Eppley Institute for Cancer Research

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2017

TET1-mediated DNA hypomethylation regulates the expression of MUC4 in lung cancer

Yokoyama, S., Higashi, M., Tsutsumida, H., Wakimoto, J., Hamada, T., Wiest, E., Matsuo, K., Kitazono, I., Goto, Y., Guo, X., Hamada, T., Yamada, S., Hiraki, T., Yonezawa, S., Batra, S. K., Hollingsworth, M. A. & Tanimoto, A., Mar 2017, In : Genes and Cancer. 8, 3-4, p. 517-527 11 p.

Research output: Contribution to journalArticle

8 Scopus citations

TGFβ/Smad3 regulates proliferation and apoptosis through IRS-1 inhibition in colon cancer cells

Bailey, K. L., Agarwal, E., Chowdhury, S., Luo, J., Brattain, M. G., Black, J. D. & Wang, J., Apr 2017, In : PloS one. 12, 4, e0176096.

Research output: Contribution to journalArticle

12 Scopus citations

The aggressive peripheral T-cell lymphomas: 2017

Armitage, J. O., Jul 2017, In : American Journal of Hematology. 92, 7, p. 706-715 10 p.

Research output: Contribution to journalArticle

32 Scopus citations

The C5 variant of the butyrylcholinesterase tetramer includes a noncovalently bound 60 kDa lamellipodin fragment

Schopfer, L. M., Delacour, H., Masson, P., Leroy, J., Krejci, E. & Lockridge, O., Jul 2017, In : Molecules. 22, 7, 1083.

Research output: Contribution to journalArticle

9 Scopus citations

The distinct metabolic phenotype of lung squamous cell carcinoma defines selective vulnerability to glycolytic inhibition

Goodwin, J., Neugent, M. L., Lee, S. Y., Choe, J. H., Choi, H., Enkins, D. M. R. J., Ruthenborg, R. J., Robinson, M. W., Jeong, J. Y., Wake, M., Abe, H., Takeda, N., Endo, H., Inoue, M., Xuan, Z., Yoo, H., Chen, M., Ahn, J. M., Minna, J. D., Helke, K. L. & 3 others, Singh, P. K., Shackelford, D. B. & Kim, J. W., May 26 2017, In : Nature communications. 8, 15503.

Research output: Contribution to journalArticle

56 Scopus citations

The extracellular role of DNA damage repair protein APE1 in regulation of IL-6 expression

Nath, S., Roychoudhury, S., Kling, M. J., Song, H., Biswas, P., Shukla, A., Band, H., Joshi, S. & Bhakat, K. K., Nov 2017, In : Cellular Signalling. 39, p. 18-31 14 p.

Research output: Contribution to journalArticle

9 Scopus citations

The miR-487b-3p/GRM3/TGFβ signaling axis is an important regulator of colon cancer tumorigenesis

Yi, H., Geng, L., Black, A., Talmon, G., Berim, L. & Wang, J., Jun 15 2017, In : Oncogene. 36, 24, p. 3477-3489 13 p.

Research output: Contribution to journalArticle

14 Scopus citations

The T-cell receptor repertoire influences the tumor microenvironment and is associated with survival in aggressive B-cell lymphoma

Keane, C., Gould, C., Jones, K., Hamm, D., Talaulikar, D., Ellis, J., Vari, F., Birch, S., Han, E., Wood, P., Le-Cao, K. A., Green, M. R., Crooks, P., Jain, S., Tobin, J., Steptoe, R. J. & Gandhi, M. K., Apr 1 2017, In : Clinical Cancer Research. 23, 7, p. 1820-1828 9 p.

Research output: Contribution to journalArticle

25 Scopus citations

The third annual BRDS on research and development of nucleic acid-based nanomedicines

Chaudhary, A. K. & Mahato, R. I., Feb 1 2017, In : Drug Delivery and Translational Research. 7, 1, p. 188-193 6 p.

Research output: Contribution to journalArticle

1 Scopus citations

Treatment Patterns and Outcomes in Early-stage Hodgkin Lymphoma in the Elderly: A National Cancer Database Analysis

Goyal, G., Maldonado, E. B., Fan, T. J., Kanmanthareddy, A., Silberstein, P. T., Go, R. S. & Armitage, J. O., Dec 2017, In : Clinical Lymphoma, Myeloma and Leukemia. 17, 12, p. 812-818 7 p.

Research output: Contribution to journalArticle

6 Scopus citations

Tuning polypeptide-based micellar carrier for efficient combination therapy of ErbB2-positive breast cancer

Soni, K. S., Lei, F., Desale, S. S., Marky, L. A., Cohen, S. M. & Bronich, T. K., Oct 28 2017, In : Journal of Controlled Release. 264, p. 276-287 12 p.

Research output: Contribution to journalArticle

3 Scopus citations

Ubiquitin-Proteasome System Regulation of an Evolutionarily Conserved RNA Polymerase II-Associated Factor 1 Involved in Pancreatic Oncogenesis

Ferdoush, J., Karmakar, S., Barman, P., Kaja, A., Uprety, B., Batra, S. K. & Bhaumik, S. R., Nov 21 2017, In : Biochemistry. 56, 46, p. 6083-6086 4 p.

Research output: Contribution to journalArticle

2 Scopus citations

White blood cell DNA methylation and risk of breast cancer in the Prostate, Lung, colorectal, and Ovarian cancer screening trial (PLCO)

Sturgeon, S. R., Pilsner, J. R., Arcaro, K. F., Ikuma, K., Wu, H., Kim, S. M., Chopra-Tandon, N., Karpf, A. R., Ziegler, R. G., Schairer, C., Balasubramanian, R. & Reckhow, D. A., Aug 18 2017, In : Breast Cancer Research. 19, 1, 94.

Research output: Contribution to journalArticle

5 Scopus citations

Yeast DNA polymerase ζ maintains consistent activity and mutagenicity across a wide range of physiological dNTP concentrations

Kochenova, O. V., Bezalel-Buch, R., Tran, P., Makarova, A. V., Chabes, A., Burgers, P. M. J. & Shcherbakova, P. V., 2017, In : Nucleic acids research. 45, 3, p. 1200-1218 19 p.

Research output: Contribution to journalArticle

5 Scopus citations
2016

Aberrant methylation of MUC1 and MUC4 promoters are potential prognostic biomarkers for pancreatic ductal adenocarcinomas

Yokoyama, S., Higashi, M., Kitamoto, S., Oeldorf, M., Knippschild, U., Kornmann, M., Maemura, K., Kurahara, H., Wiest, E., Hamada, T., Kitazono, I., Goto, Y., Tasaki, T., Hiraki, T., Hatanaka, K., Mataki, Y., Taguchi, H., Hashimoto, S., Batra, S. K., Tanimoto, A. & 2 others, Yonezawa, S. & Hollingsworth, M. A., Jul 5 2016, In : Oncotarget. 7, 27, p. 42553-42565 13 p.

Research output: Contribution to journalArticle

24 Scopus citations

Absence of caveolin-1 leads to delayed development of chronic lymphocytic leukemia in Eμ-TCL1 mouse model

Shukla, A., Cutucache, C. E., Sutton, G. L., Pitner, M. A., Rai, K., Rai, S., Opavsky, R., Swanson, P. C. & Joshi, S. S., Jan 1 2016, In : Experimental Hematology. 44, 1, p. 30-37.e1

Research output: Contribution to journalArticle

5 Scopus citations

Acetylation of mammalian ADA3 is required for its functional roles in histone acetylation and cell proliferation

Mohibi, S., Srivastava, S., Bele, A., Mirza, S., Band, H. & Band, V., 2016, In : Molecular and cellular biology. 36, 19, p. 2487-2502 16 p.

Research output: Contribution to journalArticle

5 Scopus citations

Activation induced deaminase mutational signature overlaps with CpG methylation sites in follicular lymphoma and other cancers

Rogozin, I. B., Lada, A. G., Goncearenco, A., Green, M. R., De, S., Nudelman, G., Panchenko, A. R., Koonin, E. V. & Pavlov, Y. I., Dec 7 2016, In : Scientific reports. 6, 38133.

Research output: Contribution to journalArticle

11 Scopus citations

ADA3 regulates normal and tumor mammary epithelial cell proliferation through c-MYC

Griffin, N. I., Sharma, G., Zhao, X., Mirza, S., Srivastava, S., Dave, B. J., Aleskandarany, M., Rakha, E., Mohibi, S., Band, H. & Band, V., Nov 16 2016, In : Breast Cancer Research. 18, 1, 113.

Research output: Contribution to journalArticle

7 Scopus citations

A hierarchical framework for state-space matrix inference and clustering

Zuo, C., Chen, K., Hewitt, K. J., Bresnick, E. H. & Keleş, S., Sep 2016, In : Annals of Applied Statistics. 10, 3, p. 1348-1372 25 p.

Research output: Contribution to journalArticle

2 Scopus citations

Ajuba phosphorylation by CDK1 promotes cell proliferation and tumorigenesis

Chen, X., Stauffer, S., Chen, Y. & Dong, J., Jul 8 2016, In : Journal of Biological Chemistry. 291, 28, p. 14761-14772 12 p.

Research output: Contribution to journalArticle

21 Scopus citations

Amino acid transporter SLC6A14 is a novel and effective drug target for pancreatic cancer

Coothankandaswamy, V., Cao, S., Xu, Y., Prasad, P. D., Singh, P. K., Reynolds, C. P., Yang, S., Ogura, J., Ganapathy, V. & Bhutia, Y. D., 2016, In : British Journal of Pharmacology. 173, 23, p. 3292-3306 15 p.

Research output: Contribution to journalArticle

35 Scopus citations

Anaplastic Multiple Myeloma: An Aggressive Variant With a Poor Response to Novel Therapies

Ammannagari, N., Celotto, K., Neppalli, V., Lee, K. & Holstein, S. A., Sep 1 2016, In : Clinical Lymphoma, Myeloma and Leukemia. 16, 9, p. e129-e131

Research output: Contribution to journalArticle

5 Scopus citations

An Lck-cre transgene accelerates autoantibody production and lupus development in (NZB × NZW)F1 mice

Nelson, R. K. & Gould, K. A., Feb 1 2016, In : Lupus. 25, 2, p. 137-154 18 p.

Research output: Contribution to journalArticle

4 Scopus citations

A novel CBL-Bflox/flox mouse model allows tissue-selective fully conditional CBL/CBL-B double-knockout: CD4-Cre mediated CBL/CBL-B deletion occurs in both T-cells and hematopoietic stem cells

Goetz, B., An, W., Mohapatra, B., Zutshi, N., Iseka, F., Storck, M. D., Meza, J., Sheinin, Y., Band, V. & Band, H., Aug 1 2016, In : Oncotarget. 7, 32, p. 51107-51123 17 p.

Research output: Contribution to journalArticle

4 Scopus citations

A novel interaction of Ecdysoneless (ECD) protein with R2TP complex component RUVBL1 is required for the functional role of ECD in cell cycle progression

Mir, R. A., Bele, A., Mirza, S., Srivastava, S., Olou, A. A., Ammons, S. A., Kim, J. H., Gurumurthy, C. B., Qiu, F., Band, H. & Band, V., 2016, In : Molecular and cellular biology. 36, 6, p. 886-899 14 p.

Research output: Contribution to journalArticle

12 Scopus citations

Application of differential scanning calorimetry to measure the differential binding of ions, water and protons in the unfolding of DNA molecules

Olsen, C. M., Shikiya, R., Ganugula, R., Reiling-Steffensmeier, C., Khutsishvili, I., Johnson, S. E. & Marky, L. A., May 1 2016, In : Biochimica et Biophysica Acta - General Subjects. 1860, 5, p. 990-998 9 p.

Research output: Contribution to journalArticle

10 Scopus citations

A renewed model of pancreatic cancer evolution based on genomic rearrangement patterns

Notta, F., Chan-Seng-Yue, M., Lemire, M., Li, Y., Wilson, G. W., Connor, A. A., Denroche, R. E., Liang, S. B., Brown, A. M. K., Kim, J. C., Wang, T., Simpson, J. T., Beck, T., Borgida, A., Buchner, N., Chadwick, D., Hafezi-Bakhtiari, S., Dick, J. E., Heisler, L., Hollingsworth, M. A. & 26 others, Ibrahimov, E., Jang, G. H., Johns, J., Jorgensen, L. G. T., Law, C., Ludkovski, O., Lungu, I., Ng, K., Pasternack, D., Petersen, G. M., Shlush, L. I., Timms, L., Tsao, M. S., Wilson, J. M., Yung, C. K., Zogopoulos, G., Bartlett, J. M. S., Alexandrov, L. B., Real, F. X., Cleary, S. P., Roehrl, M. H., McPherson, J. D., Stein, L. D., Hudson, T. J., Campbell, P. J. & Gallinger, S., 2016, In : Nature. 538, 7625, p. 378-382 5 p.

Research output: Contribution to journalArticle

204 Scopus citations

A translational systems biology approach in both animals and humans identifies a functionally related module of accumbal genes involved in the regulation of reward processing and binge drinking in males

Stacey, D., Lourdusamy, A., Ruggeri, B., Maroteaux, M., Jia, T., Cattrell, A., Nymberg, C., Banaschewski, T., Bhattacharyya, S., Band, H., Barker, G., Bokde, A., Büchel, C., Carvalho, F., Conrod, P., Desrivières, S., Easton, A., Fauth-Buehler, M., Fernandez-Medarde, A., Flor, H. & 23 others, Frouin, V., Gallinat, J., Garavanh, H., Heinz, A., Ittermann, B., Lathrop, M., Lawrence, C., Loth, E., Mann, K., Martinot, J. L., Nees, F., Paus, T., Pausova, Z., Rietschel, M., Rotter, A., Santos, E., Smolka, M., Sommer, W., Mameli, M., Spanagel, R., Girault, J. A., Müller, C. & Schumann, G., May 2016, In : Journal of Psychiatry and Neuroscience. 41, 3, p. 192-202 11 p.

Research output: Contribution to journalArticle

7 Scopus citations

Bax/bak activation in the absence of Bid, Bim, Puma, and p53

Zhang, J., Huang, K., O’neill, K. L., Pang, X. & Luo, X., 2016, In : Cell Death and Disease. 7, 6, e2266.

Research output: Contribution to journalArticle

34 Scopus citations

Bile acids-mediated overexpression of MUC4 via FAK-dependent c-Jun activation in pancreatic cancer

Joshi, S., Cruz, E., Rachagani, S., Guha, S., Brand, R. E., Ponnusamy, M. P., Kumar, S. & Batra, S. K., Aug 1 2016, In : Molecular Oncology. 10, 7, p. 1063-1077 15 p.

Research output: Contribution to journalArticle

5 Scopus citations

Biophysical characterization and modeling of human Ecdysoneless (ECD) protein supports a scaffolding function

Mir, R. A., Lovelace, J., Schafer, N. P., Simone, P. D., Kellezi, A., Kolar, C., Spagnol, G., Sorgen, P. L., Band, H., Band, V. & Borgstahl, G. E. O., 2016, In : AIMS Biophysics. 3, 1, p. 195-210 16 p.

Research output: Contribution to journalArticle

1 Scopus citations

Casitas B-cell lymphoma (Cbl) proteins protect mammary epithelial cells from proteotoxicity of active c-Src accumulation

Mukhopadhyay, C., Triplett, A., Bargar, T., Heckman, C., Wagner, K. U. & Naramura, M., Dec 20 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 51, p. E8228-E8237

Research output: Contribution to journalArticle

3 Scopus citations

Cell non-autonomous regulation of hepatic IGF-1 and neonatal growth by Kinase Suppressor of Ras 2 (KSR2)

Guo, L., Costanzo-Garvey, D. L., Smith, D. R., Zavorka, M. E., Venable-Kang, M., Macdonald, R. G. & Lewis, R. E., Aug 26 2016, In : Scientific reports. 6, 32093.

Research output: Contribution to journalArticle

9 Scopus citations

Central nervous system involvement in T-cell lymphoma: A single center experience

Gurion, R., Mehta, N., Migliacci, J. C., Zelenetz, A., Moskowitz, A., Lunning, M., Moskowitz, C., Hamlin, P. & Horwitz, S., May 3 2016, In : Acta Oncologica. 55, 5, p. 561-566 6 p.

Research output: Contribution to journalArticle

18 Scopus citations

Characterization and use of HapT1-derived homologous tumors as a preclinical model to evaluate therapeutic efficacy of drugs against pancreatic tumor desmoplasia

Suklabaidya, S., Das, B., Ali, S. A., Jain, S., Swaminathan, S., Mohanty, A. K., Panda, S. K., Dash, P., Chakraborty, S., Batra, S. K. & Senapati, S., Jul 5 2016, In : Oncotarget. 7, 27, p. 41825-41842 18 p.

Research output: Contribution to journalArticle

16 Scopus citations

Characterization of Promiscuous Binding of Phosphor Ligands to Breast-Cancer-Gene 1 (BRCA1) C-Terminal (BRCT): Molecular Dynamics, Free Energy, Entropy and Inhibitor Design

You, W., Huang, Y. M. M., Kizhake, S., Natarajan, A. & Chang, C. E. A., Aug 2016, In : PLoS computational biology. 12, 8, e1005057.

Research output: Contribution to journalArticle

11 Scopus citations

Cleavage by caspase 8 and mitochondrial membrane association activate the BH3-only protein bid during TRAIL-induced apoptosis

Huang, K., Zhang, J., O'Neill, K. L., Gurumurthy, C. B., Quadros, R. M., Tu, Y. & Luo, X., May 27 2016, In : Journal of Biological Chemistry. 291, 22, p. 11843-11851 9 p.

Research output: Contribution to journalArticle

43 Scopus citations

Clinicopathological and prognostic significance of mitogen-activated protein kinases (MAPK) in breast cancers

Ahmad, D. A. J., Negm, O. H., Alabdullah, M. L., Mirza, S., Hamed, M. R., Band, V., Green, A. R., Ellis, I. O. & Rakha, E. A., Oct 1 2016, In : Breast Cancer Research and Treatment. 159, 3, p. 457-467 11 p.

Research output: Contribution to journalArticle

9 Scopus citations
7 Scopus citations

Co-delivery of small molecule hedgehog inhibitor and miRNA for treating liver fibrosis

Kumar, V., Mondal, G., Dutta, R. & Mahato, R. I., 2016, In : Biomaterials. 76, p. 144-156 13 p.

Research output: Contribution to journalArticle

30 Scopus citations

Connexin43 forms supramolecular complexes through non-overlapping binding sites for drebrin, tubulin, and ZO-1

Ambrosi, C., Ren, C., Spagnol, G., Cavin, G., Cone, A., Grintsevich, E. E., Sosinsky, G. E. & Sorgen, P. L., Jun 1 2016, In : PloS one. 11, 6, e0157073.

Research output: Contribution to journalArticle

32 Scopus citations

CSF-1 receptor signalling is governed by pre-requisite EHD1 mediated receptor display on the macrophage cell surface

Cypher, L. R., Bielecki, T. A., Huang, L., An, W., Iseka, F., Tom, E., Storck, M. D., Hoppe, A. D., Band, V. & Band, H., Sep 1 2016, In : Cellular Signalling. 28, 9, p. 1325-1335 11 p.

Research output: Contribution to journalArticle

3 Scopus citations

CXCR2 signaling regulates KRAS(G12D)-induced autocrine growth of pancreatic cancer

Purohit, A., Varney, M., Rachagani, S., Ouellette, M. M., Batra, S. K. & Singh, R. K., 2016, In : Oncotarget. 7, 6, p. 7280-7296 17 p.

Research output: Contribution to journalArticle

19 Scopus citations

Divalent ions attenuate DNA synthesis by human DNA polymerase α by changing the structure of the template/primer or by perturbing the polymerase reaction

Zhang, Y., Baranovskiy, A. G., Tahirov, E. T., Tahirov, T. H. & Pavlov, Y. I., Jul 1 2016, In : DNA Repair. 43, p. 24-33 10 p.

Research output: Contribution to journalArticle

8 Scopus citations

DNA methylome analyses implicate fallopian tube epithelia as the origin for high-grade serous ovarian cancer

Klinkebiel, D., Zhang, W., Akers, S. N., Odunsi, K. & Karpf, A. R., Sep 1 2016, In : Molecular Cancer Research. 14, 9, p. 787-794 8 p.

Research output: Contribution to journalArticle

19 Scopus citations

Dnmt3a Is a Haploinsufficient Tumor Suppressor in CD8+ Peripheral T Cell Lymphoma

Haney, S. L., Upchurch, G. M., Opavska, J., Klinkebiel, D., Hlady, R. A., Roy, S., Dutta, S., Datta, K. & Opavsky, R., Sep 2016, In : PLoS genetics. 12, 9, e1006334.

Research output: Contribution to journalArticle

12 Scopus citations

Effect of acidic pH on the stability of α-synuclein dimers

Lv, Z., Krasnoslobodtsev, A. V., Zhang, Y., Ysselstein, D., Rochet, J. C., Blanchard, S. C. & Lyubchenko, Y. L., Oct 1 2016, In : Biopolymers. p. 715-724 10 p.

Research output: Contribution to journalArticle

11 Scopus citations

Effect of MUC1/β-catenin interaction on the tumorigenic capacity of pancreatic CD133+ cells

Sousa, A. M., Rei, M., Freitas, R., Ricardo, S., Caffrey, T., David, L., Almeida, R., Hollingsworth, M. A. & Santos-Silva, F., Sep 2016, In : Oncology Letters. 12, 3, p. 1811-1817 7 p.

Research output: Contribution to journalArticle

3 Scopus citations

EGFR-Targeted Polymeric Mixed Micelles Carrying Gemcitabine for Treating Pancreatic Cancer

Mondal, G., Kumar, V., Shukla, S. K., Singh, P. K. & Mahato, R. I., Jan 11 2016, In : Biomacromolecules. 17, 1, p. 301-313 13 p.

Research output: Contribution to journalArticle

21 Scopus citations