VA Nebraska-Western Iowa Health Care System

2024

Alcohol-Associated Liver Disease Outcomes: Critical Mechanisms of Liver Injury Progression

Osna, N. A., Tikhanovich, I., Ortega-Ribera, M., Mueller, S., Zheng, C., Mueller, J., Li, S., Sakane, S., Weber, R. C. G., Kim, H. Y., Lee, W., Ganguly, S., Kimura, Y., Liu, X., Dhar, D., Diggle, K., Brenner, D. A., Kisseleva, T., Attal, N. & McKillop, I. H. & 5 others, Chokshi, S., Mahato, R., Rasineni, K., Szabo, G. & Kharbanda, K. K., Apr 2024, In: Biomolecules. 14, 4, 404.

Research output: Contribution to journal › Review article › peer-review

Open Access

3 Scopus citations

Antimicrobial Activity of Gallium(III) Compounds: Pathogen-Dependent Targeting of Multiple Iron/Heme-Dependent Biological Processes

Choi, S. R., Hassan, M. A., Britigan, B. E. & Narayanasamy, P., Aug 2024, In: Current Issues in Molecular Biology. 46, 8, p. 9149-9161 13 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

Health disparities in gout

Helget, L. N. & Mikuls, T. R., Mar 1 2024, In: Current opinion in rheumatology. 36, 2, p. 120-125 6 p.

Research output: Contribution to journal › Review article › peer-review

3 Scopus citations

New Horizons in Cancer Progression and Metastasis: Hippo Signaling Pathway

Kuracha, M. R., Radhakrishna, U., Kuracha, S. V., Vegi, N., Gurung, J. L. & McVicker, B. L., Nov 2024, In: Biomedicines. 12, 11, 2552.

Research output: Contribution to journal › Review article › peer-review

Open Access

Therapeutic perspectives on PDE4B inhibition in adipose tissue dysfunction and chronic liver injury

Staller, D. W., Bennett, R. G. & Mahato, R. I., 2024, In: Expert Opinion on Therapeutic Targets. 28, 7, p. 545-573 29 p.

Research output: Contribution to journal › Review article › peer-review

2023

A biomechanical perspective on walking in patients with peripheral artery disease

Bapat, G. M., Bashir, A. Z., Malcolm, P., Johanning, J. M., Pipinos, I. I. & Myers, S. A., Feb 2023, In: Vascular Medicine. 28, 1, p. 77-84 8 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

4 Scopus citations

A critical review of recent knowledge of alcohol's effects on the immunological response in different tissues

Crotty, K., Anton, P., Coleman, L. G., Morris, N. L., Lewis, S. A., Samuelson, D. R., McMahan, R. H., Hartmann, P., Kim, A., Ratna, A., Mandrekar, P., Wyatt, T. A., Choudhry, M. A., Kovacs, E. J., McCullough, R. & Yeligar, S. M., Jan 2023, In: Alcohol: Clinical and Experimental Research. 47, 1, p. 36-44 9 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

10 Scopus citations

Alcohol Use and the Risk of Colorectal Liver Metastasis: A Systematic Mapping Review

Sapkota, R., Zakaria, J., Glenn, E., Richard, H., Rimawi, A., Tobi, M. & McVicker, B., Feb 2023, In: Biology. 12, 2, 257.

Research output: Contribution to journal › Review article › peer-review

Open Access

5 Scopus citations

A Pathogenic Role of Non-Parenchymal Liver Cells in Alcohol-Associated Liver Disease of Infectious and Non-Infectious Origin

Kharbanda, K. K., Chokshi, S., Tikhanovich, I., Weinman, S. A., New-Aaron, M., Ganesan, M. & Osna, N. A., Feb 2023, In: Biology. 12, 2, 255.

Research output: Contribution to journal › Review article › peer-review

Open Access

4 Scopus citations

Chronic Hepatitis B Infection: New Approaches towards Cure

Ogunnaike, M., Das, S., Raut, S. S., Sultana, A., Nayan, M. U., Ganesan, M., Edagwa, B. J., Osna, N. A. & Poluektova, L. Y., Aug 2023, In: Biomolecules. 13, 8, 1208.

Research output: Contribution to journal › Review article › peer-review

Open Access

10 Scopus citations

Development of Gallium(III) as an Antimicrobial Drug Targeting Pathophysiologic Iron Metabolism of Human Pathogens

Scott, Z. W., Choi, S. R., Britigan, B. E. & Narayanasamy, P., Apr 14 2023, In: ACS infectious diseases. 9, 4, p. 716-738 23 p.

Research output: Contribution to journal › Review article › peer-review

5 Scopus citations

Elucidating the role of extracellular vesicles in liver injury induced by HIV

Osna, N. A. & Poluektova, L. Y., 2023, In: Expert Review of Gastroenterology and Hepatology. 17, 7, p. 701-708 8 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

1 Scopus citations

GPCRs and fibroblast heterogeneity in fibroblast-associated diseases

Dwivedi, N. V., Datta, S., El-Kersh, K., Sadikot, R. T., Ganti, A. K., Batra, S. K. & Jain, M., Aug 2023, In: FASEB Journal. 37, 8, e23101.

Research output: Contribution to journal › Review article › peer-review

Open Access

4 Scopus citations

Mucins as Potential Biomarkers for Early Detection of Cancer

Gautam, S. K., Khan, P., Natarajan, G., Atri, P., Aithal, A., Ganti, A. K., Batra, S. K., Nasser, M. W. & Jain, M., Mar 2023, In: Cancers. 15, 6, 1640.

Research output: Contribution to journal › Review article › peer-review

Open Access

15 Scopus citations

Targeting the EGFR signaling pathway in cancer therapy: What’s new in 2023?

Halder, S., Basu, S., Lall, S. P., Ganti, A. K., Batra, S. K. & Seshacharyulu, P., 2023, In: Expert Opinion on Therapeutic Targets. 27, 4-5, p. 305-324 20 p.

Research output: Contribution to journal › Review article › peer-review

28 Scopus citations

2022

Alcohol: basic and translational research; 15th annual Charles Lieber &1st Samuel French satellite symposium

Neuman, M. G., Seitz, H. K., Tuma, P. L., Osna, N. A., Casey, C. A., Kharbanda, K. K., Cohen, L. B., Malnick, S. D. H., Adhikari, R., Mitra, R., Dagur, R. S., Ganesan, M., Srinivas, C., Madan Kumar, A., New-Aaron, M., Poluektova, L., Thomes, P. G., Rasineni, K., Opris, M. & Teschke, R., Jun 2022, In: Experimental and Molecular Pathology. 126, 104750.

Research output: Contribution to journal › Review article › peer-review

Open Access

4 Scopus citations

A review of alcohol–pathogen interactions: New insights into combined disease pathomechanisms

Osna, N. A., New-Aaron, M., Dagur, R. S., Thomes, P., Simon, L., Levitt, D., McTernan, P., Molina, P. E., Choi, H. Y., Machida, K., Sherman, K. E., Riva, A., Phillips, S., Chokshi, S., Kharbanda, K. K., Weinman, S. & Ganesan, M., Mar 2022, In: Alcoholism: Clinical and Experimental Research. 46, 3, p. 359-370 12 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

8 Scopus citations

Cell-to-Cell Communications in Alcohol-Associated Liver Disease

Osna, N. A., Eguchi, A., Feldstein, A. E., Tsukamoto, H., Dagur, R. S., Ganesan, M., New-Aaron, M., Arumugam, M. K., Chava, S., Ribeiro, M., Szabo, G., Mueller, S., Wang, S., Chen, C., Weinman, S. A. & Kharbanda, K. K., Feb 21 2022, In: Frontiers in Physiology. 13, 831004.

Research output: Contribution to journal › Review article › peer-review

Open Access

15 Scopus citations

Environmental Triggers of Hyperuricemia and Gout

Helget, L. N. & Mikuls, T. R., Nov 2022, In: Rheumatic Disease Clinics of North America. 48, 4, p. 891-906 16 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

12 Scopus citations

Epigenetic landscape of small cell lung cancer: small image of a giant recalcitrant disease

Khan, P., Siddiqui, J. A., Maurya, S. K., Lakshmanan, I., Jain, M., Ganti, A. K., Salgia, R., Batra, S. K. & Nasser, M. W., Aug 2022, In: Seminars in Cancer Biology. 83, p. 57-76 20 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

37 Scopus citations

Hippo Signaling in the Ovary: Emerging Roles in Development, Fertility, and Disease

Clark, K. L., George, J. W., Przygrodzka, E., Plewes, M. R., Hua, G., Wang, C. & Davis, J. S., Dec 1 2022, In: Endocrine reviews. 43, 6, p. 1074-1096 23 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

40 Scopus citations

Inhalant and Additional Mucosal-Related Environmental Risks for Rheumatoid Arthritis

Luedders, B. A., Mikuls, T. R., Thiele, G. M., Poole, J. A. & England, B. R., Nov 2022, In: Rheumatic Disease Clinics of North America. 48, 4, p. 781-798 18 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

3 Scopus citations

New insights into the mechanism of alcohol-mediated organ damage via its impact on immunity, metabolism, and repair pathways: A summary of the 2021 Alcohol and Immunology Research Interest Group (AIRIG) meeting

Khair, S., Brenner, L. A., Koval, M., Samuelson, D., Cucinello-Regland, J. A., Anton, P., Piano, M. R., Simon, L., Crotty, K., Sharieh, F., Travers, J. B., Singh, V., Cannon, A., Kim, A., McCullough, R. L., Yeligar, S. M., Wyatt, T. A., McMahan, R. H., Choudhry, M. A. & Kovacs, E. J., Sep 2022, In: Alcohol. 103, p. 1-7 7 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

3 Scopus citations

Pathogenesis of Alcohol-Associated Liver Disease

Osna, N. A., Rasineni, K., Ganesan, M., Donohue, T. M. & Kharbanda, K. K., Nov 1 2022, In: Journal of Clinical and Experimental Hepatology. 12, 6, p. 1492-1513 22 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

37 Scopus citations

Patient Compliance With Wearing Lower Limb Assistive Devices: A Scoping Review

Bashir, A. Z., Dinkel, D. M., Pipinos, I. I., Johanning, J. M. & Myers, S. A., Feb 2022, In: Journal of Manipulative and Physiological Therapeutics. 45, 2, p. 114-126 13 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

9 Scopus citations

Relaxin as an anti-fibrotic treatment: Perspectives, challenges and future directions

Samuel, C. S. & Bennett, R. G., Mar 2022, In: Biochemical Pharmacology. 197, 114884.

Research output: Contribution to journal › Review article › peer-review

23 Scopus citations

Role of the ghrelin system in alcohol use disorder and alcohol-associated liver disease: A narrative review

Kharbanda, K. K., Farokhnia, M., Deschaine, S. L., Bhargava, R., Rodriguez-Flores, M., Casey, C. A., Goldstone, A. P., Jerlhag, E., Leggio, L. & Rasineni, K., Dec 2022, In: Alcoholism: Clinical and Experimental Research. 46, 12, p. 2149-2159 11 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

18 Scopus citations

2021

Alcohol use disorder: A pre-existing condition for COVID-19?

Bailey, K. L., Samuelson, D. R. & Wyatt, T. A., Feb 2021, In: Alcohol. 90, p. 11-17 7 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

43 Scopus citations

A review of the role of ethanol-induced adipose tissue dysfunction in alcohol-associated liver disease

Gopal, T., Ai, W., Casey, C. A., Donohue, T. M. & Saraswathi, V., Oct 2021, In: Alcoholism: Clinical and Experimental Research. 45, 10, p. 1927-1939 13 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

19 Scopus citations

Beneficial effects of betaine: A comprehensive review

Arumugam, M. K., Paal, M. C., Donohue, T. M., Ganesan, M., Osna, N. A. & Kharbanda, K. K., 2021, In: Biology. 10, 6, 456.

Research output: Contribution to journal › Review article › peer-review

Open Access

149 Scopus citations

Driving Ability and Safety in Rheumatoid Arthritis: A Systematic Review

Zhou, D. J., Mikuls, T. R., Schmidt, C., England, B. R., Bergman, D. A., Rizzo, M., Merickel, J. & Michaud, K., Apr 2021, In: Arthritis care & research. 73, 4, p. 489-497 9 p.

Research output: Contribution to journal › Review article › peer-review

7 Scopus citations

Luteinizing hormone regulation of inter-organelle communication and fate of the corpus luteum

Przygrodzka, E., Plewes, M. R. & Davis, J. S., Sep 2021, In: International journal of molecular sciences. 22, 18, 9972.

Research output: Contribution to journal › Review article › peer-review

Open Access

29 Scopus citations

Pancreatogenic diabetes: Triggering effects of alcohol and HIV

New-Aaron, M., Ganesan, M., Dagur, R. S., Kharbanda, K. K., Poluektova, L. Y. & Osna, N. A., Feb 2021, In: Biology. 10, 2, p. 1-25 25 p., 108.

Research output: Contribution to journal › Review article › peer-review

Open Access

13 Scopus citations

RNA-based therapies: A cog in the wheel of lung cancer defense

Khan, P., Siddiqui, J. A., Lakshmanan, I., Ganti, A. K., Salgia, R., Jain, M., Batra, S. K. & Nasser, M. W., Dec 2021, In: Molecular cancer. 20, 1, 54.

Research output: Contribution to journal › Review article › peer-review

Open Access

63 Scopus citations

Role of cell-free network communication in alcohol-associated disorders and liver metastasis

Kuracha, M. R., Thomas, P., Tobi, M. & McVicker, B. L., Nov 7 2021, In: World Journal of Gastroenterology. 27, 41, p. 7080-7099 20 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

4 Scopus citations

Second hits exacerbate alcohol-related organ damage: An update

Osna, N. A., Ganesan, M., Seth, D., Wyatt, T. A., Kidambi, S. & Kharbanda, K. K., Jan 1 2021, In: Alcohol and Alcoholism. 56, 1, p. 8-16 9 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

10 Scopus citations

Therapeutic targets, novel drugs, and delivery systems for diabetes associated NAFLD and liver fibrosis

Kumar, V., Xin, X., Ma, J., Tan, C., Osna, N. & Mahato, R. I., Sep 2021, In: Advanced Drug Delivery Reviews. 176, 113888.

Research output: Contribution to journal › Review article › peer-review

Open Access

95 Scopus citations

2020

Design of the PReferences for Open Versus Endovascular Repair of Abdominal Aortic Aneurysm (PROVE-AAA) Trial

The PROVE-AAA Study Team, May 2020, In: Annals of Vascular Surgery. 65, p. 247-253 7 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

14 Scopus citations

Dual Substance Use of Electronic Cigarettes and Alcohol

Wetzel, T. J. & Wyatt, T. A., Nov 2 2020, In: Frontiers in Physiology. 11, 593803.

Research output: Contribution to journal › Review article › peer-review

Open Access

11 Scopus citations

Mechanisms, biomarkers and targets for therapy in alcohol-associated liver injury: From Genetics to nutrition: Summary of the ISBRA 2018 symposium

Kirpich, I. A., Warner, D. R., Feng, W., Joshi-Barve, S., McClain, C. J., Seth, D., Zhong, W., Zhou, Z., Osna, N. A. & Kharbanda, K. K., Mar 2020, In: Alcohol. 83, p. 105-114 10 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

15 Scopus citations

Methods in lung microbiome research

Carney, S. M., Clemente, J. C., Cox, M. J., Dickson, R. P., Huang, Y. J., Kitsios, G. D., Kloepfer, K. M., Leung, J. M., LeVan, T. D., Molyneaux, P. L., Moore, B. B., O'Dwyer, D. N., Segal, L. N. & Garantziotis, S., Mar 1 2020, In: American journal of respiratory cell and molecular biology. 62, 3, p. 283-299 17 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

108 Scopus citations

Oncology care delivery in the COVID-19 pandemic: An opportunity to study innovations and outcomes

Cinar, P., Cox, J., Kamal, A., Bickel, K., Krzyzanowska, M., Armitage, J., Ganti, A. K., Ward, J., Wong, S., Lonial, S. & Bosserman, L., 2020, In: JCO Oncology Practice. 16, 8, p. 431-435 5 p.

Research output: Contribution to journal › Review article › peer-review

13 Scopus citations

Recent advances in understanding the complexity of alcohol-induced pancreatic dysfunction and pancreatitis development

Rasineni, K., Srinivasan, M. P., Balamurugan, A. N., Kaphalia, B. S., Wang, S., Ding, W. X., Pandol, S. J., Lugea, A., Simon, L., Molina, P. E., Gao, P., Casey, C. A., Osna, N. A. & Kharbanda, K. K., May 2020, In: Biomolecules. 10, 5, 669.

Research output: Contribution to journal › Review article › peer-review

Open Access

19 Scopus citations

Relevance of the antioxidant properties of methotrexate and doxycycline to their treatment of cardiovascular disease

Clemens, D. L., Duryee, M. J., Hall, J. H., Thiele, G. M., Mikuls, T. R., Klassen, L. W., Zimmerman, M. C. & Anderson, D. R., Jan 2020, In: Pharmacology and Therapeutics. 205, 107413.

Research output: Contribution to journal › Review article › peer-review

16 Scopus citations

Role of alcohol in pathogenesis of hepatitis B virus infection

Ganesan, M., Eikenberry, A., Poluektova, L. Y., Kharbanda, K. K. & Osna, N. A., Mar 7 2020, In: World Journal of Gastroenterology. 26, 9, p. 883-903 21 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

29 Scopus citations

Role of non-Genetic Risk Factors in Exacerbating Alcohol-related organ damage

Osna, N. A., Bhatia, R., Thompson, C., Batra, S. K., Kumar, S., Cho, Y., Szabo, G., Molina, P. E., Weinman, S. A., Ganesan, M. & Kharbanda, K. K., Sep 2020, In: Alcohol. 87, p. 63-72 10 p.

Research output: Contribution to journal › Review article › peer-review

Open Access