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2005

Molecular identification of Rhizomucor pusillus as a cause of sinus-orbital zygomycosis in a patient with acute myelogenous leukemia

Iwen, P. C., Freifeld, A. G., Sigler, L. & Tarantolo, S. R., Nov 2005, In : Journal of clinical microbiology. 43, 11, p. 5819-5821 3 p.

Research output: Contribution to journalArticle

23 Scopus citations

Reaction kinetics of biotinylated organophosphorus toxicant, FP-biotin, with human acetylcholinesterase and human butyrylcholinesterase

Schopfer, L. M., Voelker, T., Bartels, C. F., Thompson, C. M. & Lockridge, O., Apr 2005, In : Chemical Research in Toxicology. 18, 4, p. 747-754 8 p.

Research output: Contribution to journalArticle

25 Scopus citations

Role of water in aging of human butyrylcholinesterase inhibited by echothiophate: The crystal structure suggests two alternative mechanisms of aging

Nachon, F., Asojo, O. A., Borgstahl, G. E. O., Masson, P. & Lockridge, O., Feb 1 2005, In : Biochemistry. 44, 4, p. 1154-1162 9 p.

Research output: Contribution to journalArticle

88 Scopus citations
2004

Administration of oral probiotic bacteria to pregnant women causes temporary infantile colonization

Schultz, M., Göttl, C., Young, R. J., Iwen, P. & Vanderhoof, J. A., Mar 2004, In : Journal of pediatric gastroenterology and nutrition. 38, 3, p. 293-297 5 p.

Research output: Contribution to journalArticle

121 Scopus citations

Damped oscillatory hysteretic behaviour of butyrylcholinesterase with benzoylcholine as substrate

Masson, P., Goldstein, B. N., Debouzy, J. C., Froment, M. T., Lockridge, O. & Schopfer, L. M., Jan 2004, In : European Journal of Biochemistry. 271, 1, p. 220-234 15 p.

Research output: Contribution to journalArticle

30 Scopus citations

Genome diversity among regional populations of Francisella tularensis subspecies tularensis and Francisella tularensis subspecies holarctica isolated from the US

Samrakandi, M. M., Zhang, C., Zhang, M., Nietfeldt, J., Kim, J., Iwen, P. C., Olson, M. E., Fey, P. D., Duhamel, G. E., Hinrichs, S. H., Cirillo, J. D. & Benson, A. K., Aug 1 2004, In : FEMS Microbiology Letters. 237, 1, p. 9-17 9 p.

Research output: Contribution to journalArticle

24 Scopus citations

Impaired formation of the inner retina in an AChE knockout mouse results in degeneration of all photoreceptors

Bytyqi, A. H., Lockridge, O., Duysen, E., Wang, Y., Wolfrum, U. & Layer, P. G., Dec 2004, In : European Journal of Neuroscience. 20, 11, p. 2953-2962 10 p.

Research output: Contribution to journalArticle

36 Scopus citations

Mycobacterium nebraskense sp. nov., a novel slowly growing scotochromogenic species

Mohamed, A. M., Iwen, P. C., Tarantolo, S. & Hinrichs, S. H., Nov 2004, In : International Journal of Systematic and Evolutionary Microbiology. 54, 6, p. 2057-2060 4 p.

Research output: Contribution to journalArticle

14 Scopus citations

Rate-determining step of butyrylcholinesterase-catalyzed hydrolysis of benzoylcholine-and benzoylthiocholine: Volumetric study of wild-type and D70G mutant behaviour

Masson, P., Bec, N., Froment, M. T., Nachon, F., Balny, C., Lockridge, O. & Schopfer, L. M., May 2004, In : European Journal of Biochemistry. 271, 10, p. 1980-1990 11 p.

Research output: Contribution to journalArticle

18 Scopus citations

Reduced acetylcholine receptor density, morphological remodeling, and butyrylcholinesterase activity can sustain muscle function in acetylcholinesterase knockout mice

Adler, M., Manley, H. A., Purcell, A. L., Deshpande, S. S., Hamilton, T. A., Kan, R. K., Oyler, G., Lockridge, O., Duysen, E. G. & Sheridan, R. E., Sep 2004, In : Muscle and Nerve. 30, 3, p. 317-327 11 p.

Research output: Contribution to journalArticle

42 Scopus citations

Resistance to organophosphorus agent toxicity in transgenic mice expressing the G117H mutant of human butyrylcholinesterase

Wang, Y., Boeck, A. T., Duysen, E. G., Van Keuren, M., Saunders, T. L. & Lockridge, O., May 1 2004, In : Toxicology and Applied Pharmacology. 196, 3, p. 356-366 11 p.

Research output: Contribution to journalArticle

25 Scopus citations

Screening assays for cholinesterases resistant to inhibition by organophosphorus toxicants

Wang, Y., Schopfer, L. M., Duysen, E. G., Nachon, F., Masson, P. & Lockridge, O., Jun 1 2004, In : Analytical Biochemistry. 329, 1, p. 131-138 8 p.

Research output: Contribution to journalArticle

9 Scopus citations

Use of a Panfungal PCR Assay for Detection of Fungal Pathogens in a Commercial Blood Culture System

Iwen, P. C., Freifeld, A. G., Bruening, T. A. & Hinrichs, S. H., May 2004, In : Journal of clinical microbiology. 42, 5, p. 2292-2293 2 p.

Research output: Contribution to journalArticle

21 Scopus citations

Utilization of the relative complexity measure to construct a phylogenetic tree for fungi

Bastola, D. R., Otu, H. H., Doukas, S. E., Sayood, K., Hinrichs, S. H. & Iwen, P. C., Feb 2004, In : Mycological Research. 108, 2, p. 117-125 9 p.

Research output: Contribution to journalArticle

20 Scopus citations
2003

Altered hippocampal muscarinic receptors in acetylcholinesterase-deficient mice

Volpicelli-Daley, L. A., Duysen, E. G., Lockridge, O. & Levey, A. I., Jun 1 2003, In : Annals of Neurology. 53, 6, p. 788-796 9 p.

Research output: Contribution to journalArticle

30 Scopus citations

Altered Striatal Function and Muscarinic Cholinergic Receptors in Acetylcholinesterase Knockout Mice

Volpicelli-Daley, L. A., Hrabovska, A., Duysen, E. G., Ferguson, S. M., Blakely, R. D., Lockridge, O. & Levey, A. I., Dec 2003, In : Molecular pharmacology. 64, 6, p. 1309-1316 8 p.

Research output: Contribution to journalArticle

51 Scopus citations

Aromatic amino-acid residues at the active and peripheral anionic sites control the binding of E2020 (Aricept®) to cholinesterases

Saxena, A., Fedorko, J. M., Vinayaka, C. R., Medhekar, R., Radić, Z., Taylor, P., Lockridge, O. & Doctor, B. P., Nov 2003, In : European Journal of Biochemistry. 270, 22, p. 4447-4458 12 p.

Research output: Contribution to journalArticle

60 Scopus citations

Crystal Structure of Human Butyrylcholinesterase and of Its Complexes with Substrate and Products

Nicolet, Y., Lockridge, O., Masson, P., Fontecilla-Camps, J. C. & Nachon, F., Oct 17 2003, In : Journal of Biological Chemistry. 278, 42, p. 41141-41147 7 p.

Research output: Contribution to journalArticle

533 Scopus citations

Dramatic depletion of cell surface m2 muscarinic receptor due to limited delivery from intracytoplasmic stores in neurons of acetylcholinesterase-deficient mice

Bernard, V., Brana, C., Liste, I., Lockridge, O. & Bloch, B., May 1 2003, In : Molecular and Cellular Neuroscience. 23, 1, p. 121-133 13 p.

Research output: Contribution to journalArticle

41 Scopus citations

Effects of sterilizing gamma irradiation on bloodspot newborn screening tests and whole blood cyclosporine and tacrolimus measurements

Stickle, D. F., McKenzie, D. A., Landmark, J. D., Pirruccello, S. J., Post, G. R., Iwen, P. C., Thompson, R. B. & Hinrichs, S. H., Feb 1 2003, In : American journal of clinical pathology. 119, 2, p. 292-297 6 p.

Research output: Contribution to journalArticle

3 Scopus citations

High activity of human butyrylcholinesterase at low pH in the presence of excess butyrylthiocholine

Masson, P., Nachon, F., Bartels, C. F., Froment, M. T., Ribes, F., Matthews, C. & Lockridge, O., 2003, In : European Journal of Biochemistry. 270, 2, p. 315-324 10 p.

Research output: Contribution to journalArticle

26 Scopus citations

PCR rapidly detects methicillin-resistant staphylococci periprosthetic infection

Tarkin, I. S., Henry, T. J., Fey, P. I., Iwen, P. C., Hinrichs, S. H. & Garvin, K. L., Sep 1 2003, In : Clinical Orthopaedics and Related Research. 414, p. 89-94 6 p.

Research output: Contribution to journalArticle

40 Scopus citations

Regulation of muscarinic acetylcholine receptor function in acetylcholinesterase knockout mice

Li, B., Duysen, E. G., Volpicelli-Daley, L. A., Levey, A. I. & Lockridge, O., Mar 2003, In : Pharmacology Biochemistry and Behavior. 74, 4, p. 977-986 10 p.

Research output: Contribution to journalArticle

65 Scopus citations

Research involving the homeless: arguments against payment-in-kind (PinK).

Schonfeld, T. L., Brown, J. S., Weniger, M. & Gordon, B., 2003, In : IRB. 25, 5, p. 17-20 4 p.

Research output: Contribution to journalArticle

9 Scopus citations
2002

Acetylcholinesterase knockouts establish central cholinergic pathways and can use butyrylcholinesterase to hydrolyze acetylcholine

Mesulam, M. M., Guillozet, A., Shaw, P., Levey, A., Duysen, E. G. & Lockridge, O., Apr 3 2002, In : Neuroscience. 110, 4, p. 627-639 13 p.

Research output: Contribution to journalArticle

452 Scopus citations

Cocaine metabolism accelerated by a re-engineered human butyrylcholinesterase

Sun, H., Shen, M. L., Pang, Y. P., Lockridge, O. & Brimijoin, S., 2002, In : Journal of Pharmacology and Experimental Therapeutics. 302, 2, p. 710-716 7 p.

Research output: Contribution to journalArticle

75 Scopus citations

Delayed diagnosis of osseous blastomycosis in two patients following environmental exposure in nonendemic areas

Veligandla, S. R., Hinrichs, S. H., Rupp, M. E., Lien, E. A., Neff, J. R. & Iwen, P. C., Oct 2002, In : American journal of clinical pathology. 118, 4, p. 536-541 6 p.

Research output: Contribution to journalArticle

11 Scopus citations
32 Scopus citations

Early weaning and culling eradicated Helicobacter hepaticus from an acetylcholinesterase knockout 129S6/SvEvTac mouse colony

Duysen, E. G., Fry, D. L. & Lockridge, O., Oct 2002, In : Comparative Medicine. 52, 5, p. 461-466 6 p.

Research output: Contribution to journalArticle

7 Scopus citations

Engineering of a monomeric and low-glycosylated form of human butyrylcholinesterase: Expression, purification, characterization and crystallization

Nachon, F., Nicolet, Y., Viguié, N., Masson, P., Fontecilla-Camps, J. C. & Lockridge, O., 2002, In : European Journal of Biochemistry. 269, 2, p. 630-637 8 p.

Research output: Contribution to journalArticle

102 Scopus citations

Naturally occurring mutation, Asp70His, in human butyrylcholinesterase

Boeck, A. T., Fry, D. L., Sastre, A. & Lockridge, O., 2002, In : Annals of Clinical Biochemistry. 39, 2, p. 154-156 3 p.

Research output: Contribution to journalArticle

13 Scopus citations

Re-engineering butyrylcholinesterase as a cocaine hydrolase

Sun, H., Pang, Y. P., Lockridge, O. & Brimijoin, S., 2002, In : Molecular pharmacology. 62, 2, p. 220-224 5 p.

Research output: Contribution to journalArticle

115 Scopus citations

Rescue of the acetylcholinesterase knockout mouse by feeding a liquid diet; phenotype of the adult acetylcholinesterase deficient mouse

Duysen, E. G., Stribley, J. A., Fry, D. L., Hinrichs, S. H. & Lockridge, O., Jul 30 2002, In : Developmental Brain Research. 137, 1, p. 43-54 12 p.

Research output: Contribution to journalArticle

103 Scopus citations

Specificity of ethephon as a butyrylcholinesterase inhibitor and phosphorylating agent

Haux, J. E., Lockridge, O. & Casida, J. E., Dec 1 2002, In : Chemical Research in Toxicology. 15, 12, p. 1527-1533 7 p.

Research output: Contribution to journalArticle

20 Scopus citations

Substrate activation in acetylcholinesterase induced by low pH or mutation in the π-cation subsite

Masson, P., Schopfer, L. M., Bartels, C. F., Froment, M. T., Ribes, F., Nachon, F. & Lockridge, O., Feb 11 2002, In : Biochimica et Biophysica Acta - Protein Structure and Molecular Enzymology. 1594, 2, p. 313-324 12 p.

Research output: Contribution to journalArticle

42 Scopus citations

Ultrastructural characterization of the neuromuscular junction in diaphragm of the acetylcholinesterase knockout mouse

Hamilton, T. A., Sheridan, R. E., Deshpande, S. S., Lockridge, O. & Adler, M., 2002, In : Microscopy and Microanalysis. 8, SUPPL. 2, p. 940-941 2 p.

Research output: Contribution to journalArticle

Open Access
77 Scopus citations
2001
40 Scopus citations

Evidence for nonacetylcholinesterase targets of organophosphorus nerve agent: Supersensitivity of acetylcholinesterase knockout mouse to VX lethality

Duysen, E. G., Li, B., Xie, W., Schopfer, L. M., Anderson, R. S., Broomfield, C. A. & Lockridge, O., 2001, In : Journal of Pharmacology and Experimental Therapeutics. 299, 2, p. 528-535 8 p.

Research output: Contribution to journalArticle

120 Scopus citations

Full hematopoietic engraftment after allogeneic bone marrow transplantation without cytoreduction in a child with severe combined immunodeficiency

Rubocki, R. J., Parsa, J. R., Hershfield, M. S., Sanger, W. G., Pirruccello, S. J., Santisteban, I., Gordon, B. G., Strandjord, S. E., Warkentin, P. I. & Coccia, P. F., Feb 1 2001, In : Blood. 97, 3, p. 809-811 3 p.

Research output: Contribution to journalArticle

18 Scopus citations

Outbreak of vancomycin-resistant enterococcus faecium in a neonatal intensive care unit

Rupp, M. E., Marion, N., Fey, P. D., Bolam, D. L., Iwen, P. C., Overfelt, C. M. & Chapman, L., May 2001, In : Infection Control and Hospital Epidemiology. 22, 5, p. 301-303 3 p.

Research output: Contribution to journalArticle

38 Scopus citations

Predicted Michaelis-Menten complexes of cocaine-butyrylcholinesterase: Engineering effective butyrylcholinesterase mutants for cocaine detoxication

Sun, H., El Yazal, J., Lockridge, O., Schopfer, L. M., Brimijoin, S. & Pang, Y. P., Mar 23 2001, In : Journal of Biological Chemistry. 276, 12, p. 9330-9336 7 p.

Research output: Contribution to journalArticle

77 Scopus citations

Sequence analysis of the RNA polymerase gene of foot-and-mouth disease virus serotype Asia 1

Manju, G., Ramamurthy, V., Bramhadev, P., Aniket, S., Gurumurthy, C. B., Divakar, H. & Chakradhar, T., 2001, In : Virus Genes. 22, 1, p. 21-26 6 p., 281660.

Research output: Contribution to journalArticle

10 Scopus citations

The active site of human paraoxonase (PON1).

Josse, D., Lockridge, O., Xie, W., Bartels, C. F., Schopfer, L. M. & Masson, P., Dec 2001, In : Journal of applied toxicology : JAT. 21 Suppl 1, p. S7-S11

Research output: Contribution to journalArticle

69 Scopus citations

The non-structural leader protein gene of foot-and-mouth disease virus is highly variable between serotypes

George, M., Venkataramanan, R., Gurumurthy, C. B. & Hemadri, D., 2001, In : Virus Genes. 22, 3, p. 271-278 8 p.

Research output: Contribution to journalArticle

20 Scopus citations
2000

Abundant tissue butyrylcholinesterase and its possible function in the acetylcholinesterase knockout mouse

Li, B., Stribley, J. A., Ticu, A., Xie, W., Schopfer, L. M., Hammond, P., Brimijoin, S., Hinrichs, S. H. & Lockridge, O., 2000, In : Journal of Neurochemistry. 75, 3, p. 1320-1331 12 p.

Research output: Contribution to journalArticle

278 Scopus citations

Ceftriaxone-resistant Salmonella infection acquired by a child from cattle

Fey, P. D., Safranek, T. J., Rupp, M. E., Dunne, E. F., Ribot, E., Iwen, P. C., Bradford, P. A., Angulo, F. J. & Hinrichs, S. H., Apr 27 2000, In : New England Journal of Medicine. 342, 17, p. 1242-1249 8 p.

Research output: Contribution to journalArticle

423 Scopus citations

Central nervous system dysfunction as the first manifestation of multiple organ dysfunction syndrome in stem cell transplant patients

Gordon, B., Lyden, E., Lynch, J., Tarantolo, S., Pavletic, Z. S., Bishop, M., Reed, E., Kessinger, A. & Haire, W., 2000, In : Bone marrow transplantation. 25, 1, p. 79-83 5 p.

Research output: Contribution to journalArticle

Open Access
19 Scopus citations

Conflict between research design and minimization of risks in pediatric research

Gordon, B., Prentice, E. & Anderson, J., 2000, In : IRB Ethics and Human Research. 22, 3, p. 1-6 6 p.

Research output: Contribution to journalArticle

2 Scopus citations

Cutaneous infection caused by Cylindrocarpon lichenicola in a patient with acute myelogenous leukemia

Iwen, P. C., Tarantolo, S. R., Sutton, D. A., Rinaldi, M. G. & Hinrichs, S. H., 2000, In : Journal of clinical microbiology. 38, 9, p. 3375-3378 4 p.

Research output: Contribution to journalArticle

Open Access
14 Scopus citations