Bradley E Britigan, MD

  • 7424 Citations
  • 49 h-Index
1985 …2019

Research output per year

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Research Output

  • 7424 Citations
  • 49 h-Index
  • 141 Article
  • 10 Review article
  • 3 Comment/debate
  • 2 Letter
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Article
2019
2 Scopus citations

Enhancing responsiveness of pancreatic cancer cells to gemcitabine treatment under hypoxia by heme oxygenase-1 inhibition

Abdalla, M. Y., Ahmad, I. M., Rachagani, S., Banerjee, K., Thompson, C. M., Maurer, H. C., Olive, K. P., Bailey, K. L., Britigan, B. E. & Kumar, S., May 2019, In : Translational Research. 207, p. 56-69 14 p.

Research output: Contribution to journalArticle

10 Scopus citations
3 Scopus citations
Open Access
2 Scopus citations
2018

Gallium disrupts bacterial iron metabolism and has therapeutic effects in mice and humans with lung infections

Goss, C. H., Kaneko, Y., Khuu, L., Anderson, G. D., Ravishankar, S., Aitken, M. L., Lechtzin, N., Zhou, G., Czyz, D. M., McLean, K., Olakanmi, O., Shuman, H. A., Teresi, M., Wilhelm, E., Caldwell, E., Salipante, S. J., Hornick, D. B., Siehnel, R. J., Becker, L., Britigan, B. E. & 1 others, Singh, P. K., Sep 26 2018, In : Science translational medicine. 10, 460, eaat7520.

Research output: Contribution to journalArticle

29 Scopus citations
4 Scopus citations
2017
9 Scopus citations

Gallium nanoparticles facilitate phagosome maturation and inhibit growth of virulent Mycobacterium tuberculosis in macrophages

Choi, S. R., Britigan, B. E., Moran, D. M. & Narayanasamy, P., May 2017, In : PloS one. 12, 5, e0177987.

Research output: Contribution to journalArticle

17 Scopus citations

Passive transfer of interferon-γ over-expressing macrophages enhances resistance of SCID mice to Mycobacterium tuberculosis infection

Pasula, R., Martin, W. J., Kesavalu, B. R., Abdalla, M. Y. & Britigan, B. E., Jul 1 2017, In : Cytokine. 95, p. 70-79 10 p.

Research output: Contribution to journalArticle

Pseudomonas quinolone signal induces oxidative stress and inhibits heme oxygenase-1 expression in lung epithelial cells

Abdalla, M. Y., Hoke, T., Seravalli, J., Switzer, B. L., Bavitz, M., Fliege, J. D., Murphy, P. J. & Britigan, B. E., Sep 1 2017, In : Infection and immunity. 85, 9, e00176-17.

Research output: Contribution to journalArticle

8 Scopus citations
2016

Airway delivery of interferon-γ overexpressing macrophages confers resistance to Mycobacterium avium infection in SCID mice

Pasula, R., Britigan, B. E., Kesavalu, B., Abdalla, M. Y. & Martin, W. J., Nov 1 2016, In : Physiological Reports. 4, 21, e13008.

Research output: Contribution to journalArticle

2 Scopus citations
2015

Gallium compounds exhibit potential as new therapeutic agents against Mycobacterium abscessus

Abdalla, M. Y., Switzer, B. L., Goss, C. H., Aitken, M. L., Singh, P. K. & Britigan, B. E., Aug 1 2015, In : Antimicrobial Agents and Chemotherapy. 59, 8, p. 4826-4834 9 p.

Research output: Contribution to journalArticle

19 Scopus citations
22 Scopus citations
26 Scopus citations
2013

Gallium nitrate is efficacious in murine models of tuberculosis and inhibits key bacterial fe-dependent enzymes

Olakanmi, O., Kesavalu, B., Pasula, R., Abdalla, M. Y., Schlesinger, L. S. & Britigan, B. E., Dec 2013, In : Antimicrobial Agents and Chemotherapy. 57, 12, p. 6074-6080 7 p.

Research output: Contribution to journalArticle

21 Scopus citations

Iron acquisition by Mycobacterium tuberculosis residing within myeloid dendritic cells

Olakanmi, O., Kesavalu, B., Abdalla, M. Y. & Britigan, B. E., Dec 1 2013, In : Microbial Pathogenesis. 65, p. 21-28 8 p.

Research output: Contribution to journalArticle

14 Scopus citations
2012

Inactivation of the potent Pseudomonas aeruginosa cytotoxin pyocyanin by airway peroxidases and nitrite

Reszka, K. J., Xiong, Y., Sallans, L., Pasula, R., Olakanmi, O., Hassett, D. J. & Britigan, B. E., May 15 2012, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 302, 10, p. L1044-L1056

Research output: Contribution to journalArticle

12 Scopus citations
2011

Active starvation responses mediate antibiotic tolerance in biofilms and nutrient-limited bacteria

Nguyen, D., Joshi-Datar, A., Lepine, F., Bauerle, E., Olakanmi, O., Beer, K., McKay, G., Siehnel, R., Schafhauser, J., Wang, Y., Britigan, B. E. & Singh, P. K., Nov 18 2011, In : Science. 334, 6058, p. 982-986 5 p.

Research output: Contribution to journalArticle

447 Scopus citations

Airway peroxidases catalyze nitration of the β2-agonist salbutamol and decrease its pharmacological activity

Reszka, K. J., Sallans, L., Macha, S., Brown, K., McGraw, D. W., Kovacic, M. B. & Britigan, B. E., Feb 1 2011, In : Journal of Pharmacology and Experimental Therapeutics. 336, 2, p. 440-449 10 p.

Research output: Contribution to journalArticle

7 Scopus citations
10 Scopus citations
2010

Gallium disrupts iron uptake by intracellular and extracellular Francisella strains and exhibits therapeutic efficacy in a murine pulmonary infection model

Olakanmi, O., Gunn, J. S., Su, S., Soni, S., Hassett, D. J. & Britigan, B. E., Jan 1 2010, In : Antimicrobial Agents and Chemotherapy. 54, 1, p. 244-253 10 p.

Research output: Contribution to journalArticle

32 Scopus citations

Quenching of singlet oxygen by pyocyanin and related phenazines

Reszka, K. J., Bilski, P. J. & Britigan, B. E., Jul 1 2010, In : Photochemistry and Photobiology. 86, 4, p. 742-746 5 p.

Research output: Contribution to journalArticle

8 Scopus citations
2009

Airway delivery of silica increases susceptibility to mycobacterial infection in mice: Potential role of repopulating macrophages

Pasula, R., Britigan, B. E., Turner, J. & Martin, W. J., Jun 1 2009, In : Journal of Immunology. 182, 11, p. 7102-7109 8 p.

Research output: Contribution to journalArticle

14 Scopus citations

Copper egress is induced by PMA in human THP-1 monocytic cell line

Afton, S. E., Caruso, J. A., Britigan, B. E. & Qin, Z., Jun 1 2009, In : BioMetals. 22, 3, p. 531-539 9 p.

Research output: Contribution to journalArticle

13 Scopus citations

Peroxidative metabolism of β2-agonists salbutamol and fenoterol and their analogues

Reszka, K. J., McGraw, D. W. & Britigan, B. E., Jun 15 2009, In : Chemical Research in Toxicology. 22, 6, p. 1137-1150 14 p.

Research output: Contribution to journalArticle

12 Scopus citations
2008

Hepatitis C core protein inhibits induction of heme oxygenase-1 and sensitizes hepatocytes to cytotoxicity

Wen, F., Brown, K. E., Britigan, B. E. & Schmidt, W. N., Apr 1 2008, In : Cell Biology and Toxicology. 24, 2, p. 175-188 14 p.

Research output: Contribution to journalArticle

28 Scopus citations

The peptidoglycan-associated lipoprotein OprL helps protect a Pseudomonas aeruginosa mutant devoid of the transactivator OxyR from hydrogen peroxide-mediated killing during planktonic and biofilm culture

Panmanee, W., Gomez, F., Witte, D., Pancholi, V., Britigan, B. E. & Hassett, D. J., May 1 2008, In : Journal of bacteriology. 190, 10, p. 3658-3669 12 p.

Research output: Contribution to journalArticle

21 Scopus citations
2007
17 Scopus citations

Hereditary hemochromatosis results in decreased iron acquisition and growth by Mycobacterium tuberculosis within human macrophages

Olakanmi, O., Schlesinger, L. S. & Britigan, B. E., Jan 1 2007, In : Journal of Leukocyte Biology. 81, 1, p. 195-204 10 p.

Research output: Contribution to journalArticle

62 Scopus citations

Inactivation of anthracyclines by serum heme proteins

Wagner, B. A., Teesch, L. M., Buettner, G. R., Britigan, B. E., Burns, C. P. & Reszka, K. J., Jun 1 2007, In : Chemical Research in Toxicology. 20, 6, p. 920-926 7 p.

Research output: Contribution to journalArticle

9 Scopus citations

The transition metal gallium disrupts Pseudomonas aeruginosa iron metabolism and has antimicrobial and antibiofilm activity

Kaneko, Y., Thoendel, M., Olakanmi, O., Britigan, B. E. & Singh, P. K., Apr 2 2007, In : Journal of Clinical Investigation. 117, 4, p. 877-888 12 p.

Research output: Contribution to journalArticle

363 Scopus citations
2006

Nitric oxide decreases the stability of DMPO spin adducts

Reszka, K. J., McCormick, M. L., Buettner, G. R., Michael Hart, C. & Britigan, B. E., Sep 1 2006, In : Nitric Oxide - Biology and Chemistry. 15, 2, p. 133-141 9 p.

Research output: Contribution to journalArticle

17 Scopus citations

Photosensitized oxidation and inactivation of pyocyanin, a virulence factor of Pseudomonas aeruginosa

Reszka, K. J., Denning, G. M. & Britigan, B. E., Mar 1 2006, In : Photochemistry and Photobiology. 82, 2, p. 466-473 8 p.

Research output: Contribution to journalArticle

17 Scopus citations
2005

Effects of peroxidase substrates on the Amplex red/peroxidase assay: Antioxidant properties of anthracyclines

Reszka, K. J., Wagner, B. A., Burns, C. P. & Britigan, B. E., Jul 15 2005, In : Analytical Biochemistry. 342, 2, p. 327-337 11 p.

Research output: Contribution to journalArticle

35 Scopus citations
7 Scopus citations

Hemin induces active chloride secretion in Caco-2 cells

Uc, A., Husted, R. F., Giriyappa, R. L., Britigan, B. E. & Stokes, J. B., Aug 1 2005, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 289, 2 52-2, p. G202-G208

Research output: Contribution to journalArticle

10 Scopus citations

Hepatitis C virus-core and non structural proteins lead to different effects on cellular antioxidant defenses

Abdalla, M. Y., Ahmad, I. M., Spitz, D. R., Schmidt, W. N. & Britigan, B. E., Aug 1 2005, In : Journal of Medical Virology. 76, 4, p. 489-497 9 p.

Research output: Contribution to journalArticle

91 Scopus citations

Inactivation of anthracyclines by cellular peroxidase

Reszka, K. J., Wagner, B. A., Teesch, L. M., Britigan, B. E., Spitz, D. R. & Burns, C. P., Jul 15 2005, In : Cancer Research. 65, 14, p. 6346-6353 8 p.

Research output: Contribution to journalArticle

14 Scopus citations

Oxidation of anthracyclines by peroxidase metabolites of salicylic acid

Reszka, K. J., Britigan, L. H. & Britigan, B. E., Oct 1 2005, In : Journal of Pharmacology and Experimental Therapeutics. 315, 1, p. 283-290 8 p.

Research output: Contribution to journalArticle

9 Scopus citations

Pseudomonas aeruginosa OxyR is required for full virulence in rodent and insect models of infection and for resistance to human neutrophils

Lau, G. W., Britigan, B. E. & Hassett, D. J., Apr 1 2005, In : Infection and immunity. 73, 4, p. 2550-2553 4 p.

Research output: Contribution to journalArticle

56 Scopus citations

Pyocyanin and its precursor phenazine-1-carboxylic acid increase IL-8 and intercellular adhesion molecule-1 expression in human airway epithelial cells by oxidant-dependent mechanisms

Look, D. C., Stoll, L. L., Romig, S. A., Humlicek, A., Britigan, B. E. & Denning, G. M., Sep 15 2005, In : Journal of Immunology. 175, 6, p. 4017-4023 7 p.

Research output: Contribution to journalArticle

Open Access
49 Scopus citations
2004

Acetaminophen stimulates the peroxidative metabolism of anthracyclines

Reszka, K. J., Britigan, L. H., Rasmussen, G. T., Wagner, B. A., Burns, C. P. & Britigan, B. E., Jul 1 2004, In : Archives of Biochemistry and Biophysics. 427, 1, p. 16-29 14 p.

Research output: Contribution to journalArticle

12 Scopus citations

Cleavage of human transferrin by Porphyromonas gingivalis gingipains promotes growth and formation of hydroxyl radicals

Goulet, V., Britigan, B., Nakayama, K. & Grenier, D., Aug 1 2004, In : Infection and immunity. 72, 8, p. 4351-4356 6 p.

Research output: Contribution to journalArticle

23 Scopus citations
49 Scopus citations

Down-regulation of heme oxygenase-1 by hepatitis C virus infection in vivo and by the in vitro expression of hepatitis C core protein

Abdalla, M. Y., Britigan, B. E., Wen, F., Icardi, M., McCormick, M. L., LaBrecque, D. R., Voigt, M., Brown, K. E. & Schmidt, W. N., Sep 15 2004, In : Journal of Infectious Diseases. 190, 6, p. 1109-1118 10 p.

Research output: Contribution to journalArticle

66 Scopus citations
41 Scopus citations

Increased Prooxidant Production and Enhanced Susceptibility to Glutathione Depletion in HepG2 Cells Co-expressing HCV Core Protein and CYP2E1

Wen, F., Abdalla, M. Y., Aloman, C., Xiang, J., Ahmad, I. M., Walewski, J., McCormick, M. L., Brown, K. E., Branch, A. D., Spitz, D. R., Britigan, B. E. & Schmidt, W. N., Feb 1 2004, In : Journal of Medical Virology. 72, 2, p. 230-240 11 p.

Research output: Contribution to journalArticle

39 Scopus citations

Oxidation of pyocyanin, a cytotoxic product from Pseudomonas aeruginosa, by microperoxidase 11 and hydrogen peroxide

Reszka, K. J., O'Malley, Y., McCormick, M. L., Denning, G. M. & Britigan, B. E., Jun 1 2004, In : Free Radical Biology and Medicine. 36, 11, p. 1448-1459 12 p.

Research output: Contribution to journalArticle

63 Scopus citations

Pseudomonas aeruginosa pyocyanin directly oxidizes glutathione and decreases its levels in airway epithelial cells

O'Malley, Y. Q., Reszka, K. J., Spitz, D. R., Denning, G. M. & Britigan, B. E., Jul 1 2004, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 287, 1 31-1, p. L94-L103

Research output: Contribution to journalArticle

117 Scopus citations

The Nature of Extracellular Iron Influences Iron Acquisition by Mycobacterium tuberculosis Residing within Human Macrophages

Olakanmi, O., Schlesinger, L. S., Ahmed, A. & Britigan, B. E., Apr 1 2004, In : Infection and immunity. 72, 4, p. 2022-2028 7 p.

Research output: Contribution to journalArticle

36 Scopus citations