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2008

Pseudo-esterase activity of human albumin: Slow turnover on tyrosine 411 and stable acetylation of 82 residues including 59 lysines

Lockridge, O., Xue, W., Gaydess, A., Grigoryan, H., Ding, S. J., Schopfer, L. M., Hinrichs, S. H. & Masson, P., Aug 15 2008, In : Journal of Biological Chemistry. 283, 33, p. 22582-22590 9 p.

Research output: Contribution to journalArticle

80 Scopus citations

The butyrylcholinesterase knockout mouse as a model for human butyrylcholinesterase deficiency

Li, B., Duysen, E. G., Carlson, M. & Lockridge, O., Mar 2008, In : Journal of Pharmacology and Experimental Therapeutics. 324, 3, p. 1146-1154 9 p.

Research output: Contribution to journalArticle

63 Scopus citations

The butyrylcholinesterase knockout mouse is obese on a high-fat diet

Li, B., Duysen, E. G. & Lockridge, O., Sep 25 2008, In : Chemico-Biological Interactions. 175, 1-3, p. 88-91 4 p.

Research output: Contribution to journalArticle

53 Scopus citations
12 Scopus citations
2007
9 Scopus citations

Aging pathways for organophosphate-inhibited human butyrylcholinesterase, including novel pathways for isomalathion, resolved by mass spectrometry

Li, H., Schopfer, L. M., Nachon, F., Froment, M. T., Masson, P. & Lockridge, O., Nov 2007, In : Toxicological Sciences. 100, 1, p. 136-145 10 p.

Research output: Contribution to journalArticle

49 Scopus citations

A medical health report on individuals with silent butyrylcholinesterase in the Vysya community of India

Manoharan, I., Boopathy, R., Darvesh, S. & Lockridge, O., Mar 2007, In : Clinica Chimica Acta. 378, 1-2, p. 128-135 8 p.

Research output: Contribution to journalArticle

68 Scopus citations
39 Scopus citations

Aryl acylamidase activity of human serum albumin with o-nitrotrifluoroacetanilide as the substrate

Masson, P., Froment, M. T., Darvesh, S., Schopfer, L. M. & Lockridge, O., Aug 2007, In : Journal of Enzyme Inhibition and Medicinal Chemistry. 22, 4, p. 463-469 7 p.

Research output: Contribution to journalArticle

22 Scopus citations

Comparison of cognitive functions between people with silent and wild-type butyrylcholinesterase

Manoharan, I., Kuznetsova, A., Fisk, J. D., Boopathy, R., Lockridge, O. & Darvesh, S., Jul 2007, In : Journal of Neural Transmission. 114, 7, p. 939-945 7 p.

Research output: Contribution to journalArticle

19 Scopus citations

Crystallization and X-ray structure of full-length recombinant human butyrylcholinesterase

Ngamelue, M. N., Homma, K., Lockridge, O. & Asojo, O. A., Aug 10 2007, In : Acta Crystallographica Section F: Structural Biology and Crystallization Communications. 63, 9, p. 723-727 5 p.

Research output: Contribution to journalArticle

49 Scopus citations

Excessive hippocampal acetylcholine levels in acetylcholinesterase- deficient mice are moderated by butyrylcholinesterase activity

Hartmann, J., Kiewert, C., Duysen, E. G., Lockridge, O., Greig, N. H. & Klein, J., Mar 2007, In : Journal of Neurochemistry. 100, 5, p. 1421-1429 9 p.

Research output: Contribution to journalArticle

97 Scopus citations

Expression of three naturally occurring genetic variants (G75R, E90D, I99M) of the BCHE gene of human butyrylcholinesterase

Mikami, L. R., Wieseler, S., Souza, R. L. R., Schopfer, L. M., Lockridge, O. & Chautard-Freire-Maia, E. A., Sep 2007, In : Pharmacogenetics and Genomics. 17, 9, p. 681-685 5 p.

Research output: Contribution to journalArticle

4 Scopus citations

Genomic deletion marking an emerging subclone of Francisella tularensis subsp. holarctica in France and the Iberian Peninsula

Dempsey, M. P., Dobson, M., Zhang, C., Zhang, M., Lion, C., Gutiérrez-Martín, C. B., Iwen, P. C., Fey, P. D., Olson, M. E., Niemeyer, D., Francesconi, S., Crawford, R., Stanley, M., Rhodes, J., Wagner, D. M., Vogler, A. J., Birdsell, D., Keim, P., Johansson, A., Hinrichs, S. H. & 1 others, Benson, A. K., Nov 2007, In : Applied and environmental microbiology. 73, 22, p. 7465-7470 6 p.

Research output: Contribution to journalArticle

30 Scopus citations

Hydrolysis of oxo- and thio-esters by human butyrylcholinesterase

Masson, P., Froment, M. T., Gillon, E., Nachon, F., Lockridge, O. & Schopfer, L. M., Jan 2007, In : Biochimica et Biophysica Acta - Proteins and Proteomics. 1774, 1, p. 16-34 19 p.

Research output: Contribution to journalArticle

16 Scopus citations
88 Scopus citations

Molecular analysis of Francisella tularensis subspecies tularensis and holarctica

Fey, P. D., Dempsey, M. M. P., Olson, M. E., Chrustowski, M. S., Engle, J. L., Jay, J. J., Dobson, M. E., Kalasinsky, K. S., Shea, A. A., Iwen, P. C., Wickert, R. C., Francesconi, S. C., Crawford, R. M. & Hinrichs, S. H., Dec 2007, In : American journal of clinical pathology. 128, 6, p. 926-935 10 p.

Research output: Contribution to journalArticle

13 Scopus citations

Mucor circinelloides was identified by molecular methods as a cause of primary cutaneous zygomycosis

Iwen, P. C., Sigler, L., Noel, R. K. & Freifeld, A. G., Feb 2007, In : Journal of clinical microbiology. 45, 2, p. 636-639 4 p.

Research output: Contribution to journalArticle

30 Scopus citations

Neuropathological and immunochemical studies of brain parenchyma in acetylcholinesterase knockout mice: Implications in Alzheimer's disease

Rice, S. G., Nowak, L., Duysen, E. G., Lockridge, O., Lahiri, D. K. & Reyes, P. F., 2007, In : Journal of Alzheimer's Disease. 11, 4, p. 481-489 9 p.

Research output: Contribution to journalArticle

8 Scopus citations

Outbreak of bloodstream infection temporally associated with the use of an intravascular needleless valve

Rupp, M. E., Sholtz, L. A., Jourdan, D. R., Marion, N. D., Tyner, L. K., Fey, P. D., Iwen, P. C. & Anderson, J. R., Jun 1 2007, In : Clinical Infectious Diseases. 44, 11, p. 1408-1414 7 p.

Research output: Contribution to journalArticle

83 Scopus citations
9 Scopus citations
68 Scopus citations

Shared as well as distinct roles of EHD proteins revealed by biochemical and functional comparisons in mammalian cells and C. elegans

George, M., Ying, G. G., Rainey, M. A., Solomon, A., Parikh, P. T., Gao, Q., Band, V. & Band, H., 2007, In : BMC Cell Biology. 8, 3.

Research output: Contribution to journalArticle

80 Scopus citations
2006

A mutation linked with autism reveals a common mechanism of endoplasmic reticulum retention for the α,β-hydrolase fold protein family

De Jaco, A., Comoletti, D., Kovarik, Z., Gaietta, G., Radić, Z., Lockridge, O., Ellisman, M. H. & Taylor, P., Apr 7 2006, In : Journal of Biological Chemistry. 281, 14, p. 9667-9676 10 p.

Research output: Contribution to journalArticle

44 Scopus citations

Designing a biocontainment unit to care for patients with serious communicable diseases: A consensus statement

Smith, P. W., Anderson, A. O., Christopher, G. W., Cieslak, T. J., Devreede, G. J., Fosdick, G. A., Greiner, C. B., Hauser, J. M., Hinrichs, S. H., Huebner, K. D., Iwen, P. C., Jourdan, D. R., Kortepeter, M. G., Landon, V. P., Lenaghan, P. A., Leopold, R. E., Marklund, L. A., Martin, J. W., Medcalf, S. J., Mussack, R. J. & 12 others, Neal, R. H., Ribner, B. S., Richmond, J. Y., Rogge, C., Roselle, G. A., Rupp, M. E., Sambol, A. R., Schaefer, J. E., Sibley, J., Streifel, A. J., Von Essen, S. G. & Warfield, K. L., 2006, In : Biosecurity and Bioterrorism. 4, 4, p. 351-365 15 p.

Research output: Contribution to journalArticle

63 Scopus citations

First report of Mycobacterium nebraskense as a cause of human infection

Iwen, P. C., Tarantolo, S. R., Mohamed, A. M. & Hinrichs, S. H., Dec 2006, In : Diagnostic Microbiology and Infectious Disease. 56, 4, p. 451-453 3 p.

Research output: Contribution to journalArticle

3 Scopus citations

Gene transfer of acetylcholinesterase protects the knockout mouse from the toxicity of DFP

Li, B., Duysen, E. G. & Lockridge, O., Sep 2006, In : Journal of Molecular Neuroscience. 30, 1-2, p. 79-80 2 p.

Research output: Contribution to journalArticle

2 Scopus citations
22 Scopus citations

Markers of organophosphate exposure in human serum

Wieseler, S., Schopfer, L. & Lockridge, O., Sep 2006, In : Journal of Molecular Neuroscience. 30, 1-2, p. 93-94 2 p.

Research output: Contribution to journalArticle

6 Scopus citations

Mutant of Bungarus fasciatus acetylcholinesterase with low affinity and low hydrolase activity toward organophosphorus esters

Poyot, T., Nachon, F., Froment, M. T., Loiodice, M., Wieseler, S., Schopfer, L. M., Lockridge, O. & Masson, P., Sep 2006, In : Biochimica et Biophysica Acta - Proteins and Proteomics. 1764, 9, p. 1470-1478 9 p.

Research output: Contribution to journalArticle

23 Scopus citations

Naturally occurring mutation Leu307Pro of human butyrylcholinesterase in the Vysya community of India

Manoharan, I., Wieseler, S., Layer, P. G., Lockridge, O. & Boopathy, R., Jul 2006, In : Pharmacogenetics and Genomics. 16, 7, p. 461-468 8 p.

Research output: Contribution to journalArticle

35 Scopus citations

Phase II study of clofarabine in pediatric patients with refractory or relapsed acute lymphoblastic leukemia

Jeha, S., Gaynon, P. S., Razzouk, B. I., Franklin, J., Kadota, R., Shen, V., Luchtman-Jones, L., Rytting, M., Bomgaars, L. R., Rheingold, S., Ritchey, K., Albano, E., Arceci, R. J., Goldman, S., Griffin, T., Altman, A., Gordon, B., Steinherz, L., Weitman, S. & Steinherz, P., Apr 20 2006, In : Journal of Clinical Oncology. 24, 12, p. 1917-1923 7 p.

Research output: Contribution to journalArticle

188 Scopus citations

Phenotype comparison of three acetylcholinesterase knockout strains

Duysen, E. G. & Lockridge, O., Sep 2006, In : Journal of Molecular Neuroscience. 30, 1-2, p. 91-92 2 p.

Research output: Contribution to journalArticle

15 Scopus citations

Production of the butyrylcholinesterase knockout mouse

Li, B., Duysen, E. G., Saunders, T. L. & Lockridge, O., Sep 2006, In : Journal of Molecular Neuroscience. 30, 1-2, p. 193-195 3 p.

Research output: Contribution to journalArticle

29 Scopus citations

Protection from the toxicity of diisopropylfluorophosphate by adeno-associated virus expressing acetylcholinesterase

Li, B., Duysen, E. G., Poluektova, L. Y., Murrin, L. C. & Lockridge, O., Jul 15 2006, In : Toxicology and Applied Pharmacology. 214, 2, p. 152-165 14 p.

Research output: Contribution to journalArticle

12 Scopus citations

"You may have already won...": An examination of the use of lottery payments in research

Brown, J. S., Schonfeld, T. L. & Gordon, B. C., Jan 2006, In : IRB Ethics and Human Research. 28, 1, p. 12-16 5 p.

Research output: Contribution to journalArticle

6 Scopus citations
2005

(20) Identification of organophosphate-reactive proteins by tandem mass spectrometry

Li, H., Schopfer, L., Spaulding, R., Thompson, C. M. & Lockridge, O., Dec 15 2005, In : Chemico-Biological Interactions. 157-158, p. 383-384 2 p.

Research output: Contribution to journalArticle

6 Scopus citations

(29) New genetic variants of human butyrylcholinesterase in the Brazilian population

Mikami, L. R., Souza, R. L. R., Chautard-Freire-Maia, E. A. & Lockridge, O., Dec 15 2005, In : Chemico-Biological Interactions. 157-158, p. 400 1 p.

Research output: Contribution to journalArticle

(33) Structural data on the aging of diethylphosphoryl- butyrylcholinesterase

Nachon, F., Asojo, O. A., Borgstahl, G., Masson, P. & Lockridge, O., Dec 15 2005, In : Chemico-Biological Interactions. 157-158, p. 408-409 2 p.

Research output: Contribution to journalArticle

3 Scopus citations

Albumin, a new biomarker of organophosphorus toxicant exposure, identified by mass spectrometry

Peeples, E. S., Schopfer, L. M., Duysen, E. G., Spaulding, R., Voelker, T., Thompson, C. M. & Lockridge, O., Feb 2005, In : Toxicological Sciences. 83, 2, p. 303-312 10 p.

Research output: Contribution to journalArticle

113 Scopus citations

Butyrylcholinesterase, paraoxonase, and albumin esterase, but not carboxylesterase, are present in human plasma

Li, B., Sedlacek, M., Manoharan, I., Boopathy, R., Duysen, E. G., Masson, P. & Lockridge, O., Nov 25 2005, In : Biochemical Pharmacology. 70, 11, p. 1673-1684 12 p.

Research output: Contribution to journalArticle

371 Scopus citations

Characteristic mass spectral fragments of the organophosphorus agent FP-biotin and FP-biotinylated peptides from trypsin and bovine albumin (Tyr410)

Schopfer, L. M., Champion, M. M., Tamblyn, N., Thompson, C. M. & Lockridge, O., Oct 1 2005, In : Analytical Biochemistry. 345, 1, p. 122-132 11 p.

Research output: Contribution to journalArticle

33 Scopus citations
22 Scopus citations

Contraception in research: A policy suggestion

Schonfeld, T. L. & Gordon, B. G., 2005, In : IRB Ethics and Human Research. 27, 2, p. 15-20 6 p.

Research output: Contribution to journalArticle

11 Scopus citations

Delivery of human acetylcholinesterase by adeno-associated virus to the acetylcholinesterase knockout mouse

Hrabovska, A., Duysen, E. G., Sanders, J. D., Murrin, L. C. & Lockridge, O., Dec 15 2005, In : Chemico-Biological Interactions. 157-158, p. 71-78 8 p.

Research output: Contribution to journalArticle

11 Scopus citations

Histoplasmosis in solid organ transplant recipients at a large Midwestern university transplant center

Freifeld, A. G., Iwen, P. C., Lesiak, B. L., Gilroy, R. K., Stevens, R. B. & Kalil, A. C., Sep 2005, In : Transplant Infectious Disease. 7, 3-4, p. 109-115 7 p.

Research output: Contribution to journalArticle

106 Scopus citations

Hysteresis of butyrylcholinesterase in the approach to steady-state kinetics

Masson, P., Schopfer, L. M., Froment, M. T., Debouzy, J. C., Nachon, F., Gillon, E., Lockridge, O., Hrabovska, A. & Goldstein, B. N., Dec 15 2005, In : Chemico-Biological Interactions. 157-158, p. 143-152 10 p.

Research output: Contribution to journalArticle

21 Scopus citations

Identification and first report of Inonotus (Phellinus) tropicalis as an etiologic agent in a patient with chronic granulomatous disease

Sutton, D. A., Thompson, E. H., Rinaldi, M. G., Iwen, P. C., Nakasone, K. K., Jung, H. S., Rosenblatt, H. M. & Paul, M. E., Feb 2005, In : Journal of clinical microbiology. 43, 2, p. 982-987 6 p.

Research output: Contribution to journalArticle

35 Scopus citations

Intraperitoneal administration of 340 kDa human plasma butyrylcholinesterase increases the level of the enzyme in the cerebrospinal fluid of rats

Sáez-Valero, J., Pérez De Gracia, J. A. & Lockridge, O., Jul 22 2005, In : Neuroscience Letters. 383, 1-2, p. 93-98 6 p.

Research output: Contribution to journalArticle

3 Scopus citations

Life without acetylcholinesterase: The implications of cholinesterase inhibitor toxicity in AChE-knockout mice

Lockridge, O., Duysen, E. G., Voelker, T., Thompson, C. M. & Schopfer, L. M., May 2005, In : Environmental Toxicology and Pharmacology. 19, 3, p. 463-469 7 p.

Research output: Contribution to journalArticle

20 Scopus citations