Eppley Institute for Cancer Research

Research Output

2019

Self-assembling lisofylline-fatty acid conjugate for effective treatment of diabetes mellitus

Italiya, K. S., Mazumdar, S., Sharma, S., Chitkara, D., Mahato, R. I. & Mittal, A., Jan 2019, In : Nanomedicine: Nanotechnology, Biology, and Medicine. 15, 1, p. 175-187 13 p.

Research output: Contribution to journalArticle

2 Scopus citations

Sequence-dependent nucleosome nanoscale structure characterized by atomic force microscopy

Stormberg, T., Stumme-Diers, M. & Lyubchenko, Y. L., 2019, In : FASEB Journal. 33, 10, p. 10916-10923 8 p.

Research output: Contribution to journalArticle

Silencing of Neuropilins and GIPC1 in pancreatic ductal adenocarcinoma exerts multiple cellular and molecular antitumor effects

Borchardt, H., Schulz, A., Datta, K., Muders, M. H. & Aigner, A., Dec 1 2019, In : Scientific reports. 9, 1, 15471.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Sox2 dosage: A critical determinant in the functions of Sox2 in both normal and tumor cells

Metz, E. P. & Rizzino, A., Nov 2019, In : Journal of Cellular Physiology. 234, 11, p. 19298-19306 9 p.

Research output: Contribution to journalReview article

3 Scopus citations

Spontaneous self-assembly of amyloid β (1-40) into dimers

Hashemi, M., Zhang, Y., Lv, Z. & Lyubchenko, Y. L., 2019, In : Nanoscale Advances. 1, 10, p. 3892-3899 8 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

SSRP1 promotes colorectal cancer progression and is negatively regulated by miR-28-5p

Wu, W., He, K., Guo, Q., Chen, J., Zhang, M., Huang, K., Yang, D., Wu, L., Deng, Y., Luo, X., Yu, H., Ding, Q. & Xiang, G., May 2019, In : Journal of cellular and molecular medicine. 23, 5, p. 3118-3129 12 p.

Research output: Contribution to journalArticle

Open Access
9 Scopus citations

Structural consequence of the most frequently recurring cancer-associated substitution in DNA polymerase ε

Parkash, V., Kulkarni, Y., ter Beek, J., Shcherbakova, P. V., Kamerlin, S. C. L. & Johansson, E., Dec 1 2019, In : Nature communications. 10, 1, 373.

Research output: Contribution to journalArticle

8 Scopus citations

Summary of the Second Annual BMT CTN Myeloma Intergroup Workshop on Minimal Residual Disease and Immune Profiling

Holstein, S. A., Ye, J. C., Howard, A., Bhutani, M., Gormley, N., Hahn, T., Hillengass, J., Krishnan, A., Landgren, C. O., Munshi, N. C., Oliva, S., Owen, R. G., Pasquini, M. C., Puig, N., Weinhold, N., Weisel, K. & McCarthy, P. L., Mar 2019, In : Biology of Blood and Marrow Transplantation. 25, 3, p. e89-e97

Research output: Contribution to journalArticle

5 Scopus citations

Supercell refinement: A cautionary tale

Lovelace, J., Petrícek, V., Murshudov, G. & Borgstahl, G. E. O., Sep 1 2019, In : Acta Crystallographica Section D: Structural Biology. 75, p. 852-860 9 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Surgical imaging of pancreatic cancer using polysaccharide-delivered near infrared fluorophores

Qi, B., Crawford, A. J., Wojtynek, N. E., Hollingsworth, M. A., Ly, Q. P. & Mohs, A. M., 2019, Molecular-Guided Surgery: Molecules, Devices, and Applications V. Pogue, B. W. & Gioux, S. (eds.). SPIE, 108620O. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; vol. 10862).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Systems Biology Approach to Identify Novel Genomic Determinants for Pancreatic Cancer Pathogenesis

Khatri, I., Ganguly, K., Sharma, S., Carmicheal, J., Kaur, S., Batra, S. K. & Bhasin, M. K., Dec 1 2019, In : Scientific reports. 9, 1, 123.

Research output: Contribution to journalArticle

3 Scopus citations

Targetable genetic alterations of TCF4 (E2-2) drive immunoglobulin expression in diffuse large B cell lymphoma

Jain, N., Hartert, K., Tadros, S., Fiskus, W., Havranek, O., Ma, M. C. J., Bouska, A., Heavican, T., Kumar, D., Deng, Q., Moore, D., Pak, C., Liu, C. L., Gentles, A. J., Hartmann, E., Kridel, R., Smedby, K. E., Juliusson, G., Rosenquist, R., Gascoyne, R. D. & 13 others, Rosenwald, A., Giancotti, F., Neelapu, S. S., Westin, J., Vose, J. M., Lunning, M. A., Greiner, T., Rodig, S., Iqbal, J., Alizadeh, A. A., Davis, R. E., Bhalla, K. & Green, M. R., 2019, In : Science translational medicine. 11, 497, eaav5599.

Research output: Contribution to journalArticle

8 Scopus citations

Targeted drug delivery and image-guided therapy of heterogeneous ovarian cancer using HER2-targeted theranostic nanoparticles

Satpathy, M., Wang, L., Zielinski, R. J., Qian, W., Wang, Y. A., Mohs, A. M., Kairdolf, B. A., Ji, X., Capala, J., Lipowska, M., Nie, S., Mao, H. & Yang, L., 2019, In : Theranostics. 9, 3, p. 778-795 18 p.

Research output: Contribution to journalArticle

Open Access
15 Scopus citations

Targeting fatty acid synthase to inhibit tumor growth and overcome taxane resistance

Souchek, J. J., Muraskin, L., Houser, L., Vu, Q. & Mohs, A. M., 2019, Visualizing and Quantifying Drug Distribution in Tissue III. Chan, K. F. & Evans, C. L. (eds.). SPIE, 1085909. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; vol. 10859).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Targeting LIF-mediated paracrine interaction for pancreatic cancer therapy and monitoring

Shi, Y., Gao, W., Lytle, N. K., Huang, P., Yuan, X., Dann, A. M., Ridinger-Saison, M., DelGiorno, K. E., Antal, C. E., Liang, G., Atkins, A. R., Erikson, G., Sun, H., Meisenhelder, J., Terenziani, E., Woo, G., Fang, L., Santisakultarm, T. P., Manor, U., Xu, R. & 18 others, Becerra, C. R., Borazanci, E., Von Hoff, D. D., Grandgenett, P. M., Hollingsworth, M. A., Leblanc, M., Umetsu, S. E., Collisson, E. A., Scadeng, M., Lowy, A. M., Donahue, T. R., Reya, T., Downes, M., Evans, R. M., Wahl, G. M., Pawson, T., Tian, R. & Hunter, T., May 2 2019, In : Nature. 569, 7754, p. 131-135 5 p.

Research output: Contribution to journalArticle

37 Scopus citations

The evolving role of maintenance therapy following autologous stem cell transplantation in multiple myeloma

Merz, A. M. A., Merz, M., Hillengass, J., Holstein, S. A. & McCarthy, P., Oct 3 2019, In : Expert review of anticancer therapy. 19, 10, p. 889-898 10 p.

Research output: Contribution to journalReview article

1 Scopus citations

The glycan CA19-9 promotes pancreatitis and pancreatic cancer in mice

Engle, D. D., Tiriac, H., Rivera, K. D., Pommier, A., Whalen, S., Oni, T. E., Alagesan, B., Lee, E. J., Yao, M. A., Lucito, M. S., Spielman, B., Silva, B. D., Schoepfer, C., Wright, K., Creighton, B., Afinowicz, L., Yu, K. H., Grützmann, R., Aust, D., Gimotty, P. A. & 8 others, Pollard, K. S., Hruban, R. H., Goggins, M. G., Pilarsky, C., Park, Y., Pappin, D. J., Hollingsworth, M. A. & Tuveson, D. A., 2019, In : Science. 364, 6446, p. 1156-1162 7 p.

Research output: Contribution to journalArticle

26 Scopus citations

The glycoprotein mucin-1 negatively regulates GalNAc transferase 5 expression in pancreatic cancer

Caffrey, T., Sagar, S., Thomas, D., Lewallen, M. E., Hollingsworth, M. A. & Radhakrishnan, P., Oct 1 2019, In : FEBS Letters. 593, 19, p. 2751-2761 11 p.

Research output: Contribution to journalArticle

1 Scopus citations

The impact of the affordable care act on breast cancer care in the USA: A multi-institutional analysis

Maxwell, J., Shats, O., Aldridge, J., Lyden, E., Krie, A., Conklin, R., Manning, K., Fahed, R., Vaziri, I., Deveras, R. A. E., Mateen, Z., Crow, K., Bjorling, V., Meschi, J. T., Makoni, S., Kruter, F. & Cowan, K., Sep 1 2019, In : Breast Journal. 25, 5, p. 948-952 5 p.

Research output: Contribution to journalArticle

The miR-17~92 cluster activates mTORC1 in mantle cell lymphoma by targeting multiple regulators in the STK11/AMPK/TSC/mTOR pathway

Jiang, C., Bi, C., Jiang, X., Tian, T., Huang, X., Wang, C., Fernandez, M. R., Iqbal, J., Chan, W. C., McKeithan, T. W., Lewis, R. E. & Fu, K., May 2019, In : British Journal of Haematology. 185, 3, p. 616-620 5 p.

Research output: Contribution to journalLetter

2 Scopus citations

The mitochondrial deoxyguanosine kinase is required for cancer cell stemness in lung adenocarcinoma

Lin, S., Huang, C., Sun, J., Bollt, O., Wang, X., Martine, E., Kang, J., Taylor, M. D., Fang, B., Singh, P. K., Koomen, J., Hao, J. & Yang, S., Dec 1 2019, In : EMBO Molecular Medicine. 11, 12, e10849.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

The neuroprotection of KIBRA in promoting neuron survival and against amyloid β-induced apoptosis

Song, L., Tang, S., Dong, L., Han, X., Cong, L., Dong, J., Han, X., Zhang, Q., Wang, Y. & Du, Y., Apr 12 2019, In : Frontiers in Cellular Neuroscience. 13, 137.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Thermodynamic contributions for the inclusion of bulges and mismatches in dna hairpin loops

Shikiya, R. & Marky, L. A., Jun 5 2019, A Closer Look at Calorimetry. Nova Science Publishers, Inc., p. 31-60 30 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Thermodynamic investigation of kissing-loop interactions

Carr, C. E. & Marky, L. A., Feb 2019, In : Biochimie. 157, p. 177-183 7 p.

Research output: Contribution to journalArticle

The use of micelles to deliver potential hedgehog pathway inhibitor for the treatment of liver fibrosis

Kumar, V., Dong, Y., Kumar, V., Almawash, S. & Mahato, R. I., 2019, In : Theranostics. 9, 25, p. 7537-7555 19 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Timely expression and activation of YAP1 in granulosa cells is essential for ovarian follicle development

Lv, X., He, C., Huang, C., Wang, H., Hua, G., Wang, Z., Zhou, J., Chen, X., Ma, B., Timm, B. K., Maclin, V., Dong, J., Rueda, B. R., Davis, J. S. & Wang, C., Sep 1 2019, In : FASEB Journal. 33, 9, p. 10049-10064 16 p.

Research output: Contribution to journalArticle

9 Scopus citations

Tolerability and activity of ublituximab, umbralisib, and ibrutinib in patients with chronic lymphocytic leukaemia and non-Hodgkin lymphoma: a phase 1 dose escalation and expansion trial

Nastoupil, L. J., Lunning, M. A., Vose, J. M., Schreeder, M. T., Siddiqi, T., Flowers, C. R., Cohen, J. B., Burger, J. A., Wierda, W. G., O'Brien, S., Sportelli, P., Miskin, H. P., Purdom, M. A., Weiss, M. S. & Fowler, N. H., Feb 2019, In : The Lancet Haematology. 6, 2, p. e100-e109

Research output: Contribution to journalArticle

23 Scopus citations

Treatment patterns and outcomes of octogenarian patients with acute myeloid leukemia

Bhatt, V. R., Shostrom, V., Armitage, J. O. & Gundabolu, K., Jun 2019, In : American Journal of Hematology. 94, 6, p. E169-E172

Research output: Contribution to journalLetter

5 Scopus citations

Trefoil factor(s) and CA19.9: A promising panel for early detection of pancreatic cancer

Jahan, R., Ganguly, K., Smith, L. M., Atri, P., Carmicheal, J., Sheinin, Y., Rachagani, S., Natarajan, G., Brand, R. E., Macha, M. A., Grandgenett, P. M., Kaur, S. & Batra, S. K., Apr 2019, In : EBioMedicine. 42, p. 375-385 11 p.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Truncated O-glycans promote epithelial-to-mesenchymal transition and stemness properties of pancreatic cancer cells

Thomas, D., Sagar, S., Caffrey, T., Grandgenett, P. M. & Radhakrishnan, P., Oct 1 2019, In : Journal of cellular and molecular medicine. 23, 10, p. 6885-6896 12 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Tumor‐associated neutrophils in cancer: Going pro

Wu, L., Saxena, S., Awaji, M. & Singh, R. K., Apr 2019, In : Cancers. 11, 4, 564.

Research output: Contribution to journalArticle

Open Access
34 Scopus citations

Tumor-stromal crosstalk in pancreatic cancer and tissue fibrosis

Thomas, D. & Radhakrishnan, P., Jan 21 2019, In : Molecular cancer. 18, 1, 14.

Research output: Contribution to journalReview article

43 Scopus citations

Ublituximab and umbralisib in relapsed/refractory B-cell non-Hodgkin lymphoma and chronic lymphocytic leukemia

Lunning, M., Vose, J., Nastoupil, L., Fowler, N., Burger, J. A., Wierda, W. G., Schreeder, M. T., Siddiqi, T., Flowers, C. R., Cohen, J. B., Sportelli, P., Miskin, H. P., Weiss, M. S. & O'Brien, S., Nov 21 2019, In : Blood. 134, 21, p. 1811-1820 10 p.

Research output: Contribution to journalArticle

10 Scopus citations
Open Access

Understanding interactions of Citropin 1.1 analogues with model membranes and their influence on biological activity

Rodrigues de Almeida, N., Catazaro, J., Krishnaiah, M., Singh Chhonker, Y., Murry, D. J., Powers, R. & Conda-Sheridan, M., Sep 2019, In : Peptides. 119, 170119.

Research output: Contribution to journalArticle

2 Scopus citations

Unraveling the journey of cancer stem cells from origin to metastasis

Nimmakayala, R. K., Batra, S. K. & Ponnusamy, M. P., Jan 2019, In : Biochimica et Biophysica Acta - Reviews on Cancer. 1871, 1, p. 50-63 14 p.

Research output: Contribution to journalReview article

15 Scopus citations

Vitamin e δ-tocotrienol sensitizes human pancreatic cancer cells to TRAIL-induced apoptosis through proteasome-mediated down-regulation of c-FLIPs

Francois, R. A., Zhang, A., Husain, K., Wang, C., Hutchinson, S., Kongnyuy, M., Batra, S. K., Coppola, D., Sebti, S. M. & Malafa, M. P., Jul 22 2019, In : Cancer Cell International. 19, 1, 189.

Research output: Contribution to journalArticle

Open Access

VU0810464, a non-urea G protein-gated inwardly rectifying K+ (Kir3/GIRK) channel activator, exhibits enhanced selectivity for neuronal Kir3 channels and reduces stress-induced hyperthermia in mice

Vo, B. N., Abney, K. K., Anderson, A., Marron Fernandez de Velasco, E., Benneyworth, M. A., Daniels, J. S., Morrison, R. D., Hopkins, C. R., Weaver, C. D. & Wickman, K., Jul 2019, In : British Journal of Pharmacology. 176, 13, p. 2238-2249 12 p.

Research output: Contribution to journalArticle

1 Scopus citations

YAP1-LATS2 feedback loop dictates senescent or malignant cell fate to maintain tissue homeostasis

He, C., Lv, X., Huang, C., Hua, G., Ma, B., Chen, X., Angeletti, P. C., Dong, J., Zhou, J., Wang, Z., Rueda, B. R., Davis, J. S. & Wang, C., Mar 2019, In : EMBO Reports. 20, 3, e44948.

Research output: Contribution to journalArticle

5 Scopus citations

ω-Hydroxy isoprenoid bisphosphonates as linkable GGDPS inhibitors

Bhuiyan, N. H., Varney, M. L., Bhattacharya, D. S., Payne, W. M., Mohs, A. M., Holstein, S. A. & Wiemer, D. F., Oct 1 2019, In : Bioorganic and Medicinal Chemistry Letters. 29, 19, 126633.

Research output: Contribution to journalArticle

2 Scopus citations
2018

3D Bioprinting of Breast Cancer Models for Drug Resistance Study

Wang, Y., Shi, W., Kuss, M., Mirza, S., Qi, D., Krasnoslobodtsev, A. V., Zeng, J., Band, H., Band, V. & Duan, B., Dec 10 2018, In : ACS Biomaterials Science and Engineering. 4, 12, p. 4401-4411 11 p.

Research output: Contribution to journalArticle

14 Scopus citations

3D hydrogel breast cancer models for studying the effects of hypoxia on epithelial to mesenchymal transition

Wang, Y., Mirza, S., Wu, S., Zeng, J., Shi, W., Band, H., Band, V. & Duan, B., Aug 14 2018, In : Oncotarget. 9, 63, p. 32191-32203 13 p.

Research output: Contribution to journalArticle

11 Scopus citations

Activity and fidelity of human DNA polymerase depend on primer structure

Baranovskiy, A. G., Duong, V. N., Babayeva, N. D., Zhang, Y., Pavlov, Y. I., Anderson, K. S. & Tahirov, T. H., May 4 2018, In : Journal of Biological Chemistry. 293, 18, p. 6824-6843 20 p.

Research output: Contribution to journalArticle

6 Scopus citations

Advanced pancreatic cancer: A meta-analysis of clinical trials over thirty years

Hall, B. R., Cannon, A., Atri, P., Wichman, C. S., Smith, L. M., Ganti, A. K., Are, C., Sasson, A. R., Kumar, S. & Batra, S. K., Apr 10 2018, In : Oncotarget. 9, 27, p. 19396-19405 10 p.

Research output: Contribution to journalArticle

13 Scopus citations

A Functional Signature Ontology (FUSION) screen detects an AMPK inhibitor with selective toxicity toward human colon tumor cells

Das, B., Neilsen, B. K., Fisher, K. W., Gehring, D., Hu, Y., Volle, D. J., Kim, H. S., McCall, J. L., Kelly, D. L., MacMillan, J. B., White, M. A. & Lewis, R. E., Dec 1 2018, In : Scientific reports. 8, 1, 3770.

Research output: Contribution to journalArticle

7 Scopus citations

AKT3 drives adenoid cystic carcinoma development in salivary glands

Zboray, K., Mohrherr, J., Stiedl, P., Pranz, K., Wandruszka, L., Grabner, B., Eferl, R., Moriggl, R., Stoiber, D., Sakamoto, K., Wagner, K. U., Popper, H., Casanova, E. & Moll, H. P., Feb 1 2018, In : Cancer Medicine. 7, 2, p. 445-453 9 p.

Research output: Contribution to journalArticle

3 Scopus citations

An Mtb-Human Protein-Protein Interaction Map Identifies a Switch between Host Antiviral and Antibacterial Responses

Penn, B. H., Netter, Z., Johnson, J. R., Von Dollen, J., Jang, G. M., Johnson, T., Ohol, Y. M., Maher, C., Bell, S. L., Geiger, K., Golovkine, G., Du, X., Choi, A., Parry, T., Mohapatra, B. C., Storck, M. D., Band, H., Chen, C., Jäger, S., Shales, M. & 5 others, Portnoy, D. A., Hernandez, R., Coscoy, L., Cox, J. S. & Krogan, N. J., Aug 16 2018, In : Molecular Cell. 71, 4, p. 637-648.e5

Research output: Contribution to journalArticle

22 Scopus citations

An update on minding the gap in cancer

Mesnil, M., Aasen, T., Boucher, J., Chépied, A., Cronier, L., Defamie, N., Kameritsch, P., Laird, D. W., Lampe, P. D., Lathia, J. D., Leithe, E., Mehta, P. P., Monvoisin, A., Pogoda, K., Sin, W. C., Tabernero, A., Yamasaki, H., Yeh, E. S., Dagli, M. L. Z. & Naus, C. C., Jan 2018, In : Biochimica et Biophysica Acta - Biomembranes. 1860, 1, p. 237-243 7 p.

Research output: Contribution to journalReview article

9 Scopus citations

A review of the catalytic mechanism of human manganese superoxide dismutase

Azadmanesh, J. & Borgstahl, G. E. O., Feb 2018, In : Antioxidants. 7, 2, 25.

Research output: Contribution to journalReview article

36 Scopus citations

Are we prepared for nuclear terrorism?

Gale, R. P. & Armitage, J. O., Mar 29 2018, In : New England Journal of Medicine. 378, 13, p. 1246-1254 9 p.

Research output: Contribution to journalArticle

8 Scopus citations