Eppley Institute for Cancer Research

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2019
1 Scopus citations

Phosphorylation of Cx43 residue Y313 by Src contributes to blocking the interaction with Drebrin and disassembling gap junctions

Zheng, L., Li, H., Cannon, A., Trease, A. J., Spagnol, G., Zheng, H., Radio, S., Patel, K., Batra, S. & Sorgen, P. L., Jan 2019, In : Journal of Molecular and Cellular Cardiology. 126, p. 36-49 14 p.

Research output: Contribution to journalArticle

1 Scopus citations

Pluronic block copolymers enhance the anti-myeloma activity of proteasome inhibitors

Hu, H., Petrosyan, A., Osna, N. A., Liu, T., Olou, A. A., Alakhova, D. Y., Singh, P. K., Kabanov, A. V., Faber, E. A. & Bronich, T. K., Jul 28 2019, In : Journal of Controlled Release. 306, p. 149-164 16 p.

Research output: Contribution to journalArticle

4 Scopus citations

Polymeric micellar delivery of novel microtubule destabilizer and hedgehog signaling inhibitor for treating chemoresistant prostate cancer

Yang, R., Chen, H., Guo, D., Dong, Y., Miller, D. D., Li, W. & Mahato, R. I., 2019, In : Journal of Pharmacology and Experimental Therapeutics. 370, 3, p. 864-875 12 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

PR55α regulatory subunit of PP2A inhibits the MOB1/LATS cascade and activates YAP in pancreatic cancer cells

Hein, A. L., Brandquist, N. D., Ouellette, C. Y., Seshacharyulu, P., Enke, C. A., Ouellette, M. M., Batra, S. K. & Yan, Y., Nov 1 2019, In : Oncogenesis. 8, 11, 63.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Probing the structure and dynamics of nucleosomes using atomic force microscopy imaging

Stumme-Diers, M. P., Stormberg, T., Sun, Z. & Lyubchenko, Y. L., Jan 2019, In : Journal of Visualized Experiments. 2019, 143, e58820.

Research output: Contribution to journalArticle

1 Scopus citations

Prostate tumor cell exosomes containing hyaluronidase Hyal1 stimulate prostate stromal cell motility by engagement of FAK-mediated integrin signaling

McAtee, C. O., Booth, C., Elowsky, C., Zhao, L., Payne, J., Fangman, T., Caplan, S., Henry, M. D. & Simpson, M. A., May 2019, In : Matrix Biology. 78-79, p. 165-179 15 p.

Research output: Contribution to journalArticle

14 Scopus citations

Proximity labeling to map host-pathogen interactions at the membrane of a bacterium-containing vacuole in chlamydia trachomatis-infected human cells

Olson, M. G., Widner, R. E., Jorgenson, L. M., Lawrence, A., Lagundzin, D., Woods, N. T., Ouellette, S. P. & Rucks, E. A., 2019, In : Infection and immunity. 87, 11, e00537-19.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

PTTG1: a Unique Regulator of Stem/Cancer Stem Cells in the Ovary and Ovarian Cancer

Parte, S., Virant-Klun, I., Patankar, M., Batra, S. K., Straughn, A. & Kakar, S. S., Dec 1 2019, In : Stem Cell Reviews and Reports. 15, 6, p. 866-879 14 p.

Research output: Contribution to journalArticle

7 Scopus citations

Regional Molecular Mapping of Primate Synapses during Normal Healthy Aging

Graham, L. C., Naldrett, M. J., Kohama, S. G., Smith, C., Lamont, D. J., McColl, B. W., Gillingwater, T. H., Skehel, P., Urbanski, H. F. & Wishart, T. M., Apr 23 2019, In : Cell Reports. 27, 4, p. 1018-1026.e4

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Regulation of Connexin32 by ephrin receptors and T-cell protein-tyrosine phosphatase

Trease, A. J., Li, H., Spagnol, G., Zheng, L., Stauch, K. L. & Sorgen, P. L., Jan 4 2019, In : Journal of Biological Chemistry. 294, 1, p. 341-350 10 p.

Research output: Contribution to journalArticle

Regulatory and Clinical Experiences with Biosimilar Filgrastim in the U.S., the European Union, Japan, and Canada

Chen, B., Nagai, S., Armitage, J. O., Witherspoon, B., Nabhan, C., Godwin, A. C., Yang, Y. T., Kommalapati, A., Tella, S. H., DeAngelis, C., Raisch, D. W., Sartor, O., Hrushesky, W. J., Ray, P. S., Yarnold, P. R., Love, B. L., Norris, L. A. B., Knopf, K., Bobolts, L., Riente, J. & 4 others, Luminari, S., Kane, R. C., Hoque, S. & Bennett, C. L., Apr 2019, In : Oncologist. 24, 4, p. 537-548 12 p.

Research output: Contribution to journalArticle

3 Scopus citations

Reproducibility of CRISPR-Cas9 methods for generation of conditional mouse alleles: A multi-center evaluation

Gurumurthy, C. B., O'Brien, A. R., Quadros, R. M., Adams, J., Alcaide, P., Ayabe, S., Ballard, J., Batra, S. K., Beauchamp, M. C., Becker, K. A., Bernas, G., Brough, D., Carrillo-Salinas, F., Chan, W., Chen, H., Dawson, R., Demambro, V., D'Hont, J., Dibb, K. M., Eudy, J. D. & 93 others, Gan, L., Gao, J., Gonzales, A., Guntur, A. R., Guo, H., Harms, D. W., Harrington, A., Hentges, K. E., Humphreys, N., Imai, S., Ishii, H., Iwama, M., Jonasch, E., Karolak, M., Keavney, B., Khin, N. C., Konno, M., Kotani, Y., Kunihiro, Y., Lakshmanan, I., Larochelle, C., Lawrence, C. B., Li, L., Lindner, V., Liu, X. D., Lopez-Castejon, G., Loudon, A., Lowe, J., Jerome-Majewska, L. A., Matsusaka, T., Miura, H., Miyasaka, Y., Morpurgo, B., Motyl, K., Nabeshima, Y. I., Nakade, K., Nakashiba, T., Nakashima, K., Obata, Y., Ogiwara, S., Ouellet, M., Oxburgh, L., Piltz, S., Pinz, I., Ponnusamy, M. P., Ray, D., Redder, R. J., Rosen, C. J., Ross, N., Ruhe, M. T., Ryzhova, L., Salvador, A. M., Alam, S. S., Sedlacek, R., Sharma, K., Smith, C., Staes, K., Starrs, L., Sugiyama, F., Takahashi, S., Tanaka, T., Trafford, A. W., Uno, Y., Vanhoutte, L., Vanrockeghem, F., Willis, B. J., Wright, C. S., Yamauchi, Y., Yi, X., Yoshimi, K., Zhang, X., Zhang, Y., Ohtsuka, M., Das, S., Garry, D. J., Hochepied, T., Thomas, P., Parker-Thornburg, J., Adamson, A. D., Yoshiki, A., Schmouth, J. F., Golovko, A., Thompson, W. R., Lloyd, K. C. K., Wood, J. A., Cowan, M., Mashimo, T., Mizuno, S., Zhu, H., Kasparek, P., Liaw, L., Miano, J. M. & Burgio, G., Aug 26 2019, In : Genome biology. 20, 1, 171.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Retromer facilitates the localization of Bcl-xL to the mitochondrial outer membrane

Farmer, T., O'Neill, K. L., Naslavsky, N., Luo, X. & Caplan, S., 2019, In : Molecular biology of the cell. 30, 10, p. 1138-1146 9 p.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

Revised adult T-cell leukemia-lymphoma international consensus meeting report

Cook, L. B., Fuji, S., Hermine, O., Bazarbachi, A., Ramos, J. C., Ratner, L., Horwitz, S., Fields, P., Tanase, A., Bumbea, H., Cwynarski, K., Taylor, G., Waldmann, T. A., Bittencourt, A., Marcais, A., Suarez, F., Sibon, D., Phillips, A., Lunning, M., Farid, R. & 12 others, Imaizumi, Y., Choi, I., Ishida, T., Ishitsuka, K., Fukushima, T., Uchimaru, K., Takaori-Kondo, A., Tokura, Y., Utsunomiya, A., Matsuoka, M., Tsukasaki, K. & Watanabe, T., Mar 10 2019, In : Journal of Clinical Oncology. 37, 8, p. 677-687 11 p.

Research output: Contribution to journalArticle

Open Access
28 Scopus citations

RNA-binding protein hur regulates both mutant and wild-type IDH1 in IDH1-mutated cancer

Zarei, M., Lal, S., Vaziri-Gohar, A., O'Hayer, K., Gunda, V., Singh, P. K., Brody, J. R. & Winter, J. M., Feb 2019, In : Molecular Cancer Research. 17, 2, p. 508-520 13 p.

Research output: Contribution to journalArticle

2 Scopus citations

Role of Estrogen in Androgen-Induced Prostate Carcinogenesis in NBL Rats

Ozten, N., Vega, K., Liehr, J., Huang, X., Horton, L., Cavalieri, E. L., Rogan, E. G. & Bosland, M. C., Jan 1 2019, In : Hormones and Cancer.

Research output: Contribution to journalArticle

5 Scopus citations

Role of keratan sulfate expression in human pancreatic cancer malignancy

Leiphrakpam, P. D., Patil, P. P., Remmers, N., Swanson, B., Grandgenett, P. M., Qiu, F., Yu, F. & Radhakrishnan, P., Dec 1 2019, In : Scientific reports. 9, 1, 9665.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

ROS-Responsive Polymeric Micelles for Triggered Simultaneous Delivery of PLK1 Inhibitor/miR-34a and Effective Synergistic Therapy in Pancreatic Cancer

Xin, X., Lin, F., Wang, Q., Yin, L. & Mahato, R. I., Apr 24 2019, In : ACS Applied Materials and Interfaces. 11, 16, p. 14647-14659 13 p.

Research output: Contribution to journalArticle

4 Scopus citations

Selective degradation of CDK6 by a palbociclib based PROTAC

Rana, S., Bendjennat, M., Kour, S., King, H. M., Kizhake, S., Zahid, M. & Natarajan, A., Jun 1 2019, In : Bioorganic and Medicinal Chemistry Letters. 29, 11, p. 1375-1379 5 p.

Research output: Contribution to journalArticle

21 Scopus citations

Selective inhibition of histone deacetylases 1/2/6 in combination with gemcitabine: A promising combination for pancreatic cancer therapy

Laschanzky, R. S., Humphrey, L. E., Ma, J., Smith, L. M., Enke, T. J., Shukla, S. K., Dasgupta, A., Singh, P. K., Howell, G. M., Brattain, M. G., Ly, Q. P., Black, A. R. & Black, J. D., Sep 2019, In : Cancers. 11, 9, 1327.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Self-Assembled Nanostructures of Peptide Amphiphiles: Charge Regulation by Size Regulation

Zaldivar, G., Vemulapalli, S., Udumula, V., Conda-Sheridan, M. & Tagliazucchi, M., Jun 24 2019, In : Journal of Physical Chemistry C. 123, 28, p. 17606-17615 10 p.

Research output: Contribution to journalArticle

5 Scopus citations

Self-assembling lisofylline-fatty acid conjugate for effective treatment of diabetes mellitus

Italiya, K. S., Mazumdar, S., Sharma, S., Chitkara, D., Mahato, R. I. & Mittal, A., Jan 2019, In : Nanomedicine: Nanotechnology, Biology, and Medicine. 15, 1, p. 175-187 13 p.

Research output: Contribution to journalArticle

2 Scopus citations

Sequence-dependent nucleosome nanoscale structure characterized by atomic force microscopy

Stormberg, T., Stumme-Diers, M. & Lyubchenko, Y. L., 2019, In : FASEB Journal. 33, 10, p. 10916-10923 8 p.

Research output: Contribution to journalArticle

Silencing of Neuropilins and GIPC1 in pancreatic ductal adenocarcinoma exerts multiple cellular and molecular antitumor effects

Borchardt, H., Schulz, A., Datta, K., Muders, M. H. & Aigner, A., Dec 1 2019, In : Scientific reports. 9, 1, 15471.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Spontaneous self-assembly of amyloid β (1-40) into dimers

Hashemi, M., Zhang, Y., Lv, Z. & Lyubchenko, Y. L., 2019, In : Nanoscale Advances. 1, 10, p. 3892-3899 8 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

SSRP1 promotes colorectal cancer progression and is negatively regulated by miR-28-5p

Wu, W., He, K., Guo, Q., Chen, J., Zhang, M., Huang, K., Yang, D., Wu, L., Deng, Y., Luo, X., Yu, H., Ding, Q. & Xiang, G., May 2019, In : Journal of cellular and molecular medicine. 23, 5, p. 3118-3129 12 p.

Research output: Contribution to journalArticle

Open Access
9 Scopus citations

Structural consequence of the most frequently recurring cancer-associated substitution in DNA polymerase ε

Parkash, V., Kulkarni, Y., ter Beek, J., Shcherbakova, P. V., Kamerlin, S. C. L. & Johansson, E., Dec 1 2019, In : Nature communications. 10, 1, 373.

Research output: Contribution to journalArticle

8 Scopus citations

Summary of the Second Annual BMT CTN Myeloma Intergroup Workshop on Minimal Residual Disease and Immune Profiling

Holstein, S. A., Ye, J. C., Howard, A., Bhutani, M., Gormley, N., Hahn, T., Hillengass, J., Krishnan, A., Landgren, C. O., Munshi, N. C., Oliva, S., Owen, R. G., Pasquini, M. C., Puig, N., Weinhold, N., Weisel, K. & McCarthy, P. L., Mar 2019, In : Biology of Blood and Marrow Transplantation. 25, 3, p. e89-e97

Research output: Contribution to journalArticle

5 Scopus citations

Supercell refinement: A cautionary tale

Lovelace, J., Petrícek, V., Murshudov, G. & Borgstahl, G. E. O., Sep 1 2019, In : Acta Crystallographica Section D: Structural Biology. 75, p. 852-860 9 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Systems Biology Approach to Identify Novel Genomic Determinants for Pancreatic Cancer Pathogenesis

Khatri, I., Ganguly, K., Sharma, S., Carmicheal, J., Kaur, S., Batra, S. K. & Bhasin, M. K., Dec 1 2019, In : Scientific reports. 9, 1, 123.

Research output: Contribution to journalArticle

3 Scopus citations

Targetable genetic alterations of TCF4 (E2-2) drive immunoglobulin expression in diffuse large B cell lymphoma

Jain, N., Hartert, K., Tadros, S., Fiskus, W., Havranek, O., Ma, M. C. J., Bouska, A., Heavican, T., Kumar, D., Deng, Q., Moore, D., Pak, C., Liu, C. L., Gentles, A. J., Hartmann, E., Kridel, R., Smedby, K. E., Juliusson, G., Rosenquist, R., Gascoyne, R. D. & 13 others, Rosenwald, A., Giancotti, F., Neelapu, S. S., Westin, J., Vose, J. M., Lunning, M. A., Greiner, T., Rodig, S., Iqbal, J., Alizadeh, A. A., Davis, R. E., Bhalla, K. & Green, M. R., 2019, In : Science translational medicine. 11, 497, eaav5599.

Research output: Contribution to journalArticle

8 Scopus citations

Targeted drug delivery and image-guided therapy of heterogeneous ovarian cancer using HER2-targeted theranostic nanoparticles

Satpathy, M., Wang, L., Zielinski, R. J., Qian, W., Wang, Y. A., Mohs, A. M., Kairdolf, B. A., Ji, X., Capala, J., Lipowska, M., Nie, S., Mao, H. & Yang, L., 2019, In : Theranostics. 9, 3, p. 778-795 18 p.

Research output: Contribution to journalArticle

Open Access
15 Scopus citations

Targeting LIF-mediated paracrine interaction for pancreatic cancer therapy and monitoring

Shi, Y., Gao, W., Lytle, N. K., Huang, P., Yuan, X., Dann, A. M., Ridinger-Saison, M., DelGiorno, K. E., Antal, C. E., Liang, G., Atkins, A. R., Erikson, G., Sun, H., Meisenhelder, J., Terenziani, E., Woo, G., Fang, L., Santisakultarm, T. P., Manor, U., Xu, R. & 18 others, Becerra, C. R., Borazanci, E., Von Hoff, D. D., Grandgenett, P. M., Hollingsworth, M. A., Leblanc, M., Umetsu, S. E., Collisson, E. A., Scadeng, M., Lowy, A. M., Donahue, T. R., Reya, T., Downes, M., Evans, R. M., Wahl, G. M., Pawson, T., Tian, R. & Hunter, T., May 2 2019, In : Nature. 569, 7754, p. 131-135 5 p.

Research output: Contribution to journalArticle

37 Scopus citations

The glycan CA19-9 promotes pancreatitis and pancreatic cancer in mice

Engle, D. D., Tiriac, H., Rivera, K. D., Pommier, A., Whalen, S., Oni, T. E., Alagesan, B., Lee, E. J., Yao, M. A., Lucito, M. S., Spielman, B., Silva, B. D., Schoepfer, C., Wright, K., Creighton, B., Afinowicz, L., Yu, K. H., Grützmann, R., Aust, D., Gimotty, P. A. & 8 others, Pollard, K. S., Hruban, R. H., Goggins, M. G., Pilarsky, C., Park, Y., Pappin, D. J., Hollingsworth, M. A. & Tuveson, D. A., 2019, In : Science. 364, 6446, p. 1156-1162 7 p.

Research output: Contribution to journalArticle

26 Scopus citations

The glycoprotein mucin-1 negatively regulates GalNAc transferase 5 expression in pancreatic cancer

Caffrey, T., Sagar, S., Thomas, D., Lewallen, M. E., Hollingsworth, M. A. & Radhakrishnan, P., Oct 1 2019, In : FEBS Letters. 593, 19, p. 2751-2761 11 p.

Research output: Contribution to journalArticle

1 Scopus citations

The impact of the affordable care act on breast cancer care in the USA: A multi-institutional analysis

Maxwell, J., Shats, O., Aldridge, J., Lyden, E., Krie, A., Conklin, R., Manning, K., Fahed, R., Vaziri, I., Deveras, R. A. E., Mateen, Z., Crow, K., Bjorling, V., Meschi, J. T., Makoni, S., Kruter, F. & Cowan, K., Sep 1 2019, In : Breast Journal. 25, 5, p. 948-952 5 p.

Research output: Contribution to journalArticle

The mitochondrial deoxyguanosine kinase is required for cancer cell stemness in lung adenocarcinoma

Lin, S., Huang, C., Sun, J., Bollt, O., Wang, X., Martine, E., Kang, J., Taylor, M. D., Fang, B., Singh, P. K., Koomen, J., Hao, J. & Yang, S., Dec 1 2019, In : EMBO Molecular Medicine. 11, 12, e10849.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

The neuroprotection of KIBRA in promoting neuron survival and against amyloid β-induced apoptosis

Song, L., Tang, S., Dong, L., Han, X., Cong, L., Dong, J., Han, X., Zhang, Q., Wang, Y. & Du, Y., Apr 12 2019, In : Frontiers in Cellular Neuroscience. 13, 137.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Thermodynamic investigation of kissing-loop interactions

Carr, C. E. & Marky, L. A., Feb 2019, In : Biochimie. 157, p. 177-183 7 p.

Research output: Contribution to journalArticle

The use of micelles to deliver potential hedgehog pathway inhibitor for the treatment of liver fibrosis

Kumar, V., Dong, Y., Kumar, V., Almawash, S. & Mahato, R. I., 2019, In : Theranostics. 9, 25, p. 7537-7555 19 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Timely expression and activation of YAP1 in granulosa cells is essential for ovarian follicle development

Lv, X., He, C., Huang, C., Wang, H., Hua, G., Wang, Z., Zhou, J., Chen, X., Ma, B., Timm, B. K., Maclin, V., Dong, J., Rueda, B. R., Davis, J. S. & Wang, C., Sep 1 2019, In : FASEB Journal. 33, 9, p. 10049-10064 16 p.

Research output: Contribution to journalArticle

9 Scopus citations

Tolerability and activity of ublituximab, umbralisib, and ibrutinib in patients with chronic lymphocytic leukaemia and non-Hodgkin lymphoma: a phase 1 dose escalation and expansion trial

Nastoupil, L. J., Lunning, M. A., Vose, J. M., Schreeder, M. T., Siddiqi, T., Flowers, C. R., Cohen, J. B., Burger, J. A., Wierda, W. G., O'Brien, S., Sportelli, P., Miskin, H. P., Purdom, M. A., Weiss, M. S. & Fowler, N. H., Feb 2019, In : The Lancet Haematology. 6, 2, p. e100-e109

Research output: Contribution to journalArticle

23 Scopus citations

Trefoil factor(s) and CA19.9: A promising panel for early detection of pancreatic cancer

Jahan, R., Ganguly, K., Smith, L. M., Atri, P., Carmicheal, J., Sheinin, Y., Rachagani, S., Natarajan, G., Brand, R. E., Macha, M. A., Grandgenett, P. M., Kaur, S. & Batra, S. K., Apr 2019, In : EBioMedicine. 42, p. 375-385 11 p.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Truncated O-glycans promote epithelial-to-mesenchymal transition and stemness properties of pancreatic cancer cells

Thomas, D., Sagar, S., Caffrey, T., Grandgenett, P. M. & Radhakrishnan, P., Oct 1 2019, In : Journal of cellular and molecular medicine. 23, 10, p. 6885-6896 12 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Tumor‐associated neutrophils in cancer: Going pro

Wu, L., Saxena, S., Awaji, M. & Singh, R. K., Apr 2019, In : Cancers. 11, 4, 564.

Research output: Contribution to journalArticle

Open Access
34 Scopus citations

Ublituximab and umbralisib in relapsed/refractory B-cell non-Hodgkin lymphoma and chronic lymphocytic leukemia

Lunning, M., Vose, J., Nastoupil, L., Fowler, N., Burger, J. A., Wierda, W. G., Schreeder, M. T., Siddiqi, T., Flowers, C. R., Cohen, J. B., Sportelli, P., Miskin, H. P., Weiss, M. S. & O'Brien, S., Nov 21 2019, In : Blood. 134, 21, p. 1811-1820 10 p.

Research output: Contribution to journalArticle

10 Scopus citations
Open Access

Understanding interactions of Citropin 1.1 analogues with model membranes and their influence on biological activity

Rodrigues de Almeida, N., Catazaro, J., Krishnaiah, M., Singh Chhonker, Y., Murry, D. J., Powers, R. & Conda-Sheridan, M., Sep 2019, In : Peptides. 119, 170119.

Research output: Contribution to journalArticle

2 Scopus citations