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2000

Determination of the DNA sequences of acetylcholinesterase and butyrylcholinesterase from cat and demonstration of the existence of both in cat plasma

Bartels, C. F., Xie, W., Miller-Lindholm, A. K., Schopfer, L. M. & Lockridge, O., Aug 15 2000, In : Biochemical Pharmacology. 60, 4, p. 479-487 9 p.

Research output: Contribution to journalArticle

29 Scopus citations

Identification of Aspergillus species using internal transcribed spacer regions 1 and 2

Henry, T., Iwen, P. C. & Hinrichs, S. H., 2000, In : Journal of clinical microbiology. 38, 4, p. 1510-1515 6 p.

Research output: Contribution to journalArticle

Open Access
277 Scopus citations

Postnatal developmental delay and supersensitivity to organophosphate in gene-targeted mice lacking acetylcholinesterase

Xie, W., Stribley, J. A., Chatonnet, A., Wilder, P. J., Rizzino, A., McComb, R. D., Taylor, P., Hinrichs, S. H. & Lockridge, O., Jun 2000, In : Journal of Pharmacology and Experimental Therapeutics. 293, 3, p. 896-902 7 p.

Research output: Contribution to journalArticle

224 Scopus citations

Protection of human subjects in the united states: A short history

Gordon, B. & Prentice, E., Nov 2000, In : Journal of Public Health Management and Practice. 6, 6, p. 1-8 8 p.

Research output: Contribution to journalArticle

8 Scopus citations

Pulmonary infection caused by Gymnascella hyalinospora in a patient with acute myelogenous leukemia

Iwen, P. C., Sigler, L., Tarantolo, S., Sutton, D. A., Rinaldi, M. G., Lackner, R. P., McCarthy, D. I. & Hinrichs, S. H., 2000, In : Journal of clinical microbiology. 38, 1, p. 375-381 7 p.

Research output: Contribution to journalArticle

19 Scopus citations

The butyrylcholinesterase K-variant shows similar cellular protein turnover and quaternary interaction to the wild-type enzyme

Altamirano, C. V., Bartels, C. F. & Lockridge, O., 2000, In : Journal of Neurochemistry. 74, 2, p. 869-877 9 p.

Research output: Contribution to journalArticle

39 Scopus citations
1999

An improved cocaine hydrolase: The A328Y mutant of human butyrylcholinesterase is 4-fold more efficient

Xie, W., Altamirano, C. V., Bartels, C. F., Speirs, R. J., Cashman, J. R. & Lockridge, O., 1999, In : Molecular pharmacology. 55, 1, p. 83-91 9 p.

Research output: Contribution to journalArticle

114 Scopus citations

Association of tetramers of human butyrylcholinesterase is mediated by conserved aromatic residues of the carboxy terminus

Altamirano, C. V. & Lockridge, O., May 14 1999, In : Chemico-Biological Interactions. 119-120, p. 53-60 8 p.

Research output: Contribution to journalArticle

28 Scopus citations

Autologous hematopoietic stem-cell transplantation for relapsed or refractory Hodgkin's disease in children and adolescents

Scott Baker, K., Gordon, B. G., Gross, T. G., Abromowitch, M. A., Lyden, E. R., Lynch, J. C., Vose, J. M., Armitage, J. O., Coccia, P. F. & Bierman, P. J., Mar 1999, In : Journal of Clinical Oncology. 17, 3, p. 825-831 7 p.

Research output: Contribution to journalArticle

70 Scopus citations

Bacteremia due to motile Enterococcus species: Clinical features and outcomes

Rupp, M. E., Ratanasuwan, W., Iwen, P. C. & Hinrichs, S. H., 1999, In : Clinical Infectious Diseases. 28, 5, p. 1175-1177 3 p.

Research output: Contribution to journalArticle

Open Access
28 Scopus citations

Conserved aromatic residues of the C-terminus of human butyrylcholinesterase mediate the association of tetramers

Altamirano, C. V. & Lockridge, O., Oct 5 1999, In : Biochemistry. 38, 40, p. 13414-13422 9 p.

Research output: Contribution to journalArticle

38 Scopus citations

Differences in active-site gorge dimensions of cholinesterases revealed by binding of inhibitors to human butyrylcholinesterase

Saxena, A., Redman, A. M. G., Jiang, X., Lockridge, O. & Doctor, B. P., May 14 1999, In : Chemico-Biological Interactions. 119-120, p. 61-69 9 p.

Research output: Contribution to journalArticle

39 Scopus citations

Evaluation of bacterial contamination of a sterile, non-air-dependent enteral feeding system in immunocompromised patients

Rupp, M. E., Weseman, R. A., Marion, N. & Iwen, P. C., 1999, In : Nutrition in Clinical Practice. 14, 3, p. 135-137 3 p.

Research output: Contribution to journalArticle

8 Scopus citations
Open Access
9 Scopus citations

Human serum paraoxonase (PON1): Identification of essential amino acid residues by group-selective labelling and site-directed mutagenesis

Josse, D., Xie, W., Masson, P. & Lockridge, O., May 14 1999, In : Chemico-Biological Interactions. 119-120, p. 71-78 8 p.

Research output: Contribution to journalArticle

14 Scopus citations

Identification of residues essential for human paraoxonase (PON1) arylesterase/organophosphatase activities

Josse, D., Xie, W., Renault, F., Rochu, D., Schopfer, L. M., Masson, P. & Lockridge, O., Mar 2 1999, In : Biochemistry. 38, 9, p. 2816-2825 10 p.

Research output: Contribution to journalArticle

81 Scopus citations

Interaction between the peripheral site residues of human butyrylcholinesterase, D70 and Y332, in binding and hydrolysis of substrates

Masson, P., Xie, W., Froment, M. T., Levitsky, V., Fortier, P. L., Albaret, C. & Lockridge, O., Aug 17 1999, In : Biochimica et Biophysica Acta - Protein Structure and Molecular Enzymology. 1433, 1-2, p. 281-293 13 p.

Research output: Contribution to journalArticle

62 Scopus citations

Knockout of one acetylcholinesterase allele in the mouse

Xie, W., Wilder, P. J., Stribley, J., Chatonnet, A., Rizzino, A., Taylor, P., Hinrichs, S. H. & Lockridge, O., May 14 1999, In : Chemico-Biological Interactions. 119-120, p. 289-299 11 p.

Research output: Contribution to journalArticle

30 Scopus citations

Polyol-induced activation by excess substrate of the D70G butyrylcholinesterase mutant

Levitsky, V., Xie, W., Froment, M. T., Lockridge, O. & Masson, P., Jan 11 1999, In : Biochimica et Biophysica Acta - Protein Structure and Molecular Enzymology. 1429, 2, p. 422-430 9 p.

Research output: Contribution to journalArticle

14 Scopus citations

Protein engineering of a human enzyme that hydrolyzes V and G nerve agents: Design, construction and characterization

Broomfield, C. A., Lockridge, O. & Millard, C. B., May 14 1999, In : Chemico-Biological Interactions. 119-120, p. 413-418 6 p.

Research output: Contribution to journalArticle

25 Scopus citations

Selective review of external adverse events: one IRB's response to the avalanche of IND safety reports.

Gordon, B. & Prentice, E., 1999, In : IRB. 21, 3, p. 10-11 2 p.

Research output: Contribution to journalArticle

3 Scopus citations

Structural and hydration changes in the active site gorge of phosporhylated butyrylcholinesterase accompanying the aging process

Masson, P., Fortier, P. L., Albaret, C., Cléry, C., Guerra, P. & Lockridge, O., May 14 1999, In : Chemico-Biological Interactions. 119-120, p. 17-27 11 p.

Research output: Contribution to journalArticle

3 Scopus citations

Tryptophan residue(s) as major components of the human serum paraoxonase active site

Josse, D., Xie, W., Masson, P., Schopfer, L. M. & Lockridge, O., May 14 1999, In : Chemico-Biological Interactions. 119-120, p. 79-84 6 p.

Research output: Contribution to journalArticle

13 Scopus citations
1998

Assay for etoposide in human serum using solid-phase extraction and high-performance liquid chromatography with fluorescence detection

Manouilov, K. K., McGuire, T. R., Gordon, B. G. & Gwilt, P. R., Apr 10 1998, In : Journal of Chromatography B: Biomedical Applications. 707, 1-2, p. 342-346 5 p.

Research output: Contribution to journalArticle

19 Scopus citations

Butyrylcholinesterase-catalysed hydrolysis of aspirin, a negatively charged ester, and aspirin-related neutral esters

Masson, P., Froment, M. T., Fortier, P. L., Visicchio, J. E., Bartels, C. F. & Lockridge, O., Sep 8 1998, In : Biochimica et Biophysica Acta - Protein Structure and Molecular Enzymology. 1387, 1-2, p. 41-52 12 p.

Research output: Contribution to journalArticle

63 Scopus citations

Disseminated aspergillosis caused by Aspergillus ustus in a patient following allogeneic peripheral stem cell transplantation

Iwen, P. C., Rupp, M. E., Bishop, M. R., Rinaldi, M. G., Sutton, D. A., Tarantolo, S. & Hinrichs, S. H., Dec 1998, In : Journal of clinical microbiology. 36, 12, p. 3713-3717 5 p.

Research output: Contribution to journalArticle

Open Access
30 Scopus citations

Environmental Contamination with Vancomycin-Resistant Enterococci in an Outpatient Setting

Smith, T. L., Iwen, P. C., Olson, S. B. & Rupp, M. E., Jul 1998, In : Infection Control and Hospital Epidemiology. 19, 7, p. 515-518 4 p.

Research output: Contribution to journalArticle

31 Scopus citations

Enzymes hydrolyzing organophosphates as potential catalytic scavengers against organophosphate poisoning

Masson, P., Josse, D., Lockridge, O., Viguié, N., Taupin, C. & Buhler, C., 1998, In : Journal of Physiology Paris. 92, 5-6, p. 357-362 6 p.

Research output: Contribution to journalArticle

56 Scopus citations

Increased platelet transfusion requirement is associated with multiple organ dysfunctions in patients undergoing hematopoietic stem cell transplantation

Gordon, B., Tarantolo, S., Ruby, E., Stephens, L., Lynch, J., Kessinger, A. & Haire, W., 1998, In : Bone marrow transplantation. 22, 10, p. 999-1003 5 p.

Research output: Contribution to journalArticle

Open Access
24 Scopus citations
Open Access
149 Scopus citations

Organophosphorus acid anhydride hydrolase activity in human butyrylcholinesterase: Synergy results in a somanase

Millard, C. B., Lockridge, O. & Broomfield, C. A., Jan 6 1998, In : Biochemistry. 37, 1, p. 237-247 11 p.

Research output: Contribution to journalArticle

96 Scopus citations

Prolonged paralysis after a test dose of mivacurium in a patient with atypical serum cholinesterase

Vanlinthout, L. E., Bartels, C. F., Lockridge, O., Callens, K. & Booij, L. H., 1998, In : Anesthesia and analgesia. 87, 5, p. 1199-1202 4 p.

Research output: Contribution to journalArticle

10 Scopus citations
14 Scopus citations

The pH dependence of dealkylation in soman-inhibited cholinesterases and their mutants: Further evidence for a push-pull mechanism

Saxena, A., Viragh, C., Frazier, D. S., Kovach, I. M., Maxwell, D. M., Lockridge, O. & Doctor, B. P., Oct 27 1998, In : Biochemistry. 37, 43, p. 15086-15096 11 p.

Research output: Contribution to journalArticle

36 Scopus citations
1997

Aging of di-isopropyl-phosphorylated human butyrylcholinesterase

Masson, P., Fortier, P. L., Albaret, C., Froment, M. T., Bartels, C. F. & Lockridge, O., Oct 15 1997, In : Biochemical Journal. 327, 2, p. 601-607 7 p.

Research output: Contribution to journalArticle

51 Scopus citations
Open Access
21 Scopus citations

A single amino acid substitution, Gly 117His, confers phosphotriesterase (organophosphorus acid anhydride hydrolase) activity on human butyrylcholinesterase

Lockridge, O., Blong, R. M., Masson, P., Froment, M. T., Millard, C. B. & Broomfield, C. A., Jan 28 1997, In : Biochemistry. 36, 4, p. 786-795 10 p.

Research output: Contribution to journalArticle

140 Scopus citations

Bartonella-like erythrocyte inclusions in thrombotic thrombocytopenic purpura [3]

Tarantolo, S. R., Landmark, J. D., Iwen, P. C., Kessinger, A., Chan, W. C. & Hinrichs, S. H., Dec 6 1997, In : Lancet. 350, 9091, p. 1602 1 p.

Research output: Contribution to journalArticle

26 Scopus citations

Change in prevalence and antibiotic resistance of Enterococcus species isolated from blood cultures over an 8-year period

Iwen, P. C., Kelly, D. M., Linder, J., Hinrichs, S. H., Dominguez, E. A. & Patil, K. D., 1997, In : Antimicrobial Agents and Chemotherapy. 41, 2, p. 494-495 2 p.

Research output: Contribution to journalArticle

Open Access
71 Scopus citations

Determining when a clinical activity should be classified as research requiring institutional review board review

Prentice, E. D., Gordon, B. G. & Lin, M. H., Jun 1997, In : Journal of Extra-Corporeal Technology. 29, 2, p. 88-91 4 p.

Research output: Contribution to journalArticle

2 Scopus citations

Differences in active site gorge dimensions of cholinesterases revealed by binding of inhibitors to human butyrylcholinesterase

Saxena, A., Redman, A. M. G., Jiang, X., Lockridge, O. & Doctor, B. P., Dec 2 1997, In : Biochemistry. 36, 48, p. 14642-14651 10 p.

Research output: Contribution to journalArticle

194 Scopus citations

Evaluation of primers for PCR amplification of RNA polymerase gene sequences of foot-and-mouth disease virus

Pattnaik, B., Sanyal, A., George, M., Tosh, C., Hemadri, D. & Venkataramanan, R., 1997, In : Acta Virologica. 41, 6, p. 333-336 4 p.

Research output: Contribution to journalArticle

10 Scopus citations

Factors predicting morbidity following hematopoietic stem cell transplantation

Gordon, B., Haire, W., Ruby, E., Kotulak, G., Stephens, L., Kessinger, A. & Armitage, J., Mar 1 1997, In : Bone marrow transplantation. 19, 5, p. 497-501 5 p.

Research output: Contribution to journalArticle

Open Access
9 Scopus citations

Importance of aspartate-70 in organophosphate inhibition, oxime re-activation and aging of human butyrylcholinesterase

Masson, P., Froment, M. T., Bartels, C. F. & Lockridge, O., Jul 1 1997, In : Biochemical Journal. 325, 1, p. 53-61 9 p.

Research output: Contribution to journalArticle

60 Scopus citations

Insect larvae: A novel expression system for human butyrylcholinesterase

Platteborze, P. L., Mellott, J. D., Broomfield, C. A. & Lockridge, O., 1997, In : Protein Engineering. 10, 3333, p. 13 1 p.

Research output: Contribution to journalArticle

Open Access
107 Scopus citations

Reaction of human butyrylchounesterase (BCHE) His-117 enzymes with carbamates

Broomfield, C. A., Mills, K. Y., Meier, B. M., Lockridge, O. & Millard, C. B., 1997, In : FASEB Journal. 11, 9, p. A1025

Research output: Contribution to journalArticle

Role of aspartate 70 and tryptophan 82 in binding of succinyldithiocholine to human butyrylcholinesterase

Masson, P., Legrand, P., Bartels, C. F., Froment, M. T., Schopfer, L. M. & Lockridge, O., Feb 25 1997, In : Biochemistry. 36, 8, p. 2266-2277 12 p.

Research output: Contribution to journalArticle

121 Scopus citations

Tetramerization domain of human butyrylcholinesterase is at the C-terminus

Blong, R. M., Bedows, E. & Lockridge, O., Nov 1 1997, In : Biochemical Journal. 327, 3, p. 747-757 11 p.

Research output: Contribution to journalArticle

72 Scopus citations
1996

Asp70 in the peripheral anionic site of human butyrylcholinesterase

Masson, P., Froment, M. T., Bartels, C. F. & Lockridge, O., 1996, In : European Journal of Biochemistry. 235, 1-2, p. 36-48 13 p.

Research output: Contribution to journalArticle

Open Access
114 Scopus citations