Eppley Institute for Cancer Research

Research Output

2019

Design of Hedgehog pathway inhibitors for cancer treatment

Bariwal, J., Kumar, V., Dong, Y. & Mahato, R. I., May 2019, In : Medicinal Research Reviews. 39, 3, p. 1137-1204 68 p.

Research output: Contribution to journalReview article

6 Scopus citations

Discovery, Structure-Activity Relationship, and Biological Characterization of a Novel Series of 6-((1 H-Pyrazolo[4,3- b]pyridin-3-yl)amino)-benzo[ d]isothiazole-3-carboxamides as Positive Allosteric Modulators of the Metabotropic Glutamate Receptor 4 (mGlu 4 )

Bollinger, S. R., Engers, D. W., Panarese, J. D., West, M., Engers, J. L., Loch, M. T., Rodriguez, A. L., Blobaum, A. L., Jones, C. K., Thompson Gray, A., Conn, P. J., Lindsley, C. W., Niswender, C. M. & Hopkins, C. R., Oct 1 2019, In : Journal of Medicinal Chemistry. 62, 1, p. 342-358 17 p.

Research output: Contribution to journalArticle

6 Scopus citations

Discovery, synthesis and characterization of a series of (1-alkyl-3-methyl-1H-pyrazol-5-yl)-2-(5-aryl-2H-tetrazol-2-yl)acetamides as novel GIRK1/2 potassium channel activators

Sharma, S., Kozek, K. A., Abney, K. K., Kumar, S., Gautam, N., Alnouti, Y., David Weaver, C. & Hopkins, C. R., Mar 15 2019, In : Bioorganic and Medicinal Chemistry Letters. 29, 6, p. 791-796 6 p.

Research output: Contribution to journalArticle

Discovery and Characterization of 2-Nitro-5-(4-(phenylsulfonyl)piperazin-1-yl)- N-(pyridin-4-ylmethyl)anilines as Novel Inhibitors of the Aedes aegypti Kir1 (AeKir1) Channel

Aretz, C. D., Morwitzer, M. J., Sanford, A. G., Hogan, A. M., Portillo, M. V., Kharade, S. V., Kramer, M., McCarthey, J. B., Trigueros, R. R., Piermarini, P. M., Denton, J. S. & Hopkins, C. R., Jun 14 2019, In : ACS infectious diseases. 5, 6, p. 917-931 15 p.

Research output: Contribution to journalArticle

1 Scopus citations

Discovery of VU2957 (Valiglurax): An mGlu 4 Positive Allosteric Modulator Evaluated as a Preclinical Candidate for the Treatment of Parkinson's Disease

Panarese, J. D., Engers, D. W., Wu, Y. J., Bronson, J. J., Macor, J. E., Chun, A., Rodriguez, A. L., Felts, A. S., Engers, J. L., Loch, M. T., Emmitte, K. A., Castelhano, A. L., Kates, M. J., Nader, M. A., Jones, C. K., Blobaum, A. L., Conn, P. J., Niswender, C. M., Hopkins, C. R. & Lindsley, C. W., Mar 14 2019, In : ACS Medicinal Chemistry Letters. 10, 3, p. 255-260 6 p.

Research output: Contribution to journalArticle

6 Scopus citations

DRP-1 functions independently of mitochondrial structural perturbations to facilitate BH3 mimetic-mediated apoptosis

Milani, M., Beckett, A. J., Al-Zebeeby, A., Luo, X., Prior, I. A., Cohen, G. M. & Varadarajan, S., Dec 1 2019, In : Cell Death Discovery. 5, 1, 117.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Dual delivery nanoscale device for miR-345 and gemcitabine co-delivery to treat pancreatic cancer

Uz, M., Kalaga, M., Pothuraju, R., Ju, J., Junker, W. M., Batra, S. K., Mallapragada, S. & Rachagani, S., Jan 28 2019, In : Journal of Controlled Release. 294, p. 237-246 10 p.

Research output: Contribution to journalArticle

6 Scopus citations

Dual responsive micelles capable of modulating miRNA-34a to combat taxane resistance in prostate cancer

Lin, F., Wen, D., Wang, X. & Mahato, R. I., Feb 2019, In : Biomaterials. 192, p. 95-108 14 p.

Research output: Contribution to journalArticle

10 Scopus citations

Editorial page, special issue honoring Professor Mark Cushman

Conda-Sheridan, M., Jul 2019, In : Medicinal Research Reviews. 39, 4, p. 1233-1234 2 p.

Research output: Contribution to journalEditorial

Open Access

Effects of center type and socioeconomic factors on early mortality and overall survival of diffuse large B-cell lymphoma

Dhakal, P., Chen, B., Giri, S., Vose, J. M., Armitage, J. O. & Bhatt, V. R., Jun 2019, In : Future Oncology. 15, 18, p. 2113-2124 12 p.

Research output: Contribution to journalArticle

Efficacy of indocyanine green-loaded hyaluronic acid nanoparticles for the surgical resection of orthotopic breast tumors

Wojtynek, N. E., Holmes, M. B., Olson, M. T., Baher, F., Silva, E. & Mohs, A. M., 2019, Molecular-Guided Surgery: Molecules, Devices, and Applications V. Pogue, B. W. & Gioux, S. (eds.). SPIE, 108621G. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; vol. 10862).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Emergency response to radiological and nuclear accidents and incidents

Gale, R. P., Armitage, J. O. & Hashmi, S. K., 2019, (Accepted/In press) In : British Journal of Haematology.

Research output: Contribution to journalReview article

1 Scopus citations

Engineering hydrogel based cancer microenvironments for in vitro breast cancer cell culture and therapeutics screening

Shi, W., Kuss, M. A., Mohapatra, B., Mirza, S., Band, H., Band, V. & Duan, B., 2019, Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Society for Biomaterials, p. 642 1 p. (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium; vol. 40).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Epigenetic activation of POTE genes in ovarian cancer

Sharma, A., Albahrani, M., Zhang, W., Kufel, C. N., James, S. R., Odunsi, K., Klinkebiel, D. & Karpf, A. R., Feb 1 2019, In : Epigenetics. 14, 2, p. 185-197 13 p.

Research output: Contribution to journalArticle

3 Scopus citations

ERK-mediated TIMELESS expression suppresses G2/M arrest in colon cancer cells

Neilsen, B. K., Frodyma, D. E., McCall, J. L., Fisher, K. W. & Lewis, R. E., Jan 2019, In : PloS one. 14, 1, e0209224.

Research output: Contribution to journalArticle

3 Scopus citations

Erratum: Initial Characterization of the Two ClpP Paralogs of Chlamydia trachomatis Suggests Unique Functionality for Each (Journal of Bacteriology (2019) 201:2 (e00635-18) DOI: 10.1128/JB.00635-18)

Wood, N. A., Chung, K. Y., Blocker, A. M., De Almeida, N. R., Conda-Sheridan, M., Fisher, D. J. & Ouellette, S. P., Dec 1 2019, In : Journal of bacteriology. 201, 24, e00613-19.

Research output: Contribution to journalComment/debate

Open Access

Erratum: O-GlcNAc Transferase Suppresses Inflammation and Necroptosis by Targeting Receptor-Interacting Serine/Threonine-Protein Kinase 3 (Immunity (2019) 50(3) (576–590.e6), (S1074761319300305), (10.1016/j.immuni.2019.01.007))

Li, X., Gong, W., Wang, H., Li, T., Attri, K. S., Lewis, R. E., Kalil, A. C., Bhinderwala, F., Powers, R., Yin, G., Herring, L. E., Asara, J. M., Lei, Y. L., Yang, X., Rodriguez, D. A., Yang, M., Green, D. R., Singh, P. K. & Wen, H., Apr 16 2019, In : Immunity. 50, 4, p. 1115 1 p.

Research output: Contribution to journalComment/debate

Estrogen Metabolism in African-American Women with and without Breast Cancer: A Pilot Study

Zahid, M., Mondal, B., Levan, T. D. & Rogan, E. G., Jan 22 2019, In : Chemical Research in Toxicology. 32, 1, p. 190-194 5 p.

Research output: Contribution to journalArticle

Evaluating the metabolic alterations in pancreatic cancer

Dasgupta, A., Shukla, S. K., Gunda, V., King, R. J. & Singh, P. K., 2019, Methods in Molecular Biology. Humana Press Inc., p. 221-228 8 p. (Methods in Molecular Biology; vol. 1882).

Research output: Chapter in Book/Report/Conference proceedingChapter

Extranodal NK/T-Cell Lymphoma, Nasal Type: Shrouded No More

Lunning, M. A., Oct 1 2019, In : Journal of oncology practice. 15, 10, p. 521-522 2 p.

Research output: Contribution to journalArticle

Fascin Controls Metastatic Colonization and Mitochondrial Oxidative Phosphorylation by Remodeling Mitochondrial Actin Filaments

Lin, S., Huang, C., Gunda, V., Sun, J., Chellappan, S. P., Li, Z., Izumi, V., Fang, B., Koomen, J., Singh, P. K., Hao, J. & Yang, S., Sep 10 2019, In : Cell Reports. 28, 11, p. 2824-2836.e8

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

FDPS cooperates with PTEN loss to promote prostate cancer progression through modulation of small GTPases/AKT axis

Seshacharyulu, P., Rachagani, S., Muniyan, S., Siddiqui, J. A., Cruz, E., Sharma, S., Krishnan, R., Killips, B. J., Sheinin, Y., Lele, S. M., Smith, L. M., Talmon, G. A., Ponnusamy, M. P., Datta, K. & Batra, S. K., Jun 27 2019, In : Oncogene. 38, 26, p. 5265-5280 16 p.

Research output: Contribution to journalArticle

5 Scopus citations

Fluorescence Guidance in Surgical Oncology: Challenges, Opportunities, and Translation

Olson, M. T., Ly, Q. P. & Mohs, A. M., Apr 15 2019, In : Molecular Imaging and Biology. 21, 2, p. 200-218 19 p.

Research output: Contribution to journalReview article

10 Scopus citations

Force clamp approach for characterization of nano-assembly in amyloid beta 42 dimer

Maity, S. & Lyubchenko, Y. L., Jul 7 2019, In : Nanoscale. 11, 25, p. 12259-12265 7 p.

Research output: Contribution to journalArticle

2 Scopus citations

Functional analysis and fine mapping of the 9p22.2 ovarian cancer susceptibility locus

Buckley, M. A., Woods, N. T., Tyrer, J. P., Mendoza-Fandiño, G., Lawrenson, K., Hazelett, D. J., Najafabadi, H. S., Gjyshi, A., Carvalho, R. S., Lyra, P. C., Coetzee, S. G., Shen, H. C., Yang, A. W., Earp, M. A., Yoder, S. J., Risch, H., Chenevix-Trench, G., Ramus, S. J., Phelan, C. M., Coetzee, G. A. & 129 others, Noushmehr, H., Hughes, T. R., Sellers, T. A., Goode, E. L., Pharoah, P. D., Gayther, S. A., Monteiro, A. N. A., Chen, Y. A., Fridley, B. L., Aben, K. K. H., Kiemeney, L. A., Anton-Culver, H., Ziogas, A., Bruinsma, F., Milne, R. L., Bandera, E. V., Giles, G. G., Bean, Y. T., Pejovic, T., Beckmann, M. W., Hein, A., Bjorge, L., Fasching, P. A., Thomsen, L. C. V., Kopperud, R. K., Bischof, K., Bogdanova, N., Dörk, T., Hillemanns, P., Brinton, L. A., Wentzensen, N., Yang, H., Brooks-Wilson, A., Bunker, C. H., Butzow, R., Nevanlinna, H., Pelttari, L. M., Campbell, I. G., Southey, M. C., Modugno, F., Carty, K., Glasspool, R., McNeish, I., Paul, J., Siddiqui, N., Chang-Claude, J., Rudolph, A., Cook, L. S., Cramer, D. W., Terry, K. L., Cunningham, J. M., Cybulski, C., Gronwald, J., Jakubowska, A., Lubinski, J., Dansonka-Mieszkowska, A., Kupryjanczyk, J., Rzepecka, I. K., Du Bois, A., Harter, P., Dicks, E., Song, H., Doherty, J. A., Rossing, M. A., Dürst, M., Easton, D. F., Eccles, D. M., Edwards, R. P., Ekici, A. B., Gao, Y. T., Gentry-Maharaj, A., Goodman, M. T., Thompson, P. J., Hasmad, H. N., Teo, S. H., Hildebrandt, M. A. T., Wu, X., Hogdall, E., Jensen, A., Kjaer, S. K., Iversen, E. S., Karlan, B. Y., Lester, J., Orsulic, S., Walsh, C. S., Kelley, J. L., Lambrechts, D., Lambrechts, S., Vergote, I., Lee, A. W., Levine, D. A., Liang, D., Lissowska, J., Lu, K., Lundvall, L., Massuger, L. F. A. G., Van Altena, A. M., Matsuo, K., McGuire, V., McLaughlin, J. R., Menon, U., Moysich, K. B., Ness, R. B., Odunsi, K., Olson, S. H., Orlow, I., Pike, M. C., Pearce, C. L., Wu, A. H., Permuth, J. B., Tsai, Y. Y., Tworoger, S. S., Poole, E. M., Rosen, B., Shu, X. O., Shvetsov, Y. B., Wilkens, L. R., Sieh, W., Spiewankiewicz, B., Sucheston-Campbell, L., Thomsen, L., Wang-Gohrke, S., Whittemore, A. S., Woo, Y. L., Zheng, W., Berchuck, A., Schildkraut, J. M., Kelemen, L. E. & Freedman, M. L., Feb 1 2019, In : Cancer Research. 79, 3, p. 467-481 15 p.

Research output: Contribution to journalArticle

2 Scopus citations

Functional impacts of the brca1-mtorc2 interaction in breast cancer

Krieger, K. L., Hu, W. F., Ripperger, T. & Woods, N. T., Dec 1 2019, In : International journal of molecular sciences. 20, 23, 5876.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Gene therapy

Wu, H., Chaudhary, A. K. & Mahato, R. I., Apr 13 2019, Pharmaceutical Biotechnology: Fundamentals and Applications. Springer International Publishing, p. 323-355 33 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Genistein treatment duration effects biomarkers of cell motility in human prostate

Zhang, H., Gordon, R., Li, W., Yang, X., Pattanayak, A., Fowler, G., Zhang, L., Catalona, W. J., Ding, Y., Xu, L., Huang, X., Jovanovic, B., Kelly, D. L., Jiang, H. & Bergan, R., Mar 2019, In : PloS one. 14, 3, e0214078.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

Half-life of chlorpyrifos oxon and other organophosphorus esters in aqueous solution

Lockridge, O., Verdier, L. & Schopfer, L. M., Sep 25 2019, In : Chemico-Biological Interactions. 311, 108788.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Hepatosplenic γ-δ T-Cell Lymphoma: Who Is on Your Speed Dial?

Krishnan, M. & Lunning, M., Jun 1 2019, In : Journal of oncology practice. 15, 6, p. 307-312 6 p.

Research output: Contribution to journalArticle

1 Scopus citations

Identification of an Anti-MRSA Cyclic Lipodepsipeptide, WBP-29479A1, by Genome Mining of Lysobacter antibioticus

Sang, M., Wang, H., Shen, Y., Rodrigues De Almeida, N., Conda-Sheridan, M., Li, S., Li, Y. & Du, L., Aug 16 2019, In : Organic Letters. 21, 16, p. 6432-6436 5 p.

Research output: Contribution to journalArticle

1 Scopus citations
Open Access
1 Scopus citations

Immunometabolic alterations by HPV infection: New dimensions to head and neck cancer disparity

Chaudhary, S., Ganguly, K., Muniyan, S., Pothuraju, R., Sayed, Z., Jones, D. T., Batra, S. K. & Macha, M. A., 2019, In : Journal of the National Cancer Institute. 111, 3, p. 233-244 12 p.

Research output: Contribution to journalReview article

Open Access
4 Scopus citations

Inactivation of XPF Sensitizes Cancer Cells to Gemcitabine

George, J. W., Bessho, M. & Bessho, T., 2019, In : Journal of Nucleic Acids. 2019, 6357609.

Research output: Contribution to journalArticle

Open Access

Inhibition of geranylgeranyl diphosphate synthase is a novel therapeutic strategy for pancreatic ductal adenocarcinoma

Haney, S. L., Varney, M. L., Chhonker, Y. S., Shin, S., Mehla, K., Crawford, A. J., Smith, H. J., Smith, L. M., Murry, D. J., Hollingsworth, M. A. & Holstein, S. A., Jun 27 2019, In : Oncogene. 38, 26, p. 5308-5320 13 p.

Research output: Contribution to journalArticle

6 Scopus citations

Inhibition of miR-328-3p impairs cancer stem cell function and prevents metastasis in ovarian cancer

Srivastava, A. K., Banerjee, A., Cui, T., Han, C., Cai, S., Liu, L., Wu, D., Cui, R., Li, Z., Zhang, X., Xie, G., Selvendiran, K., Patnaik, S., Karpf, A. R., Liu, J., Cohn, D. E. & Wang, Q. E., 2019, In : Cancer Research. 79, 9, p. 2314-2326 13 p.

Research output: Contribution to journalArticle

15 Scopus citations

Insight into the dynamics of APOBEC3G protein in complexes with DNA assessed by high speed AFM

Pan, Y., Shlyakhtenko, L. S. & Lyubchenko, Y. L., 2019, In : Nanoscale Advances. 1, 10, p. 4016-4024 9 p.

Research output: Contribution to journalArticle

Open Access

Integrated generation of induced pluripotent stem cells in a low-cost device

Lin, H., Li, Q., Du, Q., Wang, O., Wang, Z., Akert, L., Carlson, M. A., Zhang, C., Subramanian, A., Zhang, C., Lunning, M., Li, M. & Lei, Y., Jan 2019, In : Biomaterials. 189, p. 23-36 14 p.

Research output: Contribution to journalArticle

5 Scopus citations

Integration of Genomic and Transcriptional Features in Pancreatic Cancer Reveals Increased Cell Cycle Progression in Metastases

Connor, A. A., Denroche, R. E., Jang, G. H., Lemire, M., Zhang, A., Chan-Seng-Yue, M., Wilson, G., Grant, R. C., Merico, D., Lungu, I., Bartlett, J. M. S., Chadwick, D., Liang, S. B., Eagles, J., Mbabaali, F., Miller, J. K., Krzyzanowski, P., Armstrong, H., Luo, X., Jorgensen, L. G. T. & 25 others, Romero, J. M., Bavi, P., Fischer, S. E., Serra, S., Hafezi-Bakhtiari, S., Caglar, D., Roehrl, M. H. A., Cleary, S., Hollingsworth, M. A., Petersen, G. M., Thayer, S., Law, C. H. L., Nanji, S., Golan, T., Smith, A. L., Borgida, A., Dodd, A., Hedley, D., Wouters, B. G., O'Kane, G. M., Wilson, J. M., Zogopoulos, G., Notta, F., Knox, J. J. & Gallinger, S., Feb 11 2019, In : Cancer Cell. 35, 2, p. 267-282.e7

Research output: Contribution to journalArticle

20 Scopus citations
4 Scopus citations

KIBRA controls exosome secretion via inhibiting the proteasomal degradation of Rab27a

Song, L., Tang, S., Han, X., Jiang, Z., Dong, L., Liu, C., Liang, X., Dong, J., Qiu, C., Wang, Y. & Du, Y., Dec 1 2019, In : Nature communications. 10, 1, 1639.

Research output: Contribution to journalArticle

Open Access
14 Scopus citations

Label-free characterization of exosome via surface enhanced Raman spectroscopy for the early detection of pancreatic cancer

Carmicheal, J., Hayashi, C., Huang, X., Liu, L., Lu, Y., Krasnoslobodtsev, A., Lushnikov, A., Kshirsagar, P. G., Patel, A., Jain, M., Lyubchenko, Y. L., Lu, Y., Batra, S. K. & Kaur, S., Feb 2019, In : Nanomedicine: Nanotechnology, Biology, and Medicine. 16, p. 88-96 9 p.

Research output: Contribution to journalArticle

15 Scopus citations

Lactate-mediated epigenetic reprogramming regulates formation of human pancreatic cancer-associated fibroblasts

Bhagat, T. D., Von Ahgrens, D., Dawlaty, M., Zou, Y., Baddour, J., Achreja, A., Zhao, H., Yang, L., Patel, B., Kwak, C., Choudhary, G. S., Gordon-Mitchell, S., Alluri, S., Bhattacharyya, S., Sahu, S., Yu, Y., Bartenstein, M., Giricz, O., Suzuki, M., Sohal, D. & 12 others, Gupta, S., Guerrero, P., Batra, S., Goggins, M., Steidl, U., Greally, J., Agarwal, B., Pradhan, K., Banerjee, D., Nagrath, D., Maitra, A. & Verma, A., Oct 2019, In : eLife. 8, e50663.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations

LIMD1 phosphorylation in mitosis is required for mitotic progression and its tumor-suppressing activity

Zhou, J., Zhang, L., Zhou, W., Chen, Y., Cheng, Y. & Dong, J., Mar 2019, In : FEBS Journal. 286, 5, p. 963-974 12 p.

Research output: Contribution to journalArticle

1 Scopus citations

LncRNA Meg3 protects endothelial function by regulating the DNA damage response

Ali, M. S. S. H., Cheng, X., Moran, M., Haemmig, S., Naldrett, M. J., Alvarez, S., Feinberg, M. W. & Sun, X., 2019, In : Nucleic acids research. 47, 3

Research output: Contribution to journalArticle

Open Access
8 Scopus citations

Loss of FBXO9 enhances proteasome activity and promotes aggressiveness in acute myeloid leukemia

Willow Hynes-Smith, R., Swenson, S. A., Vahle, H., Wittorf, K. J., Caplan, M., Amador, C., Katherine Hyde, R. & Buckley, S. M., Nov 2019, In : Cancers. 11, 11, 1717.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Management of immunotherapy-related toxicities, version 1.2019

Thompson, J. A., Schneider, B. J., Brahmer, J., Andrews, S., Armand, P., Bhatia, S., Budde, L. E., Costa, L., Davies, M., Dunnington, D., Ernstoff, M. S., Frigault, M., Hoffner, B., Hoimes, C. J., Lacouture, M., Locke, F., Lunning, M., Mohindra, N. A., Naidoo, J., Olszanski, A. J. & 11 others, Oluwole, O., Patel, S. P., Reddy, S., Ryder, M., Santomasso, B., Shofer, S., Sosman, J. A., Wahidi, M., Wang, Y., Johnson-Chilla, A. & Scavone, J. L., Mar 2019, In : JNCCN Journal of the National Comprehensive Cancer Network. 17, 3, p. 255-289 35 p.

Research output: Contribution to journalArticle

79 Scopus citations
5 Scopus citations