Eppley Institute for Cancer Research

Research Output

2019

Mitochondrial superoxide disrupts the metabolic and epigenetic landscape of CD4+ and CD8+ T-lymphocytes

Moshfegh, C. M., Collins, C. W., Gunda, V., Vasanthakumar, A., Cao, J. Z., Singh, P. K., Godley, L. A. & Case, A. J., Oct 2019, In : Redox Biology. 27, 101141.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Modeling the Effects of Multiple Myeloma on Kidney Function

Walk, J. C., Ayati, B. P. & Holstein, S. A., Dec 1 2019, In : Scientific reports. 9, 1, 1726.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Molecular and physiological evaluation of pancreatic cancer-induced cachexia

Shukla, S. K., Dasgupta, A., Mulder, S. E. & Singh, P. K., 2019, Methods in Molecular Biology. Humana Press Inc., p. 321-333 13 p. (Methods in Molecular Biology; vol. 1882).

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Mouse models of pancreatic cancer: An ever-emerging arm of cancer drug discovery

Ganguly, K., Batra, S. K. & Kaur, S., Apr 17 2019, Animal Models in Cancer Drug Discovery. Elsevier, p. 249-266 18 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Mucin-1 is required for Coxsackie Virus B3-induced inflammation in pancreatitis

Liu, X., Clemens, D. L., Grunkemeyer, J. A., Price, J. D., O’Connell, K., Chapman, N. M., Storz, P., Wen, H., Cox, J. L., Reid, W. L., Hollingsworth, M. A. & Thayer, S., Dec 1 2019, In : Scientific reports. 9, 1, 10656.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Nano-carriers for delivery and targeting of active ingredients of Chinese medicine for hepatocellular carcinoma therapy

Chen, M., Zhou, X., Chen, R., Wang, J., Ye, R. D., Wang, Y., Wu, C. & Mahato, R. I., May 2019, In : Materials Today. 25, p. 66-87 22 p.

Research output: Contribution to journalReview article

2 Scopus citations

Nanoparticulate delivery of potent microtubule inhibitor for metastatic melanoma treatment

Bariwal, J., Kumar, V., Chen, H., Bhattarai, R. S., Peng, Y., Li, W. & Mahato, R. I., Sep 10 2019, In : Journal of Controlled Release. 309, p. 231-243 13 p.

Research output: Contribution to journalArticle

3 Scopus citations
1 Scopus citations

Novel benzimidazole phosphonates as potential inhibitors of protein prenylation

Bhuiyan, N. H., Varney, M. L., Wiemer, D. F. & Holstein, S. A., Dec 15 2019, In : Bioorganic and Medicinal Chemistry Letters. 29, 24, 126757.

Research output: Contribution to journalArticle

Novel intra-operative peripheral nerve agent for fluorescence guided imaging

Liu, X., Lovell, P., Cruz, D. R., Houser, L., Lagrange, C. A. & Mohs, A. M., 2019, Clinical and Translational Neurophotonics 2020. Madsen, S. J., Yang, V. X. D. & Thakor, N. V. (eds.). SPIE, 112250J. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; vol. 11225).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Novel therapies hijack the blood-brain barrier to eradicate glioblastoma cancer stem cells

Vengoji, R., Ponnusamy, M. P., Rachagani, S., Mahapatra, S., Batra, S. K., Shonka, N. & Macha, M. A., Mar 12 2019, In : Carcinogenesis. 40, 1, p. 2-14 13 p.

Research output: Contribution to journalReview article

4 Scopus citations

Npm-alk is a key regulator of the oncoprotein foxm1 in alk-positive anaplastic large cell lymphoma

Haque, M., Li, J., Huang, Y. H., Almowaled, M., Barger, C. J., Karpf, A. R., Wang, P., Chen, W., Turner, S. D. & Lai, R., Aug 2019, In : Cancers. 11, 8, 1119.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Nucleotide weight matrices reveal ubiquitous mutational footprints of AID/APOBEC deaminases in human cancer genomes

Rogozin, I. B., Roche-Lima, A., Lada, A. G., Belinky, F., Sidorenko, I. A., Glazko, G. V., Babenko, V. N., Cooper, D. N. & Pavlov, Y. I., Feb 2019, In : Cancers. 11, 2, 211.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

O-GlcNAc Transferase Suppresses Inflammation and Necroptosis by Targeting Receptor-Interacting Serine/Threonine-Protein Kinase 3

Li, X., Gong, W., Wang, H., Li, T., Attri, K. S., Lewis, R. E., Kalil, A. C., Bhinderwala, F., Powers, R., Yin, G., Herring, L. E., Asara, J. M., Lei, Y. L., Yang, X., Rodriguez, D. A., Yang, M., Green, D. R., Singh, P. K. & Wen, H., Mar 19 2019, In : Immunity. 50, 3, p. 576-590.e6

Research output: Contribution to journalArticle

16 Scopus citations

Organic fluorescent dye-based nanomaterials: Advances in the rational design for imaging and sensing applications

Svechkarev, D. & Mohs, A. M., 2019, In : Current medicinal chemistry. 26, 21, p. 4042-4064 23 p.

Research output: Contribution to journalReview article

5 Scopus citations

p63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas

Hsieh, M. H., Choe, J. H., Gadhvi, J., Kim, Y. J., Arguez, M. A., Palmer, M., Gerold, H., Nowak, C., Do, H., Mazambani, S., Knighton, J. K., Cha, M., Goodwin, J., Kang, M. K., Jeong, J. Y., Lee, S. Y., Faubert, B., Xuan, Z., Abel, E. D., Scafoglio, C. & 11 others, Shackelford, D. B., Minna, J. D., Singh, P. K., Shulaev, V., Bleris, L., Hoyt, K., Kim, J., Inoue, M., DeBerardinis, R. J., Kim, T. H. & Kim, J. W., Aug 13 2019, In : Cell Reports. 28, 7, p. 1860-1878.e9

Research output: Contribution to journalArticle

Open Access
13 Scopus citations

p66Shc protein through a redox mechanism enhances the progression of prostate cancer cells towards castration-resistance

Miller, D. R., Ingersoll, M. A., Chatterjee, A., Baker, B., Shrishrimal, S., Kosmacek, E. A., Zhu, Y., Cheng, P. W., Oberley-Deegan, R. E. & Lin, M. F., Aug 1 2019, In : Free Radical Biology and Medicine. 139, p. 24-34 11 p.

Research output: Contribution to journalArticle

4 Scopus citations

Pan-cancer analyses reveal genomic features of FOXM1 overexpression in cancer

Barger, C. J., Branick, C., Chee, L. & Karpf, A. R., Feb 2019, In : Cancers. 11, 2, 251 .

Research output: Contribution to journalArticle

Open Access
18 Scopus citations

Phase I/II study of dasatinib and exploratory genomic analysis in relapsed or refractory non-Hodgkin lymphoma

Umakanthan, J. M., Iqbal, J., Batlevi, C. L., Bouska, A., Smith, L. M., Shostrom, V., Nutsch, H., William, B. M., Gregory Bociek, R., Lunning, M., Bierman, P., Younes, A., Armitage, J. O. & Vose, J. M., Mar 2019, In : British Journal of Haematology. 184, 5, p. 744-752 9 p.

Research output: Contribution to journalArticle

3 Scopus citations
1 Scopus citations

Phosphorylation of Cx43 residue Y313 by Src contributes to blocking the interaction with Drebrin and disassembling gap junctions

Zheng, L., Li, H., Cannon, A., Trease, A. J., Spagnol, G., Zheng, H., Radio, S., Patel, K., Batra, S. & Sorgen, P. L., Jan 2019, In : Journal of Molecular and Cellular Cardiology. 126, p. 36-49 14 p.

Research output: Contribution to journalArticle

1 Scopus citations

Pluronic block copolymers enhance the anti-myeloma activity of proteasome inhibitors

Hu, H., Petrosyan, A., Osna, N. A., Liu, T., Olou, A. A., Alakhova, D. Y., Singh, P. K., Kabanov, A. V., Faber, E. A. & Bronich, T. K., Jul 28 2019, In : Journal of Controlled Release. 306, p. 149-164 16 p.

Research output: Contribution to journalArticle

4 Scopus citations

Polymeric micellar delivery of novel microtubule destabilizer and hedgehog signaling inhibitor for treating chemoresistant prostate cancer

Yang, R., Chen, H., Guo, D., Dong, Y., Miller, D. D., Li, W. & Mahato, R. I., 2019, In : Journal of Pharmacology and Experimental Therapeutics. 370, 3, p. 864-875 12 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

PR55α regulatory subunit of PP2A inhibits the MOB1/LATS cascade and activates YAP in pancreatic cancer cells

Hein, A. L., Brandquist, N. D., Ouellette, C. Y., Seshacharyulu, P., Enke, C. A., Ouellette, M. M., Batra, S. K. & Yan, Y., Nov 1 2019, In : Oncogenesis. 8, 11, 63.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Probing the structure and dynamics of nucleosomes using atomic force microscopy imaging

Stumme-Diers, M. P., Stormberg, T., Sun, Z. & Lyubchenko, Y. L., Jan 2019, In : Journal of Visualized Experiments. 2019, 143, e58820.

Research output: Contribution to journalArticle

1 Scopus citations

Prostate tumor cell exosomes containing hyaluronidase Hyal1 stimulate prostate stromal cell motility by engagement of FAK-mediated integrin signaling

McAtee, C. O., Booth, C., Elowsky, C., Zhao, L., Payne, J., Fangman, T., Caplan, S., Henry, M. D. & Simpson, M. A., May 2019, In : Matrix Biology. 78-79, p. 165-179 15 p.

Research output: Contribution to journalArticle

14 Scopus citations

Proximity labeling to map host-pathogen interactions at the membrane of a bacterium-containing vacuole in chlamydia trachomatis-infected human cells

Olson, M. G., Widner, R. E., Jorgenson, L. M., Lawrence, A., Lagundzin, D., Woods, N. T., Ouellette, S. P. & Rucks, E. A., 2019, In : Infection and immunity. 87, 11, e00537-19.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

PTTG1: a Unique Regulator of Stem/Cancer Stem Cells in the Ovary and Ovarian Cancer

Parte, S., Virant-Klun, I., Patankar, M., Batra, S. K., Straughn, A. & Kakar, S. S., Dec 1 2019, In : Stem Cell Reviews and Reports. 15, 6, p. 866-879 14 p.

Research output: Contribution to journalArticle

7 Scopus citations

Recent Advances in EPAC-Targeted Therapies: A Biophysical Perspective

Ahmed, A., Boulton, S., Shao, H., Akimoto, M., Natarajan, A., Cheng, X. & Melacini, G., Nov 19 2019, In : Cells. 8, 11

Research output: Contribution to journalReview article

Open Access
2 Scopus citations

Regional Molecular Mapping of Primate Synapses during Normal Healthy Aging

Graham, L. C., Naldrett, M. J., Kohama, S. G., Smith, C., Lamont, D. J., McColl, B. W., Gillingwater, T. H., Skehel, P., Urbanski, H. F. & Wishart, T. M., Apr 23 2019, In : Cell Reports. 27, 4, p. 1018-1026.e4

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Regulation of Connexin32 by ephrin receptors and T-cell protein-tyrosine phosphatase

Trease, A. J., Li, H., Spagnol, G., Zheng, L., Stauch, K. L. & Sorgen, P. L., Jan 4 2019, In : Journal of Biological Chemistry. 294, 1, p. 341-350 10 p.

Research output: Contribution to journalArticle

Regulatory and Clinical Experiences with Biosimilar Filgrastim in the U.S., the European Union, Japan, and Canada

Chen, B., Nagai, S., Armitage, J. O., Witherspoon, B., Nabhan, C., Godwin, A. C., Yang, Y. T., Kommalapati, A., Tella, S. H., DeAngelis, C., Raisch, D. W., Sartor, O., Hrushesky, W. J., Ray, P. S., Yarnold, P. R., Love, B. L., Norris, L. A. B., Knopf, K., Bobolts, L., Riente, J. & 4 others, Luminari, S., Kane, R. C., Hoque, S. & Bennett, C. L., Apr 2019, In : Oncologist. 24, 4, p. 537-548 12 p.

Research output: Contribution to journalArticle

3 Scopus citations

Relevance of Prognostic Factors in the Era of Targeted Therapies in CLL

Kittai, A. S., Lunning, M. & Danilov, A. V., Aug 15 2019, In : Current Hematologic Malignancy Reports. 14, 4, p. 302-309 8 p.

Research output: Contribution to journalReview article

4 Scopus citations

Reproducibility of CRISPR-Cas9 methods for generation of conditional mouse alleles: A multi-center evaluation

Gurumurthy, C. B., O'Brien, A. R., Quadros, R. M., Adams, J., Alcaide, P., Ayabe, S., Ballard, J., Batra, S. K., Beauchamp, M. C., Becker, K. A., Bernas, G., Brough, D., Carrillo-Salinas, F., Chan, W., Chen, H., Dawson, R., Demambro, V., D'Hont, J., Dibb, K. M., Eudy, J. D. & 93 others, Gan, L., Gao, J., Gonzales, A., Guntur, A. R., Guo, H., Harms, D. W., Harrington, A., Hentges, K. E., Humphreys, N., Imai, S., Ishii, H., Iwama, M., Jonasch, E., Karolak, M., Keavney, B., Khin, N. C., Konno, M., Kotani, Y., Kunihiro, Y., Lakshmanan, I., Larochelle, C., Lawrence, C. B., Li, L., Lindner, V., Liu, X. D., Lopez-Castejon, G., Loudon, A., Lowe, J., Jerome-Majewska, L. A., Matsusaka, T., Miura, H., Miyasaka, Y., Morpurgo, B., Motyl, K., Nabeshima, Y. I., Nakade, K., Nakashiba, T., Nakashima, K., Obata, Y., Ogiwara, S., Ouellet, M., Oxburgh, L., Piltz, S., Pinz, I., Ponnusamy, M. P., Ray, D., Redder, R. J., Rosen, C. J., Ross, N., Ruhe, M. T., Ryzhova, L., Salvador, A. M., Alam, S. S., Sedlacek, R., Sharma, K., Smith, C., Staes, K., Starrs, L., Sugiyama, F., Takahashi, S., Tanaka, T., Trafford, A. W., Uno, Y., Vanhoutte, L., Vanrockeghem, F., Willis, B. J., Wright, C. S., Yamauchi, Y., Yi, X., Yoshimi, K., Zhang, X., Zhang, Y., Ohtsuka, M., Das, S., Garry, D. J., Hochepied, T., Thomas, P., Parker-Thornburg, J., Adamson, A. D., Yoshiki, A., Schmouth, J. F., Golovko, A., Thompson, W. R., Lloyd, K. C. K., Wood, J. A., Cowan, M., Mashimo, T., Mizuno, S., Zhu, H., Kasparek, P., Liaw, L., Miano, J. M. & Burgio, G., Aug 26 2019, In : Genome biology. 20, 1, 171.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Retromer facilitates the localization of Bcl-xL to the mitochondrial outer membrane

Farmer, T., O'Neill, K. L., Naslavsky, N., Luo, X. & Caplan, S., 2019, In : Molecular biology of the cell. 30, 10, p. 1138-1146 9 p.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

Review of Transient Receptor Potential Canonical (TRPC5) Channel Modulators and Diseases

Sharma, S. & Hopkins, C. R., Sep 12 2019, In : Journal of Medicinal Chemistry. 62, 17, p. 7589-7602 14 p.

Research output: Contribution to journalReview article

5 Scopus citations

Revised adult T-cell leukemia-lymphoma international consensus meeting report

Cook, L. B., Fuji, S., Hermine, O., Bazarbachi, A., Ramos, J. C., Ratner, L., Horwitz, S., Fields, P., Tanase, A., Bumbea, H., Cwynarski, K., Taylor, G., Waldmann, T. A., Bittencourt, A., Marcais, A., Suarez, F., Sibon, D., Phillips, A., Lunning, M., Farid, R. & 12 others, Imaizumi, Y., Choi, I., Ishida, T., Ishitsuka, K., Fukushima, T., Uchimaru, K., Takaori-Kondo, A., Tokura, Y., Utsunomiya, A., Matsuoka, M., Tsukasaki, K. & Watanabe, T., Mar 10 2019, In : Journal of Clinical Oncology. 37, 8, p. 677-687 11 p.

Research output: Contribution to journalArticle

Open Access
28 Scopus citations

RNA-binding protein hur regulates both mutant and wild-type IDH1 in IDH1-mutated cancer

Zarei, M., Lal, S., Vaziri-Gohar, A., O'Hayer, K., Gunda, V., Singh, P. K., Brody, J. R. & Winter, J. M., Feb 2019, In : Molecular Cancer Research. 17, 2, p. 508-520 13 p.

Research output: Contribution to journalArticle

2 Scopus citations

Role of Estrogen in Androgen-Induced Prostate Carcinogenesis in NBL Rats

Ozten, N., Vega, K., Liehr, J., Huang, X., Horton, L., Cavalieri, E. L., Rogan, E. G. & Bosland, M. C., Jan 1 2019, In : Hormones and Cancer.

Research output: Contribution to journalArticle

5 Scopus citations

Role of keratan sulfate expression in human pancreatic cancer malignancy

Leiphrakpam, P. D., Patil, P. P., Remmers, N., Swanson, B., Grandgenett, P. M., Qiu, F., Yu, F. & Radhakrishnan, P., Dec 1 2019, In : Scientific reports. 9, 1, 9665.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Roles of microRNAs in T cell immunity: Implications for strategy development against infectious diseases

Giri, B. R., Mahato, R. I. & Cheng, G., Mar 2019, In : Medicinal Research Reviews. 39, 2, p. 706-732 27 p.

Research output: Contribution to journalReview article

1 Scopus citations

ROS-Responsive Polymeric Micelles for Triggered Simultaneous Delivery of PLK1 Inhibitor/miR-34a and Effective Synergistic Therapy in Pancreatic Cancer

Xin, X., Lin, F., Wang, Q., Yin, L. & Mahato, R. I., Apr 24 2019, In : ACS Applied Materials and Interfaces. 11, 16, p. 14647-14659 13 p.

Research output: Contribution to journalArticle

4 Scopus citations

Selective degradation of CDK6 by a palbociclib based PROTAC

Rana, S., Bendjennat, M., Kour, S., King, H. M., Kizhake, S., Zahid, M. & Natarajan, A., Jun 1 2019, In : Bioorganic and Medicinal Chemistry Letters. 29, 11, p. 1375-1379 5 p.

Research output: Contribution to journalArticle

21 Scopus citations

Selective inhibition of histone deacetylases 1/2/6 in combination with gemcitabine: A promising combination for pancreatic cancer therapy

Laschanzky, R. S., Humphrey, L. E., Ma, J., Smith, L. M., Enke, T. J., Shukla, S. K., Dasgupta, A., Singh, P. K., Howell, G. M., Brattain, M. G., Ly, Q. P., Black, A. R. & Black, J. D., Sep 2019, In : Cancers. 11, 9, 1327.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Self-Assembled Nanostructures of Peptide Amphiphiles: Charge Regulation by Size Regulation

Zaldivar, G., Vemulapalli, S., Udumula, V., Conda-Sheridan, M. & Tagliazucchi, M., Jun 24 2019, In : Journal of Physical Chemistry C. 123, 28, p. 17606-17615 10 p.

Research output: Contribution to journalArticle

5 Scopus citations

Self-assembling lisofylline-fatty acid conjugate for effective treatment of diabetes mellitus

Italiya, K. S., Mazumdar, S., Sharma, S., Chitkara, D., Mahato, R. I. & Mittal, A., Jan 2019, In : Nanomedicine: Nanotechnology, Biology, and Medicine. 15, 1, p. 175-187 13 p.

Research output: Contribution to journalArticle

2 Scopus citations

Sequence-dependent nucleosome nanoscale structure characterized by atomic force microscopy

Stormberg, T., Stumme-Diers, M. & Lyubchenko, Y. L., 2019, In : FASEB Journal. 33, 10, p. 10916-10923 8 p.

Research output: Contribution to journalArticle

Silencing of Neuropilins and GIPC1 in pancreatic ductal adenocarcinoma exerts multiple cellular and molecular antitumor effects

Borchardt, H., Schulz, A., Datta, K., Muders, M. H. & Aigner, A., Dec 1 2019, In : Scientific reports. 9, 1, 15471.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Sox2 dosage: A critical determinant in the functions of Sox2 in both normal and tumor cells

Metz, E. P. & Rizzino, A., Nov 2019, In : Journal of Cellular Physiology. 234, 11, p. 19298-19306 9 p.

Research output: Contribution to journalReview article

3 Scopus citations