Gastroenterology and Hepatology (GI)

2025

A Brief Intervention on Alcohol Use Disorder Is Associated With Treatment Access for Inpatients With Alcohol-associated Liver Disease

Twohig, P. A., Balasanova, A., Cooper, L., Le, M., Khoury, N., Manatsathit, W., Olivera, M. & Bee Peeraphatdit, T., Jan 1 2025, In: Journal of Addiction Medicine. 19, 1, p. 35-40 6 p.

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Cost-Utility Analysis of Non-Invasive Tests to Initiate Hepatocellular Carcinoma Surveillance in Metabolic Dysfunction-Associated Steatotic Liver Disease

Decharatanachart, P., Poovorawan, K., Tangkijvanich, P., Charatcharoenwitthaya, P., Peeraphatdit, T., Taychakhoonavudh, S., Treeprasertsuk, S. & Chaiteerakij, R., 2025, (Accepted/In press) In: American Journal of Gastroenterology. 3332.

Research output: Contribution to journal › Article › peer-review

Ethanol Disrupts the Protective Crosstalk Between Macrophages and HBV-Infected Hepatocytes

Ganesan, M., Pathania, A. S., Bybee, G., Kharbanda, K. K., Poluektova, L. Y. & Osna, N. A., Jan 2025, In: Biomolecules. 15, 1, 57.

Research output: Contribution to journal › Article › peer-review

Open Access

Historic p87 Is Diagnostic for Lung Cancer Preceding Clinical Presentation by at Least 4 Years

Tobi, M., Ezekwudo, D., Tobi, Y. Y., Zhao, X., Antaki, F., Rambus, M. A., Levi, E., Talwar, H. & McVicker, B., Mar 2025, In: Cancers. 17, 6, 952.

Research output: Contribution to journal › Article › peer-review

Open Access

Inflammatory Bowel Disease from the Perspective of Newer Innate Immune System Biomarkers

Tobi, M., Antaki, F., Rambus, M. A., Hellman, J., Hatfield, J., Fligiel, S. & McVicker, B., Mar 2025, In: Gastrointestinal Disorders. 7, 1, 22.

Research output: Contribution to journal › Article › peer-review

Open Access

Representation of Women in Atrial Fibrillation Ablation Randomized Controlled Trials: Systematic Review

Khaing, E., Aroudaky, A., Dircks, D., Almerstani, M., Alziadin, N., Frankel, S., Hollenberg, B., Limsiri, P., Schleifer, W., Easley, A., Tsai, S., Anderson, D., Windle, J., Khan, F., Haynatzki, G., Peeraphatdit, T., Goyal, N., Matos, C. L. D. & Naksuk, N., Jan 21 2025, In: Journal of the American Heart Association. 14, 2, e035181.

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

2024

A Practical Format to Organize Cancer Constellations Using Innate Immune System Biomarkers: Implications for Early Diagnosis and Prognostication

Tobi, M., Talwar, H., Rossi, N. F., Lockette, W. & McVicker, B., Dec 2024, In: International Journal of Translational Medicine. 4, 4, p. 726-739 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

A Prospective Multimodal Education Intervention for Providers Does Not Increase Hepatic Encephalopathy Treatment Rates

Twohig, P. A., Peeraphatdit, T. B., Samson, K., Schissel, M., Smith, L., Ashford, A., Freese, L. & McCashland, T., Jun 2024, In: Digestive Diseases and Sciences. 69, 6, p. 1996-2007 12 p.

Research output: Contribution to journal › Article › peer-review

Artificial intelligence compared with human-derived patient educational materials on cirrhosis

Pradhan, F., Fiedler, A., Samson, K., Olivera-Martinez, M., Manatsathit, W. & Peeraphatdit, T., Feb 14 2024, In: Hepatology Communications. 8, 3, e0367.

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Cancer-Associated Fibroblast Induces Acinar-to-Ductal Cell Transdifferentiation and Pancreatic Cancer Initiation Via LAMA5/ITGA4 Axis

Parte, S., Kaur, A. B., Nimmakayala, R. K., Ogunleye, A. O., Chirravuri, R., Vengoji, R., Leon, F., Nallasamy, P., Rauth, S., Alsafwani, Z. W., Lele, S., Cox, J. L., Bhat, I., Singh, S., Batra, S. K. & Ponnusamy, M. P., May 2024, In: Gastroenterology. 166, 5, p. 842-858.e5

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Coxsackievirus and adenovirus receptor expression facilitates enteroviral infections to drive the development of pancreatic cancer

Bastea, L. I., Liu, X., Fleming, A. K., Pandey, V., Döppler, H., Edenfield, B. H., Krishna, M., Zhang, L., Thompson, E. A., Grandgenett, P. M., Hollingsworth, M. A., Fairweather, D. L., Clemens, D. & Storz, P., Dec 2024, In: Nature communications. 15, 1, 10547.

Research output: Contribution to journal › Article › peer-review

Open Access

Distinct peroxisome populations differentially respond to alcohol-associated hepatic injury

Mitra, R., Adhikari, R., Davis, S. S., McVicker, B. L. & Tuma, P. L., Dec 1 2024, In: Molecular biology of the cell. 35, 12, ar156.

Research output: Contribution to journal › Article › peer-review

Effects of Interventions for Improving Awareness and Knowledge of Nonalcoholic Fatty Liver Disease Among Chinese Young Adults for Prevention of Liver Cancer—A Randomized Controlled Trial

Du, Y., Ratnapradipa, K. L., Su, D., Dong, J., Rochling, F. A. & Farazi, P. A., Jun 2024, In: Journal of Cancer Education. 39, 3, p. 253-263 11 p.

Research output: Contribution to journal › Article › peer-review

Ethanol disrupts hepatocellular lipophagy by altering Rab5-centric LD-lysosome trafficking

Schott, M. B., Rozeveld, C. N., Bhatt, S., Crossman, B., Krueger, E. W., Weller, S. G., Rasineni, K., Casey, C. A. & McNiven, M. A., May 22 2024, In: Hepatology Communications. 8, 6, e0446.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

Evaluating online patient education materials for liver cirrhosis

Twohig, P., Walsh, E., Trujillo, S., Manatsathit, W. & Peeraphatdit, T. B., Aug 2024, In: Irish Journal of Medical Science. 193, 4, p. 1799-1806 8 p.

Research output: Contribution to journal › Article › peer-review

Genetic or pharmacological GHSR blockade has sexually dimorphic effects in rodents on a high-fat diet

Lékó, A. H., Gregory-Flores, A., Marchette, R. C. N., Gomez, J. L., Vendruscolo, J. C. M., Repunte-Canonigo, V., Choung, V., Deschaine, S. L., Whiting, K. E., Jackson, S. N., Cornejo, M. P., Perello, M., You, Z. B., Eckhaus, M., Rasineni, K., Janda, K. D., Zorman, B., Sumazin, P., Koob, G. F. & Michaelides, M. & 3 others, Sanna, P. P., Vendruscolo, L. F. & Leggio, L., Dec 2024, In: Communications biology. 7, 1, 632.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

Lipid droplet-associated proteins in alcohol-associated fatty liver disease: A proteomic approach

Perumal, S. K., Day, L. Z., Arumugam, M. K., Chava, S., Kumar, V., Osna, N. A., Jacobs, J., Rasineni, K. & Kharbanda, K., Nov 2024, In: Alcohol, Clinical and Experimental Research. 48, 11, p. 2010-2021 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

PR55α-controlled protein phosphatase 2A inhibits p16 expression and blocks cellular senescence induction by γ-irradiation

Palanivel, C., Madduri, L. S. V., Hein, A. L., Jenkins, C. B., Graff, B. T., Camero, A. L., Zhou, S., Enke, C. A., Ouellette, M. M. & Yan, Y., 2024, In: Aging. 16, 5, p. 4116-4137 22 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

Predicting Regression of Barrett’s Esophagus—Can All the King’s Men Put It Together Again?

Tobi, M., Khoury, N., Al-Subee, O., Sethi, S., Talwar, H., Kam, M., Hatfield, J., Levi, E., Hallman, J., Moyer, M. P., Kresty, L., Lawson, M. J. & McVicker, B., Sep 2024, In: Biomolecules. 14, 9, 1182.

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Role of ghrelin hormone in the development of alcohol-associated liver disease

Mahalingam, S., Bellamkonda, R., Kharbanda, K. K., Arumugam, M. K., Kumar, V., Casey, C. A., Leggio, L. & Rasineni, K., May 2024, In: Biomedicine and Pharmacotherapy. 174, 116595.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

Survival Difference of Colorectal Adenocarcinoma Among Racial and Ethnic Minority Groups: A SEER Database Study

Tan, A. J., Tran, C., Aliyev, N., Rochling, F. & Sempokuya, T., Oct 2024, In: Hawai'i journal of medicine & public health : a journal of Asia Pacific Medicine & Public Health. 83, 10, p. 279-285 7 p.

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Textbook outcome in short bowel syndrome

Thompson, J. S., Rochling, F. A., Lyden, E., Merani, S., Vargas, L., Grant, W. J., Langnas, A. N. & Mercer, D. F., Dec 2024, In: American journal of surgery. 238, 115972.

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

The Innate Immune System Surveillance Biomarker p87 in African Americans and Caucasians with Small High-Grade Dysplastic Adenoma [SHiGDA] and Right-Sided JAK3 Colon Mutations May Explain the Presence of Multiple Cancers Revealing an Important Minority of Patients with JAK3 Mutations and Colorectal Neoplasia

Tobi, M., Zhao, X., Rodriquez, R., Tobi, Y. Y., Ganguly, T., Kuhn, D., McVicker, B., Lawson, M. J., Lieb, J. & Lopes, J. L., Jun 2024, In: Gastrointestinal Disorders. 6, 2, p. 497-512 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

You can't handle the truth! Comparing serum phosphatidylethanol to self-reported alcohol intake in chronic liver disease patients

Scholten, K., Twohig, P., Samson, K., Brittan, K., Fiedler, A., Warner, J., Sempokuya, T., Willet, A., Peeraphatdit, T. & Olivera, M., Jul 2024, In: Digestive and Liver Disease. 56, 7, p. 1215-1219 5 p.

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

2023

Alcohol-induced tubulin post-translational modifications directly alter hepatic protein trafficking

Adhikari, R., Mitra, R., Bennett, R. G., McVicker, B. L. & Tuma, P. L., Apr 2023, In: Hepatology Communications. 7, 4, e0103.

Research output: Contribution to journal › Article › peer-review

Open Access

11 Scopus citations

Development and Validation of a Questionnaire to Assess Awareness and Knowledge of Nonalcoholic Fatty Liver Disease, a Liver Cancer Etiological Factor, among Chinese Young Adults

Du, Y., Rochling, F. A., Su, D., Ratnapradipa, K. L., Dong, J. & Farazi, P. A., 2023, In: Asian Pacific Journal of Cancer Prevention. 24, 5, p. 1543-1551 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

Ethanol Exposure to Ethanol-Oxidizing HEPG2 Cells Induces Intracellular Protein Aggregation

Thomes, P. G., Rensch, G., Casey, C. A. & Donohue, T., Apr 2023, In: Cells. 12, 7, 1013.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

Factors Associated with Awareness and Knowledge of Nonalcoholic Fatty Liver Disease, a Liver Cancer Etiological Factor, Among Chinese Young Adults

Du, Y., Su, D., Ratnapradipa, K. L., Dong, J., Rochling, F. A. & Farazi, P. A., Aug 2023, In: Journal of Cancer Education. 38, 4, p. 1177-1186 10 p.

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Glucagon-like peptide 1 receptor agonist, exendin-4, reduces alcohol-associated fatty liver disease

Mahalingam, S., Bellamkonda, R., Arumugam, M. K., Perumal, S. K., Yoon, J., Casey, C., Kharbanda, K. & Rasineni, K., Jul 2023, In: Biochemical Pharmacology. 213, 115613.

Research output: Contribution to journal › Article › peer-review

Open Access

16 Scopus citations

Helicobacter pylori Status May Differentiate Two Distinct Pathways of Gastric Adenocarcinoma Carcinogenesis

Tobi, M., Weinstein, D., Kim, M., Hatfield, J., Sochacki, P., Levi, E., An, T., Hamre, M., Tolia, V., Fligiel, S., Marepally, R., Hallman, J., Bapat, B., Yuan, M., McVicker, B. & Gallinger, S., Sep 2023, In: Current Oncology. 30, 9, p. 7950-7963 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

Hepatocyte-Specific Triggering of Hepatic Stellate Cell Profibrotic Activation by Apoptotic Bodies: The Role of Hepatoma-Derived Growth Factor, HIV, and Ethanol

New-Aaron, M., Koganti, S. S., Ganesan, M., Kanika, S., Kumar, V., Wang, W., Makarov, E., Kharbanda, K. K., Poluektova, L. Y. & Osna, N. A., Mar 2023, In: International journal of molecular sciences. 24, 6, 5346.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

Hydroxysteroid 17β-dehydrogenase 11 accumulation on lipid droplets promotes ethanol-induced cellular steatosis

Thomes, P. G., Strupp, M. S., Donohue, T., Kubik, J. L., Sweeney, S., Mahmud, R., Schott, M. B., Schulze, R. J., McNiven, M. A. & Casey, C. A., Apr 2023, In: Journal of Biological Chemistry. 299, 4, 103071.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

Impact of Pruritus on Quality of Life and Current Treatment Patterns in Patients with Primary Biliary Cholangitis

the TARGET-PBC Investigators, Mar 1 2023, In: Digestive Diseases and Sciences. 68, 3, p. 995-1005 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

29 Scopus citations

Increased liver stiffness promotes hepatitis B progression by impairing innate immunity in CCl4-induced fibrotic HBV⁺ transgenic mice

Bybee, G., Moeun, Y., Wang, W., Kharbanda, K. K., Poluektova, L. Y., Kidambi, S., Osna, N. A. & Ganesan, M., 2023, In: Frontiers in immunology. 14, 1166171.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

In the SARS-CoV-2 Pandora Pandemic: Can the Stance of Premorbid Intestinal Innate Immune System as Measured by Fecal Adnab-9 Binding of p87:Blood Ferritin, Yielding the FERAD Ratio, Predict COVID-19 Susceptibility and Survival in a Prospective Population Database?

Tobi, M., Bluth, M. H., Rossi, N. F., Demian, E., Talwar, H., Tobi, Y. Y., Sochacki, P., Levi, E., Lawson, M. & McVicker, B., Apr 2023, In: International journal of molecular sciences. 24, 8, 7536.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

Lipidomic Analysis of Liver Lipid Droplets after Chronic Alcohol Consumption with and without Betaine Supplementation

Arumugam, M. K., Perumal, S. K., Rasineni, K., Donohue, T., Osna, N. A. & Kharbanda, K. K., Mar 2023, In: Biology. 12, 3, 462.

Research output: Contribution to journal › Article › peer-review

Open Access

8 Scopus citations

Liver Segment Disposition of Hepatocellular Carcinoma Predicts Microvascular Invasion

Forlemu, A. N., Nana Sede Mbakop, R., Bandaru, P., Gayam, V., Moparty, H., Sempokuya, T., Pradhan, F., Reddy, M. & Olivera, M., 2023, In: International Journal of Hepatology. 2023, 5727701.

Research output: Contribution to journal › Article › peer-review

Open Access

Mortality Increased Among Hospitalized Patients with Cirrhosis Before and Following Different Waves of the COVID-19 Pandemic

Twohig, P. A., Scholten, K., Schissel, M., Brittan, K., Barbaretta, J., Samson, K., Smith, L., Mailliard, M. & Peeraphatdit, T. B., Dec 2023, In: Digestive Diseases and Sciences. 68, 12, p. 4381-4388 8 p.

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Multiomics Approach Captures Hepatic Metabolic Network Altered by Chronic Ethanol Administration

Sakallioglu, I. T., Tripp, B., Kubik, J., Casey, C. A., Thomes, P. & Powers, R., Jan 2023, In: Biology. 12, 1, 28.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

New Alternative? Self-Assembling Peptide in Gastrointestinal Bleeding: A Systematic Review and Meta-Analysis

Dhindsa, B. S., Tun, K. M., Scholten, K. J., Deliwala, S., Naga, Y., Dhaliwal, A., Ramai, D., Saghir, S. M., Dahiya, D. S., Chandan, S., Singh, S. & Adler, D. G., Sep 2023, In: Digestive Diseases and Sciences. 68, 9, p. 3694-3701 8 p.

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Pictilisib-Induced Resistance Is Mediated through FOXO1-Dependent Activation of Receptor Tyrosine Kinases in Mucinous Colorectal Adenocarcinoma Cells

Kuracha, M. R., Govindarajan, V., Loggie, B. W., Tobi, M. & McVicker, B. L., Aug 2023, In: International journal of molecular sciences. 24, 15, 12331.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

Shc Is Implicated in Calreticulin-Mediated Sterile Inflammation in Alcoholic Hepatitis

Li, Y., Jiang, J. X., Fan, W., Fish, S. R., Das, S., Gupta, P., Mozes, G., Vancza, L., Sarkar, S., Kunimoto, K., Chen, D., Park, H., Clemens, D., Tomilov, A., Cortopassi, G. & Török, N. J., Jan 2023, In: CMGH. 15, 1, p. 197-211 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

The relationship between nutrition, gut dysbiosis, and pediatric sickle cell pain outcomes: A pilot study

Dike, C. R., Hanson, C., Davies, H. D., Obaro, S., Yu, F., Harper, J., Grace, H., Lebensburger, J., Raulji, C., Ma, J. & Mannon, P., Jul 2023, In: Pediatric Blood and Cancer. 70, 7, e30397.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

Tu1890 SOLID ORGAN TRANSPLANTATION CHANGES THE GUT MICROBIOME AND METAGENOME BUT THE METABOLOME IDENTIFIES METABOLIC SYNDROME POST TRANSPLANTATION

Mannon, P., Barnes, S. & Mannon, R. B., May 2023, In: Gastroenterology. 164, 6, p. S-1153

Research output: Contribution to journal › Article › peer-review

Validation of a Clinical Risk-based Classification System in a Large Nonalcoholic Fatty Liver Disease Real-world Cohort

TARGET-NASH Investigators, Oct 2023, In: Clinical Gastroenterology and Hepatology. 21, 11, p. 2889-2900.e10

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

2022

Acute ethanol-induced liver injury is prevented by betaine administration

Arumugam, M. K., Chava, S., Perumal, S. K., Paal, M. C., Rasineni, K., Ganesan, M., Donohue, T., Osna, N. A. & Kharbanda, K. K., Oct 4 2022, In: Frontiers in Physiology. 13, 940148.

Research output: Contribution to journal › Article › peer-review

Open Access

21 Scopus citations

Alcohol and HIV-Derived Hepatocyte Apoptotic Bodies Induce Hepatic Stellate Cell Activation

New-Aaron, M., Dagur, R. S., Koganti, S. S., Ganesan, M., Wang, W., Makarov, E., Ogunnaike, M., Kharbanda, K. K., Poluektova, L. Y. & Osna, N. A., Jul 2022, In: Biology. 11, 7, 1059.

Research output: Contribution to journal › Article › peer-review

Open Access

10 Scopus citations

Alcohol-Induced Liver Injury: Down-regulation and Redistribution of Rab3D Results in Atypical Protein Trafficking

Casey, C. A., Macke, A. J., Gough, R. R., Pachikov, A. N., Morris, M. E., Thomes, P. G., Kubik, J. L., Holzapfel, M. S. & Petrosyan, A., Feb 2022, In: Hepatology Communications. 6, 2, p. 374-388 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Scopus citations

An ultralong-acting tenofovir ProTide nanoformulation achieves monthslong HBV suppression

Das, S., Wang, W., Ganesan, M., Fonseca-Lanza, F., Cobb, D. A., Bybee, G., Sun, Y., Guo, L., Hanson, B., Cohen, S. M., Gendelman, H. E., Osna, N. A., Edagwa, B. J. & Poluektova, L. Y., Dec 2022, In: Science Advances. 8, 51, eade9582.

Research output: Contribution to journal › Article › peer-review

Open Access

13 Scopus citations

Cholecystectomy prior to short bowel syndrome does not alter nutritional prognosis

Thompson, J. S., Rochling, F. A., Lyden, E., Merani, S., Vargas, L. M., Grant, W. J., Langnas, A. N. & Mercer, D. F., Nov 2022, In: American journal of surgery. 224, 5, p. 1285-1288 4 p.

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Gastroenterology and Hepatology (GI)

Research output

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