Eppley Institute for Cancer Research

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2020

Targeting translation initiation by synthetic rocaglates for treating MYC-driven lymphomas

Zhang, X., Bi, C., Lu, T., Zhang, W., Yue, T., Wang, C., Tian, T., Zhang, X., Huang, Y., Lunning, M., Hao, X., Brown, L. E., Devine, W. G., Vose, J., Porco, J. A. & Fu, K., Jan 1 2020, In : Leukemia. 34, 1, p. 138-150 13 p.

Research output: Contribution to journalArticle

The proteomic landscape of pancreatic ductal adenocarcinoma liver metastases identifies molecular subtypes and associations with clinical response A C

Law, H. C. H., Lagundzin, D., Clement, E. J., Qiao, F., Wagner, Z. S., Krieger, K. L., Costanzo-Garvey, D., Caffrey, T. C., Grem, J. L., DiMaio, D. J., Grandgenett, P. M., Cook, L. M., Fisher, K. W., Yu, F., Hollingsworth, M. A. & Woods, N. T., Mar 1 2020, In : Clinical Cancer Research. 26, 5, p. 1065-1076 12 p.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Tuned near infrared fluorescent hyaluronic acid conjugates for delivery to pancreatic cancer for intraoperative imaging

Qi, B., Crawford, A. J., Wojtynek, N. E., Talmon, G. A., Hollingsworth, M. A., Ly, Q. P. & Mohs, A. M., 2020, In : Theranostics. 10, 8, p. 3413-3429 17 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Twenty-five-Year Follow-up of a Prospective Randomized Trial Comparing Preoperative Versus Postoperative FLAC/Granulocyte Colony-Stimulating Factor Chemotherapy for Stage II Breast Cancer

Malekzadeh, P., Cowan, K., Steinberg, S. M., Camphausen, K. A., Shriver, C., Merino, M. J., Good, M. L., Berman, A. & Danforth, D. N., May 1 2020, In : American journal of clinical oncology. 43, 5, p. 334-339 6 p.

Research output: Contribution to journalArticle

Twisting of Charged Nanoribbons to Helicoids Driven by Electrostatics

Zaldivar, G., Conda-Sheridan, M. & Tagliazucchi, M., Apr 16 2020, In : Journal of Physical Chemistry B. 124, 15, p. 3221-3227 7 p.

Research output: Contribution to journalArticle

U000328, a novel ALK2/3 kinase inhibitor, represses hepcidin and significantly improves the phenotype of IRIDA

Belot, A., Gourbeyre, O., Fay, A., Palin, A., Besson-Fournier, C., Latour, C., Hopkins, C. R., Tidmarsh, G. F., Coppin, H., Roth, M. P., Ritter, M. R., Hong, C. C. & Meynard, D., Mar 1 2020, In : Haematologica. 105, 3

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

UBR5 HECT domain mutations identified in mantle cell lymphoma control maturation of B cells

Swenson, S. A., Gilbreath, T. J., Vahle, H., Hynes-Smith, R. W., Graham, J. H., Law, H. C. H., Amador, C., Woods, N. T., Green, M. R. & Buckley, S. M., Jul 2020, In : Blood. 9, 3, p. 299-312 14 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Ultraviolet A light induces DNA damage and estrogen-DNA adducts in Fuchs endothelial corneal dystrophy causing females to be more affected

Liu, C., Miyajima, T., Melangath, G., Miyai, T., Vasanth, S., Deshpande, N., Kumar, V., Tone, S. O., Gupta, R., Zhu, S., Vojnovic, D., Chen, Y., Rogan, E. G., Mondal, B., Zahid, M. & Jurkunas, U. V., Jan 7 2020, In : Proceedings of the National Academy of Sciences of the United States of America. 117, 1, p. 573-583 11 p.

Research output: Contribution to journalArticle

3 Scopus citations

Upregulation of ZIP14 and altered zinc homeostasis in muscles in pancreatic cancer cachexia

Shakri, A. R., Zhong, T. J., Ma, W., Coker, C., Kim, S., Calluori, S., Scholze, H., Szabolcs, M., Caffrey, T., Grandgenett, P. M., Hollingsworth, M. A., Tanji, K., Kluger, M. D., Miller, G., Biswas, A. K. & Acharyya, S., Jan 2020, In : Cancers. 12, 1, 3.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Urban American Indian Community Health Beliefs Associated with Addressing Cancer in the Northern Plains Region

Idoate, R., Gilbert, M., King, K. M., Spellman, L., McWilliams, B., Strong, B., Bronner, L., Siahpush, M., Ramos, A. K., Clarke, M., Michaud, T., Godfrey, M. & Solheim, J., 2020, (Accepted/In press) In : Journal of Cancer Education.

Research output: Contribution to journalArticle

Venetoclax causes metabolic reprogramming independent of BCL-2 inhibition

Roca-Portoles, A., Rodriguez-Blanco, G., Sumpton, D., Cloix, C., Mullin, M., Mackay, G. M., O’Neill, K., Lemgruber, L., Luo, X. & Tait, S. W. G., Aug 1 2020, In : Cell Death and Disease. 11, 8, 616.

Research output: Contribution to journalArticle

Open Access
2019

Afatinib and Temozolomide combination inhibits tumorigenesis by targeting EGFRvIII-cMet signaling in glioblastoma cells

Vengoji, R., Macha, M. A., Nimmakayala, R. K., Rachagani, S., Siddiqui, J. A., Mallya, K., Gorantla, S., Jain, M., Ponnusamy, M. P., Batra, S. K. & Shonka, N., Jun 18 2019, In : Journal of Experimental and Clinical Cancer Research. 38, 1, 266.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

A Genome-wide Functional Signature Ontology Map and Applications to Natural Product Mechanism of Action Discovery

McMillan, E. A., Kwon, G., Clemenceau, J. R., Fisher, K. W., Vaden, R. M., Shaikh, A. F., Neilsen, B. K., Kelly, D., Potts, M. B., Sung, Y. J., Mendiratta, S., Hight, S. K., Lee, Y., MacMillan, J. B., Lewis, R. E., Kim, H. S. & White, M. A., Oct 17 2019, In : Cell Chemical Biology. 26, 10, p. 1380-1392.e6

Research output: Contribution to journalArticle

2 Scopus citations

A Human Papillomavirus-Independent Cervical Cancer Animal Model Reveals Unconventional Mechanisms of Cervical Carcinogenesis

He, C., Lv, X., Huang, C., Angeletti, P. C., Hua, G., Dong, J., Zhou, J., Wang, Z., Ma, B., Chen, X., Lambert, P. F., Rueda, B. R., Davis, J. S. & Wang, C., Mar 5 2019, In : Cell Reports. 26, 10, p. 2636-2650.e5

Research output: Contribution to journalArticle

Open Access
8 Scopus citations

Alendronate-Modified Polymeric Micelles for the Treatment of Breast Cancer Bone Metastasis

Liu, T., Romanova, S., Wang, S., Hyun, M. A., Zhang, C., Cohen, S. M., Singh, R. K. & Bronich, T. K., Jan 1 2019, In : Molecular Pharmaceutics.

Research output: Contribution to journalArticle

A mitotic CDK5-PP4 phospho-signaling cascade primes 53BP1 for DNA repair in G1

Zheng, X. F., Acharya, S. S., Choe, K. N., Nikhil, K., Adelmant, G., Satapathy, S. R., Sharma, S., Viccaro, K., Rana, S., Natarajan, A., Sicinski, P., Marto, J. A., Shah, K. & Chowdhury, D., Dec 1 2019, In : Nature communications. 10, 1, 4252.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Amphiphilic polyanhydride-based recombinant MUC4β-nanovaccine activates dendritic cells

Banerjee, K., Gautam, S. K., Kshirsagar, P., Ross, K. A., Spagnol, G., Sorgen, P., Wannemuehler, M. J., Narasimhan, B., Solheim, J. C., Kumar, S., Batra, S. K. & Jain, M., 2019, In : Genes and Cancer. 10, 3-4, p. 52-62 11 p.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Analgesic Effects of the GIRK Activator, VU0466551, Alone and in Combination with Morphine in Acute and Persistent Pain Models

Abney, K. K., Bubser, M., Du, Y., Kozek, K. A., Bridges, T. M., Linsdley, C. W., Daniels, J. S., Morrison, R. D., Wickman, K., Hopkins, C. R., Jones, C. K. & Weaver, C. D., Mar 20 2019, In : ACS Chemical Neuroscience. 10, 3, p. 1294-1299 6 p.

Research output: Contribution to journalArticle

3 Scopus citations

Anti-Claudin-1 Conjugated to a Near-Infrared Fluorophore Targets Colon Cancer in PDOX Mouse Models

Hollandsworth, H. M., Lwin, T. M., Amirfakhri, S., Filemoni, F., Batra, S. K., Hoffman, R. M., Dhawan, P. & Bouvet, M., Oct 2019, In : Journal of Surgical Research. 242, p. 145-150 6 p.

Research output: Contribution to journalArticle

5 Scopus citations

A patent review of bisphosphonates in treating bone disease

Holstein, S. A., May 4 2019, In : Expert Opinion on Therapeutic Patents. 29, 5, p. 315-325 11 p.

Research output: Contribution to journalArticle

6 Scopus citations

A polymeric nanogel-based treatment regimen for enhanced efficacy and sequential administration of synergistic drug combination in pancreatic cancer

Soni, K. S., Thomas, D., Caffrey, T., Mehla, K., Lei, F., O'Connell, K. A., Sagar, S., Lele, S. M., Hollingsworth, M. A., Radhakrishnan, P. & Bronich, T. K., 2019, In : Journal of Pharmacology and Experimental Therapeutics. 370, 3, p. 894-901 8 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

A recurrent cancer-associated substitution in DNA polymerase ε produces a hyperactive enzyme

Xing, X., Kane, D. P., Bulock, C. R., Moore, E. A., Sharma, S., Chabes, A. & Shcherbakova, P. V., Dec 1 2019, In : Nature communications. 10, 1, 374.

Research output: Contribution to journalArticle

9 Scopus citations

A simple fluorescent assay for the discovery of protein-protein interaction inhibitors

Al-Mugotir, M., Kolar, C., Vance, K., Kelly, D. L., Natarajan, A. & Borgstahl, G. E. O., Mar 15 2019, In : Analytical Biochemistry. 569, p. 46-52 7 p.

Research output: Contribution to journalArticle

2 Scopus citations

Assembly of α-synuclein aggregates on phospholipid bilayers

Lv, Z., Hashemi, M., Banerjee, S., Zagorski, K., Rochet, J. C. & Lyubchenko, Y. L., Sep 2019, In : Biochimica et Biophysica Acta - Proteins and Proteomics. 1867, 9, p. 802-812 11 p.

Research output: Contribution to journalArticle

5 Scopus citations

Beta 2-microglobulin regulates amyloid precursor-like protein 2 expression and the migration of pancreatic cancer cells

Sliker, B. H., Goetz, B. T., Peters, H. L., Poelaert, B. J., Borgstahl, G. E. O. & Solheim, J. C., Jun 3 2019, In : Cancer Biology and Therapy. 20, 6, p. 931-940 10 p.

Research output: Contribution to journalArticle

1 Scopus citations

BH3-only proteins are dispensable for apoptosis induced by pharmacological inhibition of both MCL-1 and BCL-XL

Greaves, G., Milani, M., Butterworth, M., Carter, R. J., Byrne, D. P., Eyers, P. A., Luo, X., Cohen, G. M. & Varadarajan, S., Jun 1 2019, In : Cell Death and Differentiation. 26, 6, p. 1037-1047 11 p.

Research output: Contribution to journalArticle

19 Scopus citations

BH3-only proteins target BCL-xL/MCL-1, not BAX/BAK, to initiate apoptosis

Huang, K., O’Neill, K. L., Li, J., Zhou, W., Han, N., Pang, X., Wu, W., Struble, L., Borgstahl, G., Liu, Z., Zhang, L. & Luo, X., Nov 1 2019, In : Cell Research. 29, 11, p. 942-952 11 p.

Research output: Contribution to journalArticle

11 Scopus citations

BORIS expression in ovarian cancer precursor cells alters the CTCF cistrome and enhances invasiveness through GALNT14

Hillman, J. C., Pugacheva, E. M., Barger, C. J., Sribenja, S., Rosario, S., Albahrani, M., Truskinovsky, A. M., Stablewski, A., Liu, S., Loukinov, D. I., Zentner, G. E., Lobanenkov, V. V., Karpf, A. R. & Higgins, M. J., Oct 1 2019, In : Molecular Cancer Research. 17, 10, p. 2051-2062 12 p.

Research output: Contribution to journalArticle

6 Scopus citations

Brassicaceae-specific Gretchen Hagen 3 acyl acid amido synthetases conjugate amino acids to chorismate, a precursor of aromatic amino acids and salicylic acid

Holland, C. K., Westfall, C. S., Schaffer, J. E., De Santiago, A., Zubieta, C., Alvarez, S. & Jez, J. M., Nov 8 2019, In : Journal of Biological Chemistry. 294, 45, p. 16855-16864 10 p.

Research output: Contribution to journalArticle

2 Scopus citations

Breast Cancer Collaborative Registry informs understanding of factors predicting sleep quality

Berger, A. M., Kupzyk, K. A., Djalilova, D. M. & Cowan, K. H., Apr 1 2019, In : Supportive Care in Cancer. 27, 4, p. 1365-1373 9 p.

Research output: Contribution to journalArticle

2 Scopus citations

Cancer-Associated Fibroblasts Enhance Survival and Progression of the Aggressive Pancreatic Tumor Via FGF-2 and CXCL8

Awaji, M., Futakuchi, M., Heavican, T., Iqbal, J. & Singh, R. K., Apr 1 2019, In : Cancer Microenvironment. 12, 1, p. 37-46 10 p.

Research output: Contribution to journalArticle

4 Scopus citations

Catalytically inactive Dnmt3b rescues mouse embryonic development by accessory and repressive functions

Nowialis, P., Lopusna, K., Opavska, J., Haney, S. L., Abraham, A., Sheng, P., Riva, A., Natarajan, A., Guryanova, O., Simpson, M., Hlady, R., Xie, M. & Opavsky, R., Dec 1 2019, In : Nature communications. 10, 1, 4374.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Caveat medicus: Clinician experiences in publishing reports of serious oncology-associated adverse drug reactions

Bennett, C. L., Schooley, B., Taylor, M. A., Witherspoon, B. J., Godwin, A., Vemula, J., Ausdenmoore, H. C., Sartor, O., Tony Yang, Y., Armitage, J. O., Hrushesky, W. J., Restaino, J., Thomsen, H. S., Yarnold, P. R., Young, T., Knopf, K. B. & Chen, B., Jul 1 2019, In : PloS one. 14, 7, e0219521.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

CDK5 inhibitor downregulates Mcl-1 and sensitizes pancreatic cancer cell lines to navitoclax

Kour, S., Rana, S., Contreras, J. I., King, H. M., Robb, C. M., Sonawane, Y. A., Bendjennat, M., Crawford, A. J., Barger, C. J., Kizhake, S., Luo, X., Hollingsworth, M. A. & Natarajan, A., Oct 2019, In : Molecular pharmacology. 96, 4, p. 419-429 11 p.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Clinical impact of Internet-based tools to guide therapeutic decisions for mantle cell lymphoma

Gopalsamy, S. N., Rosenthal, K. M., Ayers, A. A., Goy, A., Leonard, J. P., Vose, J. M., Obholz, K. L., Armitage, J. O. & Flowers, C. R., Jul 29 2019, In : Leukemia and Lymphoma. 60, 9, p. 2255-2263 9 p.

Research output: Contribution to journalArticle

Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer

Bryant, K. L., Stalnecker, C. A., Zeitouni, D., Klomp, J. E., Peng, S., Tikunov, A. P., Gunda, V., Pierobon, M., Waters, A. M., George, S. D., Tomar, G., Papke, B., Hobbs, G. A., Yan, L., Hayes, T. K., Diehl, J. N., Goode, G. D., Chaika, N. V., Wang, Y., Zhang, G. F. & 11 others, Witkiewicz, A. K., Knudsen, E. S., Petricoin, E. F., Singh, P. K., Macdonald, J. M., Tran, N. L., Lyssiotis, C. A., Ying, H., Kimmelman, A. C., Cox, A. D. & Der, C. J., Apr 1 2019, In : Nature Medicine. 25, 4, p. 628-640 13 p.

Research output: Contribution to journalArticle

87 Scopus citations

Common genetic variants contribute to incomplete penetrance: evidence from cancer-free BRCA1 mutation carriers

Downs, B., Sherman, S., Cui, J., Kim, Y. C., Snyder, C., Christensen, M., Luo, J., Lynch, H. & Wang, S. M., Jan 2019, In : European Journal of Cancer. 107, p. 68-78 11 p.

Research output: Contribution to journalArticle

1 Scopus citations
Open Access
2 Scopus citations

Computer-designed active human butyrylcholinesterase double mutant with a new catalytic triad

Grigorenko, B. L., Novichkova, D. A., Lushchekina, S. V., Zueva, I. V., Schopfer, L. M., Nemukhin, A. V., Varfolomeev, S. D., Lockridge, O. & Masson, P., Jun 1 2019, In : Chemico-Biological Interactions. 306, p. 138-146 9 p.

Research output: Contribution to journalArticle

2 Scopus citations

CTDP1 regulates breast cancer survival and DNA repair through BRCT-specific interactions with FANCI

Hu, W. F., Krieger, K. L., Lagundžin, D., Li, X., Cheung, R. S., Taniguchi, T., Johnson, K. R., Bessho, T., Monteiro, A. N. A. & Woods, N. T., Dec 1 2019, In : Cell Death Discovery. 5, 1, 105.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

CXCR2: A novel mediator of mammary tumor bone metastasis

Sharma, B., Nannuru, K. C., Saxena, S., Varney, M. L. & Singh, R. K., Mar 2019, In : International journal of molecular sciences. 20, 5, 1237.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Cyclin-dependent kinase 1-mediated AMPK phosphorylation regulates chromosome alignment and mitotic progression

Stauffer, S., Zeng, Y., Santos, M., Zhou, J., Chen, Y. & Dong, J., 2019, In : Journal of cell science. 132, 20, jcs236000.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Cyclin-dependent kinase 1-mediated phosphorylation of SET at serine 7 is essential for its oncogenic activity

Yin, L., Zeng, Y., Xiao, Y., Chen, Y., Shen, H. & Dong, J., Jun 1 2019, In : Cell Death and Disease. 10, 6, 385.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Delineating the role of FANCA in glucose-stimulated insulin secretion in β cells through its protein interactome

Lagundžin, D., Hu, W. F., Law, H. C. H., Krieger, K. L., Qiao, F., Clement, E. J., Drincic, A. T., Nedić, O., Naldrett, M. J., Alvarez, S. & Woods, N. T., Aug 1 2019, In : PloS one. 14, 8, e0220568.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Discovery, Structure-Activity Relationship, and Biological Characterization of a Novel Series of 6-((1 H-Pyrazolo[4,3- b]pyridin-3-yl)amino)-benzo[ d]isothiazole-3-carboxamides as Positive Allosteric Modulators of the Metabotropic Glutamate Receptor 4 (mGlu 4 )

Bollinger, S. R., Engers, D. W., Panarese, J. D., West, M., Engers, J. L., Loch, M. T., Rodriguez, A. L., Blobaum, A. L., Jones, C. K., Thompson Gray, A., Conn, P. J., Lindsley, C. W., Niswender, C. M. & Hopkins, C. R., Oct 1 2019, In : Journal of Medicinal Chemistry. 62, 1, p. 342-358 17 p.

Research output: Contribution to journalArticle

6 Scopus citations

Discovery, synthesis and characterization of a series of (1-alkyl-3-methyl-1H-pyrazol-5-yl)-2-(5-aryl-2H-tetrazol-2-yl)acetamides as novel GIRK1/2 potassium channel activators

Sharma, S., Kozek, K. A., Abney, K. K., Kumar, S., Gautam, N., Alnouti, Y., David Weaver, C. & Hopkins, C. R., Mar 15 2019, In : Bioorganic and Medicinal Chemistry Letters. 29, 6, p. 791-796 6 p.

Research output: Contribution to journalArticle

Discovery and Characterization of 2-Nitro-5-(4-(phenylsulfonyl)piperazin-1-yl)- N-(pyridin-4-ylmethyl)anilines as Novel Inhibitors of the Aedes aegypti Kir1 (AeKir1) Channel

Aretz, C. D., Morwitzer, M. J., Sanford, A. G., Hogan, A. M., Portillo, M. V., Kharade, S. V., Kramer, M., McCarthey, J. B., Trigueros, R. R., Piermarini, P. M., Denton, J. S. & Hopkins, C. R., Jun 14 2019, In : ACS infectious diseases. 5, 6, p. 917-931 15 p.

Research output: Contribution to journalArticle

1 Scopus citations

Discovery of VU2957 (Valiglurax): An mGlu 4 Positive Allosteric Modulator Evaluated as a Preclinical Candidate for the Treatment of Parkinson's Disease

Panarese, J. D., Engers, D. W., Wu, Y. J., Bronson, J. J., Macor, J. E., Chun, A., Rodriguez, A. L., Felts, A. S., Engers, J. L., Loch, M. T., Emmitte, K. A., Castelhano, A. L., Kates, M. J., Nader, M. A., Jones, C. K., Blobaum, A. L., Conn, P. J., Niswender, C. M., Hopkins, C. R. & Lindsley, C. W., Mar 14 2019, In : ACS Medicinal Chemistry Letters. 10, 3, p. 255-260 6 p.

Research output: Contribution to journalArticle

6 Scopus citations

DRP-1 functions independently of mitochondrial structural perturbations to facilitate BH3 mimetic-mediated apoptosis

Milani, M., Beckett, A. J., Al-Zebeeby, A., Luo, X., Prior, I. A., Cohen, G. M. & Varadarajan, S., Dec 1 2019, In : Cell Death Discovery. 5, 1, 117.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations