Eppley Institute for Cancer Research

Research Output

2018

Assembly of centromere chromatin for characterization by high-speed time-lapse atomic force microscopy

Stumme-Diers, M. P., Banerjee, S., Sun, Z. & Lyubchenko, Y. L., 2018, Methods in Molecular Biology. Humana Press Inc., p. 225-242 18 p. (Methods in Molecular Biology; vol. 1814).

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Astrocyte EV-Induced lincRNA-Cox2 Regulates Microglial Phagocytosis: Implications for Morphine-Mediated Neurodegeneration

Hu, G., Liao, K., Niu, F., Yang, L., Dallon, B. W., Callen, S., Tian, C., Shu, J., Cui, J., Sun, Z., Lyubchenko, Y. L., Ka, M., Chen, X. M. & Buch, S., Dec 7 2018, In : Molecular Therapy - Nucleic Acids. 13, p. 450-463 14 p.

Research output: Contribution to journalArticle

20 Scopus citations

Axed MUC4 (MUC4/X) aggravates pancreatic malignant phenotype by activating integrin-β1/FAK/ERK pathway

Jahan, R., Macha, M. A., Rachagani, S., Das, S., Smith, L. M., Kaur, S. & Batra, S. K., Aug 2018, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1864, 8, p. 2538-2549 12 p.

Research output: Contribution to journalArticle

8 Scopus citations

Biphasic changes in airway epithelial cell EGF receptor binding and phosphorylation induced by components of hogbarn dust

Dodmane, P. R., Schulte, N. A., Heires, A. J., Band, H., Romberger, D. J. & Toews, M. L., Nov 26 2018, In : Experimental Lung Research. 44, 10, p. 443-454 12 p.

Research output: Contribution to journalArticle

BRD4 profiling identifies critical chronic lymphocytic leukemia oncogenic circuits and reveals sensitivity to PLX51107, a novel structurally distinct bet inhibitor

Ozer, H. G., El-Gamal, D., Powell, B., Hing, Z. A., Blachly, J. S., Harrington, B., Mitchell, S., Grieselhuber, N. R., Williams, K., Lai, T. H., Alinari, L., Baiocchi, R. A., Brinton, L., Baskin, E., Cannon, M., Beaver, L., Goettl, V. M., Lucas, D. M., Woyach, J. A., Sampath, D. & 27 others, Lehman, A. M., Yu, L., Zhang, J., Ma, Y., Zhang, Y., Spevak, W., Shi, S., Severson, P., Shellooe, R., Carias, H., Tsang, G., Dong, K., Ewing, T., Marimuthu, A., Tantoy, C., Walters, J., Sanftner, L., Rezaei, H., Nespi, M., Matusow, B., Habets, G., Ibrahim, P., Zhang, C., Mathe, E. A., Bollag, G., Byrd, J. C. & Lapalombella, R., Apr 2018, In : Cancer Discovery. 8, 4, p. 458-477 20 p.

Research output: Contribution to journalArticle

33 Scopus citations

Cardiac toxicity

Yahalom, J. & Lunning, M. A., Nov 16 2018, DeVita, Hellman, and Rosenberg's Cancer: Principles & Practice of Oncology. Wolters Kluwer Health Pharma Solutions (Europe) Ltd, p. 2120-2128 9 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Characterization of butyrylcholinesterase from porcine milk

Saxena, A., Belinskaya, T., Schopfer, L. M. & Lockridge, O., Aug 15 2018, In : Archives of Biochemistry and Biophysics. 652, p. 38-49 12 p.

Research output: Contribution to journalArticle

6 Scopus citations

Characterization of CDK(5) inhibitor, 20-223 (aka CP668863) for colorectal cancer therapy

Robb, C. M., Kour, S., Contreras, J. I., Agarwal, E., Barger, C. J., Rana, S., Sonawane, Y., Neilsen, B. K., Taylor, M., Kizhake, S., Thakare, R. N., Chowdhury, S., Wang, J., Black, J. D., Hollingsworth, M. A., Brattain, M. G. & Natarajan, A., 2018, In : Oncotarget. 9, 4, p. 5216-5232 17 p.

Research output: Contribution to journalArticle

8 Scopus citations

Characterization of stem cell and cancer stem cell populations in ovary and ovarian tumors

Parte, S. C., Batra, S. K. & Kakar, S. S., Aug 18 2018, In : Journal of Ovarian Research. 11, 1, 69.

Research output: Contribution to journalArticle

19 Scopus citations

Chemical Genetic Screens Identify Kinase Inhibitor Combinations that Target Anti-Apoptotic Proteins for Cancer Therapy

Contreras, J. I., Robb, C. M., King, H. M., Baxter, J., Crawford, A. J., Kour, S., Kizhake, S., Sonawane, Y. A., Rana, S., Hollingsworth, M. A., Luo, X. & Natarajan, A., May 18 2018, In : ACS chemical biology. 13, 5, p. 1148-1152 5 p.

Research output: Contribution to journalArticle

4 Scopus citations
6 Scopus citations

Cholesterol and Morpholine Grafted Cationic Amphiphilic Copolymers for miRNA-34a Delivery

Sharma, S., Mazumdar, S., Italiya, K. S., Date, T., Mahato, R. I., Mittal, A. & Chitkara, D., Jun 4 2018, In : Molecular Pharmaceutics. 15, 6, p. 2391-2402 12 p.

Research output: Contribution to journalArticle

8 Scopus citations

Cigarette Smoke Induces Stem Cell Features of Pancreatic Cancer Cells via PAF1

Nimmakayala, R. K., Seshacharyulu, P., Lakshmanan, I., Rachagani, S., Chugh, S., Karmakar, S., Rauth, S., Vengoji, R., Atri, P., Talmon, G. A., Lele, S. M., Smith, L. M., Thapa, I., Bastola, D., Ouellette, M. M., Batra, S. K. & Ponnusamy, M. P., Sep 2018, In : Gastroenterology. 155, 3, p. 892-908.e6

Research output: Contribution to journalArticle

20 Scopus citations
2 Scopus citations

Co-delivery of siAlox15 and sunitinib for reversing the new-onset of type 1 diabetes in non-obese diabetic mice

Peng, Y., Wen, D., Lin, F. & Mahato, R. I., Dec 28 2018, In : Journal of Controlled Release. 292, p. 1-12 12 p.

Research output: Contribution to journalArticle

2 Scopus citations

Combination of mAb-AR20.5, anti-PD-L1 and PolyICLC inhibits tumor progression and prolongs survival of MUC1.Tg mice challenged with pancreatic tumors

Mehla, K., Tremayne, J., Grunkemeyer, J. A., O’Connell, K. A., Steele, M. M., Caffrey, T. C., Zhu, X., Yu, F., Singh, P. K., Schultes, B. C., Madiyalakan, R., Nicodemus, C. F. & Hollingsworth, M. A., Mar 1 2018, In : Cancer Immunology, Immunotherapy. 67, 3, p. 445-457 13 p.

Research output: Contribution to journalArticle

8 Scopus citations

Concise Review: Current Status of Three-Dimensional Organoids as Preclinical Models

Kaushik, G., Ponnusamy, M. P. & Batra, S. K., Sep 2018, In : STEM CELLS. 36, 9, p. 1329-1340 12 p.

Research output: Contribution to journalReview article

24 Scopus citations

Connexin43 carboxyl-terminal domain directly interacts with β-catenin

Spagnol, G., Trease, A. J., Zheng, L., Gutierrez, M., Basu, I., Sarmiento, C., Moore, G., Cervantes, M. & Sorgen, P. L., Jun 2018, In : International journal of molecular sciences. 19, 6, 1562.

Research output: Contribution to journalArticle

12 Scopus citations

Correction: KSR1 is required for cell cycle reinitiation following DNA damage.(Journal of Biological Chemistry (2018)284 (6705– 6715))

Razidlo, G. L., Johnson, H. J., Stoeger, S. M., Cowan, K. H., Bessho, T. & Lewis, R. E., Dec 7 2018, In : Journal of Biological Chemistry. 293, 49, p. 19136 1 p.

Research output: Contribution to journalComment/debate

Correction: An essential role of cbl and cbl-b ubiquitin ligases in mammary stem cell maintenance (doi: 10.1242/dev.138164)

Mohapatra, B., Zutshi, N., An, W., Goetz, B., Arya, P., Bielecki, T. A., Mushtaq, I., Storck, M. D., Meza, J. L., Band, V. & Band, H., 2018, In : Development (Cambridge). 145, 21, dev172650.

Research output: Contribution to journalComment/debate

1 Scopus citations

Crosstalk between PKCα and PI3K/AKT Signaling Is Tumor Suppressive in the Endometrium

Hsu, A. H., Lum, M. A., Shim, K. S., Frederick, P. J., Morrison, C. D., Chen, B., Lele, S. M., Sheinin, Y. M., Daikoku, T., Dey, S. K., Leone, G., Black, A. R. & Black, J. D., Jul 17 2018, In : Cell Reports. 24, 3, p. 655-669 15 p.

Research output: Contribution to journalArticle

5 Scopus citations

Cryo-EM structure of the native butyrylcholinesterase tetramer reveals a dimer of dimers stabilized by a superhelical assembly

Leung, M. R., van Bezouwen, L. S., Schopfer, L. M., Sussman, J. L., Silman, I., Lockridge, O. & Zeev-Ben-Mordehai, T., Dec 26 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 52, p. 13270-13275 6 p.

Research output: Contribution to journalArticle

5 Scopus citations

Current and emerging treatment options for a patient with a second relapse of Hodgkin’s lymphoma

Kallam, A. & Armitage, J. O., Apr 3 2018, In : Expert Review of Hematology. 11, 4, p. 293-300 8 p.

Research output: Contribution to journalReview article

5 Scopus citations

Cyclin-dependent kinase 1-mediated phosphorylation of YES links mitotic arrest and apoptosis during antitubulin chemotherapy

Wang, Z., Chen, X., Zhong, M. Z., Yang, S., Zhou, J., Klinkebiel, D. L., Karpf, A. R., Chen, Y. & Dong, J., Dec 2018, In : Cellular Signalling. 52, p. 137-146 10 p.

Research output: Contribution to journalArticle

4 Scopus citations

Deletion of the DEF1 gene does not confer UV-immutability but frequently leads to self-diploidization in yeast Saccharomyces cerevisiae

Stepchenkova, E. I., Shiriaeva, A. A. & Pavlov, Y. I., Oct 2018, In : DNA Repair. 70, p. 49-54 6 p.

Research output: Contribution to journalArticle

1 Scopus citations

Delipidation of plasma has minimal effects on human butyrylcholinesterase

Onder, S., Tacal, O. & Lockridge, O., Feb 15 2018, In : Frontiers in Pharmacology. 9, FEB, 117.

Research output: Contribution to journalArticle

2 Scopus citations

Desmoplasia in pancreatic ductal adenocarcinoma: Insight into pathological function and therapeutic potential

Cannon, A., Thompson, C., Hall, B. R., Jain, M., Kumar, S. & Batra, S. K., Mar 2018, In : Genes and Cancer. 9, 3-4, p. 78-86 9 p.

Research output: Contribution to journalArticle

14 Scopus citations

Development and characterization of carboxy-terminus specific monoclonal antibodies for understanding MUC16 cleavage in human ovarian cancer

Aithal, A., Junker, W. M., Kshirsagar, P., Das, S., Kaur, S., Orzechowski, C., Gautam, S. K., Jahan, R., Sheinin, Y. M., Lakshmanan, I., Ponnusamy, M. P., Batra, S. K. & Jain, M., Apr 2018, In : PloS one. 13, 4, e0193907.

Research output: Contribution to journalArticle

5 Scopus citations

Diagnosis and treatment of non-hodgkin’s lymphoma of adults

Crockett, D. G., Armitage, J. O. & Vose, J. M., Jan 1 2018, Neoplastic Diseases of the Blood. Springer International Publishing, p. 951-973 23 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Dileucine-like motifs in the C-terminal tail of connexin32 control its endocytosis and assembly into gap junctions

Ray, A., Katoch, P., Jain, N. & Mehta, P. P., Mar 1 2018, In : Journal of cell science. 131, 5, jcs207340.

Research output: Contribution to journalArticle

2 Scopus citations

Direct AFM visualization of the nanoscale dynamics of biomolecular complexes

Lyubchenko, Y. L., Aug 20 2018, In : Journal of Physics D: Applied Physics. 51, 40, 403001.

Research output: Contribution to journalReview article

5 Scopus citations

Disruption of C1galt1 Gene Promotes Development and Metastasis of Pancreatic Adenocarcinomas in Mice

Chugh, S., Barkeer, S., Rachagani, S., Nimmakayala, R. K., Perumal, N., Pothuraju, R., Atri, P., Mahapatra, S., Thapa, I., Talmon, G. A., Smith, L. M., Yu, X., Neelamegham, S., Fu, J., Xia, L., Palanimuthu Ponnusamy, M. & Batra, S. K., Nov 2018, In : Gastroenterology. 155, 5, p. 1608-1624 17 p.

Research output: Contribution to journalArticle

13 Scopus citations

DNA polymerase η mutational signatures are found in a variety of different types of cancer

Rogozin, I. B., Goncearenco, A., Lada, A. G., De, S., Yurchenko, V., Nudelman, G., Panchenko, A. R., Cooper, D. N. & Pavlov, Y. I., Feb 1 2018, In : Cell Cycle. 17, 3, p. 348-355 8 p.

Research output: Contribution to journalArticle

12 Scopus citations

Do you know TAFRO?

Lunning, M. A. & Armitage, J. O., Nov 15 2018, In : Blood. 132, 20, p. 2109-2110 2 p.

Research output: Contribution to journalReview article

Dynamics of the Interaction of RecG Protein with Stalled Replication Forks

Sun, Z., Hashemi, M., Warren, G., Bianco, P. R. & Lyubchenko, Y. L., Apr 3 2018, In : Biochemistry. 57, 13, p. 1967-1976 10 p.

Research output: Contribution to journalArticle

7 Scopus citations

Effect of dC → d(m5C) substitutions on the folding of intramolecular triplexes with mixed TAT and C+GC base triplets

Carr, C. E., Ganugula, R., Shikiya, R., Soto, A. M. & Marky, L. A., Mar 2018, In : Biochimie. 146, p. 156-165 10 p.

Research output: Contribution to journalArticle

1 Scopus citations

Effect of GCAA stabilizing loops on three- and four-way intramolecular junctions

Carr, C. E. & Marky, L. A., 2018, In : Physical Chemistry Chemical Physics. 20, 7, p. 5046-5056 11 p.

Research output: Contribution to journalArticle

1 Scopus citations
1 Scopus citations

Emerging Roles of Electrospun Nanofibers in Cancer Research

Chen, S., Boda, S. K., Batra, S. K., Li, X. & Xie, J., Mar 21 2018, In : Advanced Healthcare Materials. 7, 6, 1701024.

Research output: Contribution to journalArticle

28 Scopus citations

Emerging therapeutic potential of graviola and its constituents in cancers

Qazi, A. K., Siddiqui, J. A., Jahan, R., Chaudhary, S., Walker, L. A., Sayed, Z., Jones, D. T., Batra, S. K. & Macha, M. A., Apr 5 2018, In : Carcinogenesis. 39, 4, p. 522-533 12 p.

Research output: Contribution to journalReview article

11 Scopus citations

Emerging trends in the immunotherapy of pancreatic cancer

Banerjee, K., Kumar, S., Ross, K. A., Gautam, S., Poelaert, B., Nasser, M. W., Aithal, A., Bhatia, R., Wannemuehler, M. J., Narasimhan, B., Solheim, J. C., Batra, S. K. & Jain, M., Mar 28 2018, In : Cancer Letters. 417, p. 35-46 12 p.

Research output: Contribution to journalShort survey

27 Scopus citations

Energetics, Ion, and Water Binding of the Unfolding of AA/UU Base Pair Stacks and UAU/UAU Base Triplet Stacks in RNA

Carr, C. E., Khutsishvili, I. & Marky, L. A., Jul 19 2018, In : Journal of Physical Chemistry B. 122, 28, p. 7057-7065 9 p.

Research output: Contribution to journalArticle

ErbB-2 signaling in advanced prostate cancer progression and potential therapy

Miller, D. R., Ingersoll, M. A. & Lin, M. F., 2018, In : Endocrine-Related Cancer. 26, 4, p. R195-R209

Research output: Contribution to journalReview article

2 Scopus citations

Esterases

Lockridge, O., Quinn, D. M. & Radić, Z., 2018, Biotransformation. Elsevier Inc., Vol. 10-15. p. 277-307 31 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Evaluating the metabolic impact of hypoxia on pancreatic cancer cells

Murthy, D., Vernucci, E., Goode, G., Abrego, J. & Singh, P. K., 2018, Methods in Molecular Biology. Humana Press Inc., p. 81-93 13 p. (Methods in Molecular Biology; vol. 1742).

Research output: Chapter in Book/Report/Conference proceedingChapter

Evaluation of macrophage polarization in pancreatic cancer microenvironment under hypoxia

Attri, K. S., Mehla, K. & Singh, P. K., 2018, Methods in Molecular Biology. Humana Press Inc., p. 265-276 12 p. (Methods in Molecular Biology; vol. 1742).

Research output: Chapter in Book/Report/Conference proceedingChapter

7 Scopus citations

Expression of the POTE gene family in human ovarian cancer

Barger, C. J., Zhang, W., Sharma, A., Chee, L., James, S. R., Kufel, C. N., Miller, A., Meza, J., Drapkin, R., Odunsi, K., Klinkebiel, D. & Karpf, A. R., Dec 1 2018, In : Scientific reports. 8, 1, 17136.

Research output: Contribution to journalArticle

4 Scopus citations

Ferulic acid Dimer as a non-opioid therapeutic for acute pain

Priebe, A., Hunke, M., Tonello, R., Sonawane, Y., Berta, T., Natarajan, A., Bhuvanesh, N., Pattabiraman, M. & Chandra, S., Jun 6 2018, In : Journal of Pain Research. 11, p. 1075-1085 11 p.

Research output: Contribution to journalArticle

7 Scopus citations

Focal adhesion kinase a potential therapeutic target for pancreatic cancer and malignant pleural mesothelioma

Kanteti, R., Mirzapoiazova, T., Riehm, J. J., Dhanasingh, I., Mambetsariev, B., Wang, J., Kulkarni, P., Kaushik, G., Seshacharyulu, P., Ponnusamy, M. P., Kindler, H. L., Nasser, M. W., Batra, S. K. & Salgia, R., Apr 3 2018, In : Cancer Biology and Therapy. 19, 4, p. 316-327 12 p.

Research output: Contribution to journalArticle

28 Scopus citations