Eppley Institute for Cancer Research

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2018

Increased Flexibility between Stems of Intramolecular Three-Way Junctions by the Insertion of Bulges

Carr, C. E. & Marky, L. A., Jun 19 2018, In : Biophysical journal. 114, 12, p. 2764-2774 11 p.

Research output: Contribution to journalArticle

2 Scopus citations

Indocyanine green loaded hyaluronan-derived nanoparticles for fluorescence-enhanced surgical imaging of pancreatic cancer

Qi, B., Crawford, A. J., Wojtynek, N. E., Holmes, M. B., Souchek, J. J., Almeida-Porada, G., Ly, Q. P., Cohen, S. M., Hollingsworth, M. A. & Mohs, A. M., Apr 2018, In : Nanomedicine: Nanotechnology, Biology, and Medicine. 14, 3, p. 769-780 12 p.

Research output: Contribution to journalArticle

18 Scopus citations

Inhibiting crosstalk between MET signaling and mitochondrial dynamics and morphology: a novel therapeutic approach for lung cancer and mesothelioma

Wang, J., Mirzapoiazova, T., Carol Tan, Y. H., Pang, K. M., Pozhitkov, A., Wang, Y., Wang, Y., Mambetsariev, B., Wang, E., Nasser, M. W., Batra, S. K., Raz, D., Reckamp, K., Kulkarni, P., Zheng, Y. & Salgia, R., Nov 2 2018, In : Cancer Biology and Therapy. 19, 11, p. 1023-1032 10 p.

Research output: Contribution to journalArticle

4 Scopus citations

Insights into gemcitabine resistance and the potential for therapeutic monitoring

Gebregiworgis, T., Bhinderwala, F., Purohit, V., Chaika, N. V., Singh, P. K. & Powers, R., Dec 1 2018, In : Metabolomics. 14, 12, 156.

Research output: Contribution to journalArticle

6 Scopus citations

Intracellular amyloid beta expression leads to dysregulation of the mitogen-activated protein kinase and bone morphogenetic protein-2 signaling axis

Cruz, E., Kumar, S., Yuan, L., Arikkath, J. & Batra, S. K., Feb 2018, In : PloS one. 13, 2, e0191696.

Research output: Contribution to journalArticle

5 Scopus citations

Loss of the nuclear pool of Ubiquitin ligase CHIP/STUB1 in breast cancer unleashes the MZF1-cathepsin pro-oncogenic program

Luan, H., Mohapatra, B., Bielecki, T. A., Mushtaq, I., Mirza, S., Jennings, T. A., Clubb, R. J., An, W., Ahmed, D., El-Ansari, R., Storck, M. D., Mishra, N. K., Guda, C., Sheinin, Y. M., Meza, J. L., Raja, S., Rakha, E. A., Band, V. & Band, H., May 15 2018, In : Cancer Research. 78, 10, p. 2524-2535 12 p.

Research output: Contribution to journalArticle

12 Scopus citations

Macrophage-derived neuropilin-2 exhibits novel tumor-promoting functions

Roy, S., Bag, A. K., Dutta, S., Polavaram, N. S., Islam, R., Schellenburg, S., Banwait, J., Guda, C., Ran, S., Hollingsworth, M. A., Singh, R. K., Talmadge, J. E., Muders, M. H., Batra, S. K. & Datta, K., Oct 1 2018, In : Cancer Research. 78, 19, p. 5600-5617 18 p.

Research output: Contribution to journalArticle

13 Scopus citations

Mass Spectral Detection of Diethoxyphospho-Tyrosine Adducts on Proteins from HEK293 Cells Using Monoclonal Antibody depY for Enrichment

Onder, S., Schopfer, L. M., Tacal, O., Blake, T. A., Johnson, R. C. & Lockridge, O., Jun 18 2018, In : Chemical Research in Toxicology. 31, 6, p. 520-530 11 p.

Research output: Contribution to journalArticle

5 Scopus citations

MASTL induces Colon Cancer progression and Chemoresistance by promoting Wnt/β-catenin signaling

Uppada, S. B., Gowrikumar, S., Ahmad, R., Kumar, B., Szeglin, B., Chen, X., Smith, J. J., Batra, S. K., Singh, A. B. & Dhawan, P., Aug 1 2018, In : Molecular cancer. 17, 1, 111.

Research output: Contribution to journalArticle

19 Scopus citations

Metastatic cancers promote cachexia through ZIP14 upregulation in skeletal muscle

Wang, G., Biswas, A. K., Ma, W., Kandpal, M., Coker, C., Grandgenett, P. M., Hollingsworth, M. A., Jain, R., Tanji, K., López-Pintado, S., Borczuk, A., Hebert, D., Jenkitkasemwong, S., Hojyo, S., Davuluri, R. V., Knutson, M. D., Fukada, T. & Acharyya, S., Jun 1 2018, In : Nature Medicine. 24, 6, p. 770-781 12 p.

Research output: Contribution to journalArticle

34 Scopus citations

Met receptor inhibitor SU11274 localizes in the endoplasmic reticulum

Wiest, E. J., Smith, H. J. & Hollingsworth, M. A., Jul 2 2018, In : Biochemical and Biophysical Research Communications. 501, 4, p. 858-862 5 p.

Research output: Contribution to journalArticle

1 Scopus citations

Microscale Gene Expression Analysis of Tumor-Associated Macrophages

Attri, K. S., Mehla, K., Shukla, S. K. & Singh, P. K., Dec 1 2018, In : Scientific reports. 8, 1, 2408.

Research output: Contribution to journalArticle

3 Scopus citations

Modulation of Cellular Response to Arsenic Trioxide Toxicity by Resveratrol

Mondal, B., Chen, H., Wen, W., Cavalieri, E. L., Rogan, E. G. & Zahid, M., May 21 2018, In : ACS Omega. 3, 5, p. 5511-5515 5 p.

Research output: Contribution to journalArticle

4 Scopus citations

Nanoscale dynamics of centromere nucleosomes and the critical roles of CENP-A

Stumme-Diers, M. P., Banerjee, S., Hashemi, M., Sun, Z. & Lyubchenko, Y. L., 2018, In : Nucleic acids research. 46, 1, p. 94-103 10 p.

Research output: Contribution to journalArticle

10 Scopus citations
6 Scopus citations

Novel CIL-102 derivatives as potential therapeutic agents for docetaxel-resistant prostate cancer

Miller, D. R., Tzeng, C. C., Farmer, T., Keller, E. T., Caplan, S., Chen, Y. S., Chen, Y. L. & Lin, M. F., Nov 1 2018, In : Cancer Letters. 436, p. 96-108 13 p.

Research output: Contribution to journalArticle

4 Scopus citations

Novel role of O-glycosyltransferases GALNT3 and B3GNT3 in the self-renewal of pancreatic cancer stem cells

Barkeer, S., Chugh, S., Karmakar, S., Kaushik, G., Rauth, S., Rachagani, S., Batra, S. K. & Ponnusamy, M. P., Nov 22 2018, In : BMC cancer. 18, 1, 1157.

Research output: Contribution to journalArticle

8 Scopus citations

NY-ESO-1 vaccination in combination with decitabine induces antigen-specific T-lymphocyte responses in patients with myelodysplastic syndrome

Griffiths, E. A., Srivastava, P., Matsuzaki, J., Brumberger, Z., Wang, E. S., Kocent, J., Miller, A., Roloff, G. W., Wong, H. Y., Paluch, B. E., Lutgen-Dunckley, L. G., Martens, B. L., Odunsi, K., Karpf, A. R., Hourigan, C. S. & Nemeth, M. J., Mar 1 2018, In : Clinical Cancer Research. 24, 5, p. 1019-1029 11 p.

Research output: Contribution to journalArticle

26 Scopus citations

O-GlcNAc Transferase Links Glucose Metabolism to MAVS-Mediated Antiviral Innate Immunity

Li, T., Li, X., Attri, K. S., Liu, C., Li, L., Herring, L. E., Asara, J. M., Lei, Y. L., Singh, P. K., Gao, C. & Wen, H., Dec 12 2018, In : Cell Host and Microbe. 24, 6, p. 791-803.e6

Research output: Contribution to journalArticle

16 Scopus citations

Optimization of cholinesterase-based catalytic bioscavengers against organophosphorus agents

Lushchekina, S. V., Schopfer, L. M., Grigorenko, B. L., Nemukhin, A. V., Varfolomeev, S. D., Lockridge, O. & Masson, P., Mar 13 2018, In : Frontiers in Pharmacology. 9, MAR, 211.

Research output: Contribution to journalArticle

14 Scopus citations

Organoid profiling identifies common responders to chemotherapy in pancreatic cancer

Tiriac, H., Belleau, P., Engle, D. D., Plenker, D., Deschênes, A., Somerville, T. D. D., Froeling, F. E. M., Burkhart, R. A., Denroche, R. E., Jang, G. H., Miyabayashi, K., Young, C. M., Patel, H., Ma, M., Lacomb, J. F., Palmaira, R. L. D., Javed, A. A., Huynh, J. C., Johnson, M., Arora, K. & 50 others, Robine, N., Shah, M., Sanghvi, R., Goetz, A. B., Lowder, C. Y., Martello, L., Driehuis, E., Lecomte, N., Askan, G., Iacobuzio-Donahue, C. A., Clevers, H., Wood, L. D., Hruban, R. H., Thompson, E., Aguirre, A. J., Wolpin, B. M., Sasson, A., Kim, J., Wu, M., Bucobo, J. C., Allen, P., Sejpal, D. V., Nealon, W., Sullivan, J. D., Winter, J. M., Gimotty, P. A., Grem, J. L., Dimaio, D. J., Buscaglia, J. M., Grandgenett, P. M., Brody, J. R., Hollingsworth, M. A., O’kane, G. M., Notta, F., Kim, E., Crawford, J. M., Devoe, C., Ocean, A., Wolfgang, C. L., Yu, K. H., Li, E., Vakoc, C. R., Hubert, B., Fischer, S. E., Wilson, J. M., Moffitt, R., Knox, J., Krasnitz, A., Gallinger, S. & Tuveson, D. A., Sep 2018, In : Cancer Discovery. 8, 9, p. 1112-1129 18 p.

Research output: Contribution to journalArticle

137 Scopus citations

p66Shc regulates migration of castration-resistant prostate cancer cells

Ingersoll, M. A., Chou, Y. W., Lin, J. S., Yuan, T. C., Miller, D. R., Xie, Y., Tu, Y., Oberley-Deegan, R. E., Batra, S. K. & Lin, M. F., Jun 2018, In : Cellular Signalling. 46, p. 1-14 14 p.

Research output: Contribution to journalArticle

9 Scopus citations

Pathological and functional significance of Semaphorin-5A in pancreatic cancer progression and metastasis

Saxena, S., Hayashi, Y., Wu, L., Awaji, M., Atri, P., Varney, M. L., Purohit, A., Rachagani, S., Batra, S. K. & Singh, R. K., 2018, In : Oncotarget. 9, 5, p. 5931-5943 13 p.

Research output: Contribution to journalArticle

11 Scopus citations

Pegaspargase-related high-grade hepatotoxicity in a pediatric-inspired adult acute lymphoblastic leukemia regimen does not predict recurrent hepatotoxicity with subsequent doses

Burke, P. W., Aldoss, I., Lunning, M. A., Devlin, S. M., Tallman, M. S., Pullarkat, V., Mohrbacher, A. M. & Douer, D., Mar 2018, In : Leukemia Research. 66, p. 49-56 8 p.

Research output: Contribution to journalArticle

5 Scopus citations

Phase 1 trial of ibrutinib and carfilzomib combination therapy for relapsed or relapsed and refractory multiple myeloma

Chari, A., Larson, S., Holkova, B., Cornell, R. F., Gasparetto, C., Karanes, C., Matous, J. V., Niesvizky, R., Valent, J., Lunning, M., Usmani, S. Z., Anderson, L. D., Chang, L., Lee, Y., Pak, Y., Salman, Z., Graef, T., Bilotti, E. & Chhabra, S., Nov 2 2018, In : Leukemia and Lymphoma. 59, 11, p. 2588-2594 7 p.

Research output: Contribution to journalArticle

11 Scopus citations

Probing Intermolecular Interactions within the Amyloid β Trimer Using a Tethered Polymer Nanoarray

Maity, S., Pramanik, A. & Lyubchenko, Y. L., Aug 15 2018, In : Bioconjugate Chemistry. 29, 8, p. 2755-2762 8 p.

Research output: Contribution to journalArticle

4 Scopus citations

Purification of recombinant human butyrylcholinesterase on Hupresin®

Lockridge, O., David, E., Schopfer, L. M., Masson, P., Brazzolotto, X. & Nachon, F., Dec 1 2018, In : Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences. 1102-1103, p. 109-115 7 p.

Research output: Contribution to journalArticle

2 Scopus citations

Redox manipulation of the manganese metal in human manganese superoxide dismutase for neutron diffraction

Azadmanesh, J., Lutz, W. E., Weiss, K. L., Coates, L. & Borgstahl, G. E. O., Oct 2018, In : Acta Crystallographica Section F: Structural Biology Communications. 74, 10, p. 677-687 11 p.

Research output: Contribution to journalArticle

4 Scopus citations

Role of the EHD Family of Endocytic Recycling Regulators for TCR Recycling and T Cell Function

Iseka, F. M., Goetz, B. T., Mushtaq, I., An, W., Cypher, L. R., Bielecki, T. A., Tom, E. C., Arya, P., Bhattacharyya, S., Storck, M. D., Semerad, C. L., Talmadge, J. E., Mosley, R. L., Band, V. & Band, H., Jan 15 2018, In : Journal of Immunology. 200, 2, p. 483-499 17 p.

Research output: Contribution to journalArticle

3 Scopus citations

Semaphorin-5A maintains epithelial phenotype of malignant pancreatic cancer cells

Saxena, S., Purohit, A., Varney, M. L., Hayashi, Y. & Singh, R. K., Dec 22 2018, In : BMC cancer. 18, 1, 1283.

Research output: Contribution to journalArticle

6 Scopus citations

Synthesis of aminopyrazole analogs and their evaluation as CDK inhibitors for cancer therapy

Rana, S., Sonawane, Y. A., Taylor, M. A., Kizhake, S., Zahid, M. & Natarajan, A., Dec 15 2018, In : Bioorganic and Medicinal Chemistry Letters. 28, 23-24, p. 3736-3740 5 p.

Research output: Contribution to journalArticle

5 Scopus citations

Targeting PARP1 in XRCC1-deficient sporadic invasive breast cancer or preinvasive ductal carcinoma in situ induces synthetic lethality and chemoprevention

Ali, R., Al-Kawaz, A., Toss, M. S., Green, A. R., Miligy, I. M., Mesquita, K. A., Seedhouse, C., Mirza, S., Band, V., Rakha, E. A. & Madhusudan, S., Dec 15 2018, In : Cancer Research. 78, 24, p. 6818-6827 10 p.

Research output: Contribution to journalArticle

5 Scopus citations

TGF and IGF1R signaling activates protein kinase A through differential regulation of ezrin phosphorylation in colon cancer cells

Leiphrakpam, P. D., Brattain, M. G., Black, J. D. & Wang, J., May 25 2018, In : Journal of Biological Chemistry. 293, 21, p. 8242-8254 13 p.

Research output: Contribution to journalArticle

6 Scopus citations

The Enzymatic Activity of APOBE3G Multimers

Pan, Y., Zagorski, K., Shlyakhtenko, L. S. & Lyubchenko, Y. L., Dec 1 2018, In : Scientific reports. 8, 1, 17953.

Research output: Contribution to journalArticle

2 Scopus citations

The fourth annual BRDS on genome editing and silencing for precision medicines

Chaudhary, A. K., Bhattarai, R. S. & Mahato, R. I., Feb 1 2018, In : Drug Delivery and Translational Research. 8, 1, p. 266-272 7 p.

Research output: Contribution to journalArticle

Therapeutic Potential of OMe-PS-miR-29b1 for Treating Liver Fibrosis

Kumar, V., Kumar, V., Luo, J. & Mahato, R. I., Dec 5 2018, In : Molecular Therapy. 26, 12, p. 2798-2811 14 p.

Research output: Contribution to journalArticle

3 Scopus citations

Thermodynamic Stability of DNA Duplexes Comprising the Simplest T → du Substitutions

Carr, C. E., Khutsishvili, I., Gold, B. & Marky, L. A., Oct 2 2018, In : Biochemistry. 57, 39, p. 5666-5671 6 p.

Research output: Contribution to journalArticle

3 Scopus citations

Unfolding and Targeting Thermodynamics of a DNA Intramolecular Complex with Joined Triplex-Duplex Domains

Johnson, S. E., Reiling-Steffensmeier, C., Lee, H. T. & Marky, L. A., Jan 25 2018, In : Journal of Physical Chemistry B. 122, 3, p. 1102-1111 10 p.

Research output: Contribution to journalArticle

Use of Hupresin to Capture Red Blood Cell Acetylcholinesterase for Detection of Soman Exposure

Onder, S., Schopfer, L. M., Cashman, J. R., Tacal, O., Johnson, R. C., Blake, T. A. & Lockridge, O., Jan 2 2018, In : Analytical chemistry. 90, 1, p. 974-979 6 p.

Research output: Contribution to journalArticle

4 Scopus citations

Using Watershed Boundaries to Map Adverse Health Outcomes: Examples From Nebraska, USA

Corley, B., Bartelt-Hunt, S., Rogan, E., Coulter, D., Sparks, J., Baccaglini, L., Howell, M., Liaquat, S., Commack, R. & Kolok, A. S., 2018, In : Environmental Health Insights. 12

Research output: Contribution to journalArticle

Open Access

Utilization of initial chemotherapy for newly diagnosed acute myeloid leukemia in the United States

Bhatt, V. R., Shostrom, V., Gundabolu, K. & Armitage, J. O., Jun 12 2018, In : Blood Advances. 2, 11, p. 1277-1282 6 p.

Research output: Contribution to journalArticle

13 Scopus citations

Vesicular trafficking plays a role in centriole disengagement and duplication

Xie, S., Reinecke, J. B., Farmer, T., Bahl, K., Yeow, I., Nichols, B. J., McLamarrah, T. A., Naslavsky, N., Rogers, G. C. & Caplan, S., Nov 1 2018, In : Molecular biology of the cell. 29, 22, p. 2622-2631 10 p.

Research output: Contribution to journalArticle

5 Scopus citations

WDR5 supports colon cancer cells by promoting methylation of H3K4 and suppressing DNA damage

Neilsen, B. K., Chakraborty, B., McCall, J. L., Frodyma, D. E., Sleightholm, R. L., Fisher, K. W. & Lewis, R. E., Jun 20 2018, In : BMC cancer. 18, 1, 673.

Research output: Contribution to journalArticle

5 Scopus citations

Zyxin promotes colon cancer tumorigenesis in a mitotic phosphorylation-dependent manner and through CDK8-mediated YAP activation

Zhou, J., Zeng, Y., Cui, L., Chen, X., Stauffer, S., Wang, Z., Yu, F., Lele, S. M., Talmon, G. A., Black, A. R., Chen, Y. & Dong, J., Jul 17 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 29, p. E6760-E6769

Research output: Contribution to journalArticle

9 Scopus citations
2017

A Combination of MUC5AC and CA19-9 Improves the Diagnosis of Pancreatic Cancer: A Multicenter Study

Kaur, S., Smith, L. M., Patel, A., Menning, M., Watley, D. C., Malik, S. S., Krishn, S. R., Mallya, K., Aithal, A., Sasson, A. R., Johansson, S. L., Jain, M., Singh, S., Guha, S., Are, C., Raimondo, M., Hollingsworth, M. A., Brand, R. E. & Batra, S. K., Jan 1 2017, In : American Journal of Gastroenterology. 112, 1, p. 172-183 12 p.

Research output: Contribution to journalArticle

35 Scopus citations

Adult high-grade B-cell lymphoma with Burkitt lymphoma signature: Genomic features and potential therapeutic targets

Bouska, A., Bi, C., Lone, W., Zhang, W., Kedwaii, A., Heavican, T., Lachel, C. M., Yu, J., Ferro, R., Eldorghamy, N., Greiner, T. C., Vose, J., Weisenburger, D. D., Gascoyne, R. D., Rosenwald, A., Ott, G., Campo, E., Rimsza, L. M., Jaffe, E. S., Braziel, R. M. & 12 others, Siebert, R., Miles, R. R., Dave, S., Reddy, A., Delabie, J., Staudt, L. M., Song, J. Y., McKeithan, T. W., Fu, K., Green, M., Chan, W. C. & Iqbal, J., Oct 19 2017, In : Blood. 130, 16, p. 1819-1831 13 p.

Research output: Contribution to journalArticle

28 Scopus citations

Afatinib radiosensitizes head and neck squamous cell carcinoma cells by targeting cancer stem cells

Macha, M. A., Rachagani, S., Qazi, A. K., Jahan, R., Gupta, S., Patel, A. A., Seshacharyulu, P., Lin, C., Li, S., Wang, S., Verma, V., Kishida, S., Kishida, M., Nakamura, N., Kibe, T., Lydiatt, W. M., Smith, R. B., Ganti, A. K., Jones, D. T., Batra, S. K. & 1 others, Jain, M., 2017, In : Oncotarget. 8, 13, p. 20961-20973 13 p.

Research output: Contribution to journalArticle

18 Scopus citations

An essential role of CBL and CBL-B ubiquitin ligases in mammary stem cell maintenance

Mohapatra, B., Zutshi, N., An, W., Goetz, B., Arya, P., Bielecki, T. A., Mustaq, I., Storck, M. D., Meza, J. L., Band, V. & Band, H., Apr 1 2017, In : Journal of Cell Science. 130, 7, p. 1072-1086 15 p.

Research output: Contribution to journalArticle

8 Scopus citations

A novel pathway for amyloids self-assembly in aggregates at nanomolar concentration mediated by the interaction with surfaces

Banerjee, S., Hashemi, M., Lv, Z., Maity, S., Rochet, J. C. & Lyubchenko, Y. L., Mar 30 2017, In : Scientific reports. 7, 45592.

Research output: Contribution to journalArticle

20 Scopus citations