Eppley Institute for Cancer Research

Research Output

2020

Pancreatic Stellate Cells: The Key Orchestrator of The Pancreatic Tumor Microenvironment

Thomas, D. & Radhakrishnan, P., 2020, Advances in Experimental Medicine and Biology. Springer, p. 57-70 14 p. (Advances in Experimental Medicine and Biology; vol. 1234).

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Participation of TDP1 in the repair of formaldehyde-induced DNA-protein crosslinks in chicken DT40 cells

Nakano, T., Shoulkamy, M. I., Tsuda, M., Sasanuma, H., Hirota, K., Takata, M., Masunaga, S. I., Takeda, S., Ide, H., Bessho, T. & Tano, K., Jun 2020, In : PloS one. 15, 6 June, e0234859.

Research output: Contribution to journalArticle

Open Access

Polyanhydride nanoparticles stabilize pancreatic cancer antigen MUC4β

Liu, L., Kshirsagar, P., Christiansen, J., Gautam, S. K., Aithal, A., Gulati, M., Kumar, S., Solheim, J. C., Batra, S. K., Jain, M., Wannemuehler, M. J. & Narasimhan, B., 2020, (Accepted/In press) In : Journal of Biomedical Materials Research - Part A.

Research output: Contribution to journalArticle

Polyproline-rich peptides associated with Torpedo californica acetylcholinesterase tetramers

Toker, L., Silman, I., Zeev-Ben-Mordehai, T., Sussman, J. L., Schopfer, L. M. & Lockridge, O., Mar 1 2020, In : Chemico-Biological Interactions. 319, 109007.

Research output: Contribution to journalArticle

Open Access

Potent, specific MEPicides for treatment of zoonotic staphylococci

Edwards, R. L., Heueck, I., Lee, S. G., Shah, I. T., Miller, J. J., Jezewski, A. J., Mikati, M. O., Wang, X., Brothers, R. C., Heidel, K. M., Osbourn, D. M., Burnham, C. A. D., Alvarez, S., Fritz, S. A., Dowd, C. S., Jez, J. M. & Odom John, A. R., Jun 2020, In : PLoS pathogens. 16, 6, e1007806.

Research output: Contribution to journalArticle

Open Access

Precision medicine and actionable alterations in lung cancer: A single institution experience

Mambetsariev, I., Wang, Y., Chen, C., Nadaf, S., Pharaon, R., Fricke, J., Amanam, I., Amini, A., Bild, A., Chu, P., Erhunmwunsee, L., Kim, J., Munu, J., Pillai, R., Raz, D., Sampath, S., Vora, L., Qiu, F., Smith, L., Batra, S. K. & 4 others, Massarelli, E., Koczywas, M., Reckamp, K. & Salgia, R., Feb 1 2020, In : PloS one. 15, 2, e0228188.

Research output: Contribution to journalArticle

Open Access

Predicted Prognosis of Patients with Pancreatic Cancer by Machine Learning

Yokoyama, S., Hamada, T., Higashi, M., Matsuo, K., Maemura, K., Kurahara, H., Horinouchi, M., Hiraki, T., Sugimoto, T., Akahane, T., Yonezawa, S., Kornmann, M., Batra, S. K., Hollingsworth, M. A. & Tanimoto, A., May 15 2020, In : Clinical Cancer Research. 26, 10, p. 2411-2421 11 p.

Research output: Contribution to journalArticle

Presence and structure-activity relationship of intrinsically disordered regions across mucins

Carmicheal, J., Atri, P., Sharma, S., Kumar, S., Chirravuri Venkata, R., Kulkarni, P., Salgia, R., Ghersi, D., Kaur, S. & Batra, S. K., Feb 1 2020, In : FASEB Journal. 34, 2, p. 1939-1957 19 p.

Research output: Contribution to journalArticle

Open Access

Primary cutaneous lymphomas, version 2.2020. Featured updates to the NCCN guidelines

Mehta-Shah, N., Horwitz, S. M., Ansell, S., Ai, W. Z., Barnes, J., Barta, S. K., Clemens, M. W., Dogan, A., Fisher, K., Goodman, A. M., Goyal, G., Guitart, J., Halwani, A., Haverkos, B. M., Hoppe, R. T., Jacobsen, E., Jagadeesh, D., Lunning, M. A., Mehta, A., Olsen, E. A. & 14 others, Pro, B., Rajguru, S. A., Shanbhag, S., Shaver, A., Shustov, A., Sokol, L., Torka, P., Torres-Cabala, C., Wilcox, R., William, B. M., Zain, J., Dwyer, M. A., Sundar, H. & Kim, Y. H., May 2020, In : JNCCN Journal of the National Comprehensive Cancer Network. 18, 5, p. 522-536 15 p.

Research output: Contribution to journalArticle

Open Access

Prognostic and therapeutic implications of NHERF1 expression and regulation in colorectal cancer

Leiphrakpam, P. D., Lazenby, A. J., Chowdhury, S., Smith, L. M., Mathiesen, M., Brattain, M. G., Wang, J., Black, J. D. & Are, C., Mar 1 2020, In : Journal of Surgical Oncology. 121, 3, p. 547-560 14 p.

Research output: Contribution to journalArticle

Proline 285 is integral for the reactivation of organophosphate-inhibited human butyrylcholinesterase by 2-PAM*

diTargiani, R. C., Belinskaya, T., Tipparaju, P., Lockridge, O. & Saxena, A., Jun 1 2020, In : Chemico-Biological Interactions. 324, 109092.

Research output: Contribution to journalArticle

Protecting groups in peptide synthesis

Conda-Sheridan, M. & Krishnaiah, M., 2020, Methods in Molecular Biology. Humana Press Inc., p. 111-128 18 p. (Methods in Molecular Biology; vol. 2103).

Research output: Chapter in Book/Report/Conference proceedingChapter

Radiomics-based outcome prediction for pancreatic cancer following stereotactic body radiotherapy

Parr, E., Du, Q., Zhang, C., Lin, C., Kamal, A., McAlister, J., Liang, X., Bavitz, K., Rux, G., Hollingsworth, M., Baine, M. & Zheng, D., Apr 2020, In : Cancers. 12, 4, 1051.

Research output: Contribution to journalArticle

Open Access

Radiomics in stratification of pancreatic cystic lesions: Machine learning in action

Dalal, V., Carmicheal, J., Dhaliwal, A., Jain, M., Kaur, S. & Batra, S. K., Jan 28 2020, In : Cancer Letters. 469, p. 228-237 10 p.

Research output: Contribution to journalReview article

2 Scopus citations

Repair and regeneration of small intestine: A review of current engineering approaches

Qi, D., Shi, W., Black, A. R., Kuss, M. A., Pang, X., He, Y., Liu, B. & Duan, B., May 2020, In : Biomaterials. 240, 119832.

Research output: Contribution to journalReview article

1 Scopus citations

Reprogramming of ovarian granulosa cells by YAP1 leads to development of high-grade cancer with mesenchymal lineage and serous features

Lv, X., He, C., Huang, C., Hua, G., Chen, X., Timm, B. K., Maclin, V. M., Haggerty, A. A., Aust, S. K., Golden, D. M., Dave, B. J., Tseng, Y. A., Chen, L., Wang, H., Chen, P., Klinkebiel, D. L., Karpf, A. R., Dong, J., Drapkin, R. I., Rueda, B. R. & 2 others, Davis, J. S. & Wang, C., Aug 15 2020, In : Science Bulletin. 65, 15, p. 1281-1296 16 p.

Research output: Contribution to journalArticle

Rilpivirine-associated aggregation-induced emission enables cell-based nanoparticle tracking

Mukadam, I. Z., Machhi, J., Herskovitz, J., Hasan, M., Oleynikov, M. D., Blomberg, W. R., Svechkarev, D., Mohs, A. M., Zhou, Y., Dash, P., McMillan, J. E., Gorantla, S., Garrison, J., Gendelman, H. E. & Kevadiya, B. D., Feb 2020, In : Biomaterials. 231, 119669.

Research output: Contribution to journalArticle

Role of non-Genetic Risk Factors in Exacerbating Alcohol-related organ damage

Osna, N. A., Bhatia, R., Thompson, C., Batra, S. K., Kumar, S., Cho, Y., Szabo, G., Molina, P. E., Weinman, S. A., Ganesan, M. & Kharbanda, K. K., Sep 2020, In : Alcohol. 87, p. 63-72 10 p.

Research output: Contribution to journalReview article

Role of tumor and stroma-derived IGF/IGFBPS in pancreatic cancer

Thomas, D. & Radhakrishnan, P., May 2020, In : Cancers. 12, 5, 1228.

Research output: Contribution to journalReview article

Open Access

Safety at the time of the COVID-19 Pandemic: How to keep our oncology patients and healthcare workers safe

Cinar, P., Kubal, T., Freifeld, A., Mishra, A., Shulman, L., Bachman, J., Fonseca, R., Uronis, H., Klemanski, D., Slusser, K., Lunning, M. & Liu, C., May 2020, In : JNCCN Journal of the National Comprehensive Cancer Network. 18, 5, p. 504-509 6 p.

Research output: Contribution to journalArticle

Open Access
17 Scopus citations
10 Scopus citations

Selective α7 nicotinic receptor agonists and positive allosteric modulators for the treatment of schizophrenia–a review

Antonio-Tolentino, K. & Hopkins, C. R., Jun 2 2020, In : Expert Opinion on Investigational Drugs. 29, 6, p. 603-610 8 p.

Research output: Contribution to journalReview article

Signature Ions in MS/MS Spectra for Dansyl-Aminohexyl-QQIV Adducts on Lysine

Schopfer, L. M. & Lockridge, O., Jun 8 2020, In : Molecules. 25, 11

Research output: Contribution to journalArticle

Open Access

Sirt1–nox4 signaling axis regulates cancer cachexia

Dasgupta, A., Shukla, S. K., Vernucci, E., King, R. J., Abrego, J., Mulder, S. E., Mullen, N. J., Graves, G., Buettner, K., Thakur, R., Murthy, D., Attri, K. S., Wang, D., Chaika, N. V., Pacheco, C. G., Rai, I., Engle, D. D., Grandgenett, P. M., Punsoni, M., Reames, B. N. & 10 others, Teoh-Fitzgerald, M., Oberley-Deegan, R., Yu, F., Klute, K. A., Hollingsworth, M. A., Zimmerman, M. C., Mehla, K., Sadoshima, J., Tuveson, D. A. & Singh, P. K., Jul 6 2020, In : Journal of Experimental Medicine. 217, 7, e20190745.

Research output: Contribution to journalArticle

1 Scopus citations

Solvent tuning of photochemistry upon excited-state symmetry breaking

Dereka, B., Svechkarev, D., Rosspeintner, A., Aster, A., Lunzer, M., Liska, R., Mohs, A. M. & Vauthey, E., Dec 1 2020, In : Nature communications. 11, 1, 1925.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Sorting nexin 17 (SNX17) links endosomal sorting to Eps15 homology domain protein 1 (EHD1)-mediated fission machinery

Dhawan, K., Naslavsky, N., Caplan, S. & Hanson, P. I., Mar 20 2020, In : Journal of Biological Chemistry. 295, 12, p. 3837-3850 14 p.

Research output: Contribution to journalArticle

1 Scopus citations

Spatiotemporally controlled overexpression of cyclin D1 triggers generation of supernumerary cells in the postnatal mouse inner ear

Tarang, S., Pyakurel, U., Weston, M. D., Vijayakumar, S., Jones, T., Wagner, K. U. & Rocha-Sanchez, S. M., May 2020, In : Hearing Research. 390, 107951.

Research output: Contribution to journalArticle

1 Scopus citations

Squamous trans-differentiation of pancreatic cancer cells promotes stromal inflammation

Somerville, T. D. D., Biffi, G., Daßler-Plenker, J., Hur, S. K., He, X. Y., Vance, K. E., Miyabayashi, K., Xu, Y., Maia-Silva, D., Klingbeil, O., Demerdash, O. E., Preall, J. B., Hollingsworth, M. A., Egeblad, M., Tuveson, D. A. & Vakoc, C. R., Apr 2020, In : eLife. 9, e53381.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Sterile α-motif domain requirement for cellular signaling and survival

Ray, S., Chee, L., Matson, D. R., Palermo, N. Y., Bresnick, E. H. & Hewitt, K. J., May 15 2020, In : Journal of Biological Chemistry. 295, 20, p. 7113-7125 13 p.

Research output: Contribution to journalArticle

Open Access

Stromal Modulation and Treatment of Metastatic Pancreatic Cancer with Local Intraperitoneal Triple miRNA/siRNA Nanotherapy

Xie, Y., Hang, Y., Wang, Y., Sleightholm, R., Prajapati, D. R., Bader, J., Yu, A., Tang, W., Jaramillo, L., Li, J., Singh, R. K. & Oupický, D., Jan 28 2020, In : ACS Nano. 14, 1, p. 255-271 17 p.

Research output: Contribution to journalArticle

4 Scopus citations

Sulfation Modulates the Targeting Properties of Hyaluronic Acid to P-Selectin and CD44

Bhattacharya, D. S., Svechkarev, D., Bapat, A., Patil, P., Hollingsworth, M. A. & Mohs, A. M., Jun 8 2020, In : ACS Biomaterials Science and Engineering. 6, 6, p. 3585-3598 14 p.

Research output: Contribution to journalArticle

Summary of the 2019 Blood and Marrow Transplant Clinical Trials Network Myeloma Intergroup Workshop on Minimal Residual Disease and Immune Profiling

Holstein, S. A., Howard, A., Avigan, D., Bhutani, M., Cohen, A. D., Costa, L. J., Dhodapkar, M. V., Gay, F., Gormley, N., Green, D. J., Hillengass, J., Korde, N., Li, Z., Mailankody, S., Neri, P., Parekh, S., Pasquini, M. C., Puig, N., Roodman, G. D., Samur, M. K. & 7 others, Shah, N., Shah, U. A., Shi, Q., Spencer, A., Suman, V. J., Usmani, S. Z. & McCarthy, P. L., 2020, (Accepted/In press) In : Biology of Blood and Marrow Transplantation.

Research output: Contribution to journalReview article

Summary of the Third Annual Blood and Marrow Transplant Clinical Trials Network Myeloma Intergroup Workshop on Minimal Residual Disease and Immune Profiling

Holstein, S. A., Al-Kadhimi, Z., Costa, L. J., Hahn, T., Hari, P., Hillengass, J., Jacob, A., Munshi, N. C., Oliva, S., Pasquini, M. C., Shi, Q., Stadtmauer, E. A., Waldvogel, S. L. & McCarthy, P. L., Jan 2020, In : Biology of Blood and Marrow Transplantation. 26, 1, p. e7-e15

Research output: Contribution to journalReview article

4 Scopus citations

Surveillance in Patients With Diffuse Large B Cell Lymphoma

Kallam, A., Adusumalli, J. & Armitage, J. O., Jan 2020, In : Mayo Clinic Proceedings. 95, 1, p. 157-163 7 p.

Research output: Contribution to journalReview article

Open Access

Symbiotic prodrugs (SymProDs) dual targeting of NFkappaB and CDK

Rana, S., Kour, S., Sonawane, Y. A., Robb, C. M., Contreras, J. I., Kizhake, S., Zahid, M., Karpf, A. R. & Natarajan, A., Aug 1 2020, In : Chemical Biology and Drug Design. 96, 2, p. 773-784 12 p.

Research output: Contribution to journalArticle

Synthesis and Antichlamydial Activity of Molecules Based on Dysregulators of Cylindrical Proteases

Seleem, M. A., Rodrigues De Almeida, N., Chhonker, Y. S., Murry, D. J., Guterres, Z. D. R., Blocker, A. M., Kuwabara, S., Fisher, D. J., Leal, E. S., Martinefski, M. R., Bollini, M., Monge, M. E., Ouellette, S. P. & Conda-Sheridan, M., Apr 23 2020, In : Journal of Medicinal Chemistry. 63, 8, p. 4370-4387 18 p.

Research output: Contribution to journalArticle

Targeting histone chaperone FACT complex overcomes 5-fluorouracil resistance in colon cancer

Song, H., Zeng, J., Roychoudhury, S., Biswas, P., Mohapatra, B., Ray, S., Dowlatshahi, K., Wang, J., Band, V., Talmon, G. & Bhakat, K. K., 2020, In : Molecular cancer therapeutics. 19, 1, p. 258-269 12 p.

Research output: Contribution to journalArticle

Targeting the IκB Kinase Enhancer and Its Feedback Circuit in Pancreatic Cancer

Challa, S., Husain, K., Kim, R., Coppola, D., Batra, S. K., Cheng, J. Q. & Malafa, M. P., Feb 2020, In : Translational Oncology. 13, 2, p. 481-489 9 p.

Research output: Contribution to journalArticle

Open Access

Targeting the Tumor Core: Hypoxia-Responsive Nanoparticles for the Delivery of Chemotherapy to Pancreatic Tumors

Confeld, M. I., Mamnoon, B., Feng, L., Jensen-Smith, H., Ray, P., Froberg, J., Kim, J., Hollingsworth, M. A., Quadir, M., Choi, Y. & Mallik, S., Aug 3 2020, In : Molecular Pharmaceutics. 17, 8, p. 2849-2863 15 p.

Research output: Contribution to journalArticle

Targeting translation initiation by synthetic rocaglates for treating MYC-driven lymphomas

Zhang, X., Bi, C., Lu, T., Zhang, W., Yue, T., Wang, C., Tian, T., Zhang, X., Huang, Y., Lunning, M., Hao, X., Brown, L. E., Devine, W. G., Vose, J., Porco, J. A. & Fu, K., Jan 1 2020, In : Leukemia. 34, 1, p. 138-150 13 p.

Research output: Contribution to journalArticle

The Changing Face of Oncology Research, Drug Development, and Clinical Practice: Toward Patient-Focused Precision Therapeutics

Venkatakrishnan, K., van der Graaf, P. H. & Holstein, S. A., Sep 1 2020, In : Clinical Pharmacology and Therapeutics. 108, 3, p. 399-404 6 p.

Research output: Contribution to journalEditorial

The proteomic landscape of pancreatic ductal adenocarcinoma liver metastases identifies molecular subtypes and associations with clinical response A C

Law, H. C. H., Lagundzin, D., Clement, E. J., Qiao, F., Wagner, Z. S., Krieger, K. L., Costanzo-Garvey, D., Caffrey, T. C., Grem, J. L., DiMaio, D. J., Grandgenett, P. M., Cook, L. M., Fisher, K. W., Yu, F., Hollingsworth, M. A. & Woods, N. T., Mar 1 2020, In : Clinical Cancer Research. 26, 5, p. 1065-1076 12 p.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

The third model of Bax/Bak activation: A Bcl-2 family feud finally resolved?

Luo, X., O'Neill, K. L. & Huang, K., 2020, In : F1000Research. 9, 935.

Research output: Contribution to journalReview article

Open Access

Tuned near infrared fluorescent hyaluronic acid conjugates for delivery to pancreatic cancer for intraoperative imaging

Qi, B., Crawford, A. J., Wojtynek, N. E., Talmon, G. A., Hollingsworth, M. A., Ly, Q. P. & Mohs, A. M., 2020, In : Theranostics. 10, 8, p. 3413-3429 17 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Twenty-five-Year Follow-up of a Prospective Randomized Trial Comparing Preoperative Versus Postoperative FLAC/Granulocyte Colony-Stimulating Factor Chemotherapy for Stage II Breast Cancer

Malekzadeh, P., Cowan, K., Steinberg, S. M., Camphausen, K. A., Shriver, C., Merino, M. J., Good, M. L., Berman, A. & Danforth, D. N., May 1 2020, In : American journal of clinical oncology. 43, 5, p. 334-339 6 p.

Research output: Contribution to journalArticle

Twisting of Charged Nanoribbons to Helicoids Driven by Electrostatics

Zaldivar, G., Conda-Sheridan, M. & Tagliazucchi, M., Apr 16 2020, In : Journal of Physical Chemistry B. 124, 15, p. 3221-3227 7 p.

Research output: Contribution to journalArticle

U000328, a novel ALK2/3 kinase inhibitor, represses hepcidin and significantly improves the phenotype of IRIDA

Belot, A., Gourbeyre, O., Fay, A., Palin, A., Besson-Fournier, C., Latour, C., Hopkins, C. R., Tidmarsh, G. F., Coppin, H., Roth, M. P., Ritter, M. R., Hong, C. C. & Meynard, D., Mar 1 2020, In : Haematologica. 105, 3

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

UBR5 HECT domain mutations identified in mantle cell lymphoma control maturation of B cells

Swenson, S. A., Gilbreath, T. J., Vahle, H., Hynes-Smith, R. W., Graham, J. H., Law, H. C. H., Amador, C., Woods, N. T., Green, M. R. & Buckley, S. M., Jul 2020, In : Blood. 9, 3, p. 299-312 14 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Ultraviolet A light induces DNA damage and estrogen-DNA adducts in Fuchs endothelial corneal dystrophy causing females to be more affected

Liu, C., Miyajima, T., Melangath, G., Miyai, T., Vasanth, S., Deshpande, N., Kumar, V., Tone, S. O., Gupta, R., Zhu, S., Vojnovic, D., Chen, Y., Rogan, E. G., Mondal, B., Zahid, M. & Jurkunas, U. V., Jan 7 2020, In : Proceedings of the National Academy of Sciences of the United States of America. 117, 1, p. 573-583 11 p.

Research output: Contribution to journalArticle

3 Scopus citations