Functional Genetics Laboratory

Research output

Research output per year 2008 2010 2014 2019

• 18 Article
• 1 Comment/debate
• 1 Letter
• 1 Review article

Research output per year

Research output per year

Search results

• 2019

  Author Correction: Quinoxaline protects zebrafish lateral line hair cells from cisplatin and aminoglycosides damage (Scientific Reports, (2018), 8, 1, (15119), 10.1038/s41598-018-33520-w)

  Rocha-Sanchez, S. M., Fuson, O., Tarang, S., Goodman, L., Pyakurel, U., Liu, H., He, D. Z. & Zallocchi, M., Dec 1 2019, In: Scientific reports. 9, 1, 8720.

  Research output: Contribution to journal › Comment/debate › peer-review

  Open Access

  • Quinoxalines 100%
  • Aminoglycosides 75%
  • Zebrafish 69%
  • Cisplatin 61%
• 2018

  Quinoxaline protects zebrafish lateral line hair cells from cisplatin and aminoglycosides damage

  Sanchez, S. M. R., Fuson, O., Tarang, S., Goodman, L., Pyakurel, U., Liu, H., He, D. Z. & Zallocchi, M., Dec 1 2018, In: Scientific reports. 8, 1, 15119.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Quinoxalines 100%
  • Aminoglycosides 75%
  • Zebrafish 69%
  • Cisplatin 61%
  • Noise 25%
  11 Scopus citations
• 2017

  Integrin α8 and Pcdh15 act as a complex to regulate cilia biogenesis in sensory cells

  Goodman, L. & Zallocchi, M., 2017, In: Journal of cell science. 130, 21, p. 3698-3712 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Cilia 100%
  • Integrins 80%
  • Monomeric GTP-Binding Proteins 25%
  • Loss of Function Mutation 24%
  • Zebrafish 21%
  16 Scopus citations
• 2016

  Endothelin-1 mediated induction of extracellular matrix genes in strial marginal cells underlies strial pathology in Alport mice

  Meehan, D. T., Delimont, D., Dufek, B., Zallocchi, M., Phillips, G., Gratton, M. A. & Cosgrove, D., Nov 1 2016, In: Hearing Research. 341, p. 100-108 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Endothelin-1 100%
  • Extracellular Matrix 77%
  • Basement Membrane 64%
  • Pathology 58%
  • Endothelin A Receptors 53%
  20 Scopus citations
• 2014

  Clarin-1 acts as a modulator of mechanotransduction activity and presynaptic ribbon assembly

  Ogun, O. & Zallocchi, M., 2014, In: Journal of Cell Biology. 207, 3, p. 375-391 17 p.

  Research output: Contribution to journal › Article › peer-review

  • FM1 43 100%
  • Deaf-Blind Disorders 98%
  • Usher Syndromes 95%
  • Photoreceptor Cells 78%
  • Mutation 69%
  26 Scopus citations

• EIAV-based retinal gene therapy in the shaker1 mouse model for usher syndrome type 1B: Development of UshStat

  Zallocchi, M., Binley, K., Lad, Y., Ellis, S., Widdowson, P., Iqball, S., Scripps, V., Kelleher, M., Loader, J., Miskin, J., Peng, Y. W., Wang, W. M., Cheung, L., Delimont, D., Mitrophanous, K. A. & Cosgrove, D., Apr 4 2014, In: PloS one. 9, 4, e94272.

  Research output: Contribution to journal › Article › peer-review

  • Type 1B Usher syndrome 100%
  • Equine infectious anemia virus 78%
  • gene therapy 69%
  • Retinal 56%
  • photoreceptors 50%
  84 Scopus citations

• Laminin α2-mediated focal adhesion kinase activation triggers Alport glomerular pathogenesis

  Delimont, D., Dufek, B. M., Meehan, D. T., Zallocchi, M., Gratton, M. A., Phillips, G. & Cosgrove, D., Jun 10 2014, In: PloS one. 9, 6, e99083.

  Research output: Contribution to journal › Article › peer-review

  • Focal Adhesion Kinase 2 100%
  • non-specific protein-tyrosine kinase 94%
  • laminin 78%
  • Phosphotransferase Inhibitor 77%
  • Laminin 67%
  42 Scopus citations

• Photoreceptors in whirler mice show defective transducin translocation and are susceptible to short-term light/dark changes-induced degeneration

  Tian, M., Wang, W., Delimont, D., Cheung, L., Zallocchi, M., Cosgrove, D. & Peng, Y. W., Jan 2014, In: Experimental Eye Research. 118, p. 145-153 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Transducin 100%
  • Light 48%
  • Usher Syndromes 44%
  • Autosomal Recessive 31 Deafness 20%
  • Retinal Photoreceptor Cell Inner Segment 16%
  18 Scopus citations

• Usher protein functions in hair cells and photoreceptors

  Cosgrove, D. & Zallocchi, M., Jan 2014, In: International Journal of Biochemistry and Cell Biology. 46, 1, p. 80-89 10 p.

  Research output: Contribution to journal › Review article › peer-review

  • Photoreceptor Cells 100%
  • Usher Syndromes 69%
  • Stereocilia 50%
  • Protein 32%
  • Proteins 29%
  76 Scopus citations
• 2013

  Light-Induced Translocation of RGS9-1 and Gβ5L in Mouse Rod Photoreceptors

  Tian, M., Zallocchi, M., Wang, W., Chen, C. K., Palczewski, K., Delimont, D., Cosgrove, D. & Peng, Y. W., Mar 28 2013, In: PloS one. 8, 3, e58832.

  Research output: Contribution to journal › Article › peer-review

  • Dark Adaptation 100%
  • dark adaptation 95%
  • Retinal Rod Photoreceptor Cells 92%
  • rods (retina) 81%
  • Rod Like Crystal 64%
  12 Scopus citations

• α1β1 Integrin/rac1-dependent mesangial invasion of glomerular capillaries in alport syndrome

  Zallocchi, M., Johnson, B. M., Meehan, D. T., Delimont, D. & Cosgrove, D., Oct 2013, In: American Journal of Pathology. 183, 4, p. 1269-1280 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Hereditary Nephritis 100%
  • Laminin 74%
  • Capillaries 66%
  • Mesangial Cells 65%
  • Integrins 64%
  31 Scopus citations
• 2012

  Regulated vesicular trafficking of specific PCDH15 and VLGR1 variants in auditory hair cells

  Zallocchi, M., Delimont, D., Meehan, D. T. & Cosgrove, D., Oct 3 2012, In: Journal of Neuroscience. 32, 40, p. 13841-13859 19 p.

  Research output: Contribution to journal › Article › peer-review

  • Auditory Hair Cells 100%
  • Stereocilia 41%
  • Proteins 25%
  • Usher Syndromes 21%
  • Hearing Disorders 20%
  20 Scopus citations

• Role for a novel Usher protein complex in hair cell synaptic maturation

  Zallocchi, M., Meehan, D. T., Delimont, D., Rutledge, J., Gratton, M. A., Flannery, J. & Cosgrove, D., Feb 17 2012, In: PloS one. 7, 2, e30573.

  Research output: Contribution to journal › Article › peer-review

  • cadherins 100%
  • Cadherins 75%
  • G-Protein-Coupled Receptors 75%
  • Stereocilia 74%
  • hairs 70%
  39 Scopus citations
• 2011

  Moderate Light-Induced Degeneration of Rod Photoreceptors with Delayed Transducin Translocation in shaker1 Mice

  Peng, Y. W., Zallocchi, M., Wang, W. M., Delimont, D. & Cosgrove, D., Aug 2011, In: Investigative Ophthalmology and Visual Science. 52, 9, p. 6421-6427 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Transducin 100%
  • Retinal Rod Photoreceptor Cells 90%
  • Light 48%
  • Usher Syndromes 34%
  • Myosin VIIa 20%
  38 Scopus citations
• 2010

  Biochemical characterization of native usher protein complexes from a vesicular subfraction of tracheal epithelial cells

  Zallocchi, M., Sisson, J. H. & Cosgrove, D., Feb 16 2010, In: Biochemistry. 49, 6, p. 1236-1247 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Epithelial Cells 100%
  • Transport Vesicles 72%
  • Protein 57%
  • rab5 GTP-Binding Proteins 51%
  • Proteins 51%
  13 Scopus citations

• Clarin-1 protein expression in photoreceptors

  Cosgrove, D. & Zallocchi, M., Jan 2010, In: Hearing Research. 259, 1-2, p. 117 1 p.

  Research output: Contribution to journal › Letter › peer-review
  3 Scopus citations

• Collagen XIII induced in vascular endothelium mediates α1β1 integrin-dependent transmigration of monocytes in renal fibrosis

  Dennis, J., Meehan, D. T., Delimont, D., Zallocchi, M., Perry, G. A., O'Brien, S., Tu, H., Pihlajaniemi, T. & Cosgrove, D., Nov 2010, In: American Journal of Pathology. 177, 5, p. 2527-2540 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Vascular Endothelium 100%
  • Integrins 85%
  • Monocytes 74%
  • Collagen 68%
  • Fibrosis 67%
  33 Scopus citations
• 2009

  Biomechanical strain causes maladaptive gene regulation, contributing to alport glomerular disease

  Meehan, D. T., Delimont, D., Cheung, L., Zallocchi, M., Sansom, S. C., Holzclaw, J. D., Rao, V. & Cosgrove, D., Nov 2009, In: Kidney International. 76, 9, p. 968-976 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Matrix Metalloproteinase 3 100%
  • Matrix Metalloproteinase 10 87%
  • Glomerular Basement Membrane 66%
  • Podocytes 64%
  • Interleukin-6 60%
  54 Scopus citations

• Localization and expression of clarin-1, the Clrn1 gene product, in auditory hair cells and photoreceptors

  Zallocchi, M., Meehan, D. T., Delimont, D., Askew, C., Garige, S., Gratton, M. A., Rothermund-Franklin, C. A. & Cosgrove, D., Sep 2009, In: Hearing Research. 255, 1-2, p. 109-120 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Auditory Hair Cells 100%
  • Protein Isoforms 56%
  • Cochlea 43%
  • Retina 36%
  • Genes 28%
  43 Scopus citations
• 2008

  Integrin α1β1 regulates matrix metalloproteinases via p38 mitogen-activated protein kinase in mesangial cells: Implications for alport syndrome

  Cosgrove, D., Meehan, D. T., Delimont, D., Pozzi, A., Chen, X., Rodgers, K. D., Tempero, R. M., Zallocchi, M. & Rao, V. H., Mar 2008, In: American Journal of Pathology. 172, 3, p. 761-773 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Matrix Metalloproteinase 11 100%
  • Hereditary Nephritis 87%
  • Mesangial Cells 71%
  • p38 Mitogen-Activated Protein Kinases 61%
  • Integrins 56%
  32 Scopus citations

• Progressive morphological and functional defects in retinas from α1 integrin-null mice

  Peng, Y. W., Zallocchi, M., Meehan, D. T., Delimont, D., Chang, B., Hawes, N., Wang, W. & Cosgrove, D., Oct 2008, In: Investigative Ophthalmology and Visual Science. 49, 10, p. 4647-4654 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Integrins 100%
  • Retina 91%
  • Basement Membrane 62%
  • Transducin 46%
  • Retinal Pigments 38%
  13 Scopus citations