Pharmacology & Experimental Neuroscience (PEN)

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2020

Abnormal methylation of PIK3AP1 was involved in regulating the immune inflammatory response of GES-1 cells induced by Helicobacter pylori

Zhang, A., Yan, S., Cao, M., Wu, D., Zhou, J., Yu, Z., Wu, M., Liu, Y., Lu, S., Hu, G. & Zhao, J., Mar 26 2020, In : Biochemical and Biophysical Research Communications. 524, 1, p. 36-42 7 p.

Research output: Contribution to journalArticle

Accuracy analysis of fMRI and MEG activations determined by intraoperative mapping

Ellis, D. G., White, M. L., Hayasaka, S., Warren, D. E., Wilson, T. W. & Aizenberg, M. R., Feb 1 2020, In : Neurosurgical focus. 48, 2, p. E13

Research output: Contribution to journalArticle

Open Access

Activation of LXRβ Signaling in the Amygdala Confers Anxiolytic Effects Through Rebalancing Excitatory and Inhibitory Neurotransmission upon Acute Stress

Yu, W., Wang, L., Yang, L., Li, Y. J., Wang, M., Qiu, C., Yang, Q., Li, X. B., Huang, Y. L., Liu, R. & Wu, Y. M., Jan 1 2020, (Accepted/In press) In : Neurotherapeutics.

Research output: Contribution to journalArticle

Agonist-specific desensitization of PGE2-stimulated cAMP signaling due to upregulated phosphodiesterase expression in human lung fibroblasts

Nunez, F. J., Schulte, N. A., Fogel, D. M., Michalski, J., Rennard, S. I., Penn, R. B., Toews, M. L. & Ostrom, R. S., May 1 2020, In : Naunyn-Schmiedeberg's Archives of Pharmacology. 393, 5, p. 843-856 14 p.

Research output: Contribution to journalArticle

Open Access

A long-acting 3TC ProTide nanoformulation suppresses HBV replication in humanized mice

Wang, W., Smith, N., Makarov, E., Sun, Y., Gebhart, C. L., Ganesan, M., Osna, N. A., Gendelman, H. E., Edagwa, B. J. & Poluektova, L. Y., Aug 2020, In : Nanomedicine: Nanotechnology, Biology, and Medicine. 28, 102185.

Research output: Contribution to journalArticle

Open Access

Amplification of Replication Competent HIV-1 by Adoptive Transfer of Human Cells From Infected Humanized Mice

Su, H., Sravanam, S., Gorantla, S., Kaminski, R., Khalili, K., Poluektova, L., Gendelman, H. E. & Dash, P. K., Feb 11 2020, In : Frontiers in Cellular and Infection Microbiology. 10, 38.

Research output: Contribution to journalArticle

Open Access

An elvitegravir nanoformulation crosses the blood–brain barrier and suppresses HIV-1 replication in microglia

Gong, Y., Zhi, K., Nagesh, P. K. B., Sinha, N., Chowdhury, P., Chen, H., Gorantla, S., Yallapu, M. M. & Kumar, S., May 2020, In : Viruses. 12, 5, 564.

Research output: Contribution to journalArticle

Open Access

A single lentivector DNA based immunization contains a late heterologous SIVmac251 mucosal challenge infection

Chebloune, Y., Moussa, M., Arrode-Brusés, G., Ronfort, C., Bose, D., Gagnon, J., Gumber, S., Villinger, T., Byrareddy, S. N., Kozlowski, P. A., Gosse, L., Dereuddre-Bosquet, N., Le Grand, R. & Villinger, F., May 6 2020, In : Vaccine. 38, 21, p. 3729-3739 11 p.

Research output: Contribution to journalArticle

Attention/working memory, learning and memory in adult cameroonians: Normative data, effects of HIV infection and viral genotype

Kanmogne, G. D., Fonsah, J. Y., Umlauf, A., Moul, J., Doh, R. F., Kengne, A. M., Tang, B., Tagny, C. T., Nchindap, E., Kenmogne, L., Franklin, D., Njamnshi, D. M., Mbanya, D., Njamnshi, A. K. & Heaton, R. K., Jan 1 2020, (Accepted/In press) In : Journal of the International Neuropsychological Society.

Research output: Contribution to journalArticle

A year-long extended release nanoformulated cabotegravir prodrug

Kulkarni, T. A., Bade, A. N., Sillman, B., Shetty, B. L. D., Wojtkiewicz, M. S., Gautam, N., Hilaire, J. R., Sravanam, S., Szlachetka, A., Lamberty, B. G., Morsey, B. M., Fox, H. S., Alnouti, Y., McMillan, J. E. M., Mosley, R. L., Meza, J., Domanico, P. L., Yue, T. Y., Moore, G., Edagwa, B. J. & 1 others, Gendelman, H. E., Jan 1 2020, (Accepted/In press) In : Nature Materials.

Research output: Contribution to journalArticle

Cocaine self-administration differentially activates microglia in the mouse brain

Burkovetskaya, M. E., Small, R., Guo, L., Buch, S. & Guo, M. L., May 29 2020, In : Neuroscience Letters. 728, 134951.

Research output: Contribution to journalArticle

Cyclophilin D Contributes to Anesthesia Neurotoxicity in the Developing Brain

Zhang, Y., Lu, P., Liang, F., Liufu, N., Dong, Y., Zheng, J. C. & Xie, Z., Feb 11 2020, In : Frontiers in Cell and Developmental Biology. 7, 396.

Research output: Contribution to journalArticle

Open Access

Feasibility of known rna polymerase inhibitors as anti-sars-cov-2 drugs

Neogi, U., Hill, K. J., Ambikan, A. T., Heng, X., Quinn, T. P., Byrareddy, S. N., Sönnerborg, A., Sarafianos, S. G. & Singh, K., May 2020, In : Pathogens. 9, 5, 320.

Research output: Contribution to journalArticle

Open Access

Glutaminase 1 Regulates Neuroinflammation After Cerebral Ischemia Through Enhancing Microglial Activation and Pro-Inflammatory Exosome Release

Gao, G., Li, C., Zhu, J., Wang, Y., Huang, Y., Zhao, S., Sheng, S., Song, Y., Ji, C., Li, C., Yang, X., Ye, L., Qi, X., Zhang, Y., Xia, X. & Zheng, J. C., Feb 7 2020, In : Frontiers in immunology. 11, 161.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

HIV-1 tat-mediated astrocytic amyloidosis involves the HIF-1α/lncRNA BACE1-AS axis

Sil, S., Hu, G., Liao, K., Niu, F., Callen, S., Periyasamy, P., Fox, H. S. & Buch, S., May 1 2020, In : PLoS biology. 18, 5, e3000660.

Research output: Contribution to journalArticle

Open Access

HIV Tat-mediated induction of autophagy regulates the disruption of ZO-1 in brain endothelial cells

Liao, K., Niu, F., Hu, G., Guo, M. L., Sil, S. & Buch, S., Jan 1 2020, (Accepted/In press) In : Tissue Barriers. 1748983.

Research output: Contribution to journalArticle

Identification and phylogenetic characterization of bovine ephemeral fever virus (BEFV) of Middle Eastern lineage associated with 2018–2019 outbreaks in India

Pyasi, S., Sahu, B. P., Sahoo, P., Dubey, P. K., Sahoo, N., Byrareddy, S. N. & Nayak, D., Jan 1 2020, (Accepted/In press) In : Transboundary and Emerging Diseases.

Research output: Contribution to journalArticle

Male HIV-1 transgenic rats show reduced cocaine-maintained lever-pressing compared to F344 wildtype rats despite similar baseline locomotion

Huynh, Y. W., Thompson, B. M., Larsen, C. E., Buch, S., Guo, M. L., Bevins, R. A. & Murray, J. E., Mar 1 2020, In : Journal of the experimental analysis of behavior. 113, 2, p. 468-484 17 p.

Research output: Contribution to journalArticle

miR-15a-5p, miR-15b-5p, and miR-16-5p inhibit tumor progression by directly targeting MYCN in neuroblastoma

Chava, S., Reynolds, C. P., Pathania, A. S., Gorantla, S., Poluektova, L. Y., Coulter, D. W., Gupta, S. C., Pandey, M. K. & Challagundla, K. B., Jan 1 2020, In : Molecular Oncology. 14, 1, p. 180-196 17 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Mitigation of cocaine-mediated mitochondrial damage, defective mitophagy and microglial activation by superoxide dismutase mimetics

Thangaraj, A., Periyasamy, P., Guo, M. L., Chivero, E. T., Callen, S. & Buch, S., Feb 1 2020, In : Autophagy. 16, 2, p. 289-312 24 p.

Research output: Contribution to journalArticle

4 Scopus citations

Monocyte metabolic reprogramming promotes pro-inflammatory activity and Staphylococcus aureus biofilm clearance

Yamada, K. J., Heim, C. E., Xi, X., Attri, K. S., Wang, D., Zhang, W., Singh, P. K., Bronich, T. K. & Kielian, T., Jan 1 2020, In : PLoS pathogens. 16, 3, e1008354.

Research output: Contribution to journalArticle

Open Access

Multiple inflammatory profiles of microglia and altered neuroimages in APP/PS1 transgenic AD mice

Liu, L., Liu, Y., Li, N., Huang, R., Zheng, X., Huang, L., Hou, S. & Yuan, Q., Mar 2020, In : Brain Research Bulletin. 156, p. 86-104 19 p.

Research output: Contribution to journalArticle

1 Scopus citations

MyD88 regulates a prolonged adaptation response to environmental dust exposure-induced lung disease

Johnson, A. N., Harkema, J. R., Nelson, A. J., Dickinson, J. D., Kalil, J., Duryee, M. J., Thiele, G. M., Kumar, B., Singh, A. B., Gaurav, R., Glover, S. C., Tang, Y., Romberger, D. J., Kielian, T. & Poole, J. A., Apr 22 2020, In : Respiratory Research. 21, 1, 97.

Research output: Contribution to journalArticle

Open Access

Neuronal-derived extracellular vesicles are enriched in the brain and serum of HIV-1 transgenic rats

Dagur, R. S., Liao, K., Sil, S., Niu, F., Sun, Z., Lyubchenko, Y. L., Peeples, E. S., Hu, G. & Buch, S., Jan 1 2020, In : Journal of Extracellular Vesicles. 9, 1, 1703249.

Research output: Contribution to journalArticle

Open Access

Neutrophils are mediators of metastatic prostate cancer progression in bone

Costanzo-Garvey, D. L., Keeley, T., Case, A. J., Watson, G. F., Alsamraae, M., Yu, Y., Su, K., Heim, C. E., Kielian, T., Morrissey, C., Frieling, J. S. & Cook, L. M., Jun 1 2020, In : Cancer Immunology, Immunotherapy. 69, 6, p. 1113-1130 18 p.

Research output: Contribution to journalArticle

Open Access

NF-κB Duplications in the Promoter-Variant HIV-1C LTR Impact Inflammation Without Altering Viral Replication in the Context of Simian Human Immunodeficiency Viruses and Opioid-Exposure

Dave, R. S., Ali, H., Sil, S., Knight, L. A., Pandey, K., Madduri, L. S. V., Qiu, F., Ranga, U., Buch, S. & Byrareddy, S. N., Jan 31 2020, In : Frontiers in immunology. 11, 95.

Research output: Contribution to journalArticle

Open Access

NMDA receptors containing GluN2C and GluN2D subunits have opposing roles in modulating neuronal oscillations; potential mechanism for bidirectional feedback

Mao, Z., He, S., Mesnard, C., Synowicki, P., Zhang, Y., Chung, L., Wiesman, A. I., Wilson, T. W. & Monaghan, D. T., Jan 15 2020, In : Brain Research. 1727, 146571.

Research output: Contribution to journalArticle

Reprogrammed astrocytes display higher neurogenic competence, migration ability and cell death resistance than reprogrammed fibroblasts

Xia, X., Li, C., Wang, Y., Deng, X., Ma, Y., Ding, L. & Zheng, J., Feb 8 2020, In : Translational Neurodegeneration. 9, 1, 6.

Research output: Contribution to journalArticle

Open Access

Rilpivirine-associated aggregation-induced emission enables cell-based nanoparticle tracking

Mukadam, I. Z., Machhi, J., Herskovitz, J., Hasan, M., Oleynikov, M. D., Blomberg, W. R., Svechkarev, D., Mohs, A. M., Zhou, Y., Dash, P., McMillan, J. E., Gorantla, S., Garrison, J., Gendelman, H. E. & Kevadiya, B. D., Feb 2020, In : Biomaterials. 231, 119669.

Research output: Contribution to journalArticle

Rod-shape theranostic nanoparticles facilitate antiretroviral drug biodistribution and activity in human immunodeficiency virus susceptible cells and tissues

Kevadiya, B. D., Ottemann, B., Mukadam, I. Z., Castellanos, L., Sikora, K., Hilaire, J. R., Machhi, J., Herskovitz, J., Soni, D., Hasan, M., Zhang, W., Anandakumar, S., Garrison, J., McMillan, J. E., Edagwa, B., Mosley, R. L., Vachet, R. W. & Gendelman, H. E., Jan 1 2020, In : Theranostics. 10, 2, p. 630-656 27 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

SARS-CoV-2 Infection Leads to Neurological Dysfunction

Acharya, A., Kevadiya, B. D., Gendelman, H. E. & Byrareddy, S. N., Jun 1 2020, In : Journal of Neuroimmune Pharmacology. 15, 2, p. 167-173 7 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Simultaneous Release of Multiple Vesicles from Rods Involves Synaptic Ribbons and Syntaxin 3B

Hays, C. L., Grassmeyer, J. J., Wen, X., Janz, R., Heidelberger, R. & Thoreson, W. B., Feb 25 2020, In : Biophysical journal. 118, 4, p. 967-979 13 p.

Research output: Contribution to journalArticle

1 Scopus citations

Small animal models for human immunodeficiency virus (HIV), hepatitis b, and tuberculosis: Proceedings of an NIAID workshop

Akkina, R., Barber, D. L., Bility, M. T., Bissig, K. D., Burwitz, B. J., Eichelberg, K., Endsley, J. J., Garcia, J. V., Hafner, R., Karakousis, P. C., Korba, B. E., Koshy, R., Lambros, C., Menne, S., Nuermberger, E. L., Ploss, A., Podell, B. K., Poluektova, L. Y., Sanders-Beer, B. E., Subbian, S. & 1 others, Wahl, A., Jan 1 2020, In : Current HIV research. 18, 1, p. 19-28 10 p.

Research output: Contribution to journalArticle

1 Scopus citations

Staphylococcus aureus fibronectin binding protein a mediates biofilm development and infection

Gries, C. M., Biddle, T., Bose, J. L., Kielian, T. & Lo, D. D., Apr 1 2020, In : Infection and immunity. 88, 5, e00859-19.

Research output: Contribution to journalArticle

Structural basis of subtype-selective competitive antagonism for GluN2C/2D-containing NMDA receptors

Wang, J. X., Irvine, M. W., Burnell, E. S., Sapkota, K., Thatcher, R. J., Li, M., Simorowski, N., Volianskis, A., Collingridge, G. L., Monaghan, D. T., Jane, D. E. & Furukawa, H., Dec 1 2020, In : Nature communications. 11, 1, 423.

Research output: Contribution to journalArticle

Open Access

Synthesis and Characterization of Long-Acting Darunavir Prodrugs

Banoub, M. G., Bade, A. N., Lin, Z., Cobb, D., Gautam, N., Dyavar Shetty, B. L., Wojtkiewicz, M., Alnouti, Y., McMillan, J., Gendelman, H. E. & Edagwa, B., Jan 6 2020, In : Molecular Pharmaceutics. 17, 1, p. 155-166 12 p.

Research output: Contribution to journalArticle

1 Scopus citations

TLR2 and caspase-1 signaling are critical for bacterial containment but not clearance during craniotomy-associated biofilm infection

Aldrich, A. L., Heim, C. E., Shi, W., Fallet, R. W., Duan, B. & Kielian, T., Apr 14 2020, In : Journal of Neuroinflammation. 17, 1, 114.

Research output: Contribution to journalArticle

Open Access

Urban airborne PM2.5-activated microglia mediate neurotoxicity through glutaminase-containing extracellular vesicles in olfactory bulb

Chen, X., Guo, J., Huang, Y., Liu, S., Huang, Y., Zhang, Z., Zhang, F., Lu, Z., Li, F., Zheng, J. C. & Ding, W., Sep 2020, In : Environmental Pollution. 264, 114716.

Research output: Contribution to journalArticle

Open Access

Variability in HIV-1 integrase gene and 3’-polypurine tract sequences in cameroon clinical isolates, and implications for integrase inhibitors efficacy

Acharya, A., Tagny, C. T., Mbanya, D., Fonsah, J. Y., Nchindap, E., Kenmogne, L., Jihyun, M., Njamnshi, A. K. & Kanmogne, G. D., Mar 1 2020, In : International journal of molecular sciences. 21, 5, 1553.

Research output: Contribution to journalArticle

Open Access
2019
5 Scopus citations

Acetaldehyde suppresses the display of HBV-MHC class I complexes on HBV-expressing hepatocytes

Ganesan, M., Krutik, V. M., Makarov, E., Mathews, S., Kharbanda, K. K., Poluektova, L. Y., Casey, C. A. & Osna, N. A., Aug 2019, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 317, 2, p. G127-G140

Research output: Contribution to journalArticle

3 Scopus citations

Adaptation of an R5 simian-human immunodeficiency virus encoding an HIV clade a envelope with or without ablation of adaptive host immunity: Differential selection of viral mutants

Zhou, M., Humbert, M., Mukhtar, M. M., Scinto, H. B., Vyas, H. K., Lakhashe, S. K., Byrareddy, S. N., Maurer, G., Thorat, S., Owuor, J., Lai, Z., Chen, Y., Griffiths, A., Chenine, A. L., Gumber, S., Villinger, F., Montefiori, D. & Ruprecht, R. M., May 1 2019, In : Journal of virology. 93, 9, e02267-18.

Research output: Contribution to journalArticle

Afatinib and Temozolomide combination inhibits tumorigenesis by targeting EGFRvIII-cMet signaling in glioblastoma cells

Vengoji, R., Macha, M. A., Nimmakayala, R. K., Rachagani, S., Siddiqui, J. A., Mallya, K., Gorantla, S., Jain, M., Ponnusamy, M. P., Batra, S. K. & Shonka, N., Jun 18 2019, In : Journal of Experimental and Clinical Cancer Research. 38, 1, 266.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Alcohol metabolism potentiates HIV-induced hepatotoxicity: Contribution to end-stage liver disease

Ganesan, M., New-Aaron, M., Dagur, R. S., Makarov, E., Wang, W., Kharbanda, K. K., Kidambi, S., Poluektova, L. Y. & Osna, N. A., Dec 2019, In : Biomolecules. 9, 12, 851.

Research output: Contribution to journalArticle

Open Access

A long acting nanoformulated lamivudine ProTide

Smith, N., Bade, A. N., Soni, D., Gautam, N., Alnouti, Y., Herskovitz, J., Ibrahim, I. M., Wojtkiewicz, M. S., Dyavar Shetty, B. L., McMillan, J. E., Gendelman, H. E. & Edagwa, B., Dec 2019, In : Biomaterials. 223, 119476.

Research output: Contribution to journalArticle

4 Scopus citations

A mouse model of seizures in anti–N-methyl-d-aspartate receptor encephalitis

Taraschenko, O., Fox, H. S., Pittock, S. J., Zekeridou, A., Gafurova, M., Eldridge, E., Liu, J., Dravid, S. M. & Dingledine, R., Mar 2019, In : Epilepsia. 60, 3, p. 452-463 12 p.

Research output: Contribution to journalArticle

6 Scopus citations

Association between Caregiver Depression and Emergency Department Use among Patients with Dementia

Guterman, E. L., Allen, I. E., Josephson, S. A., Merrilees, J. J., Dulaney, S., Chiong, W., Lee, K., Bonasera, S. J., Miller, B. L. & Possin, K. L., Oct 2019, In : JAMA Neurology. 76, 10, p. 1166-1173 8 p.

Research output: Contribution to journalArticle

3 Scopus citations

Astrocytes in juvenile neuronal ceroid lipofuscinosis (CLN3) display metabolic and calcium signaling abnormalities

Bosch, M. E. & Kielian, T., Mar 2019, In : Journal of Neurochemistry. 148, 5, p. 612-624 13 p.

Research output: Contribution to journalArticle

4 Scopus citations