Eppley Institute for Cancer Research

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2019

Vitamin e δ-tocotrienol sensitizes human pancreatic cancer cells to TRAIL-induced apoptosis through proteasome-mediated down-regulation of c-FLIPs

Francois, R. A., Zhang, A., Husain, K., Wang, C., Hutchinson, S., Kongnyuy, M., Batra, S. K., Coppola, D., Sebti, S. M. & Malafa, M. P., Jul 22 2019, In : Cancer Cell International. 19, 1, 189.

Research output: Contribution to journalArticle

Open Access

VU0810464, a non-urea G protein-gated inwardly rectifying K+ (Kir3/GIRK) channel activator, exhibits enhanced selectivity for neuronal Kir3 channels and reduces stress-induced hyperthermia in mice

Vo, B. N., Abney, K. K., Anderson, A., Marron Fernandez de Velasco, E., Benneyworth, M. A., Daniels, J. S., Morrison, R. D., Hopkins, C. R., Weaver, C. D. & Wickman, K., Jul 2019, In : British Journal of Pharmacology. 176, 13, p. 2238-2249 12 p.

Research output: Contribution to journalArticle

1 Scopus citations

YAP1-LATS2 feedback loop dictates senescent or malignant cell fate to maintain tissue homeostasis

He, C., Lv, X., Huang, C., Hua, G., Ma, B., Chen, X., Angeletti, P. C., Dong, J., Zhou, J., Wang, Z., Rueda, B. R., Davis, J. S. & Wang, C., Mar 2019, In : EMBO Reports. 20, 3, e44948.

Research output: Contribution to journalArticle

5 Scopus citations

ω-Hydroxy isoprenoid bisphosphonates as linkable GGDPS inhibitors

Bhuiyan, N. H., Varney, M. L., Bhattacharya, D. S., Payne, W. M., Mohs, A. M., Holstein, S. A. & Wiemer, D. F., Oct 1 2019, In : Bioorganic and Medicinal Chemistry Letters. 29, 19, 126633.

Research output: Contribution to journalArticle

2 Scopus citations
2018

3D Bioprinting of Breast Cancer Models for Drug Resistance Study

Wang, Y., Shi, W., Kuss, M., Mirza, S., Qi, D., Krasnoslobodtsev, A. V., Zeng, J., Band, H., Band, V. & Duan, B., Dec 10 2018, In : ACS Biomaterials Science and Engineering. 4, 12, p. 4401-4411 11 p.

Research output: Contribution to journalArticle

14 Scopus citations

3D hydrogel breast cancer models for studying the effects of hypoxia on epithelial to mesenchymal transition

Wang, Y., Mirza, S., Wu, S., Zeng, J., Shi, W., Band, H., Band, V. & Duan, B., Aug 14 2018, In : Oncotarget. 9, 63, p. 32191-32203 13 p.

Research output: Contribution to journalArticle

11 Scopus citations

Activity and fidelity of human DNA polymerase depend on primer structure

Baranovskiy, A. G., Duong, V. N., Babayeva, N. D., Zhang, Y., Pavlov, Y. I., Anderson, K. S. & Tahirov, T. H., May 4 2018, In : Journal of Biological Chemistry. 293, 18, p. 6824-6843 20 p.

Research output: Contribution to journalArticle

6 Scopus citations

Advanced pancreatic cancer: A meta-analysis of clinical trials over thirty years

Hall, B. R., Cannon, A., Atri, P., Wichman, C. S., Smith, L. M., Ganti, A. K., Are, C., Sasson, A. R., Kumar, S. & Batra, S. K., Apr 10 2018, In : Oncotarget. 9, 27, p. 19396-19405 10 p.

Research output: Contribution to journalArticle

13 Scopus citations

A Functional Signature Ontology (FUSION) screen detects an AMPK inhibitor with selective toxicity toward human colon tumor cells

Das, B., Neilsen, B. K., Fisher, K. W., Gehring, D., Hu, Y., Volle, D. J., Kim, H. S., McCall, J. L., Kelly, D. L., MacMillan, J. B., White, M. A. & Lewis, R. E., Dec 1 2018, In : Scientific reports. 8, 1, 3770.

Research output: Contribution to journalArticle

7 Scopus citations

AKT3 drives adenoid cystic carcinoma development in salivary glands

Zboray, K., Mohrherr, J., Stiedl, P., Pranz, K., Wandruszka, L., Grabner, B., Eferl, R., Moriggl, R., Stoiber, D., Sakamoto, K., Wagner, K. U., Popper, H., Casanova, E. & Moll, H. P., Feb 1 2018, In : Cancer Medicine. 7, 2, p. 445-453 9 p.

Research output: Contribution to journalArticle

3 Scopus citations

An Mtb-Human Protein-Protein Interaction Map Identifies a Switch between Host Antiviral and Antibacterial Responses

Penn, B. H., Netter, Z., Johnson, J. R., Von Dollen, J., Jang, G. M., Johnson, T., Ohol, Y. M., Maher, C., Bell, S. L., Geiger, K., Golovkine, G., Du, X., Choi, A., Parry, T., Mohapatra, B. C., Storck, M. D., Band, H., Chen, C., Jäger, S., Shales, M. & 5 others, Portnoy, D. A., Hernandez, R., Coscoy, L., Cox, J. S. & Krogan, N. J., Aug 16 2018, In : Molecular Cell. 71, 4, p. 637-648.e5

Research output: Contribution to journalArticle

22 Scopus citations

Are we prepared for nuclear terrorism?

Gale, R. P. & Armitage, J. O., Mar 29 2018, In : New England Journal of Medicine. 378, 13, p. 1246-1254 9 p.

Research output: Contribution to journalArticle

8 Scopus citations

Astrocyte EV-Induced lincRNA-Cox2 Regulates Microglial Phagocytosis: Implications for Morphine-Mediated Neurodegeneration

Hu, G., Liao, K., Niu, F., Yang, L., Dallon, B. W., Callen, S., Tian, C., Shu, J., Cui, J., Sun, Z., Lyubchenko, Y. L., Ka, M., Chen, X. M. & Buch, S., Dec 7 2018, In : Molecular Therapy - Nucleic Acids. 13, p. 450-463 14 p.

Research output: Contribution to journalArticle

20 Scopus citations

Axed MUC4 (MUC4/X) aggravates pancreatic malignant phenotype by activating integrin-β1/FAK/ERK pathway

Jahan, R., Macha, M. A., Rachagani, S., Das, S., Smith, L. M., Kaur, S. & Batra, S. K., Aug 2018, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1864, 8, p. 2538-2549 12 p.

Research output: Contribution to journalArticle

8 Scopus citations

Biphasic changes in airway epithelial cell EGF receptor binding and phosphorylation induced by components of hogbarn dust

Dodmane, P. R., Schulte, N. A., Heires, A. J., Band, H., Romberger, D. J. & Toews, M. L., Nov 26 2018, In : Experimental Lung Research. 44, 10, p. 443-454 12 p.

Research output: Contribution to journalArticle

BRD4 profiling identifies critical chronic lymphocytic leukemia oncogenic circuits and reveals sensitivity to PLX51107, a novel structurally distinct bet inhibitor

Ozer, H. G., El-Gamal, D., Powell, B., Hing, Z. A., Blachly, J. S., Harrington, B., Mitchell, S., Grieselhuber, N. R., Williams, K., Lai, T. H., Alinari, L., Baiocchi, R. A., Brinton, L., Baskin, E., Cannon, M., Beaver, L., Goettl, V. M., Lucas, D. M., Woyach, J. A., Sampath, D. & 27 others, Lehman, A. M., Yu, L., Zhang, J., Ma, Y., Zhang, Y., Spevak, W., Shi, S., Severson, P., Shellooe, R., Carias, H., Tsang, G., Dong, K., Ewing, T., Marimuthu, A., Tantoy, C., Walters, J., Sanftner, L., Rezaei, H., Nespi, M., Matusow, B., Habets, G., Ibrahim, P., Zhang, C., Mathe, E. A., Bollag, G., Byrd, J. C. & Lapalombella, R., Apr 2018, In : Cancer Discovery. 8, 4, p. 458-477 20 p.

Research output: Contribution to journalArticle

33 Scopus citations

Characterization of butyrylcholinesterase from porcine milk

Saxena, A., Belinskaya, T., Schopfer, L. M. & Lockridge, O., Aug 15 2018, In : Archives of Biochemistry and Biophysics. 652, p. 38-49 12 p.

Research output: Contribution to journalArticle

6 Scopus citations

Characterization of CDK(5) inhibitor, 20-223 (aka CP668863) for colorectal cancer therapy

Robb, C. M., Kour, S., Contreras, J. I., Agarwal, E., Barger, C. J., Rana, S., Sonawane, Y., Neilsen, B. K., Taylor, M., Kizhake, S., Thakare, R. N., Chowdhury, S., Wang, J., Black, J. D., Hollingsworth, M. A., Brattain, M. G. & Natarajan, A., 2018, In : Oncotarget. 9, 4, p. 5216-5232 17 p.

Research output: Contribution to journalArticle

8 Scopus citations

Characterization of stem cell and cancer stem cell populations in ovary and ovarian tumors

Parte, S. C., Batra, S. K. & Kakar, S. S., Aug 18 2018, In : Journal of Ovarian Research. 11, 1, 69.

Research output: Contribution to journalArticle

19 Scopus citations

Chemical Genetic Screens Identify Kinase Inhibitor Combinations that Target Anti-Apoptotic Proteins for Cancer Therapy

Contreras, J. I., Robb, C. M., King, H. M., Baxter, J., Crawford, A. J., Kour, S., Kizhake, S., Sonawane, Y. A., Rana, S., Hollingsworth, M. A., Luo, X. & Natarajan, A., May 18 2018, In : ACS chemical biology. 13, 5, p. 1148-1152 5 p.

Research output: Contribution to journalArticle

4 Scopus citations
6 Scopus citations

Cholesterol and Morpholine Grafted Cationic Amphiphilic Copolymers for miRNA-34a Delivery

Sharma, S., Mazumdar, S., Italiya, K. S., Date, T., Mahato, R. I., Mittal, A. & Chitkara, D., Jun 4 2018, In : Molecular Pharmaceutics. 15, 6, p. 2391-2402 12 p.

Research output: Contribution to journalArticle

8 Scopus citations

Cigarette Smoke Induces Stem Cell Features of Pancreatic Cancer Cells via PAF1

Nimmakayala, R. K., Seshacharyulu, P., Lakshmanan, I., Rachagani, S., Chugh, S., Karmakar, S., Rauth, S., Vengoji, R., Atri, P., Talmon, G. A., Lele, S. M., Smith, L. M., Thapa, I., Bastola, D., Ouellette, M. M., Batra, S. K. & Ponnusamy, M. P., Sep 2018, In : Gastroenterology. 155, 3, p. 892-908.e6

Research output: Contribution to journalArticle

20 Scopus citations
2 Scopus citations

Co-delivery of siAlox15 and sunitinib for reversing the new-onset of type 1 diabetes in non-obese diabetic mice

Peng, Y., Wen, D., Lin, F. & Mahato, R. I., Dec 28 2018, In : Journal of Controlled Release. 292, p. 1-12 12 p.

Research output: Contribution to journalArticle

2 Scopus citations

Combination of mAb-AR20.5, anti-PD-L1 and PolyICLC inhibits tumor progression and prolongs survival of MUC1.Tg mice challenged with pancreatic tumors

Mehla, K., Tremayne, J., Grunkemeyer, J. A., O’Connell, K. A., Steele, M. M., Caffrey, T. C., Zhu, X., Yu, F., Singh, P. K., Schultes, B. C., Madiyalakan, R., Nicodemus, C. F. & Hollingsworth, M. A., Mar 1 2018, In : Cancer Immunology, Immunotherapy. 67, 3, p. 445-457 13 p.

Research output: Contribution to journalArticle

8 Scopus citations

Connexin43 carboxyl-terminal domain directly interacts with β-catenin

Spagnol, G., Trease, A. J., Zheng, L., Gutierrez, M., Basu, I., Sarmiento, C., Moore, G., Cervantes, M. & Sorgen, P. L., Jun 2018, In : International journal of molecular sciences. 19, 6, 1562.

Research output: Contribution to journalArticle

12 Scopus citations

Crosstalk between PKCα and PI3K/AKT Signaling Is Tumor Suppressive in the Endometrium

Hsu, A. H., Lum, M. A., Shim, K. S., Frederick, P. J., Morrison, C. D., Chen, B., Lele, S. M., Sheinin, Y. M., Daikoku, T., Dey, S. K., Leone, G., Black, A. R. & Black, J. D., Jul 17 2018, In : Cell Reports. 24, 3, p. 655-669 15 p.

Research output: Contribution to journalArticle

5 Scopus citations

Cryo-EM structure of the native butyrylcholinesterase tetramer reveals a dimer of dimers stabilized by a superhelical assembly

Leung, M. R., van Bezouwen, L. S., Schopfer, L. M., Sussman, J. L., Silman, I., Lockridge, O. & Zeev-Ben-Mordehai, T., Dec 26 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 52, p. 13270-13275 6 p.

Research output: Contribution to journalArticle

5 Scopus citations

Cyclin-dependent kinase 1-mediated phosphorylation of YES links mitotic arrest and apoptosis during antitubulin chemotherapy

Wang, Z., Chen, X., Zhong, M. Z., Yang, S., Zhou, J., Klinkebiel, D. L., Karpf, A. R., Chen, Y. & Dong, J., Dec 2018, In : Cellular Signalling. 52, p. 137-146 10 p.

Research output: Contribution to journalArticle

4 Scopus citations

Deletion of the DEF1 gene does not confer UV-immutability but frequently leads to self-diploidization in yeast Saccharomyces cerevisiae

Stepchenkova, E. I., Shiriaeva, A. A. & Pavlov, Y. I., Oct 2018, In : DNA Repair. 70, p. 49-54 6 p.

Research output: Contribution to journalArticle

1 Scopus citations

Delipidation of plasma has minimal effects on human butyrylcholinesterase

Onder, S., Tacal, O. & Lockridge, O., Feb 15 2018, In : Frontiers in Pharmacology. 9, FEB, 117.

Research output: Contribution to journalArticle

2 Scopus citations

Desmoplasia in pancreatic ductal adenocarcinoma: Insight into pathological function and therapeutic potential

Cannon, A., Thompson, C., Hall, B. R., Jain, M., Kumar, S. & Batra, S. K., Mar 2018, In : Genes and Cancer. 9, 3-4, p. 78-86 9 p.

Research output: Contribution to journalArticle

14 Scopus citations

Development and characterization of carboxy-terminus specific monoclonal antibodies for understanding MUC16 cleavage in human ovarian cancer

Aithal, A., Junker, W. M., Kshirsagar, P., Das, S., Kaur, S., Orzechowski, C., Gautam, S. K., Jahan, R., Sheinin, Y. M., Lakshmanan, I., Ponnusamy, M. P., Batra, S. K. & Jain, M., Apr 2018, In : PloS one. 13, 4, e0193907.

Research output: Contribution to journalArticle

5 Scopus citations

Dileucine-like motifs in the C-terminal tail of connexin32 control its endocytosis and assembly into gap junctions

Ray, A., Katoch, P., Jain, N. & Mehta, P. P., Mar 1 2018, In : Journal of cell science. 131, 5, jcs207340.

Research output: Contribution to journalArticle

2 Scopus citations

Disruption of C1galt1 Gene Promotes Development and Metastasis of Pancreatic Adenocarcinomas in Mice

Chugh, S., Barkeer, S., Rachagani, S., Nimmakayala, R. K., Perumal, N., Pothuraju, R., Atri, P., Mahapatra, S., Thapa, I., Talmon, G. A., Smith, L. M., Yu, X., Neelamegham, S., Fu, J., Xia, L., Palanimuthu Ponnusamy, M. & Batra, S. K., Nov 2018, In : Gastroenterology. 155, 5, p. 1608-1624 17 p.

Research output: Contribution to journalArticle

13 Scopus citations

DNA polymerase η mutational signatures are found in a variety of different types of cancer

Rogozin, I. B., Goncearenco, A., Lada, A. G., De, S., Yurchenko, V., Nudelman, G., Panchenko, A. R., Cooper, D. N. & Pavlov, Y. I., Feb 1 2018, In : Cell Cycle. 17, 3, p. 348-355 8 p.

Research output: Contribution to journalArticle

12 Scopus citations

Dynamics of the Interaction of RecG Protein with Stalled Replication Forks

Sun, Z., Hashemi, M., Warren, G., Bianco, P. R. & Lyubchenko, Y. L., Apr 3 2018, In : Biochemistry. 57, 13, p. 1967-1976 10 p.

Research output: Contribution to journalArticle

7 Scopus citations

Effect of dC → d(m5C) substitutions on the folding of intramolecular triplexes with mixed TAT and C+GC base triplets

Carr, C. E., Ganugula, R., Shikiya, R., Soto, A. M. & Marky, L. A., Mar 2018, In : Biochimie. 146, p. 156-165 10 p.

Research output: Contribution to journalArticle

1 Scopus citations

Effect of GCAA stabilizing loops on three- and four-way intramolecular junctions

Carr, C. E. & Marky, L. A., 2018, In : Physical Chemistry Chemical Physics. 20, 7, p. 5046-5056 11 p.

Research output: Contribution to journalArticle

1 Scopus citations
1 Scopus citations

Emerging Roles of Electrospun Nanofibers in Cancer Research

Chen, S., Boda, S. K., Batra, S. K., Li, X. & Xie, J., Mar 21 2018, In : Advanced Healthcare Materials. 7, 6, 1701024.

Research output: Contribution to journalArticle

28 Scopus citations

Energetics, Ion, and Water Binding of the Unfolding of AA/UU Base Pair Stacks and UAU/UAU Base Triplet Stacks in RNA

Carr, C. E., Khutsishvili, I. & Marky, L. A., Jul 19 2018, In : Journal of Physical Chemistry B. 122, 28, p. 7057-7065 9 p.

Research output: Contribution to journalArticle

Expression of the POTE gene family in human ovarian cancer

Barger, C. J., Zhang, W., Sharma, A., Chee, L., James, S. R., Kufel, C. N., Miller, A., Meza, J., Drapkin, R., Odunsi, K., Klinkebiel, D. & Karpf, A. R., Dec 1 2018, In : Scientific reports. 8, 1, 17136.

Research output: Contribution to journalArticle

4 Scopus citations

Ferulic acid Dimer as a non-opioid therapeutic for acute pain

Priebe, A., Hunke, M., Tonello, R., Sonawane, Y., Berta, T., Natarajan, A., Bhuvanesh, N., Pattabiraman, M. & Chandra, S., Jun 6 2018, In : Journal of Pain Research. 11, p. 1075-1085 11 p.

Research output: Contribution to journalArticle

7 Scopus citations

Focal adhesion kinase a potential therapeutic target for pancreatic cancer and malignant pleural mesothelioma

Kanteti, R., Mirzapoiazova, T., Riehm, J. J., Dhanasingh, I., Mambetsariev, B., Wang, J., Kulkarni, P., Kaushik, G., Seshacharyulu, P., Ponnusamy, M. P., Kindler, H. L., Nasser, M. W., Batra, S. K. & Salgia, R., Apr 3 2018, In : Cancer Biology and Therapy. 19, 4, p. 316-327 12 p.

Research output: Contribution to journalArticle

28 Scopus citations

Follicular large cleaved cell (centrocytic) lymphoma: an unrecognized variant of follicular lymphoma

El Behery, R., Laurini, J. A., Weisenburger, D. D., Smith, L. M., Dave, B. J., Yuan, J., Fu, K., Chan, W. C., Nathwani, B. N., Bierman, P. J., Bociek, R. G., Vose, J. M., Armitage, J. O., Greiner, T. C. & Aoun, P., Feb 2018, In : Human Pathology. 72, p. 180-190 11 p.

Research output: Contribution to journalArticle

2 Scopus citations

Functional analysis of cancer-associated DNA polymerase ε variants in Saccharomyces cerevisiae

Barbari, S. R., Kane, D. P., Moore, E. A. & Shcherbakova, P. V., Mar 1 2018, In : G3: Genes, Genomes, Genetics. 8, 3, p. 1019-1029 11 p.

Research output: Contribution to journalArticle

14 Scopus citations

High-speed atomic force microscopy reveals structural dynamics of α -synuclein monomers and dimers

Zhang, Y., Hashemi, M., Lv, Z., Williams, B., Popov, K. I., Dokholyan, N. V. & Lyubchenko, Y. L., Mar 28 2018, In : Journal of Chemical Physics. 148, 12, 123322.

Research output: Contribution to journalArticle

21 Scopus citations