Eppley Institute for Cancer Research

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2017

Impact of structurally modifying hyaluronic acid on CD44 interaction

Bhattacharya, D. S., Svechkarev, D., Souchek, J. J., Hill, T. K., Taylor, M. A., Natarajan, A. & Mohs, A. M., 2017, In : Journal of Materials Chemistry B. 5, 41, p. 8183-8192 10 p.

Research output: Contribution to journalArticle

23 Scopus citations

Inhibitors of telomerase and poly(ADP-ribose) polymerases synergize to limit the lifespan of pancreatic cancer cells

Burchett, K. M., Etekpo, A., Batra, S. K., Yan, Y. & Ouellette, M. M., 2017, In : Oncotarget. 8, 48, p. 83754-83767 14 p.

Research output: Contribution to journalArticle

6 Scopus citations

Intramolecular signaling in a cardiac connexin: Role of cytoplasmic domain dimerization

Trease, A. J., Capuccino, J. M. V., Contreras, J., Harris, A. L. & Sorgen, P. L., Oct 2017, In : Journal of Molecular and Cellular Cardiology. 111, p. 69-80 12 p.

Research output: Contribution to journalArticle

3 Scopus citations

Investigation of the Melting Behavior of DNA Three-Way Junctions in the Closed and Open States

Carr, C. E. & Marky, L. A., Aug 8 2017, In : Biophysical journal. 113, 3, p. 529-539 11 p.

Research output: Contribution to journalArticle

2 Scopus citations

Iron-Sulfur Clusters in DNA Polymerases and Primases of Eukaryotes

Baranovskiy, A. G., Siebler, H. M., Pavlov, Y. I. & Tahirov, T. H., Jan 1 2017, (Accepted/In press) In : Methods in Enzymology.

Research output: Contribution to journalArticle

8 Scopus citations

Janus Kinase 2 (JAK2) dissociates hepatosteatosis from hepatocellular carcinoma in mice

Shi, S. Y., Luk, C. T., Schroer, S. A., Kim, M. J., Dodington, D. W., Sivasubramaniyam, T., Lin, L., Cai, E. P., Lu, S. Y., Wagner, K. U., Bazinet, R. P. & Woo, M., Mar 3 2017, In : Journal of Biological Chemistry. 292, 9, p. 3789-3799 11 p.

Research output: Contribution to journalArticle

8 Scopus citations

Kinase Suppressor of Ras 2 (KSR2) expression in the brain regulates energy balance and glucose homeostasis

Guo, L., Costanzo-Garvey, D. L., Smith, D. R., Neilsen, B. K., MacDonald, R. G. & Lewis, R. E., Feb 1 2017, In : Molecular Metabolism. 6, 2, p. 194-205 12 p.

Research output: Contribution to journalArticle

6 Scopus citations

Leukemic transformation in patients with myeloproliferative neoplasms: A population-based retrospective study

Shrestha, R., Giri, S., Armitage, J. O. & Bhatt, V. R., Jun 2017, In : Future Oncology. 13, 14, p. 1239-1246 8 p.

Research output: Contribution to journalArticle

Loss of claudin-3 expression induces IL6/gp130/Stat3 signaling to promote colon cancer malignancy by hyperactivating Wnt/β-catenin signaling

Ahmad, R., Kumar, B., Chen, Z., Chen, X., Müller, D., Lele, S. M., Washington, M. K., Batra, S. K., Dhawan, P. & Singh, A. B., Nov 23 2017, In : Oncogene. 36, 47, p. 6592-6604 13 p.

Research output: Contribution to journalArticle

36 Scopus citations

Macrophage JAK2 deficiency protects against high-fat diet-induced inflammation

Desai, H. R., Sivasubramaniyam, T., Revelo, X. S., Schroer, S. A., Luk, C. T., Rikkala, P. R., Metherel, A. H., Dodington, D. W., Park, Y. J., Kim, M. J., Rapps, J. A., Besla, R., Robbins, C. S., Wagner, K. U., Bazinet, R. P., Winer, D. A. & Woo, M., Dec 1 2017, In : Scientific reports. 7, 1, 7653.

Research output: Contribution to journalArticle

15 Scopus citations

Mammalian ECD protein is a novel negative regulator of the PERK arm of the unfolded protein response

Olou, A. A., Sarkar, A., Bele, A., Gurumurthy, C. B., Mir, R. A., Ammons, S. A., Mirza, S., Saleem, I., Urano, F., Band, H. & Band, V., Sep 1 2017, In : Molecular and cellular biology. 37, 18, e00030-17.

Research output: Contribution to journalArticle

1 Scopus citations

Measuring deaminated nucleotide surveillance enzyme ITPA activity with an ATP-releasing nucleotide chimera

Ji, D., Stepchenkova, E. I., Cui, J., Menezes, M. R., Pavlov, Y. I. & Kool, E. T., 2017, In : Nucleic acids research. 45, 20, p. 11515-11524 10 p.

Research output: Contribution to journalArticle

3 Scopus citations

Melting Behavior of a DNA Four-Way Junction Using Spectroscopic and Calorimetric Techniques

Carr, C. E. & Marky, L. A., Oct 18 2017, In : Journal of the American Chemical Society. 139, 41, p. 14443-14455 13 p.

Research output: Contribution to journalArticle

5 Scopus citations

Micellar delivery of miR-34a modulator rubone and paclitaxel in resistant prostate cancer

Wen, D., Peng, Y., Lin, F., Singh, R. K. & Mahato, R. I., Jun 15 2017, In : Cancer Research. 77, 12, p. 3244-3254 11 p.

Research output: Contribution to journalArticle

28 Scopus citations

Momelotinib inhibits ACVR1/ALK2, decreases hepcidin production, and ameliorates anemia of chronic disease in rodents

Asshoff, M., Petzer, V., Warr, M. R., Haschka, D., Tymoszuk, P., Demetz, E., Seifert, M., Posch, W., Nairz, M., Maciejewski, P., Fowles, P., Burns, C. J., Smith, G., Wagner, K. U., Weiss, G., Whitney, J. A. & Theurl, I., Mar 30 2017, In : Blood. 129, 13, p. 1823-1830 8 p.

Research output: Contribution to journalArticle

50 Scopus citations

Monoclonal Antibody That Recognizes Diethoxyphosphotyrosine-Modified Proteins and Peptides Independent of Surrounding Amino Acids

Onder, S., Dafferner, A. J., Schopfer, L. M., Xiao, G., Yerramalla, U., Tacal, O., Blake, T. A., Johnson, R. C. & Lockridge, O., Dec 18 2017, In : Chemical Research in Toxicology. 30, 12, p. 2218-2228 11 p.

Research output: Contribution to journalArticle

2 Scopus citations

MUC16 regulates TSPYL5 for lung cancer cell growth and chemoresistance by suppressing p53

Lakshmanan, I., Salfity, S., Seshacharyulu, P., Rachagani, S., Thomas, A., Das, S., Majhi, P. D., Nimmakayala, R. K., Vengoji, R., Lele, S. M., Ponnusamy, M. P., Batra, S. K. & Ganti, A. K., Jul 15 2017, In : Clinical Cancer Research. 23, 14, p. 3906-3917 12 p.

Research output: Contribution to journalArticle

22 Scopus citations

MUC1 and HIF-1alpha Signaling Crosstalk Induces Anabolic Glucose Metabolism to Impart Gemcitabine Resistance to Pancreatic Cancer

Shukla, S. K., Purohit, V., Mehla, K., Gunda, V., Chaika, N. V., Vernucci, E., King, R. J., Abrego, J., Goode, G. D., Dasgupta, A., Illies, A. L., Gebregiworgis, T., Dai, B., Augustine, J. J., Murthy, D., Attri, K. S., Mashadova, O., Grandgenett, P. M., Powers, R., Ly, Q. P. & 17 others, Lazenby, A. J., Grem, J. L., Yu, F., Matés, J. M., Asara, J. M., Kim, J. W., Hankins, J. H., Weekes, C., Hollingsworth, M. A., Serkova, N. J., Sasson, A. R., Fleming, J. B., Oliveto, J. M., Lyssiotis, C. A., Cantley, L. C., Berim, L. & Singh, P. K., Jul 10 2017, In : Cancer Cell. 32, 1, p. 71-87.e7

Research output: Contribution to journalArticle

120 Scopus citations

MUC1 facilitates metabolomic reprogramming in triple-negative breast cancer

Goode, G., Gunda, V., Chaika, N. V., Purohit, V., Yu, F. & Singh, P. K., May 2017, In : PloS one. 12, 5, e0176820.

Research output: Contribution to journalArticle

16 Scopus citations

MUC1-mediated metabolic alterations regulate response to radiotherapy in pancreatic cancer

Gunda, V., Souchek, J., Abrego, J., Shukla, S. K., Goode, G. D., Vernucci, E., Dasgupta, A., Chaika, N. V., King, R. J., Li, S., Wang, S., Yu, F., Bessho, T., Lin, C. & Singh, P. K., Oct 1 2017, In : Clinical Cancer Research. 23, 19, p. 5881-5891 11 p.

Research output: Contribution to journalArticle

20 Scopus citations

Mucins and associated O-glycans based immunoprofile for stratification of colorectal polyps: Clinical implication for improved colon surveillance

Krishn, S. R., Kaur, S., Sheinin, Y. M., Smith, L. M., Gautam, S. K., Patel, A., Jain, M., Juvvigunta, V., Pai, P., Lazenby, A. J., Roy, H. K. & Batra, S. K., 2017, In : Oncotarget. 8, 4, p. 7025-7038 14 p.

Research output: Contribution to journalArticle

9 Scopus citations

Mutational signatures and mutable motifs in cancer genomes

Rogozin, I. B., Pavlov, Y. I., Goncearenco, A., De, S., Lada, A. G., Poliakov, E., Panchenko, A. R. & Cooper, D. N., May 30 2017, In : Briefings in bioinformatics. 19, 6, p. 1085-1101 17 p.

Research output: Contribution to journalArticle

15 Scopus citations

Nano-Assembly of amyloid β peptide: Role of the hairpin fold

Maity, S., Hashemi, M. & Lyubchenko, Y. L., Dec 1 2017, In : Scientific reports. 7, 1, 2344.

Research output: Contribution to journalArticle

13 Scopus citations

Nanomedicines for the Treatment of CNS Diseases

Reynolds, J. L. & Mahato, R. I., Mar 1 2017, In : Journal of Neuroimmune Pharmacology. 12, 1

Research output: Contribution to journalArticle

14 Scopus citations

Nanoscale Characterization of Interaction of APOBEC3G with RNA

Pan, Y., Sun, Z., Maiti, A., Kanai, T., Matsuo, H., Li, M., Harris, R. S., Shlyakhtenko, L. S. & Lyubchenko, Y. L., Mar 14 2017, In : Biochemistry. 56, 10, p. 1473-1481 9 p.

Research output: Contribution to journalArticle

10 Scopus citations

Nanoscale Dynamics of Amyloid β-42 Oligomers As Revealed by High-Speed Atomic Force Microscopy

Banerjee, S., Sun, Z., Hayden, E. Y., Teplow, D. B. & Lyubchenko, Y. L., Dec 26 2017, In : ACS Nano. 11, 12, p. 12202-12209 8 p.

Research output: Contribution to journalArticle

40 Scopus citations

Nucleotide selectivity defect and mutator phenotype conferred by a colon cancer-associated DNA polymerase δ mutation in human cells

Mertz, T. M., Baranovskiy, A. G., Wang, J., Tahirov, T. H. & Shcherbakova, P. V., Aug 1 2017, In : Oncogene. 36, 31, p. 4427-4433 7 p.

Research output: Contribution to journalArticle

8 Scopus citations

Ovarian Cancer Stem Cells: Unraveling a Germline Connection

Parte, S. C., Smolenkov, A., Batra, S. K., Ratajczak, M. Z. & Kakar, S. S., Dec 15 2017, In : Stem Cells and Development. 26, 24, p. 1781-1803 23 p.

Research output: Contribution to journalArticle

7 Scopus citations

Pharmacokinetics and Biodistribution of GDC-0449 Loaded Micelles in Normal and Liver Fibrotic Mice

Dutta, R., Kumar, V., Peng, Y., Evande, R. E., Grem, J. L. & Mahato, R. I., Mar 1 2017, In : Pharmaceutical Research. 34, 3, p. 564-578 15 p.

Research output: Contribution to journalArticle

8 Scopus citations

Polymer conjugate of a microtubule destabilizer inhibits lung metastatic melanoma

Yang, R., Mondal, G., Ness, R. A., Arnst, K., Mundra, V., Miller, D. D., Li, W. & Mahato, R. I., Mar 10 2017, In : Journal of Controlled Release. 249, p. 32-41 10 p.

Research output: Contribution to journalArticle

2 Scopus citations

Preliminary neutron diffraction analysis of challenging human manganese superoxide dismutase crystals

Azadmanesh, J., Trickel, S. R., Weiss, K. L., Coates, L. & Borgstahl, G. E. O., Apr 1 2017, In : Acta Crystallographica Section:F Structural Biology Communications. 73, 4, p. 235-240 6 p.

Research output: Contribution to journalArticle

10 Scopus citations

Protein phosphatase 1 and phosphatase 1 nuclear targeting subunit-dependent regulation of DNA-dependent protein kinase and non-homologous end joining

Zhu, S., Fisher, L. A., Bessho, T. & Peng, A., Oct 1 2017, In : Nucleic acids research. 45, 18, p. 10583-10594 12 p.

Research output: Contribution to journalArticle

10 Scopus citations

Recombination is responsible for the increased recovery of drug-resistant mutants with hypermutated genomes in resting Yeast Diploids Expressing APOBEC deaminases

Lada, A. G., Stepchenkova, E. I., Zhuk, A. S., Kliver, S. F., Rogozin, I. B., Polev, D. E., Dhar, A. & Pavlov, Y. I., Dec 12 2017, In : Frontiers in Genetics. 8, DEC, 202.

Research output: Contribution to journalArticle

2 Scopus citations

Regulation of Cx37 channel and growth-suppressive properties by phosphorylation

Jacobsen, N. L., Pontifex, T. K., Li, H., Solan, J. L., Lampe, P. D., Sorgen, P. L. & Burt, J. M., 2017, In : Journal of cell science. 130, 19, p. 3308-3321 14 p.

Research output: Contribution to journalArticle

11 Scopus citations
10 Scopus citations
4 Scopus citations

Role of Akt2 in regulation of metastasis suppressor 1 expression and colorectal cancer metastasis

Agarwal, E., Robb, C. M., Smith, L. M., Brattain, M. G., Wang, J., Black, J. D. & Chowdhury, S., Jun 1 2017, In : Oncogene. 36, 22, p. 3104-3118 15 p.

Research output: Contribution to journalArticle

16 Scopus citations

R-Spondin1/LGR5 activates TGFβ signaling and suppresses colon cancer metastasis

Zhou, X., Geng, L., Wang, D., Yi, H., Talmon, G. & Wang, J., Dec 1 2017, In : Cancer Research. 77, 23, p. 6589-6602 14 p.

Research output: Contribution to journalArticle

20 Scopus citations
7 Scopus citations

Single-molecule probing of amyloid nano-ensembles using the polymer nanoarray approach

Maity, S., Viazovkina, E., Gall, A. & Lyubchenko, Y. L., 2017, In : Physical Chemistry Chemical Physics. 19, 25, p. 16387-16394 8 p.

Research output: Contribution to journalArticle

5 Scopus citations

Stromal content is correlated with tissue site, contrast retention, and survival in pancreatic adenocarcinoma

Torphy, R. J., Wang, Z., True-Yasaki, A., Volmar, K. E., Rashid, N., Yeh, B., Johansen, J. S., Hollingsworth, M. A., Yeh, J. J. & Collisson, E. A., 2017, In : JCO Precision Oncology. 1

Research output: Contribution to journalArticle

5 Scopus citations

Structural Insight into the Unbound State of the DNA Analogue of the PreQ1 Riboswitch: A Thermodynamic Approach

Reiling-Steffensmeier, C. & Marky, L. A., Nov 28 2017, In : Biochemistry. 56, 47, p. 6231-6239 9 p.

Research output: Contribution to journalArticle

Structure-Activity Relationship Studies with Tetrahydroquinoline Analogs as EPAC Inhibitors

Sonawane, Y. A., Zhu, Y., Garrison, J. C., Ezell, E. L., Zahid, M., Cheng, X. & Natarajan, A., Nov 9 2017, In : ACS Medicinal Chemistry Letters. 8, 11, p. 1183-1187 5 p.

Research output: Contribution to journalArticle

11 Scopus citations

Substrate-analog binding and electrostatic surfaces of human manganese superoxide dismutase

Azadmanesh, J., Trickel, S. R. & Borgstahl, G. E. O., Jul 2017, In : Journal of Structural Biology. 199, 1, p. 68-75 8 p.

Research output: Contribution to journalArticle

5 Scopus citations
4 Scopus citations

TET1-mediated DNA hypomethylation regulates the expression of MUC4 in lung cancer

Yokoyama, S., Higashi, M., Tsutsumida, H., Wakimoto, J., Hamada, T., Wiest, E., Matsuo, K., Kitazono, I., Goto, Y., Guo, X., Hamada, T., Yamada, S., Hiraki, T., Yonezawa, S., Batra, S. K., Hollingsworth, M. A. & Tanimoto, A., Mar 2017, In : Genes and Cancer. 8, 3-4, p. 517-527 11 p.

Research output: Contribution to journalArticle

8 Scopus citations

TGFβ/Smad3 regulates proliferation and apoptosis through IRS-1 inhibition in colon cancer cells

Bailey, K. L., Agarwal, E., Chowdhury, S., Luo, J., Brattain, M. G., Black, J. D. & Wang, J., Apr 2017, In : PloS one. 12, 4, e0176096.

Research output: Contribution to journalArticle

12 Scopus citations

The aggressive peripheral T-cell lymphomas: 2017

Armitage, J. O., Jul 2017, In : American Journal of Hematology. 92, 7, p. 706-715 10 p.

Research output: Contribution to journalArticle

32 Scopus citations

The C5 variant of the butyrylcholinesterase tetramer includes a noncovalently bound 60 kDa lamellipodin fragment

Schopfer, L. M., Delacour, H., Masson, P., Leroy, J., Krejci, E. & Lockridge, O., Jul 2017, In : Molecules. 22, 7, 1083.

Research output: Contribution to journalArticle

9 Scopus citations

The distinct metabolic phenotype of lung squamous cell carcinoma defines selective vulnerability to glycolytic inhibition

Goodwin, J., Neugent, M. L., Lee, S. Y., Choe, J. H., Choi, H., Enkins, D. M. R. J., Ruthenborg, R. J., Robinson, M. W., Jeong, J. Y., Wake, M., Abe, H., Takeda, N., Endo, H., Inoue, M., Xuan, Z., Yoo, H., Chen, M., Ahn, J. M., Minna, J. D., Helke, K. L. & 3 others, Singh, P. K., Shackelford, D. B. & Kim, J. W., May 26 2017, In : Nature communications. 8, 15503.

Research output: Contribution to journalArticle

56 Scopus citations