Eppley Institute for Cancer Research

Research Output

2020

Unraveling mucin domains in cancer and metastasis: when protectors become predators

Ganguly, K., Rauth, S., Marimuthu, S., Kumar, S. & Batra, S. K., Sep 1 2020, In : Cancer and Metastasis Reviews. 39, 3, p. 647-659 13 p.

Research output: Contribution to journalReview article

Upregulation of ZIP14 and altered zinc homeostasis in muscles in pancreatic cancer cachexia

Shakri, A. R., Zhong, T. J., Ma, W., Coker, C., Kim, S., Calluori, S., Scholze, H., Szabolcs, M., Caffrey, T., Grandgenett, P. M., Hollingsworth, M. A., Tanji, K., Kluger, M. D., Miller, G., Biswas, A. K. & Acharyya, S., Jan 2020, In : Cancers. 12, 1, 3.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Urban American Indian Community Health Beliefs Associated with Addressing Cancer in the Northern Plains Region

Idoate, R., Gilbert, M., King, K. M., Spellman, L., McWilliams, B., Strong, B., Bronner, L., Siahpush, M., Ramos, A. K., Clarke, M., Michaud, T., Godfrey, M. & Solheim, J., 2020, (Accepted/In press) In : Journal of Cancer Education.

Research output: Contribution to journalArticle

Use of molecularly-cloned haematopoietic growth factors in persons exposed to acute high-dose, high-dose rate whole-body ionizing radiations

Gale, R. P. & Armitage, J. O., 2020, (Accepted/In press) In : Blood Reviews. 100690.

Research output: Contribution to journalReview article

1 Scopus citations

Venetoclax causes metabolic reprogramming independent of BCL-2 inhibition

Roca-Portoles, A., Rodriguez-Blanco, G., Sumpton, D., Cloix, C., Mullin, M., Mackay, G. M., O’Neill, K., Lemgruber, L., Luo, X. & Tait, S. W. G., Aug 1 2020, In : Cell Death and Disease. 11, 8, 616.

Research output: Contribution to journalArticle

Open Access

Visual Pathway Degeneration in Chemotherapy-Related Neurotoxicity: A Review and Directions for Future Research

Anderson, D. E., Holstein, S. A. & Kedar, S., May 3 2020, In : Neuro-Ophthalmology. 44, 3, p. 139-147 9 p.

Research output: Contribution to journalReview article

2019

Aberrations in DNA repair pathways in cancer and therapeutic significances

Motegi, A., Masutani, M., Yoshioka, K. I. & Bessho, T., Oct 2019, In : Seminars in Cancer Biology. 58, p. 29-46 18 p.

Research output: Contribution to journalReview article

10 Scopus citations

Afatinib and Temozolomide combination inhibits tumorigenesis by targeting EGFRvIII-cMet signaling in glioblastoma cells

Vengoji, R., Macha, M. A., Nimmakayala, R. K., Rachagani, S., Siddiqui, J. A., Mallya, K., Gorantla, S., Jain, M., Ponnusamy, M. P., Batra, S. K. & Shonka, N., Jun 18 2019, In : Journal of Experimental and Clinical Cancer Research. 38, 1, 266.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

A Genome-wide Functional Signature Ontology Map and Applications to Natural Product Mechanism of Action Discovery

McMillan, E. A., Kwon, G., Clemenceau, J. R., Fisher, K. W., Vaden, R. M., Shaikh, A. F., Neilsen, B. K., Kelly, D., Potts, M. B., Sung, Y. J., Mendiratta, S., Hight, S. K., Lee, Y., MacMillan, J. B., Lewis, R. E., Kim, H. S. & White, M. A., Oct 17 2019, In : Cell Chemical Biology. 26, 10, p. 1380-1392.e6

Research output: Contribution to journalArticle

2 Scopus citations

A Human Papillomavirus-Independent Cervical Cancer Animal Model Reveals Unconventional Mechanisms of Cervical Carcinogenesis

He, C., Lv, X., Huang, C., Angeletti, P. C., Hua, G., Dong, J., Zhou, J., Wang, Z., Ma, B., Chen, X., Lambert, P. F., Rueda, B. R., Davis, J. S. & Wang, C., Mar 5 2019, In : Cell Reports. 26, 10, p. 2636-2650.e5

Research output: Contribution to journalArticle

Open Access
8 Scopus citations

Alendronate-Modified Polymeric Micelles for the Treatment of Breast Cancer Bone Metastasis

Liu, T., Romanova, S., Wang, S., Hyun, M. A., Zhang, C., Cohen, S. M., Singh, R. K. & Bronich, T. K., Jan 1 2019, In : Molecular Pharmaceutics.

Research output: Contribution to journalArticle

ALK-positive anaplastic large-cell lymphoma in adults: An individual patient data pooled analysis of 263 patients

Sibon, D., Nguyen, D. P., Schmitz, N., Suzuki, R., Feldman, A. L., Gressin, R., Lamant, L., Weisenburger, D. D., Rosenwald, A., Nakamura, S., Ziepert, M., Maurer, M. J., Bast, M., Armitage, J. O., Vose, J. M., Tilly, H., Jais, J. P. & Savage, K. J., 2019, In : Haematologica. 104, 12, p. E562-E565

Research output: Contribution to journalLetter

Open Access
4 Scopus citations

A mitotic CDK5-PP4 phospho-signaling cascade primes 53BP1 for DNA repair in G1

Zheng, X. F., Acharya, S. S., Choe, K. N., Nikhil, K., Adelmant, G., Satapathy, S. R., Sharma, S., Viccaro, K., Rana, S., Natarajan, A., Sicinski, P., Marto, J. A., Shah, K. & Chowdhury, D., Dec 1 2019, In : Nature communications. 10, 1, 4252.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Amphiphilic polyanhydride-based recombinant MUC4β-nanovaccine activates dendritic cells

Banerjee, K., Gautam, S. K., Kshirsagar, P., Ross, K. A., Spagnol, G., Sorgen, P., Wannemuehler, M. J., Narasimhan, B., Solheim, J. C., Kumar, S., Batra, S. K. & Jain, M., 2019, In : Genes and Cancer. 10, 3-4, p. 52-62 11 p.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Analgesic Effects of the GIRK Activator, VU0466551, Alone and in Combination with Morphine in Acute and Persistent Pain Models

Abney, K. K., Bubser, M., Du, Y., Kozek, K. A., Bridges, T. M., Linsdley, C. W., Daniels, J. S., Morrison, R. D., Wickman, K., Hopkins, C. R., Jones, C. K. & Weaver, C. D., Mar 20 2019, In : ACS Chemical Neuroscience. 10, 3, p. 1294-1299 6 p.

Research output: Contribution to journalArticle

3 Scopus citations

Animal models of cancer-associated cachexia

Shukla, S. K. & Singh, P. K., Apr 17 2019, Animal Models in Cancer Drug Discovery. Elsevier, p. 59-74 16 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Anti-Claudin-1 Conjugated to a Near-Infrared Fluorophore Targets Colon Cancer in PDOX Mouse Models

Hollandsworth, H. M., Lwin, T. M., Amirfakhri, S., Filemoni, F., Batra, S. K., Hoffman, R. M., Dhawan, P. & Bouvet, M., Oct 2019, In : Journal of Surgical Research. 242, p. 145-150 6 p.

Research output: Contribution to journalArticle

5 Scopus citations

A patent review of bisphosphonates in treating bone disease

Holstein, S. A., May 4 2019, In : Expert Opinion on Therapeutic Patents. 29, 5, p. 315-325 11 p.

Research output: Contribution to journalArticle

6 Scopus citations

Aperiodic order coming of age: From inorganic materials to dynamic protein superstructures

Borgstahl, G., Goldman, A. I. & Thiel, P. A., 2019, In : Acta Crystallographica Section A: Foundations and Advances. 75, p. 212-213 2 p.

Research output: Contribution to journalEditorial

Open Access
1 Scopus citations

A polymeric nanogel-based treatment regimen for enhanced efficacy and sequential administration of synergistic drug combination in pancreatic cancer

Soni, K. S., Thomas, D., Caffrey, T., Mehla, K., Lei, F., O'Connell, K. A., Sagar, S., Lele, S. M., Hollingsworth, M. A., Radhakrishnan, P. & Bronich, T. K., 2019, In : Journal of Pharmacology and Experimental Therapeutics. 370, 3, p. 894-901 8 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

A recurrent cancer-associated substitution in DNA polymerase ε produces a hyperactive enzyme

Xing, X., Kane, D. P., Bulock, C. R., Moore, E. A., Sharma, S., Chabes, A. & Shcherbakova, P. V., Dec 1 2019, In : Nature communications. 10, 1, 374.

Research output: Contribution to journalArticle

9 Scopus citations

A review of the molecular design and biological activities of RXR agonists

de Almeida, N. R. & Conda-Sheridan, M., Jul 2019, In : Medicinal Research Reviews. 39, 4, p. 1372-1397 26 p.

Research output: Contribution to journalReview article

2 Scopus citations

A simple fluorescent assay for the discovery of protein-protein interaction inhibitors

Al-Mugotir, M., Kolar, C., Vance, K., Kelly, D. L., Natarajan, A. & Borgstahl, G. E. O., Mar 15 2019, In : Analytical Biochemistry. 569, p. 46-52 7 p.

Research output: Contribution to journalArticle

2 Scopus citations

Assembly of α-synuclein aggregates on phospholipid bilayers

Lv, Z., Hashemi, M., Banerjee, S., Zagorski, K., Rochet, J. C. & Lyubchenko, Y. L., Sep 2019, In : Biochimica et Biophysica Acta - Proteins and Proteomics. 1867, 9, p. 802-812 11 p.

Research output: Contribution to journalArticle

5 Scopus citations

Beta 2-microglobulin regulates amyloid precursor-like protein 2 expression and the migration of pancreatic cancer cells

Sliker, B. H., Goetz, B. T., Peters, H. L., Poelaert, B. J., Borgstahl, G. E. O. & Solheim, J. C., Jun 3 2019, In : Cancer Biology and Therapy. 20, 6, p. 931-940 10 p.

Research output: Contribution to journalArticle

1 Scopus citations

BH3-only proteins are dispensable for apoptosis induced by pharmacological inhibition of both MCL-1 and BCL-XL

Greaves, G., Milani, M., Butterworth, M., Carter, R. J., Byrne, D. P., Eyers, P. A., Luo, X., Cohen, G. M. & Varadarajan, S., Jun 1 2019, In : Cell Death and Differentiation. 26, 6, p. 1037-1047 11 p.

Research output: Contribution to journalArticle

19 Scopus citations

BH3-only proteins target BCL-xL/MCL-1, not BAX/BAK, to initiate apoptosis

Huang, K., O’Neill, K. L., Li, J., Zhou, W., Han, N., Pang, X., Wu, W., Struble, L., Borgstahl, G., Liu, Z., Zhang, L. & Luo, X., Nov 1 2019, In : Cell Research. 29, 11, p. 942-952 11 p.

Research output: Contribution to journalArticle

11 Scopus citations

BORIS expression in ovarian cancer precursor cells alters the CTCF cistrome and enhances invasiveness through GALNT14

Hillman, J. C., Pugacheva, E. M., Barger, C. J., Sribenja, S., Rosario, S., Albahrani, M., Truskinovsky, A. M., Stablewski, A., Liu, S., Loukinov, D. I., Zentner, G. E., Lobanenkov, V. V., Karpf, A. R. & Higgins, M. J., Oct 1 2019, In : Molecular Cancer Research. 17, 10, p. 2051-2062 12 p.

Research output: Contribution to journalArticle

6 Scopus citations

Brassicaceae-specific Gretchen Hagen 3 acyl acid amido synthetases conjugate amino acids to chorismate, a precursor of aromatic amino acids and salicylic acid

Holland, C. K., Westfall, C. S., Schaffer, J. E., De Santiago, A., Zubieta, C., Alvarez, S. & Jez, J. M., Nov 8 2019, In : Journal of Biological Chemistry. 294, 45, p. 16855-16864 10 p.

Research output: Contribution to journalArticle

2 Scopus citations

Breast Cancer Collaborative Registry informs understanding of factors predicting sleep quality

Berger, A. M., Kupzyk, K. A., Djalilova, D. M. & Cowan, K. H., Apr 1 2019, In : Supportive Care in Cancer. 27, 4, p. 1365-1373 9 p.

Research output: Contribution to journalArticle

2 Scopus citations

Cancer-Associated Fibroblasts Enhance Survival and Progression of the Aggressive Pancreatic Tumor Via FGF-2 and CXCL8

Awaji, M., Futakuchi, M., Heavican, T., Iqbal, J. & Singh, R. K., Apr 1 2019, In : Cancer Microenvironment. 12, 1, p. 37-46 10 p.

Research output: Contribution to journalArticle

4 Scopus citations

Cancer-associated fibroblasts’ functional heterogeneity in pancreatic ductal adenocarcinoma

Awaji, M. & Singh, R. K., Mar 2019, In : Cancers. 11, 3, 290.

Research output: Contribution to journalReview article

Open Access
9 Scopus citations

Cancer-associated mucins: role in immune modulation and metastasis

Bhatia, R., Gautam, S. K., Cannon, A., Thompson, C., Hall, B. R., Aithal, A., Banerjee, K., Jain, M., Solheim, J. C., Kumar, S. & Batra, S. K., Jun 15 2019, In : Cancer and Metastasis Reviews. 38, 1-2, p. 223-236 14 p.

Research output: Contribution to journalReview article

22 Scopus citations

Catalytically inactive Dnmt3b rescues mouse embryonic development by accessory and repressive functions

Nowialis, P., Lopusna, K., Opavska, J., Haney, S. L., Abraham, A., Sheng, P., Riva, A., Natarajan, A., Guryanova, O., Simpson, M., Hlady, R., Xie, M. & Opavsky, R., Dec 1 2019, In : Nature communications. 10, 1, 4374.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Caveat medicus: Clinician experiences in publishing reports of serious oncology-associated adverse drug reactions

Bennett, C. L., Schooley, B., Taylor, M. A., Witherspoon, B. J., Godwin, A., Vemula, J., Ausdenmoore, H. C., Sartor, O., Tony Yang, Y., Armitage, J. O., Hrushesky, W. J., Restaino, J., Thomsen, H. S., Yarnold, P. R., Young, T., Knopf, K. B. & Chen, B., Jul 1 2019, In : PloS one. 14, 7, e0219521.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

CDK5 inhibitor downregulates Mcl-1 and sensitizes pancreatic cancer cell lines to navitoclax

Kour, S., Rana, S., Contreras, J. I., King, H. M., Robb, C. M., Sonawane, Y. A., Bendjennat, M., Crawford, A. J., Barger, C. J., Kizhake, S., Luo, X., Hollingsworth, M. A. & Natarajan, A., Oct 2019, In : Molecular pharmacology. 96, 4, p. 419-429 11 p.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Clinical impact of Internet-based tools to guide therapeutic decisions for mantle cell lymphoma

Gopalsamy, S. N., Rosenthal, K. M., Ayers, A. A., Goy, A., Leonard, J. P., Vose, J. M., Obholz, K. L., Armitage, J. O. & Flowers, C. R., Jul 29 2019, In : Leukemia and Lymphoma. 60, 9, p. 2255-2263 9 p.

Research output: Contribution to journalArticle

Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer

Bryant, K. L., Stalnecker, C. A., Zeitouni, D., Klomp, J. E., Peng, S., Tikunov, A. P., Gunda, V., Pierobon, M., Waters, A. M., George, S. D., Tomar, G., Papke, B., Hobbs, G. A., Yan, L., Hayes, T. K., Diehl, J. N., Goode, G. D., Chaika, N. V., Wang, Y., Zhang, G. F. & 11 others, Witkiewicz, A. K., Knudsen, E. S., Petricoin, E. F., Singh, P. K., Macdonald, J. M., Tran, N. L., Lyssiotis, C. A., Ying, H., Kimmelman, A. C., Cox, A. D. & Der, C. J., Apr 1 2019, In : Nature Medicine. 25, 4, p. 628-640 13 p.

Research output: Contribution to journalArticle

87 Scopus citations

Combination therapies and drug delivery platforms in combating pancreatic cancer

Lei, F., Xi, X., Batra, S. K. & Bronich, T. K., 2019, In : Journal of Pharmacology and Experimental Therapeutics. 370, 3, p. 682-694 13 p.

Research output: Contribution to journalReview article

Open Access
1 Scopus citations

Comment on “A commensal strain of Staphylococcus epidermidis protects against skin neoplasia” by Nakatsuji et al.

Kozmin, S. G., Rogozin, I. B., Moore, E. A., Abney, M., Schaaper, R. M. & Pavlov, Y. I., Sep 11 2019, In : Science Advances. 5, 9, eaaw3915.

Research output: Contribution to journalReview article

Open Access
1 Scopus citations

Common genetic variants contribute to incomplete penetrance: evidence from cancer-free BRCA1 mutation carriers

Downs, B., Sherman, S., Cui, J., Kim, Y. C., Snyder, C., Christensen, M., Luo, J., Lynch, H. & Wang, S. M., Jan 2019, In : European Journal of Cancer. 107, p. 68-78 11 p.

Research output: Contribution to journalArticle

1 Scopus citations
Open Access
2 Scopus citations

Computer-designed active human butyrylcholinesterase double mutant with a new catalytic triad

Grigorenko, B. L., Novichkova, D. A., Lushchekina, S. V., Zueva, I. V., Schopfer, L. M., Nemukhin, A. V., Varfolomeev, S. D., Lockridge, O. & Masson, P., Jun 1 2019, In : Chemico-Biological Interactions. 306, p. 138-146 9 p.

Research output: Contribution to journalArticle

2 Scopus citations

Contribution of cytosine desaminases of AID/APOBEC family to carcinogenesis

Zotova, I., Stepchenkova, E. & Pavlov, Y., Jun 2019, In : Biological Communications. 64, 2, p. 110-123 14 p.

Research output: Contribution to journalReview article

Open Access

Correction to: Analgesic effects of the GIRK activator, VU0466551, Alone and in combination with morphine in acute and persistent pain models (ACS Chemical Neuroscience (2019) 10:3 (1294-1299) DOI: 10.1021/acschemneuro.8b00370)

Abney, K. K., Bubser, M., Du, Y., Kozek, K. A., Bridges, T. M., Lindsley, C. W., Daniels, J. S., Morrison, R. D., Wickman, K., Hopkins, C. R., Jones, C. K. & Weaver, C. D., May 15 2019, In : ACS Chemical Neuroscience. 10, 5, p. 2621 1 p.

Research output: Contribution to journalComment/debate

Open Access

CTDP1 regulates breast cancer survival and DNA repair through BRCT-specific interactions with FANCI

Hu, W. F., Krieger, K. L., Lagundžin, D., Li, X., Cheung, R. S., Taniguchi, T., Johnson, K. R., Bessho, T., Monteiro, A. N. A. & Woods, N. T., Dec 1 2019, In : Cell Death Discovery. 5, 1, 105.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

CXCR2: A novel mediator of mammary tumor bone metastasis

Sharma, B., Nannuru, K. C., Saxena, S., Varney, M. L. & Singh, R. K., Mar 2019, In : International journal of molecular sciences. 20, 5, 1237.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Cyclin-dependent kinase 1-mediated AMPK phosphorylation regulates chromosome alignment and mitotic progression

Stauffer, S., Zeng, Y., Santos, M., Zhou, J., Chen, Y. & Dong, J., 2019, In : Journal of cell science. 132, 20, jcs236000.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Cyclin-dependent kinase 1-mediated phosphorylation of SET at serine 7 is essential for its oncogenic activity

Yin, L., Zeng, Y., Xiao, Y., Chen, Y., Shen, H. & Dong, J., Jun 1 2019, In : Cell Death and Disease. 10, 6, 385.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Delineating the role of FANCA in glucose-stimulated insulin secretion in β cells through its protein interactome

Lagundžin, D., Hu, W. F., Law, H. C. H., Krieger, K. L., Qiao, F., Clement, E. J., Drincic, A. T., Nedić, O., Naldrett, M. J., Alvarez, S. & Woods, N. T., Aug 1 2019, In : PloS one. 14, 8, e0220568.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations