Eppley Institute for Cancer Research

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2017

Antigen presentation profiling reveals recognition of lymphoma immunoglobulin neoantigens

Khodadoust, M. S., Olsson, N., Wagar, L. E., Haabeth, O. A. W., Chen, B., Swaminathan, K., Rawson, K., Liu, C. L., Steiner, D., Lund, P., Rao, S., Zhang, L., Marceau, C., Stehr, H., Newman, A. M., Czerwinski, D. K., Carlton, V. E. H., Moorhead, M., Faham, M., Kohrt, H. E. & 6 others, Carette, J., Green, M. R., Davis, M. M., Levy, R., Elias, J. E. & Alizadeh, A. A., Mar 30 2017, In : Nature. 543, 7647, p. 723-727 5 p.

Research output: Contribution to journalArticle

107 Scopus citations

Assessment of vascularity in glioblastoma and its implications on patient outcomes

McGahan, B. G., Neilsen, B. K., Kelly, D. L., McComb, R. D., Kazmi, S. A. J., White, M. L., Zhang, Y. & Aizenberg, M. R., Mar 1 2017, In : Journal of Neuro-Oncology. 132, 1, p. 35-44 10 p.

Research output: Contribution to journalArticle

5 Scopus citations

Association of distinct mutational signatures with correlates of increased immune activity in pancreatic ductal adenocarcinoma

Connor, A. A., Denroche, R. E., Jang, G. H., Timms, L., Kalimuthu, S. N., Selander, I., McPherson, T., Wilson, G. W., Chan-Seng-Yue, M. A., Borozan, I., Ferretti, V., Grant, R. C., Lungu, I. M., Costello, E., Greenhalf, W., Palmer, D., Ghaneh, P., Neoptolemos, J. P., Buchler, M., Petersen, G. & 20 others, Thayer, S., Hollingsworth, M. A., Sherker, A., Durocher, D., Dhani, N., Hedley, D., Serra, S., Pollett, A., Roehrl, M. H. A., Bavi, P., Bartlett, J. M. S., Cleary, S., Wilson, J. M., Alexandrov, L. B., Moore, M., Wouters, B. G., McPherson, J. D., Notta, F., Stein, L. D. & Gallinger, S., Jun 2017, In : JAMA Oncology. 3, 6, p. 774-783 10 p.

Research output: Contribution to journalArticle

97 Scopus citations

Autocrine IGF1 Signaling Mediates Pancreatic Tumor Cell Dormancy in the Absence of Oncogenic Drivers

Rajbhandari, N., Lin, W. C., Wehde, B. L., Triplett, A. A. & Wagner, K. U., Feb 28 2017, In : Cell Reports. 18, 9, p. 2243-2255 13 p.

Research output: Contribution to journalArticle

16 Scopus citations

Biodistribution of Self-Assembling Polymer-Gemcitabine Conjugate after Systemic Administration into Orthotopic Pancreatic Tumor Bearing Mice

Kattel, K., Mondal, G., Lin, F., Kumar, V. & Mahato, R. I., May 1 2017, In : Molecular Pharmaceutics. 14, 5, p. 1365-1372 8 p.

Research output: Contribution to journalArticle

11 Scopus citations

CBL family E3 ubiquitin ligases control JAK2 ubiquitination and stability in hematopoietic stem cells and myeloid malignancies

Kaosheng, L., Jiang, J., Donaghy, R., Riling, C. R., Cheng, Y., Chandra, V., Rozenova, K., An, W., Mohapatra, B. C., Goetz, B. T., Pillai, V., Han, X., Todd, E. A., Jeschke, G. R., Langdon, W. Y., Kumar, S., Hexner, E. O., Band, H. & Tong, W., May 15 2017, In : Genes and Development. 31, 10, p. 1007-1023 17 p.

Research output: Contribution to journalArticle

11 Scopus citations

CDK1-mediated mitotic phosphorylation of PBK is involved in cytokinesis and inhibits its oncogenic activity

Stauffer, S., Zeng, Y., Zhou, J., Chen, X., Chen, Y. & Dong, J., Nov 2017, In : Cellular Signalling. 39, p. 74-83 10 p.

Research output: Contribution to journalArticle

11 Scopus citations

Characterization of butyrylcholinesterase in bovine serum

Dafferner, A. J., Lushchekina, S., Masson, P., Xiao, G., Schopfer, L. M. & Lockridge, O., Mar 25 2017, In : Chemico-Biological Interactions. 266, p. 17-27 11 p.

Research output: Contribution to journalArticle

10 Scopus citations

Chemically induced degradation of CDK9 by a proteolysis targeting chimera (PROTAC)

Robb, C. M., Contreras, J. I., Kour, S., Taylor, M. A., Abid, M., Sonawane, Y. A., Zahid, M., Murry, D. J., Natarajan, A. & Rana, S., 2017, In : Chemical Communications. 53, 54, p. 7577-7580 4 p.

Research output: Contribution to journalArticle

70 Scopus citations

Chemical shift assignments of the connexin37 carboxyl terminal domain

Li, H., Spagnol, G., Pontifex, T. K., Burt, J. M. & Sorgen, P. L., Oct 1 2017, In : Biomolecular NMR Assignments. 11, 2, p. 137-141 5 p.

Research output: Contribution to journalArticle

3 Scopus citations

Chemosensitization and inhibition of pancreatic cancer stem cell proliferation by overexpression of microRNA-205

Chaudhary, A. K., Mondal, G., Kumar, V., Kattel, K. & Mahato, R. I., Aug 28 2017, In : Cancer Letters. 402, p. 1-8 8 p.

Research output: Contribution to journalArticle

39 Scopus citations

Combination therapy of paclitaxel and cyclopamine polymer-drug conjugates to treat advanced prostate cancer

Yang, R., Mondal, G., Wen, D. & Mahato, R. I., Feb 1 2017, In : Nanomedicine: Nanotechnology, Biology, and Medicine. 13, 2, p. 391-401 11 p.

Research output: Contribution to journalArticle

22 Scopus citations

Combination treatment with orlistat-containing nanoparticles and taxanes is synergistic and enhances microtubule stability in taxane-resistant prostate cancer cells

Souchek, J. J., Davis, A. L., Hill, T. K., Holmes, M. B., Qi, B., Singh, P. K., Kridel, S. J. & Mohs, A. M., Sep 2017, In : Molecular cancer therapeutics. 16, 9, p. 1819-1830 12 p.

Research output: Contribution to journalArticle

15 Scopus citations

Computational Model and Dynamics of Monomeric Full-Length APOBEC3G

Gorle, S., Pan, Y., Sun, Z., Shlyakhtenko, L. S., Harris, R. S., Lyubchenko, Y. L. & Vuković, L., Nov 22 2017, In : ACS Central Science. 3, 11, p. 1180-1188 9 p.

Research output: Contribution to journalArticle

10 Scopus citations

Control of mitochondrial homeostasis by endocytic regulatory proteins

Farmer, T., Reinecke, J. B., Xie, S., Bahl, K., Naslavsky, N. & Caplan, S., Jul 15 2017, In : Journal of cell science. 130, 14, p. 2359-2370 12 p.

Research output: Contribution to journalArticle

17 Scopus citations

Crebbp loss cooperates with Bcl2 overexpression to promote lymphoma in mice

García-Ramírez, I., Tadros, S., González-Herrero, I., Martín-Lorenzo, A., Rodríguez-Hernández, G., Moore, D., Ruiz-Roca, L., Blanco, O., Alonso-López, D., De Las Rivas, J., Hartert, K., Duval, R., Klinkebiel, D., Bast, M., Vose, J., Lunning, M., Fu, K., Greiner, T., Rodrigues-Lima, F., Jiménez, R. & 7 others, Criado, F. J. G., Cenador, M. B. G., Brindle, P., Vicente-Dueñas, C., Alizadeh, A., Sánchez-García, I. & Green, M. R., May 11 2017, In : Blood. 129, 19, p. 2645-2656 12 p.

Research output: Contribution to journalArticle

32 Scopus citations

Crystal structure of the human Polε B-subunit in complex with the C-terminal domain of the catalytic subunit

Baranovskiy, A. G., Gu, J., Babayeva, N. D., Kurinov, I., Pavlov, Y. I. & Tahirov, T. H., Sep 22 2017, In : Journal of Biological Chemistry. 292, 38, p. 15717-15730 14 p.

Research output: Contribution to journalArticle

Open Access
14 Scopus citations

CXCR1/2 chemokine network regulates melanoma resistance to chemotherapies mediated by NF-κB

Wu, S., Saxena, S., Varney, M. L. & Singh, R. K., Jul 1 2017, In : Current Molecular Medicine. 17, 6, p. 436-449 14 p.

Research output: Contribution to journalArticle

6 Scopus citations

Cyclin-dependent kinase 1 (CDK1)-mediated mitotic phosphorylation of the transcriptional co-repressor Vgll4 inhibits its tumor-suppressing activity

Zeng, Y., Stauffer, S., Zhou, J., Chen, X., Chen, Y. & Dong, J., Sep 8 2017, In : Journal of Biological Chemistry. 292, 36, p. 15028-15038 11 p.

Research output: Contribution to journalArticle

8 Scopus citations

Cyproterone acetate enhances TRAIL-induced androgen-independent prostate cancer cell apoptosis via up-regulation of death receptor 5

Chen, L., Wolff, D. W., Xie, Y., Lin, M. F. & Tu, Y., Mar 7 2017, In : BMC cancer. 17, 1, 179.

Research output: Contribution to journalArticle

7 Scopus citations

Defect of Fe-S cluster binding by DNA polymerase δ in yeast suppresses UV-induced mutagenesis, but enhances DNA polymerase ζ – dependent spontaneous mutagenesis

Stepchenkova, E. I., Tarakhovskaya, E. R., Siebler, H. M. & Pavlov, Y. I., Jan 1 2017, In : DNA Repair. 49, p. 60-69 10 p.

Research output: Contribution to journalArticle

7 Scopus citations

De Novo lipid synthesis facilitates gemcitabine resistance through endoplasmic reticulum stress in pancreatic cancer

Tadros, S., Shukla, S. K., King, R. J., Gunda, V., Vernucci, E., Abrego, J., Chaika, N. V., Yu, F., Lazenby, A. J., Berim, L., Grem, J., Sasson, A. R. & Singh, P. K., Oct 15 2017, In : Cancer Research. 77, 20, p. 5503-5517 15 p.

Research output: Contribution to journalArticle

35 Scopus citations

Design, Synthesis and Biological Evaluation of novel Hedgehog Inhibitors for treating Pancreatic Cancer

Kumar, V., Chaudhary, A. K., Dong, Y., Zhong, H. A., Mondal, G., Lin, F., Kumar, V. & Mahato, R. I., Dec 1 2017, In : Scientific reports. 7, 1, 1665.

Research output: Contribution to journalArticle

15 Scopus citations

Development of 1-((1,4-trans)-4-Aryloxycyclohexyl)-3-arylurea Activators of Heme-Regulated Inhibitor as Selective Activators of the Eukaryotic Initiation Factor 2 Alpha (eIF2α) Phosphorylation Arm of the Integrated Endoplasmic Reticulum Stress Response

Yefidoff-Freedman, R., Fan, J., Yan, L., Zhang, Q., Dos Santos, G. R. R., Rana, S., Contreras, J. I., Sahoo, R., Wan, D., Young, J., Dias Teixeira, K. L., Morisseau, C., Halperin, J., Hammock, B., Natarajan, A., Wang, P., Chorev, M. & Aktas, B. H., Jul 13 2017, In : Journal of Medicinal Chemistry. 60, 13, p. 5392-5406 15 p.

Research output: Contribution to journalArticle

7 Scopus citations

Differential responsiveness of MET inhibition in non-small-cell lung cancer with altered CBL

Tan, Y. H. C., Mirzapoiazova, T., Won, B. M., Zhu, L., Srivastava, M. K., Vokes, E. E., Husain, A. N., Batra, S. K., Sharma, S. & Salgia, R., Dec 1 2017, In : Scientific reports. 7, 1, 9192.

Research output: Contribution to journalArticle

6 Scopus citations

Discovery and characterization of small molecule Rac1 inhibitors

Arnst, J. L., Hein, A. L., Taylor, M. A., Palermo, N. Y., Contreras, J. I., Sonawane, Y. A., Wahl, A. O., Ouellette, M. M., Natarajan, A. & Yan, Y., 2017, In : Oncotarget. 8, 21, p. 34586-34600 15 p.

Research output: Contribution to journalArticle

8 Scopus citations

Discovery of novel brain permeable and G protein-biased beta-1 adrenergic receptor partial agonists for the treatment of neurocognitive disorders

Yi, B., Jahangir, A., Evans, A. K., Briggs, D., Ravina, K., Ernest, J., Farimani, A. B., Sun, W., Rajadas, J., Green, M., Feinberg, E. N., Pande, V. S. & Shamloo, M., Jul 2017, In : PloS one. 12, 7, e0180319.

Research output: Contribution to journalArticle

9 Scopus citations

Discrimination of tumor from normal tissues in a mouse model of breast cancer using CARS spectroscopy combined with PC-DFA methodology

Huang, X., Yuan, Y., Bielecki, T. A., Mohapatra, B. C., Luan, H., Silva-Lopez, E., West, W. W., Band, V., Lu, Y., Band, H. & Zhang, T. C., Sep 2017, In : Journal of Raman Spectroscopy. 48, 9, p. 1166-1170 5 p.

Research output: Contribution to journalArticle

3 Scopus citations

Distinct patterns of B-cell receptor signaling in non-Hodgkin lymphomas identified by single-cell profiling

Myklebust, J. H., Brody, J., Kohrt, H. E., Kolstad, A., Czerwinski, D. K., Wälchli, S., Green, M. R., Trøen, G., Liestø, K., Beiske, K., Houot, R., Delabie, J., Alizadeh, A. A., Irish, J. M. & Levy, R., Feb 9 2017, In : Blood. 129, 6, p. 759-770 12 p.

Research output: Contribution to journalArticle

36 Scopus citations

Easi-CRISPR: A robust method for one-step generation of mice carrying conditional and insertion alleles using long ssDNA donors and CRISPR ribonucleoproteins

Quadros, R. M., Miura, H., Harms, D. W., Akatsuka, H., Sato, T., Aida, T., Redder, R., Richardson, G. P., Inagaki, Y., Sakai, D., Buckley, S. M., Seshacharyulu, P., Batra, S. K., Behlke, M. A., Zeiner, S. A., Jacobi, A. M., Izu, Y., Thoreson, W. B., Urness, L. D., Mansour, S. L. & 2 others, Ohtsuka, M. & Gurumurthy, C. B., May 17 2017, In : Genome biology. 18, 1, 92.

Research output: Contribution to journalArticle

113 Scopus citations

Effect of Loop Length and Sequence on the Stability of DNA Pyrimidine Triplexes with TAT Base Triplets

Lee, H. T., Carr, C. E., Khutsishvili, I. & Marky, L. A., Oct 5 2017, In : Journal of Physical Chemistry B. 121, 39, p. 9175-9184 10 p.

Research output: Contribution to journalArticle

4 Scopus citations

EGFR-Targeted Cationic Polymeric Mixed Micelles for Codelivery of Gemcitabine and miR-205 for Treating Advanced Pancreatic Cancer

Mondal, G., Almawash, S., Chaudhary, A. K. & Mahato, R. I., Sep 5 2017, In : Molecular Pharmaceutics. 14, 9, p. 3121-3133 13 p.

Research output: Contribution to journalArticle

16 Scopus citations

EHD4 is a novel regulator of urinary water homeostasis

Rahman, S. S., Moffitt, A. E. J., Trease, A. J., Foster, K. W., Storck, M. D., Band, H. & Boesen, E. I., 2017, In : FASEB Journal. 31, 12, p. 5217-5233 17 p.

Research output: Contribution to journalArticle

1 Scopus citations

Enhancer Reprogramming Promotes Pancreatic Cancer Metastasis

Roe, J. S., Hwang, C. I., Somerville, T. D. D., Milazzo, J. P., Lee, E. J., Da Silva, B., Maiorino, L., Tiriac, H., Young, C. M., Miyabayashi, K., Filippini, D., Creighton, B., Burkhart, R. A., Buscaglia, J. M., Kim, E. J., Grem, J. L., Lazenby, A. J., Grunkemeyer, J. A., Hollingsworth, M. A., Grandgenett, P. M. & 4 others, Egeblad, M., Park, Y., Tuveson, D. A. & Vakoc, C. R., Aug 24 2017, In : Cell. 170, 5, p. 875-888.e20

Research output: Contribution to journalArticle

117 Scopus citations

Epidermal Growth Factor Receptor activation promotes ADA3 acetylation through the AKT-p300 pathway

Srivastava, S., Mohibi, S., Mirza, S., Band, H. & Band, V., Aug 18 2017, In : Cell Cycle. 16, 16, p. 1515-1525 11 p.

Research output: Contribution to journalArticle

8 Scopus citations

Estrogen receptor alpha promotes lupus in (NZB × NZW)F1 mice in a B cell intrinsic manner

Tabor, D. E. & Gould, K. A., Jan 1 2017, In : Clinical Immunology. 174, p. 41-52 12 p.

Research output: Contribution to journalArticle

11 Scopus citations

Evaluation of methods of synchronization of cell division in yeast Saccharomyces cerevisiae

Zhuk, A. S., Stepchenkova, E. I., Pavlov, Y. I. & Inge-Vechtomov, S. G., Mar 1 2017, In : Cell and Tissue Biology. 11, 2, p. 111-122 12 p.

Research output: Contribution to journalArticle

Evaluation of Rint1 as a modifier of intestinal tumorigenesis and cancer risk

Otterpohl, K. L. & Gould, K. A., Mar 2017, In : PloS one. 12, 3, e0172247.

Research output: Contribution to journalArticle

3 Scopus citations

G-1 Inhibits breast cancer cell growth via targeting colchicine-binding site of tubulin to interfere with microtubule assembly

Lv, X., He, C., Huang, C., Hua, G., Wang, Z., Remmenga, S. W., Rodabough, K. J., Karpf, A. R., Dong, J., Davis, J. S. & Wang, C., Jun 2017, In : Molecular cancer therapeutics. 16, 6, p. 1080-1091 12 p.

Research output: Contribution to journalArticle

13 Scopus citations

GATA Factor-Regulated Samd14 Enhancer Confers Red Blood Cell Regeneration and Survival in Severe Anemia

Hewitt, K. J., Katsumura, K. R., Matson, D. R., Devadas, P., Tanimura, N., Hebert, A. S., Coon, J. J., Kim, J. S., Dewey, C. N., Keles, S., Hao, S., Paulson, R. F. & Bresnick, E. H., Aug 7 2017, In : Developmental cell. 42, 3, p. 213-225.e4

Research output: Contribution to journalArticle

10 Scopus citations

General Linker Diversification Approach to Bivalent Ligand Assembly: Generation of an Array of Ligands for the Cation-Independent Mannose 6-Phosphate Receptor

Fei, X., Zavorka, M. E., Malik, G., Connelly, C. M., MacDonald, R. G. & Berkowitz, D. B., Aug 18 2017, In : Organic Letters. 19, 16, p. 4267-4270 4 p.

Research output: Contribution to journalArticle

4 Scopus citations

Generation of Functional Human Retinal Ganglion Cells with Target Specificity from Pluripotent Stem Cells by Chemically Defined Recapitulation of Developmental Mechanism

Teotia, P., Chopra, D. A., Dravid, S. M., Van Hook, M. J., Qiu, F., Morrison, J., Rizzino, A. & Ahmad, I., Mar 1 2017, In : STEM CELLS. 35, 3, p. 572-585 14 p.

Research output: Contribution to journalArticle

28 Scopus citations

Glucose limitation alters glutamine metabolism in MUC1- overexpressing pancreatic cancer cells

Gebregiworgis, T., Purohit, V., Shukla, S. K., Tadros, S., Chaika, N. V., Abrego, J., Mulder, S. E., Gunda, V., Singh, P. K. & Powers, R., Oct 6 2017, In : Journal of proteome research. 16, 10, p. 3536-3546 11 p.

Research output: Contribution to journalArticle

9 Scopus citations

GOT1-mediated anaplerotic glutamine metabolism regulates chronic acidosis stress in pancreatic cancer cells

Abrego, J., Gunda, V., Vernucci, E., Shukla, S. K., King, R. J., Dasgupta, A., Goode, G., Murthy, D., Yu, F. & Singh, P. K., Aug 1 2017, In : Cancer Letters. 400, p. 37-46 10 p.

Research output: Contribution to journalArticle

25 Scopus citations
4 Scopus citations

hPaf1/PD2 interacts with OCT3/4 to promote self-renewal of ovarian cancer stem cells

Karmakar, S., Seshacharyulu, P., Lakshmanan, I., Vaz, A. P., Chugh, S., Sheinin, Y. M., Mahapatra, S., Batra, S. K. & Palanimuthu Ponnusamy, M., 2017, In : Oncotarget. 8, 9, p. 14806-14820 15 p.

Research output: Contribution to journalArticle

12 Scopus citations

Human apurinic/apyrimidinic endonuclease (APE1) is acetylated at DNA damage sites in chromatin, and acetylation modulates its DNA repair activity

Roychoudhury, S., Nath, S., Song, H., Hegde, M. L., Bellot, L. J., Mantha, A. K., Sengupta, S., Ray, S., Natarajan, A. & Bhakat, K. K., 2017, In : Molecular and cellular biology. 37, 6, e00401-16.

Research output: Contribution to journalArticle

22 Scopus citations

Hupresin retains binding capacity for butyrylcholinesterase and acetylcholinesterase after sanitation with sodium hydroxide

Onder, S., David, E., Tacal, O., Schopfer, L. M. & Lockridge, O., Oct 10 2017, In : Frontiers in Pharmacology. 8, OCT, 713.

Research output: Contribution to journalArticle

8 Scopus citations

Immunohistochemical expression of mucin antigens in gallbladder adenocarcinoma: MUC1-positive and MUC2-negative expression is associated with vessel invasion and shortened survival

Hiraki, T., Yamada, S., Higashi, M., Hatanaka, K., Yokoyama, S., Kitazono, I., Goto, Y., Kirishima, M., Batra, S. K., Yonezawa, S. & Tanimoto, A., Jun 2017, In : Histology and Histopathology. 32, 6, p. 585-596 12 p.

Research output: Contribution to journalArticle

7 Scopus citations

Immunopurification of Acetylcholinesterase from Red Blood Cells for Detection of Nerve Agent Exposure

Dafferner, A. J., Schopfer, L. M., Xiao, G., Cashman, J. R., Yerramalla, U., Johnson, R. C., Blake, T. A. & Lockridge, O., Oct 16 2017, In : Chemical Research in Toxicology. 30, 10, p. 1897-1910 14 p.

Research output: Contribution to journalArticle

5 Scopus citations