Eppley Institute for Cancer Research

Research Output

2018

Purification of recombinant human butyrylcholinesterase on Hupresin®

Lockridge, O., David, E., Schopfer, L. M., Masson, P., Brazzolotto, X. & Nachon, F., Dec 1 2018, In : Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences. 1102-1103, p. 109-115 7 p.

Research output: Contribution to journalArticle

2 Scopus citations

Ramifications of secreted mucin MUC5AC in malignant journey: A holistic view

Krishn, S. R., Ganguly, K., Kaur, S. & Batra, S. K., 2018, In : Carcinogenesis. 39, 5, p. 633-651 19 p.

Research output: Contribution to journalReview article

7 Scopus citations

Redox manipulation of the manganese metal in human manganese superoxide dismutase for neutron diffraction

Azadmanesh, J., Lutz, W. E., Weiss, K. L., Coates, L. & Borgstahl, G. E. O., Oct 2018, In : Acta Crystallographica Section F: Structural Biology Communications. 74, 10, p. 677-687 11 p.

Research output: Contribution to journalArticle

4 Scopus citations

Role of the EHD Family of Endocytic Recycling Regulators for TCR Recycling and T Cell Function

Iseka, F. M., Goetz, B. T., Mushtaq, I., An, W., Cypher, L. R., Bielecki, T. A., Tom, E. C., Arya, P., Bhattacharyya, S., Storck, M. D., Semerad, C. L., Talmadge, J. E., Mosley, R. L., Band, V. & Band, H., Jan 15 2018, In : Journal of Immunology. 200, 2, p. 483-499 17 p.

Research output: Contribution to journalArticle

3 Scopus citations

Semaphorin-5A maintains epithelial phenotype of malignant pancreatic cancer cells

Saxena, S., Purohit, A., Varney, M. L., Hayashi, Y. & Singh, R. K., Dec 22 2018, In : BMC cancer. 18, 1, 1283.

Research output: Contribution to journalArticle

6 Scopus citations

Superoxide dismutases (SODs) and SOD mimetics

Borgstahl, G. E. O. & Oberley-Deegan, R. E., Nov 2 2018, In : Antioxidants. 7, 11, 156.

Research output: Contribution to journalEditorial

4 Scopus citations

Supported lipid bilayers for atomic force microscopy studies

Lv, Z., Banerjee, S., Zagorski, K. & Lyubchenko, Y. L., 2018, Methods in Molecular Biology. Humana Press Inc., p. 129-143 15 p. (Methods in Molecular Biology; vol. 1814).

Research output: Chapter in Book/Report/Conference proceedingChapter

9 Scopus citations

Synthesis of aminopyrazole analogs and their evaluation as CDK inhibitors for cancer therapy

Rana, S., Sonawane, Y. A., Taylor, M. A., Kizhake, S., Zahid, M. & Natarajan, A., Dec 15 2018, In : Bioorganic and Medicinal Chemistry Letters. 28, 23-24, p. 3736-3740 5 p.

Research output: Contribution to journalArticle

5 Scopus citations

Targeting hypoxia-inducible factor-1a/pyruvate dehydrogenase kinase 1 axis by dichloroacetate suppresses bleomycin-induced pulmonary fibrosis

Goodwin, J., Choi, H., Hsieh, M. H., Neugent, M. L., Ahn, J. M., Hayenga, H. N., Singh, P. K., Shackelford, D. B., Lee, I. K., Shulaev, V., Dhar, S., Takeda, N. & Kim, J. W., Feb 2018, In : American journal of respiratory cell and molecular biology. 58, 2, p. 216-231 16 p.

Research output: Contribution to journalEditorial

23 Scopus citations

Targeting PARP1 in XRCC1-deficient sporadic invasive breast cancer or preinvasive ductal carcinoma in situ induces synthetic lethality and chemoprevention

Ali, R., Al-Kawaz, A., Toss, M. S., Green, A. R., Miligy, I. M., Mesquita, K. A., Seedhouse, C., Mirza, S., Band, V., Rakha, E. A. & Madhusudan, S., Dec 15 2018, In : Cancer Research. 78, 24, p. 6818-6827 10 p.

Research output: Contribution to journalArticle

5 Scopus citations

T-Cell Lymphomas, Version 2.2018 Featured Updates to the NCCN Guidelines

Horwitz, S. M., Ansell, S. M., Ai, W. Z., Barnes, J., Barta, S. K., Choi, M., Clemens, M. W., Dogan, A., Greer, J. P., Halwani, A., Bradley, M. H., Hoppe, R. T., Jacobsen, E., Jagadeesh, D., Kim, Y. H., Lunning, M. A., Mehta, A., Mehta-Shah, N., Oki, Y., Olsen, E. A. & 11 others, Pro, B., Rajguru, S. A., Shanbhag, S., Shustov, A., Sokol, L., Torka, P., Wilcox, R., William, B., Zain, J., Dwyer, M. A. & Sundar, H., Feb 1 2018, In : JNCCN Journal of the National Comprehensive Cancer Network. 16, 2, p. 123-135 13 p.

Research output: Contribution to journalReview article

17 Scopus citations

TGF and IGF1R signaling activates protein kinase A through differential regulation of ezrin phosphorylation in colon cancer cells

Leiphrakpam, P. D., Brattain, M. G., Black, J. D. & Wang, J., May 25 2018, In : Journal of Biological Chemistry. 293, 21, p. 8242-8254 13 p.

Research output: Contribution to journalArticle

6 Scopus citations

The enigmatic endosome - Sorting the ins and outs of endocytic trafficking

Naslavsky, N. & Caplan, S., Jul 1 2018, In : Journal of cell science. 131, 13, jcs216499.

Research output: Contribution to journalReview article

39 Scopus citations

The Enzymatic Activity of APOBE3G Multimers

Pan, Y., Zagorski, K., Shlyakhtenko, L. S. & Lyubchenko, Y. L., Dec 1 2018, In : Scientific reports. 8, 1, 17953.

Research output: Contribution to journalArticle

2 Scopus citations
4 Scopus citations

The fourth annual BRDS on genome editing and silencing for precision medicines

Chaudhary, A. K., Bhattarai, R. S. & Mahato, R. I., Feb 1 2018, In : Drug Delivery and Translational Research. 8, 1, p. 266-272 7 p.

Research output: Contribution to journalArticle

Therapeutic Potential of OMe-PS-miR-29b1 for Treating Liver Fibrosis

Kumar, V., Kumar, V., Luo, J. & Mahato, R. I., Dec 5 2018, In : Molecular Therapy. 26, 12, p. 2798-2811 14 p.

Research output: Contribution to journalArticle

3 Scopus citations

Thermodynamic Stability of DNA Duplexes Comprising the Simplest T → du Substitutions

Carr, C. E., Khutsishvili, I., Gold, B. & Marky, L. A., Oct 2 2018, In : Biochemistry. 57, 39, p. 5666-5671 6 p.

Research output: Contribution to journalArticle

3 Scopus citations

Transcriptional profiling using RNA-seq to study hypoxia-mediated gene regulation

Shukla, S. K., King, R. J. & Singh, P. K., 2018, Methods in Molecular Biology. Humana Press Inc., p. 55-66 12 p. (Methods in Molecular Biology; vol. 1742).

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Tying trafficking to fusion and fission at the mighty mitochondria

Farmer, T., Naslavsky, N. & Caplan, S., Aug 2018, In : Traffic. 19, 8, p. 569-577 9 p.

Research output: Contribution to journalReview article

18 Scopus citations

Unfolding and Targeting Thermodynamics of a DNA Intramolecular Complex with Joined Triplex-Duplex Domains

Johnson, S. E., Reiling-Steffensmeier, C., Lee, H. T. & Marky, L. A., Jan 25 2018, In : Journal of Physical Chemistry B. 122, 3, p. 1102-1111 10 p.

Research output: Contribution to journalArticle

Unfolding thermodynamics of nucleic acids: Determining heat capacity effects using differential scanning calorimetry (DSC)

Carr, C. E., Reiling-Steffensmeier, C., Khutsishvili, I. & Marky, L. A., Jan 1 2018, Differential Scanning Calorimetry: Basics and Applications. Nova Science Publishers, Inc., p. 1-41 41 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Use of Hupresin to Capture Red Blood Cell Acetylcholinesterase for Detection of Soman Exposure

Onder, S., Schopfer, L. M., Cashman, J. R., Tacal, O., Johnson, R. C., Blake, T. A. & Lockridge, O., Jan 2 2018, In : Analytical chemistry. 90, 1, p. 974-979 6 p.

Research output: Contribution to journalArticle

4 Scopus citations

Using Watershed Boundaries to Map Adverse Health Outcomes: Examples From Nebraska, USA

Corley, B., Bartelt-Hunt, S., Rogan, E., Coulter, D., Sparks, J., Baccaglini, L., Howell, M., Liaquat, S., Commack, R. & Kolok, A. S., 2018, In : Environmental Health Insights. 12

Research output: Contribution to journalArticle

Open Access

Utilization of initial chemotherapy for newly diagnosed acute myeloid leukemia in the United States

Bhatt, V. R., Shostrom, V., Gundabolu, K. & Armitage, J. O., Jun 12 2018, In : Blood Advances. 2, 11, p. 1277-1282 6 p.

Research output: Contribution to journalArticle

13 Scopus citations

Venetoclax in chronic lymphocytic leukaemia: a possible cure?

Kallam, A. & Armitage, J. O., Sep 2018, In : The Lancet Oncology. 19, 9, p. 1143-1144 2 p.

Research output: Contribution to journalComment/debate

1 Scopus citations

Vesicular trafficking plays a role in centriole disengagement and duplication

Xie, S., Reinecke, J. B., Farmer, T., Bahl, K., Yeow, I., Nichols, B. J., McLamarrah, T. A., Naslavsky, N., Rogers, G. C. & Caplan, S., Nov 1 2018, In : Molecular biology of the cell. 29, 22, p. 2622-2631 10 p.

Research output: Contribution to journalArticle

5 Scopus citations

Watch and Wait, Salvage Later

Kallam, A. & Armitage, J. O., Mar 1 2018, In : International Journal of Radiation Oncology Biology Physics. 100, 3, p. 549-550 2 p.

Research output: Contribution to journalLetter

WDR5 supports colon cancer cells by promoting methylation of H3K4 and suppressing DNA damage

Neilsen, B. K., Chakraborty, B., McCall, J. L., Frodyma, D. E., Sleightholm, R. L., Fisher, K. W. & Lewis, R. E., Jun 20 2018, In : BMC cancer. 18, 1, 673.

Research output: Contribution to journalArticle

5 Scopus citations

Zyxin promotes colon cancer tumorigenesis in a mitotic phosphorylation-dependent manner and through CDK8-mediated YAP activation

Zhou, J., Zeng, Y., Cui, L., Chen, X., Stauffer, S., Wang, Z., Yu, F., Lele, S. M., Talmon, G. A., Black, A. R., Chen, Y. & Dong, J., Jul 17 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 29, p. E6760-E6769

Research output: Contribution to journalArticle

9 Scopus citations
2017

A Combination of MUC5AC and CA19-9 Improves the Diagnosis of Pancreatic Cancer: A Multicenter Study

Kaur, S., Smith, L. M., Patel, A., Menning, M., Watley, D. C., Malik, S. S., Krishn, S. R., Mallya, K., Aithal, A., Sasson, A. R., Johansson, S. L., Jain, M., Singh, S., Guha, S., Are, C., Raimondo, M., Hollingsworth, M. A., Brand, R. E. & Batra, S. K., Jan 1 2017, In : American Journal of Gastroenterology. 112, 1, p. 172-183 12 p.

Research output: Contribution to journalArticle

35 Scopus citations

Adult high-grade B-cell lymphoma with Burkitt lymphoma signature: Genomic features and potential therapeutic targets

Bouska, A., Bi, C., Lone, W., Zhang, W., Kedwaii, A., Heavican, T., Lachel, C. M., Yu, J., Ferro, R., Eldorghamy, N., Greiner, T. C., Vose, J., Weisenburger, D. D., Gascoyne, R. D., Rosenwald, A., Ott, G., Campo, E., Rimsza, L. M., Jaffe, E. S., Braziel, R. M. & 12 others, Siebert, R., Miles, R. R., Dave, S., Reddy, A., Delabie, J., Staudt, L. M., Song, J. Y., McKeithan, T. W., Fu, K., Green, M., Chan, W. C. & Iqbal, J., Oct 19 2017, In : Blood. 130, 16, p. 1819-1831 13 p.

Research output: Contribution to journalArticle

28 Scopus citations

Afatinib radiosensitizes head and neck squamous cell carcinoma cells by targeting cancer stem cells

Macha, M. A., Rachagani, S., Qazi, A. K., Jahan, R., Gupta, S., Patel, A. A., Seshacharyulu, P., Lin, C., Li, S., Wang, S., Verma, V., Kishida, S., Kishida, M., Nakamura, N., Kibe, T., Lydiatt, W. M., Smith, R. B., Ganti, A. K., Jones, D. T., Batra, S. K. & 1 others, Jain, M., 2017, In : Oncotarget. 8, 13, p. 20961-20973 13 p.

Research output: Contribution to journalArticle

18 Scopus citations

An essential role of CBL and CBL-B ubiquitin ligases in mammary stem cell maintenance

Mohapatra, B., Zutshi, N., An, W., Goetz, B., Arya, P., Bielecki, T. A., Mustaq, I., Storck, M. D., Meza, J. L., Band, V. & Band, H., Apr 1 2017, In : Journal of Cell Science. 130, 7, p. 1072-1086 15 p.

Research output: Contribution to journalArticle

8 Scopus citations

Angioimmunoblastic T-cell lymphoma: The many-faced lymphoma

Lunning, M. A. & Vose, J. M., Mar 2 2017, In : Blood. 129, 9, p. 1095-1102 8 p.

Research output: Contribution to journalReview article

39 Scopus citations

An introduction to single molecule biophysics

Lyubchenko, Y. L., Jan 1 2017, CRC Press. 234 p.

Research output: Book/ReportBook

2 Scopus citations

A novel pathway for amyloids self-assembly in aggregates at nanomolar concentration mediated by the interaction with surfaces

Banerjee, S., Hashemi, M., Lv, Z., Maity, S., Rochet, J. C. & Lyubchenko, Y. L., Mar 30 2017, In : Scientific reports. 7, 45592.

Research output: Contribution to journalArticle

20 Scopus citations

Antigen presentation profiling reveals recognition of lymphoma immunoglobulin neoantigens

Khodadoust, M. S., Olsson, N., Wagar, L. E., Haabeth, O. A. W., Chen, B., Swaminathan, K., Rawson, K., Liu, C. L., Steiner, D., Lund, P., Rao, S., Zhang, L., Marceau, C., Stehr, H., Newman, A. M., Czerwinski, D. K., Carlton, V. E. H., Moorhead, M., Faham, M., Kohrt, H. E. & 6 others, Carette, J., Green, M. R., Davis, M. M., Levy, R., Elias, J. E. & Alizadeh, A. A., Mar 30 2017, In : Nature. 543, 7647, p. 723-727 5 p.

Research output: Contribution to journalArticle

107 Scopus citations

Assessment of vascularity in glioblastoma and its implications on patient outcomes

McGahan, B. G., Neilsen, B. K., Kelly, D. L., McComb, R. D., Kazmi, S. A. J., White, M. L., Zhang, Y. & Aizenberg, M. R., Mar 1 2017, In : Journal of Neuro-Oncology. 132, 1, p. 35-44 10 p.

Research output: Contribution to journalArticle

5 Scopus citations

Association of distinct mutational signatures with correlates of increased immune activity in pancreatic ductal adenocarcinoma

Connor, A. A., Denroche, R. E., Jang, G. H., Timms, L., Kalimuthu, S. N., Selander, I., McPherson, T., Wilson, G. W., Chan-Seng-Yue, M. A., Borozan, I., Ferretti, V., Grant, R. C., Lungu, I. M., Costello, E., Greenhalf, W., Palmer, D., Ghaneh, P., Neoptolemos, J. P., Buchler, M., Petersen, G. & 20 others, Thayer, S., Hollingsworth, M. A., Sherker, A., Durocher, D., Dhani, N., Hedley, D., Serra, S., Pollett, A., Roehrl, M. H. A., Bavi, P., Bartlett, J. M. S., Cleary, S., Wilson, J. M., Alexandrov, L. B., Moore, M., Wouters, B. G., McPherson, J. D., Notta, F., Stein, L. D. & Gallinger, S., Jun 2017, In : JAMA Oncology. 3, 6, p. 774-783 10 p.

Research output: Contribution to journalArticle

97 Scopus citations

Atomic force microscope for topographic studies

Lyubchenko, Y. L., Jan 1 2017, An Introduction to Single Molecule Biophysics. CRC Press, p. 21-78 58 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Autocrine IGF1 Signaling Mediates Pancreatic Tumor Cell Dormancy in the Absence of Oncogenic Drivers

Rajbhandari, N., Lin, W. C., Wehde, B. L., Triplett, A. A. & Wagner, K. U., Feb 28 2017, In : Cell Reports. 18, 9, p. 2243-2255 13 p.

Research output: Contribution to journalArticle

16 Scopus citations

Bariatric implant-associated anaplastic large-cell lymphoma

Umakanthan, J. M., McBride, C. L., Greiner, T., Yuan, J., Sanmann, J., Bierman, P. J., Lunning, M. A. & Bociek, R. G., Dec 2017, In : Journal of oncology practice. 13, 12, p. 838-839 2 p.

Research output: Contribution to journalShort survey

5 Scopus citations

Bioconjugate Therapeutics: Current Progress and Future Perspective

Li, F. & Mahato, R. I., May 1 2017, In : Molecular Pharmaceutics. 14, 5, p. 1321-1324 4 p.

Research output: Contribution to journalEditorial

9 Scopus citations

Biodistribution of Self-Assembling Polymer-Gemcitabine Conjugate after Systemic Administration into Orthotopic Pancreatic Tumor Bearing Mice

Kattel, K., Mondal, G., Lin, F., Kumar, V. & Mahato, R. I., May 1 2017, In : Molecular Pharmaceutics. 14, 5, p. 1365-1372 8 p.

Research output: Contribution to journalArticle

11 Scopus citations

Biological determinants of radioresistance and their remediation in pancreatic cancer

Seshacharyulu, P., Baine, M. J., Souchek, J. J., Menning, M., Kaur, S., Yan, Y., Ouellette, M. M., Jain, M., Lin, C. & Batra, S. K., Aug 1 2017, In : Biochimica et Biophysica Acta - Reviews on Cancer. 1868, 1, p. 69-92 24 p.

Research output: Contribution to journalReview article

21 Scopus citations

Biosimilar and generic cancer drugs unlikely to bend cost curve in the USA

Bennett, C. L., Sartor, O. A., Armitage, J. O. & Kantarjian, H., Jan 1 2017, In : The Lancet Oncology. 18, 1, p. 22-23 2 p.

Research output: Contribution to journalComment/debate

6 Scopus citations

CBL family E3 ubiquitin ligases control JAK2 ubiquitination and stability in hematopoietic stem cells and myeloid malignancies

Kaosheng, L., Jiang, J., Donaghy, R., Riling, C. R., Cheng, Y., Chandra, V., Rozenova, K., An, W., Mohapatra, B. C., Goetz, B. T., Pillai, V., Han, X., Todd, E. A., Jeschke, G. R., Langdon, W. Y., Kumar, S., Hexner, E. O., Band, H. & Tong, W., May 15 2017, In : Genes and Development. 31, 10, p. 1007-1023 17 p.

Research output: Contribution to journalArticle

11 Scopus citations

CDK1-mediated mitotic phosphorylation of PBK is involved in cytokinesis and inhibits its oncogenic activity

Stauffer, S., Zeng, Y., Zhou, J., Chen, X., Chen, Y. & Dong, J., Nov 2017, In : Cellular Signalling. 39, p. 74-83 10 p.

Research output: Contribution to journalArticle

11 Scopus citations