Neurochemistry Laboratory

2022

Loss of α-9 Nicotinic Acetylcholine Receptor Subunit Predominantly Results in Impaired Postural Stability Rather Than Gaze Stability

Chang, H. H. V., Morley, B. J. & Cullen, K. E., Jan 13 2022, In: Frontiers in Cellular Neuroscience. 15, 799752.

Research output: Contribution to journal › Article › peer-review

Open Access

2021

Efferent feedback controls bilateral auditory spontaneous activity

Wang, Y., Sanghvi, M., Gribizis, A., Zhang, Y., Song, L., Morley, B., Barson, D. G., Santos-Sacchi, J., Navaratnam, D. & Crair, M., Dec 1 2021, In: Nature communications. 12, 1, 2449.

Research output: Contribution to journal › Article › peer-review

Open Access

13 Scopus citations

2019

Attenuation in nicotinic acetylcholine receptor α9 and α10 subunit double knock-out mice of experimental autoimmune encephalomyelitis

Liu, Q., Li, M., Whiteaker, P., Shi, F. D., Morley, B. J. & Lukas, R. J., Dec 2019, In: Biomolecules. 9, 12, 827.

Research output: Contribution to journal › Article › peer-review

Open Access

19 Scopus citations

Nicotinic acetylcholine receptor subunit α₇-knockout mice exhibit degraded auditory temporal processing

Felix, R. A., Chavez, V. A., Novicio, D. M., Morley, B. J. & Portfors, C. V., Aug 2019, In: Journal of Neurophysiology. 122, 2, p. 451-465 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

20 Scopus citations

2017

A time to listen: perinatal smoking affects the development of temporal sound processing

Morley, B. J. & Felix, R. A., Jun 1 2017, In: Journal of Physiology. 595, 11, p. 3241-3242 2 p.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

Distinctive roles for α7- and α9-nicotinic acetylcholine receptors in inflammatory and autoimmune responses in the murine experimental autoimmune encephalomyelitis model of multiple sclerosis

Liu, Q., Whiteaker, P., Morley, B. J., Shi, F. D. & Lukas, R. J., Sep 22 2017, In: Frontiers in Cellular Neuroscience. 11, 287.

Research output: Contribution to journal › Article › peer-review

Open Access

26 Scopus citations

Dopamine D1A directly interacts with otoferlin synaptic pathway proteins: Ca²⁺ and phosphorylation underlie an NSF-to-AP2mu1 molecular switch

Selvakumar, D., Drescher, M. J., Deckard, N. A., Ramakrishnan, N. A., Morley, B. J. & Drescher, D. G., Jan 1 2017, In: Biochemical Journal. 474, 1, p. 79-104 26 p.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Scopus citations

Generation and characterization of α9 and α10 nicotinic acetylcholine receptor subunit knockout mice on a C57BL/6J background

Morley, B. J., Dolan, D. F., Ohlemiller, K. K. & Simmons, D. D., Sep 21 2017, In: Frontiers in Neuroscience. 11, SEP, 516.

Research output: Contribution to journal › Article › peer-review

Open Access

13 Scopus citations

Nicotinic acetylcholine receptors regulate vestibular afferent gain and activation timing

Morley, B. J., Lysakowski, A., Vijayakumar, S., Menapace, D. & Jones, T. A., Apr 1 2017, In: Journal of Comparative Neurology. 525, 5, p. 1216-1233 18 p.

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

2016

Infiltration of CCR2⁺Ly6C^high proinflammatory monocytes and neutrophils into the central nervous system is modulated by nicotinic acetylcholine receptors in a model of multiple sclerosis

Jiang, W., St-Pierre, S., Roy, P., Morley, B. J., Hao, J. & Simard, A. R., Mar 1 2016, In: Journal of Immunology. 196, 5, p. 2095-2108 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

58 Scopus citations

Nicotinic acetylcholine receptors modulate bone marrow-derived pro-inflammatory monocyte production and survival

St-Pierre, S., Jiang, W., Roy, P., Champigny, C., LeBlanc, É., Morley, B. J., Hao, J. & Simard, A. R., Feb 2016, In: PloS one. 11, 2, e0150230.

Research output: Contribution to journal › Article › peer-review

Open Access

58 Scopus citations

2015

Essential role of GluD1 in dendritic spine development and GluN2B to GluN2A NMDAR subunit switch in the cortex and hippocampus reveals ability of GluN2B inhibition in correcting hyperconnectivity

Gupta, S. C., Yadav, R., Pavuluri, R., Morley, B. J., Stairs, D. J. & Dravid, S. M., Jun 2015, In: Neuropharmacology. 93, p. 274-284 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

48 Scopus citations

2014

Acetylcholine receptors in the retinas of the α7 nicotinic acetylcholine receptor knockout mouse

Smith, M. L., Oliveira Souza, F. G., Bruce, K. S., Strang, C. E., Morley, B. J. & Keyser, K. T., Sep 20 2014, In: Molecular Vision. 20, p. 1328-1356 29 p.

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Calcium regulates molecular interactions of otoferlin with soluble NSF attachment protein receptor (SNARE) proteins required for hair cell exocytosis

Ramakrishnan, N. A., Drescher, M. J., Morley, B. J., Kelley, P. M. & Drescher, D. G., Mar 30 2014, In: Journal of Biological Chemistry. 289, 13, p. 8750-8766 17 p.

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

2013

Dendritic spine alterations in the hippocampus and parietal cortex of alpha7 nicotinic acetylcholine receptor knockout mice

Morley, B. J. & Mervis, R. F., Mar 3 2013, In: Neuroscience. 233, p. 54-63 10 p.

Research output: Contribution to journal › Article › peer-review

44 Scopus citations

Differential modulation of EAE by α9- and β2- nicotinic acetylcholine receptors

Simard, A. R., Gan, Y., St-Pierre, S., Kousari, A., Patel, V., Whiteaker, P., Morley, B. J., Lukas, R. J. & Shi, F. D., Mar 2013, In: Immunology and Cell Biology. 91, 3, p. 195-200 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

46 Scopus citations

2011

Spatial and temporal expression patterns of nicotinic acetylcholine alpha 9 and alpha 10 subunits in the embryonic and early postnatal inner ear

Simmons, D. D. & Morley, B. J., Oct 27 2011, In: Neuroscience. 194, p. 326-336 11 p.

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

2005

Nicotinic cholinergic intercellular communication: Implications for the developing auditory system

Morley, B. J., Aug 2005, In: Hearing Research. 206, 1-2, p. 74-88 15 p.

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

2004

A phenotype for the α7 nicotinic acetylcholine receptor null mutant

Morley, B. J. & Rodriguez-Sierra, J. F., Oct 8 2004, In: Brain Research. 1023, 1, p. 41-47 7 p.

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Distribution and postnatal development of α7 nicotinic acetylcholine receptors in the rodent lower auditory brainstem

Happe, H. K. & Morley, B. J., Oct 15 2004, In: Developmental Brain Research. 153, 1, p. 29-37 9 p.

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Transient expression of acetylcholinesterase in the posterior ventral cochlear nucleus of rat brain

Morley, B. J., Warr, W. B. & Rodriguez-Sierra, J., Dec 2004, In: JARO - Journal of the Association for Research in Otolaryngology. 5, 4, p. 391-403 13 p.

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

2002

Developmental mRNA expression of the α10 nicotinic acetylcholine receptor subunit in the rat cochlea

Morley, B. J. & Simmons, D. D., Nov 15 2002, In: Developmental Brain Research. 139, 1, p. 87-96 10 p.

Research output: Contribution to journal › Article › peer-review

46 Scopus citations

2000

Cholinergic receptors: Dual roles in transduction and plasticity

Morley, B. J. & Happe, H. K., Sep 2000, In: Hearing Research. 147, 1-2, p. 104-112 9 p.

Research output: Contribution to journal › Article › peer-review

64 Scopus citations

1999

Olivocochlear neurons in the chinchilla: A retrograde fluorescent labelling study

Azeredo, W. J., Kliment, M. L., Morley, B. J., Relkin, E., Slepecky, N. B., Sterns, A., Warr, W. B., Weekly, J. M. & Woods, C. I., Aug 1999, In: Hearing Research. 134, 1-2, p. 57-70 14 p.

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

1998

ARIA is heavily expressed in rat peripheral auditory and vestibular ganglia

Morley, B. J., Feb 1998, In: Molecular Brain Research. 54, 1, p. 170-174 5 p.

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Differential expression of the α9 nicotinic acetylcholine receptor subunit in neonatal and adult cochlear hair cells

Simmons, D. D. & Morley, B. J., May 1998, In: Molecular Brain Research. 56, 1-2, p. 287-292 6 p.

Research output: Contribution to journal › Article › peer-review

57 Scopus citations

Identification of the subunits of the nicotinic cholinergic receptors in the rat cochlea using RT-PCR and in situ hybridization

Morley, B. J., Li, H. S., Hiel, H., Drescher, D. G. & Elgoyhen, A. B., Jan 1998, In: Molecular Brain Research. 53, 1-2, p. 78-87 10 p.

Research output: Contribution to journal › Article › peer-review

74 Scopus citations

Nicotinic acetylcholine receptors in rat cochlear nucleus: [¹²⁵I]- α-bungarotoxin receptor autoradiography and in situ hybridization of α7 nAChR subunit mRNA

Happe, H. K. & Morley, B. J., Jul 27 1998, In: Journal of Comparative Neurology. 397, 2, p. 163-180 18 p.

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

1997

The embryonic and post-natal expression of the nicotinic receptor α₃-subunit in rat lower brainstem

Morley, B. J., Sep 1997, In: Molecular Brain Research. 48, 2, p. 407-412 6 p.

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

1996

Expression of nicotinic acetylcholine receptor mRNA in the adult rat peripheral vestibular system

Hiel, H., Elgoyhen, A. B., Drescher, D. G. & Morley, B. J., Nov 4 1996, In: Brain Research. 738, 2, p. 347-352 6 p.

Research output: Contribution to journal › Article › peer-review

76 Scopus citations

Regional distribution of a creatine transporter in rat auditory brainstem: An in-situ hybridization study

Hiel, H., Happe, H. K., Warr, W. B. & Morley, B. J., Sep 1 1996, In: Hearing Research. 98, 1-2, p. 29-37 9 p.

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

1995

Analysis of nicotinic acetylcholine receptor subunits in the cochlea of the mouse

Drescher, D. G., Khan, K. M., Green, G. E., Morley, B. J., Beisel, K. W., Kaul, H., Gordon, D., Gupta, A. K., Drescher, M. J. & Barretto, R. L., Nov 1995, In: Comparative Biochemistry and Physiology. Part C: Comparative. 112, 3, p. 267-273 7 p.

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

1994

Identification of a glutamate / aspartate transporter in the rat cochlea

Li, H. S., Niedzielski, A. S., Beisel, K. W., Hiel, H., Wenthold, R. J. & Morley, B. J., Aug 1994, In: Hearing Research. 78, 2, p. 235-242 8 p.

Research output: Contribution to journal › Article › peer-review

54 Scopus citations

Solid‐phase peptide synthesis and biological activity of bovine thymopoietin II (bTP–11)

SMITH, D. D., CONLON, J. M., PETZEL, J., CHEN, L., MURPHY, R. F. & MORLEY, B. J., Aug 1994, In: International Journal of Peptide and Protein Research. 44, 2, p. 183-191 9 p.

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

1993

Analysis of γ‐Aminobutyric Acid_A Receptor Subunits in the Mouse Cochlea by Means of the Polymerase Chain Reaction

Drescher, D. G., Green, G. E., Khan, K. M., Hajela, K., Beisel, K. W., Morley, B. J. & Gupta, A. K., Sep 1993, In: Journal of Neurochemistry. 61, 3, p. 1167-1170 4 p.

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

Effects of neonatal thymectomy on the densities of nicotinic cholinergic receptors in skeletal muscle and brain

Morley, B. J. & Murphy, R., Apr 1993, In: Experimental Neurology. 120, 2, p. 277-282 6 p.

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

The chronic infusion of nicotine into the developing chick embryo does not alter tensity of (-)-[³H]nicotine-binding sites or vestibular function

Roll, R. L., Jones, T. A., Benowitz, N. L. & Morley, B. J., Feb 26 1993, In: Brain Research. 604, 1-2, p. 260-265 6 p.

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

1991

Selective degeneration of a putative cholinergic pathway in the chinchilla cochlea following infusion with ethylcholine aziridinium ion

Morley, B. J., Spangler, K. M., Schneider, B. L. & Javel, E., Mar 22 1991, In: Brain Research. 544, 1, p. 94-100 7 p.

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

1990

AF64A depletes hippocampal high-affinity choline uptake but does not alter the density of α-bungarotoxin binding sites or modify the effect of exogenous choline

Morley, B. J. & Garner, L. L., Jun 11 1990, In: Brain Research. 519, 1-2, p. 1-5 5 p.

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Light-dark variation in response to chronic nicotine treatment and the density of hypothalamic α-bungarotoxin receptors

Morley, B. J. & Garner, L. L., Oct 1990, In: Pharmacology, Biochemistry and Behavior. 37, 2, p. 239-245 7 p.

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

1989

AF64 depletes hypothalamic high-affinity choline uptake and disrupts the circadian rhythm of locomotor activity without altering the density of nicotinic acetylcholine receptors

Morley, B. J. & Charies Murrin, L., Dec 18 1989, In: Brain Research. 504, 2, p. 238-246 9 p.

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

α-Bungarotoxin receptors in the CNS

Morley, B. J., Jan 1 1989, In: Progress in Brain Research. 79, C, p. 101-108 8 p.

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

1987

A time course and dose-response study of the regulation of brain nicotinic receptors by dietary choline

Morley, B. J. & Fleck, D. L., Sep 22 1987, In: Brain Research. 421, 1-2, p. 21-29 9 p.

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Somatostatin‐like immunoreactivity in the midbrain of the cat

Spangler, K. M. & Morley, B. J., Jun 1 1987, In: Journal of Comparative Neurology. 260, 1, p. 87-97 11 p.

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

1986

Ganglionic nAChRs and high-affinity nicotinic binding sites are not equivalent

Kemp, G. & Morley, B. J., Sep 15 1986, In: FEBS Letters. 205, 2, p. 265-268 4 p.

Research output: Contribution to journal › Article › peer-review

Open Access

23 Scopus citations

Increases in the concentration of brain α-bungarotoxin binding sites induced by dietary choline are age-dependent

Morley, B. J. & Garner, L. L., Jul 23 1986, In: Brain Research. 378, 2, p. 315-319 5 p.

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

The interpeduncular nucleus

Morley, B. J., Jan 1986, In: International Review of Neurobiology. 28, C, p. 157-182 26 p.

Research output: Contribution to journal › Article › peer-review

63 Scopus citations

1985

Evidence that cell bodies in the arcuate nucleus of the hypothalamus are not cholinergic¹

Rodriguez-Sierra, J. F. & Morley, B. J., 1985, In: Neuroendocrinology. 41, 5, p. 427-431 5 p.

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Purification and characterization of the α-bungarotoxin binding protein from rat brain

Kemp, G., Bentley, L., McNamee, M. G. & Morley, B. J., Nov 18 1985, In: Brain Research. 347, 2, p. 274-283 10 p.

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

The development of somatostatin immunoreactivity in the interpeduncular nucleus of the cat

Morley, B. J., Spangler, K. M. & Javel, E., Jun 1985, In: Developmental Brain Research. 20, 2, p. 241-248 8 p.

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Neurochemistry Laboratory

Research output

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