Eppley Institute for Cancer Research

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2019

Dual delivery nanoscale device for miR-345 and gemcitabine co-delivery to treat pancreatic cancer

Uz, M., Kalaga, M., Pothuraju, R., Ju, J., Junker, W. M., Batra, S. K., Mallapragada, S. & Rachagani, S., Jan 28 2019, In : Journal of Controlled Release. 294, p. 237-246 10 p.

Research output: Contribution to journalArticle

6 Scopus citations

Dual responsive micelles capable of modulating miRNA-34a to combat taxane resistance in prostate cancer

Lin, F., Wen, D., Wang, X. & Mahato, R. I., Feb 2019, In : Biomaterials. 192, p. 95-108 14 p.

Research output: Contribution to journalArticle

10 Scopus citations

Effects of center type and socioeconomic factors on early mortality and overall survival of diffuse large B-cell lymphoma

Dhakal, P., Chen, B., Giri, S., Vose, J. M., Armitage, J. O. & Bhatt, V. R., Jun 2019, In : Future Oncology. 15, 18, p. 2113-2124 12 p.

Research output: Contribution to journalArticle

Epigenetic activation of POTE genes in ovarian cancer

Sharma, A., Albahrani, M., Zhang, W., Kufel, C. N., James, S. R., Odunsi, K., Klinkebiel, D. & Karpf, A. R., Feb 1 2019, In : Epigenetics. 14, 2, p. 185-197 13 p.

Research output: Contribution to journalArticle

3 Scopus citations

ERK-mediated TIMELESS expression suppresses G2/M arrest in colon cancer cells

Neilsen, B. K., Frodyma, D. E., McCall, J. L., Fisher, K. W. & Lewis, R. E., Jan 2019, In : PloS one. 14, 1, e0209224.

Research output: Contribution to journalArticle

3 Scopus citations

Estrogen Metabolism in African-American Women with and without Breast Cancer: A Pilot Study

Zahid, M., Mondal, B., Levan, T. D. & Rogan, E. G., Jan 22 2019, In : Chemical Research in Toxicology. 32, 1, p. 190-194 5 p.

Research output: Contribution to journalArticle

Extranodal NK/T-Cell Lymphoma, Nasal Type: Shrouded No More

Lunning, M. A., Oct 1 2019, In : Journal of oncology practice. 15, 10, p. 521-522 2 p.

Research output: Contribution to journalArticle

Fascin Controls Metastatic Colonization and Mitochondrial Oxidative Phosphorylation by Remodeling Mitochondrial Actin Filaments

Lin, S., Huang, C., Gunda, V., Sun, J., Chellappan, S. P., Li, Z., Izumi, V., Fang, B., Koomen, J., Singh, P. K., Hao, J. & Yang, S., Sep 10 2019, In : Cell Reports. 28, 11, p. 2824-2836.e8

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

FDPS cooperates with PTEN loss to promote prostate cancer progression through modulation of small GTPases/AKT axis

Seshacharyulu, P., Rachagani, S., Muniyan, S., Siddiqui, J. A., Cruz, E., Sharma, S., Krishnan, R., Killips, B. J., Sheinin, Y., Lele, S. M., Smith, L. M., Talmon, G. A., Ponnusamy, M. P., Datta, K. & Batra, S. K., Jun 27 2019, In : Oncogene. 38, 26, p. 5265-5280 16 p.

Research output: Contribution to journalArticle

5 Scopus citations

Force clamp approach for characterization of nano-assembly in amyloid beta 42 dimer

Maity, S. & Lyubchenko, Y. L., Jul 7 2019, In : Nanoscale. 11, 25, p. 12259-12265 7 p.

Research output: Contribution to journalArticle

2 Scopus citations

Functional analysis and fine mapping of the 9p22.2 ovarian cancer susceptibility locus

Buckley, M. A., Woods, N. T., Tyrer, J. P., Mendoza-Fandiño, G., Lawrenson, K., Hazelett, D. J., Najafabadi, H. S., Gjyshi, A., Carvalho, R. S., Lyra, P. C., Coetzee, S. G., Shen, H. C., Yang, A. W., Earp, M. A., Yoder, S. J., Risch, H., Chenevix-Trench, G., Ramus, S. J., Phelan, C. M., Coetzee, G. A. & 129 others, Noushmehr, H., Hughes, T. R., Sellers, T. A., Goode, E. L., Pharoah, P. D., Gayther, S. A., Monteiro, A. N. A., Chen, Y. A., Fridley, B. L., Aben, K. K. H., Kiemeney, L. A., Anton-Culver, H., Ziogas, A., Bruinsma, F., Milne, R. L., Bandera, E. V., Giles, G. G., Bean, Y. T., Pejovic, T., Beckmann, M. W., Hein, A., Bjorge, L., Fasching, P. A., Thomsen, L. C. V., Kopperud, R. K., Bischof, K., Bogdanova, N., Dörk, T., Hillemanns, P., Brinton, L. A., Wentzensen, N., Yang, H., Brooks-Wilson, A., Bunker, C. H., Butzow, R., Nevanlinna, H., Pelttari, L. M., Campbell, I. G., Southey, M. C., Modugno, F., Carty, K., Glasspool, R., McNeish, I., Paul, J., Siddiqui, N., Chang-Claude, J., Rudolph, A., Cook, L. S., Cramer, D. W., Terry, K. L., Cunningham, J. M., Cybulski, C., Gronwald, J., Jakubowska, A., Lubinski, J., Dansonka-Mieszkowska, A., Kupryjanczyk, J., Rzepecka, I. K., Du Bois, A., Harter, P., Dicks, E., Song, H., Doherty, J. A., Rossing, M. A., Dürst, M., Easton, D. F., Eccles, D. M., Edwards, R. P., Ekici, A. B., Gao, Y. T., Gentry-Maharaj, A., Goodman, M. T., Thompson, P. J., Hasmad, H. N., Teo, S. H., Hildebrandt, M. A. T., Wu, X., Hogdall, E., Jensen, A., Kjaer, S. K., Iversen, E. S., Karlan, B. Y., Lester, J., Orsulic, S., Walsh, C. S., Kelley, J. L., Lambrechts, D., Lambrechts, S., Vergote, I., Lee, A. W., Levine, D. A., Liang, D., Lissowska, J., Lu, K., Lundvall, L., Massuger, L. F. A. G., Van Altena, A. M., Matsuo, K., McGuire, V., McLaughlin, J. R., Menon, U., Moysich, K. B., Ness, R. B., Odunsi, K., Olson, S. H., Orlow, I., Pike, M. C., Pearce, C. L., Wu, A. H., Permuth, J. B., Tsai, Y. Y., Tworoger, S. S., Poole, E. M., Rosen, B., Shu, X. O., Shvetsov, Y. B., Wilkens, L. R., Sieh, W., Spiewankiewicz, B., Sucheston-Campbell, L., Thomsen, L., Wang-Gohrke, S., Whittemore, A. S., Woo, Y. L., Zheng, W., Berchuck, A., Schildkraut, J. M., Kelemen, L. E. & Freedman, M. L., Feb 1 2019, In : Cancer Research. 79, 3, p. 467-481 15 p.

Research output: Contribution to journalArticle

2 Scopus citations

Functional impacts of the brca1-mtorc2 interaction in breast cancer

Krieger, K. L., Hu, W. F., Ripperger, T. & Woods, N. T., Dec 1 2019, In : International journal of molecular sciences. 20, 23, 5876.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Genistein treatment duration effects biomarkers of cell motility in human prostate

Zhang, H., Gordon, R., Li, W., Yang, X., Pattanayak, A., Fowler, G., Zhang, L., Catalona, W. J., Ding, Y., Xu, L., Huang, X., Jovanovic, B., Kelly, D. L., Jiang, H. & Bergan, R., Mar 2019, In : PloS one. 14, 3, e0214078.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

Half-life of chlorpyrifos oxon and other organophosphorus esters in aqueous solution

Lockridge, O., Verdier, L. & Schopfer, L. M., Sep 25 2019, In : Chemico-Biological Interactions. 311, 108788.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Hepatosplenic γ-δ T-Cell Lymphoma: Who Is on Your Speed Dial?

Krishnan, M. & Lunning, M., Jun 1 2019, In : Journal of oncology practice. 15, 6, p. 307-312 6 p.

Research output: Contribution to journalArticle

1 Scopus citations

Identification of an Anti-MRSA Cyclic Lipodepsipeptide, WBP-29479A1, by Genome Mining of Lysobacter antibioticus

Sang, M., Wang, H., Shen, Y., Rodrigues De Almeida, N., Conda-Sheridan, M., Li, S., Li, Y. & Du, L., Aug 16 2019, In : Organic Letters. 21, 16, p. 6432-6436 5 p.

Research output: Contribution to journalArticle

1 Scopus citations
Open Access
1 Scopus citations

Inactivation of XPF Sensitizes Cancer Cells to Gemcitabine

George, J. W., Bessho, M. & Bessho, T., 2019, In : Journal of Nucleic Acids. 2019, 6357609.

Research output: Contribution to journalArticle

Open Access

Inhibition of geranylgeranyl diphosphate synthase is a novel therapeutic strategy for pancreatic ductal adenocarcinoma

Haney, S. L., Varney, M. L., Chhonker, Y. S., Shin, S., Mehla, K., Crawford, A. J., Smith, H. J., Smith, L. M., Murry, D. J., Hollingsworth, M. A. & Holstein, S. A., Jun 27 2019, In : Oncogene. 38, 26, p. 5308-5320 13 p.

Research output: Contribution to journalArticle

6 Scopus citations

Inhibition of miR-328-3p impairs cancer stem cell function and prevents metastasis in ovarian cancer

Srivastava, A. K., Banerjee, A., Cui, T., Han, C., Cai, S., Liu, L., Wu, D., Cui, R., Li, Z., Zhang, X., Xie, G., Selvendiran, K., Patnaik, S., Karpf, A. R., Liu, J., Cohn, D. E. & Wang, Q. E., 2019, In : Cancer Research. 79, 9, p. 2314-2326 13 p.

Research output: Contribution to journalArticle

15 Scopus citations

Insight into the dynamics of APOBEC3G protein in complexes with DNA assessed by high speed AFM

Pan, Y., Shlyakhtenko, L. S. & Lyubchenko, Y. L., 2019, In : Nanoscale Advances. 1, 10, p. 4016-4024 9 p.

Research output: Contribution to journalArticle

Open Access

Integrated generation of induced pluripotent stem cells in a low-cost device

Lin, H., Li, Q., Du, Q., Wang, O., Wang, Z., Akert, L., Carlson, M. A., Zhang, C., Subramanian, A., Zhang, C., Lunning, M., Li, M. & Lei, Y., Jan 2019, In : Biomaterials. 189, p. 23-36 14 p.

Research output: Contribution to journalArticle

5 Scopus citations

Integration of Genomic and Transcriptional Features in Pancreatic Cancer Reveals Increased Cell Cycle Progression in Metastases

Connor, A. A., Denroche, R. E., Jang, G. H., Lemire, M., Zhang, A., Chan-Seng-Yue, M., Wilson, G., Grant, R. C., Merico, D., Lungu, I., Bartlett, J. M. S., Chadwick, D., Liang, S. B., Eagles, J., Mbabaali, F., Miller, J. K., Krzyzanowski, P., Armstrong, H., Luo, X., Jorgensen, L. G. T. & 25 others, Romero, J. M., Bavi, P., Fischer, S. E., Serra, S., Hafezi-Bakhtiari, S., Caglar, D., Roehrl, M. H. A., Cleary, S., Hollingsworth, M. A., Petersen, G. M., Thayer, S., Law, C. H. L., Nanji, S., Golan, T., Smith, A. L., Borgida, A., Dodd, A., Hedley, D., Wouters, B. G., O'Kane, G. M., Wilson, J. M., Zogopoulos, G., Notta, F., Knox, J. J. & Gallinger, S., Feb 11 2019, In : Cancer Cell. 35, 2, p. 267-282.e7

Research output: Contribution to journalArticle

20 Scopus citations
4 Scopus citations

KIBRA controls exosome secretion via inhibiting the proteasomal degradation of Rab27a

Song, L., Tang, S., Han, X., Jiang, Z., Dong, L., Liu, C., Liang, X., Dong, J., Qiu, C., Wang, Y. & Du, Y., Dec 1 2019, In : Nature communications. 10, 1, 1639.

Research output: Contribution to journalArticle

Open Access
14 Scopus citations

Label-free characterization of exosome via surface enhanced Raman spectroscopy for the early detection of pancreatic cancer

Carmicheal, J., Hayashi, C., Huang, X., Liu, L., Lu, Y., Krasnoslobodtsev, A., Lushnikov, A., Kshirsagar, P. G., Patel, A., Jain, M., Lyubchenko, Y. L., Lu, Y., Batra, S. K. & Kaur, S., Feb 2019, In : Nanomedicine: Nanotechnology, Biology, and Medicine. 16, p. 88-96 9 p.

Research output: Contribution to journalArticle

15 Scopus citations

Lactate-mediated epigenetic reprogramming regulates formation of human pancreatic cancer-associated fibroblasts

Bhagat, T. D., Von Ahgrens, D., Dawlaty, M., Zou, Y., Baddour, J., Achreja, A., Zhao, H., Yang, L., Patel, B., Kwak, C., Choudhary, G. S., Gordon-Mitchell, S., Alluri, S., Bhattacharyya, S., Sahu, S., Yu, Y., Bartenstein, M., Giricz, O., Suzuki, M., Sohal, D. & 12 others, Gupta, S., Guerrero, P., Batra, S., Goggins, M., Steidl, U., Greally, J., Agarwal, B., Pradhan, K., Banerjee, D., Nagrath, D., Maitra, A. & Verma, A., Oct 2019, In : eLife. 8, e50663.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations

LIMD1 phosphorylation in mitosis is required for mitotic progression and its tumor-suppressing activity

Zhou, J., Zhang, L., Zhou, W., Chen, Y., Cheng, Y. & Dong, J., Mar 2019, In : FEBS Journal. 286, 5, p. 963-974 12 p.

Research output: Contribution to journalArticle

1 Scopus citations

LncRNA Meg3 protects endothelial function by regulating the DNA damage response

Ali, M. S. S. H., Cheng, X., Moran, M., Haemmig, S., Naldrett, M. J., Alvarez, S., Feinberg, M. W. & Sun, X., 2019, In : Nucleic acids research. 47, 3

Research output: Contribution to journalArticle

Open Access
8 Scopus citations

Loss of FBXO9 enhances proteasome activity and promotes aggressiveness in acute myeloid leukemia

Willow Hynes-Smith, R., Swenson, S. A., Vahle, H., Wittorf, K. J., Caplan, M., Amador, C., Katherine Hyde, R. & Buckley, S. M., Nov 2019, In : Cancers. 11, 11, 1717.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Management of immunotherapy-related toxicities, version 1.2019

Thompson, J. A., Schneider, B. J., Brahmer, J., Andrews, S., Armand, P., Bhatia, S., Budde, L. E., Costa, L., Davies, M., Dunnington, D., Ernstoff, M. S., Frigault, M., Hoffner, B., Hoimes, C. J., Lacouture, M., Locke, F., Lunning, M., Mohindra, N. A., Naidoo, J., Olszanski, A. J. & 11 others, Oluwole, O., Patel, S. P., Reddy, S., Ryder, M., Santomasso, B., Shofer, S., Sosman, J. A., Wahidi, M., Wang, Y., Johnson-Chilla, A. & Scavone, J. L., Mar 2019, In : JNCCN Journal of the National Comprehensive Cancer Network. 17, 3, p. 255-289 35 p.

Research output: Contribution to journalArticle

79 Scopus citations
5 Scopus citations

MICAL-L1 coordinates ciliogenesis by recruiting EHD1 to the primary cilium

Xie, S., Farmer, T., Naslavsky, N. & Caplan, S., 2019, In : Journal of cell science. 132, 22, jcs233973.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Mitochondrial superoxide disrupts the metabolic and epigenetic landscape of CD4+ and CD8+ T-lymphocytes

Moshfegh, C. M., Collins, C. W., Gunda, V., Vasanthakumar, A., Cao, J. Z., Singh, P. K., Godley, L. A. & Case, A. J., Oct 2019, In : Redox Biology. 27, 101141.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Modeling the Effects of Multiple Myeloma on Kidney Function

Walk, J. C., Ayati, B. P. & Holstein, S. A., Dec 1 2019, In : Scientific reports. 9, 1, 1726.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Mucin-1 is required for Coxsackie Virus B3-induced inflammation in pancreatitis

Liu, X., Clemens, D. L., Grunkemeyer, J. A., Price, J. D., O’Connell, K., Chapman, N. M., Storz, P., Wen, H., Cox, J. L., Reid, W. L., Hollingsworth, M. A. & Thayer, S., Dec 1 2019, In : Scientific reports. 9, 1, 10656.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Nanoparticulate delivery of potent microtubule inhibitor for metastatic melanoma treatment

Bariwal, J., Kumar, V., Chen, H., Bhattarai, R. S., Peng, Y., Li, W. & Mahato, R. I., Sep 10 2019, In : Journal of Controlled Release. 309, p. 231-243 13 p.

Research output: Contribution to journalArticle

3 Scopus citations
1 Scopus citations

Novel benzimidazole phosphonates as potential inhibitors of protein prenylation

Bhuiyan, N. H., Varney, M. L., Wiemer, D. F. & Holstein, S. A., Dec 15 2019, In : Bioorganic and Medicinal Chemistry Letters. 29, 24, 126757.

Research output: Contribution to journalArticle

Npm-alk is a key regulator of the oncoprotein foxm1 in alk-positive anaplastic large cell lymphoma

Haque, M., Li, J., Huang, Y. H., Almowaled, M., Barger, C. J., Karpf, A. R., Wang, P., Chen, W., Turner, S. D. & Lai, R., Aug 2019, In : Cancers. 11, 8, 1119.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Nucleotide weight matrices reveal ubiquitous mutational footprints of AID/APOBEC deaminases in human cancer genomes

Rogozin, I. B., Roche-Lima, A., Lada, A. G., Belinky, F., Sidorenko, I. A., Glazko, G. V., Babenko, V. N., Cooper, D. N. & Pavlov, Y. I., Feb 2019, In : Cancers. 11, 2, 211.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

O-GlcNAc Transferase Suppresses Inflammation and Necroptosis by Targeting Receptor-Interacting Serine/Threonine-Protein Kinase 3

Li, X., Gong, W., Wang, H., Li, T., Attri, K. S., Lewis, R. E., Kalil, A. C., Bhinderwala, F., Powers, R., Yin, G., Herring, L. E., Asara, J. M., Lei, Y. L., Yang, X., Rodriguez, D. A., Yang, M., Green, D. R., Singh, P. K. & Wen, H., Mar 19 2019, In : Immunity. 50, 3, p. 576-590.e6

Research output: Contribution to journalArticle

16 Scopus citations

p63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas

Hsieh, M. H., Choe, J. H., Gadhvi, J., Kim, Y. J., Arguez, M. A., Palmer, M., Gerold, H., Nowak, C., Do, H., Mazambani, S., Knighton, J. K., Cha, M., Goodwin, J., Kang, M. K., Jeong, J. Y., Lee, S. Y., Faubert, B., Xuan, Z., Abel, E. D., Scafoglio, C. & 11 others, Shackelford, D. B., Minna, J. D., Singh, P. K., Shulaev, V., Bleris, L., Hoyt, K., Kim, J., Inoue, M., DeBerardinis, R. J., Kim, T. H. & Kim, J. W., Aug 13 2019, In : Cell Reports. 28, 7, p. 1860-1878.e9

Research output: Contribution to journalArticle

Open Access
13 Scopus citations

p66Shc protein through a redox mechanism enhances the progression of prostate cancer cells towards castration-resistance

Miller, D. R., Ingersoll, M. A., Chatterjee, A., Baker, B., Shrishrimal, S., Kosmacek, E. A., Zhu, Y., Cheng, P. W., Oberley-Deegan, R. E. & Lin, M. F., Aug 1 2019, In : Free Radical Biology and Medicine. 139, p. 24-34 11 p.

Research output: Contribution to journalArticle

4 Scopus citations

Pan-cancer analyses reveal genomic features of FOXM1 overexpression in cancer

Barger, C. J., Branick, C., Chee, L. & Karpf, A. R., Feb 2019, In : Cancers. 11, 2, 251 .

Research output: Contribution to journalArticle

Open Access
18 Scopus citations

Phase I/II study of dasatinib and exploratory genomic analysis in relapsed or refractory non-Hodgkin lymphoma

Umakanthan, J. M., Iqbal, J., Batlevi, C. L., Bouska, A., Smith, L. M., Shostrom, V., Nutsch, H., William, B. M., Gregory Bociek, R., Lunning, M., Bierman, P., Younes, A., Armitage, J. O. & Vose, J. M., Mar 2019, In : British Journal of Haematology. 184, 5, p. 744-752 9 p.

Research output: Contribution to journalArticle

3 Scopus citations
1 Scopus citations

Phosphorylation of Cx43 residue Y313 by Src contributes to blocking the interaction with Drebrin and disassembling gap junctions

Zheng, L., Li, H., Cannon, A., Trease, A. J., Spagnol, G., Zheng, H., Radio, S., Patel, K., Batra, S. & Sorgen, P. L., Jan 2019, In : Journal of Molecular and Cellular Cardiology. 126, p. 36-49 14 p.

Research output: Contribution to journalArticle

1 Scopus citations

Pluronic block copolymers enhance the anti-myeloma activity of proteasome inhibitors

Hu, H., Petrosyan, A., Osna, N. A., Liu, T., Olou, A. A., Alakhova, D. Y., Singh, P. K., Kabanov, A. V., Faber, E. A. & Bronich, T. K., Jul 28 2019, In : Journal of Controlled Release. 306, p. 149-164 16 p.

Research output: Contribution to journalArticle

4 Scopus citations

Polymeric micellar delivery of novel microtubule destabilizer and hedgehog signaling inhibitor for treating chemoresistant prostate cancer

Yang, R., Chen, H., Guo, D., Dong, Y., Miller, D. D., Li, W. & Mahato, R. I., 2019, In : Journal of Pharmacology and Experimental Therapeutics. 370, 3, p. 864-875 12 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations