMT and Chemoradioresistance in Bladder Cancer

Schulz, A., Gorodetska, I., Behrendt, R., Fuessel, S., Erdmann, K., Foerster, S., Datta, K., Mayr, T., Dubrovska, A. & Muders, M. H., Jan 21 2020, In : Frontiers in Oncology. 9, 1461.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Local and systemic immunosuppression in pancreatic cancer: Targeting the stalwarts in tumor's arsenal

Mundry, C. S., Eberle, K. C., Singh, P. K., Hollingsworth, M. A. & Mehla, K., Aug 2020, In : Biochimica et Biophysica Acta - Reviews on Cancer. 1874, 1, 188387.

Research output: Contribution to journalReview article

Open Access

Long-Term Follow-up of CALGB (Alliance) 100001: Autologous Followed by Nonmyeloablative Allogeneic Transplant for Multiple Myeloma

Holstein, S. A., Suman, V. J., Owzar, K., Santo, K., Benson, D. M., Shea, T. C., Martin, T., Silverman, M., Isola, L., Vij, R., Cheson, B. D., Linker, C., Anderson, K. C., Richardson, P. G. & McCarthy, P. L., Aug 2020, In : Biology of Blood and Marrow Transplantation. 26, 8, p. 1414-1424 11 p.

Research output: Contribution to journalArticle

Loss of NQO1 generates genotoxic estrogen-DNA adducts in Fuchs Endothelial Corneal Dystrophy

Miyajima, T., Melangath, G., Zhu, S., Deshpande, N., Vasanth, S., Mondal, B., Kumar, V., Chen, Y., Price, M. O., Price, F. W., Rogan, E. G., Zahid, M. & Jurkunas, U. V., Feb 1 2020, In : Free Radical Biology and Medicine. 147, p. 69-79 11 p.

Research output: Contribution to journalArticle

2 Scopus citations

Macrophages potentiate STAT3 signaling in skeletal muscles and regulate pancreatic cancer cachexia

Shukla, S. K., Markov, S. D., Attri, K. S., Vernucci, E., King, R. J., Dasgupta, A., Grandgenett, P. M., Hollingsworth, M. A., Singh, P. K., Yu, F. & Mehla, K., Aug 1 2020, In : Cancer Letters. 484, p. 29-39 11 p.

Research output: Contribution to journalArticle

1 Scopus citations

Management of immunotherapy-related toxicities, version 1.2020 featured updates to the NCCN guidelines

Thompson, J. A., Schneider, B. J., Brahmer, J., Andrews, S., Armand, P., Bhatia, S., Budde, L. E., Costa, L., Davies, M., Dunnington, D., Ernstoff, M. S., Frigault, M., Kaffenberger, B. H., Lunning, M., McGettigan, S., McPherson, J., Mohindra, N. A., Naidoo, J., Olszanski, A. J., Oluwole, O. & 12 others, Patel, S. P., Pennell, N., Reddy, S., Ryder, M., Santomasso, B., Shofer, S., Sosman, J. A., Wang, Y., Weight, R. M., Johnson-Chilla, A., Zuccarino-Catania, G. & Engh, A., 2020, In : JNCCN Journal of the National Comprehensive Cancer Network. 18, 3, p. 231-241 11 p.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

MARCH5-dependent degradation of MCL1/NOXA complexes defines susceptibility to antimitotic drug treatment

Haschka, M. D., Karbon, G., Soratroi, C., O’Neill, K. L., Luo, X. & Villunger, A., Aug 1 2020, In : Cell Death and Differentiation. 27, 8, p. 2297-2312 16 p.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Mechanistic and functional shades of mucins and associated glycans in colon cancer

Pothuraju, R., Krishn, S. R., Gautam, S. K., Pai, P., Ganguly, K., Chaudhary, S., Rachagani, S., Kaur, S. & Batra, S. K., Mar 2020, In : Cancers. 12, 3, 649.

Research output: Contribution to journalReview article

Open Access
1 Scopus citations

Metabolic alterations in pancreatic cancer progression

Vernucci, E., Abrego, J., Gunda, V., Shukla, S. K., Dasgupta, A., Rai, V., Chaika, N., Buettner, K., Illies, A., Yu, F., Lazenby, A. J., Swanson, B. J. & Singh, P. K., Jan 2020, In : Cancers. 12, 1, 2.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Metabolic subtyping for novel personalized therapies against pancreatic cancer

Mehla, K. & Singh, P. K., Jan 1 2020, In : Clinical Cancer Research. 26, 1, p. 6-8 3 p.

Research output: Contribution to journalArticle

2 Scopus citations

MicroRNAs Orchestrate Pathophysiology of Breast Cancer Brain Metastasis: Advances in Therapy

Kanchan, R. K., Siddiqui, J. A., Mahapatra, S., Batra, S. K. & Nasser, M. W., Feb 15 2020, In : Molecular cancer. 19, 1, 29.

Research output: Contribution to journalReview article

Open Access
2 Scopus citations

MiR-1253 exerts tumor-suppressive effects in medulloblastoma via inhibition of CDK6 and CD276 (B7-H3)

Kanchan, R. K., Perumal, N., Atri, P., Chirravuri Venkata, R., Thapa, I., Klinkebiel, D. L., Donson, A. M., Perry, D., Punsoni, M., Talmon, G. A., Coulter, D. W., Boue’, D. R., Snuderl, M., Nasser, M. W., Batra, S. K., Vibhakar, R. & Mahapatra, S., Jul 1 2020, In : Brain Pathology. 30, 4, p. 732-745 14 p.

Research output: Contribution to journalArticle

1 Scopus citations

Molecular implications of MUC5AC-CD44 axis in colorectal cancer progression and chemoresistance

Pothuraju, R., Rachagani, S., Krishn, S. R., Chaudhary, S., Nimmakayala, R. K., Siddiqui, J. A., Ganguly, K., Lakshmanan, I., Cox, J. L., Mallya, K., Kaur, S. & Batra, S. K., Feb 25 2020, In : Molecular cancer. 19, 1, 37.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Molecular Model for the Surface-Catalyzed Protein Self-Assembly

Pan, Y., Banerjee, S., Zagorski, K., Shlyakhtenko, L. S., Kolomeisky, A. B. & Lyubchenko, Y. L., Jan 16 2020, In : Journal of Physical Chemistry B. 124, 2, p. 366-372 7 p.

Research output: Contribution to journalArticle

3 Scopus citations

Monocyte metabolic reprogramming promotes pro-inflammatory activity and Staphylococcus aureus biofilm clearance

Yamada, K. J., Heim, C. E., Xi, X., Attri, K. S., Wang, D., Zhang, W., Singh, P. K., Bronich, T. K. & Kielian, T., 2020, In : PLoS pathogens. 16, 3, e1008354.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

MUC16 as a potential target for the surgical detection of pancreatic cancer

Olson, M. T., Wojtynek, N. E., Caffrey, T. C., Radhakrishnan, P., Ly, Q. P., Talmon, G. A., Hollingsworth, M. A. & Mohs, A. M., 2020, Molecular-Guided Surgery: Molecules, Devices, and Applications VI. Gioux, S., Gibbs, S. L. & Pogue, B. W. (eds.). SPIE, 112220M. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; vol. 11222).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

MUC1 oncoprotein mitigates ER stress via CDA-mediated reprogramming of pyrimidine metabolism

Olou, A. A., King, R. J., Yu, F. & Singh, P. K., Apr 16 2020, In : Oncogene. 39, 16, p. 3381-3395 15 p.

Research output: Contribution to journalArticle

1 Scopus citations

MUCIN-4 (MUC4) is a novel tumor antigen in pancreatic cancer immunotherapy

Gautam, S. K., Kumar, S., Dam, V., Ghersi, D., Jain, M. & Batra, S. K., Feb 2020, In : Seminars in Immunology. 47, 101391.

Research output: Contribution to journalReview article

1 Scopus citations

Nanoformulation of CCL21 greatly increases its effectiveness as an immunotherapy for neuroblastoma

Poelaert, B. J., Romanova, S., Knoche, S. M., Olson, M. T., Sliker, B. H., Smits, K., Dickey, B. L., Moffitt-Holida, A. E. J., Goetz, B. T., Khan, N., Smith, L., Band, H., Mohs, A. M., Coulter, D. W., Bronich, T. K. & Solheim, J. C., Nov 10 2020, In : Journal of Controlled Release. 327, p. 266-283 18 p.

Research output: Contribution to journalArticle

Nanoparticle Formulation of Indocyanine Green Improves Image-Guided Surgery in a Murine Model of Breast Cancer

Wojtynek, N. E., Olson, M. T., Bielecki, T. A., An, W., Bhat, A. M., Band, H., Lauer, S. R., Silva-Lopez, E. & Mohs, A. M., Aug 1 2020, In : Molecular Imaging and Biology. 22, 4, p. 891-903 13 p.

Research output: Contribution to journalArticle

1 Scopus citations

Nanoscale interaction of RecG with mobile fork DNA

Sun, Z., Wang, Y., Bianco, P. R. & Lyubchenko, Y. L., Mar 2020, In : Nanoscale Advances. 2, 3, p. 1318-1324 7 p.

Research output: Contribution to journalArticle

Open Access

Neuronal-derived extracellular vesicles are enriched in the brain and serum of HIV-1 transgenic rats

Dagur, R. S., Liao, K., Sil, S., Niu, F., Sun, Z., Lyubchenko, Y. L., Peeples, E. S., Hu, G. & Buch, S., Jan 1 2020, In : Journal of Extracellular Vesicles. 9, 1, 1703249.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Neuropilin-2 is an independent prognostic factor for shorter cancer-specific survival in patients with acinar adenocarcinoma of the prostate

Borkowetz, A., Froehner, M., Rauner, M., Conrad, S., Erdmann, K., Mayr, T., Datta, K., Hofbauer, L. C., Baretton, G. B., Wirth, M., Fuessel, S., Toma, M. & Muders, M. H., May 1 2020, In : International Journal of Cancer. 146, 9, p. 2619-2627 9 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Neutrophils in the Tumor Microenvironment

Wu, L., Saxena, S. & Singh, R. K., 2020, Advances in Experimental Medicine and Biology. Springer, p. 1-20 20 p. (Advances in Experimental Medicine and Biology; vol. 1224).

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Nonsynonymous mutations in linker-2 of the PDR5 multidrug transporter identify a new RNA stability element

Rahman, H., Rudrow, A., Carneglia, J., Patrick Joly, S. S., Nicotera, D., Naldrett, M., Choy, J., Ambudkar, S. V. & Golin, J., Jan 1 2020, In : G3: Genes, Genomes, Genetics. 10, 1, p. 357-369 13 p.

Research output: Contribution to journalArticle

Open Access

Odyssey of trefoil factors in cancer: Diagnostic and therapeutic implications

Jahan, R., Shah, A., Kisling, S. G., Macha, M. A., Thayer, S., Batra, S. K. & Kaur, S., Apr 2020, In : Biochimica et Biophysica Acta - Reviews on Cancer. 1873, 2, 188362.

Research output: Contribution to journalReview article

Oncology care delivery in the COVID-19 pandemic: An opportunity to study innovations and outcomes

Cinar, P., Cox, J., Kamal, A., Bickel, K., Krzyzanowska, M., Armitage, J., Ganti, A. K., Ward, J., Wong, S., Lonial, S. & Bosserman, L., 2020, In : JCO Oncology Practice. 16, 8, p. 431-435 5 p.

Research output: Contribution to journalReview article

Oncology Treatment in the Era of COVID-19: We Cannot Afford to Hit the Pause Button

Holstein, S. A. & Vose, J. M., Sep 1 2020, In : Clinical Pharmacology and Therapeutics. 108, 3, p. 422-424 3 p.

Research output: Contribution to journalComment/debate

Open Access
2 Scopus citations

Pan-cancer analysis of whole genomes

The ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium, Feb 6 2020, In : Nature. 578, 7793, p. 82-93 12 p.

Research output: Contribution to journalArticle

Open Access
109 Scopus citations

Pan-Cancer Analysis Reveals the Diverse Landscape of Novel Sense and Antisense Fusion Transcripts

Vellichirammal, N. N., Albahrani, A., Banwait, J. K., Mishra, N. K., Li, Y., Roychoudhury, S., Kling, M. J., Mirza, S., Bhakat, K. K., Band, V., Joshi, S. S. & Guda, C., Mar 6 2020, In : Molecular Therapy - Nucleic Acids. 19, p. 1379-1398 20 p.

Research output: Contribution to journalArticle

Open Access

Pancreatic ductal adenocarcinoma progression is restrained by stromal matrix

Jiang, H., Torphy, R. J., Steiger, K., Hongo, H., Ritchie, A. J., Kriegsmann, M., Horst, D., Umetsu, S. E., Joseph, N. M., McGregor, K., Pishvaian, M. J., Edik, M. B., Lu, B., Li, M., Hollingsworth, M., Stashko, C., Volmar, K., Yeh, J. J., Weaver, V. M., Wang, Z. J. & 3 others, Tempero, M. A., Weichert, W. & Collisson, E. A., Sep 1 2020, In : Journal of Clinical Investigation. 130, 9, p. 4704-4709 6 p.

Research output: Contribution to journalArticle

Open Access