Brian D Lowes, MD, PhD

  • 6047 Citations
  • 38 h-Index
1978 …2020

Research output per year

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Research Output

2020

Association of Clinical Outcomes with Left Ventricular Assist Device Use by Bridge to Transplant or Destination Therapy Intent: The Multicenter Study of MagLev Technology in Patients Undergoing Mechanical Circulatory Support Therapy with HeartMate 3 (MOMENTUM 3) Randomized Clinical Trial

Goldstein, D. J., Naka, Y., Horstmanshof, D., Ravichandran, A. K., Schroder, J., Ransom, J., Itoh, A., Uriel, N., Cleveland, J. C., Raval, N. Y., Cogswell, R., Suarez, E. E., Lowes, B. D., Kim, G., Bonde, P., Sheikh, F. H., Sood, P., Farrar, D. J. & Mehra, M. R., Apr 2020, In : JAMA Cardiology. 5, 4, p. 411-419 9 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Percutaneous Deactivation of Left Ventricular Assist Devices

Albulushi, A., Goldsweig, A. M., Stoller, D., Delaney, J. W., Um, J., Lowes, B. & Zolty, R., 2020, (Accepted/In press) In : Seminars in Thoracic and Cardiovascular Surgery.

Research output: Contribution to journalArticle

1 Scopus citations

Pre-Heart Transplant Spirometry Predicts Post-Transplant Survival

Lundgren, S., Lowes, B., Lyden, E., Zolty, R., Hyden, M., Burdorf, A., Um, J. Y. & Stoller, D., Apr 1 2020, In : The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation. 39, 4, p. S280

Research output: Contribution to journalArticle

Recurrent pump thrombosis is common after axial continuous-flow left ventricular assist device exchange

Urban, M., Um, J., Moulton, M., Stoller, D., Zolty, R., Lowes, B., Macdonald, C., McCain, N. & Siddique, A., Feb 1 2020, In : International Journal of Artificial Organs. 43, 2, p. 109-118 10 p.

Research output: Contribution to journalArticle

1 Scopus citations

Variant interpretation for dilated cardiomyopathy

DCM Precision Medicine study & DCM Consortium, 2020, (Accepted/In press) In : Circulation: Genomic and Precision Medicine. p. 43-51 9 p.

Research output: Contribution to journalArticle

1 Scopus citations
2019

A fully magnetically levitated left ventricular assist device - Final report

Mehra, M. R., Uriel, N., Naka, Y., Cleveland, J. C., Yuzefpolskaya, M., Salerno, C. T., Walsh, M. N., Milano, C. A., Patel, C. B., Hutchins, S. W., Ransom, J., Ewald, G. A., Itoh, A., Raval, N. Y., Silvestry, S. C., Cogswell, R., John, R., Bhimaraj, A., Bruckner, B. A., Lowes, B. D. & 20 others, Um, J. Y., Jeevanandam, V., Sayer, G., Mangi, A. A., Molina, E. J., Sheikh, F., Aaronson, K., Pagani, F. D., Cotts, W. G., Tatooles, A. J., Babu, A., Chomsky, D., Katz, J. N., Tessmann, P. B., Dean, D., Krishnamoorthy, A., Chuang, J., Topuria, I., Sood, P. & Goldstein, D. J., Apr 25 2019, In : New England Journal of Medicine. 380, 17, p. 1618-1627 10 p.

Research output: Contribution to journalArticle

108 Scopus citations

Can we expect improvements in outcomes with centrifugal vs axial flow left ventricular assist devices in patients transitioned from extracorporeal life support?

Urban, M., Siddique, A., Moulton, M. M., Castleberry, A. W., Merritt-Genore, H. M., Ryan, T., Lowes, B. & Um, J. Y., Nov 1 2019, In : Journal of cardiac surgery. 34, 11, p. 1228-1234 7 p.

Research output: Contribution to journalArticle

Elevated Heart Rate Following Heart Transplantation Is Associated With Increased Graft Vasculopathy and Mortality

Liebo, M., Newman, J., Joshi, A., Lowes, B. D., Peled-Potashnik, Y., Basha, H. I., Zolty, R., Um, J. Y., McGee, E., Heroux, A. & Raichlin, E., Apr 2019, In : Journal of Cardiac Failure. 25, 4, p. 249-256 8 p.

Research output: Contribution to journalArticle

1 Scopus citations

Erratum: Sequential analysis of myocardial gene expression with phenotypic change: Use of cross-platform concordance to strengthen biologic relevance (PLoS ONE (2019) 14: 8 (e0221519) DOI: 10.1371/journal.pone.0221519)

Toni, L. S., Carroll, I. A., Jones, K. L., Schwisow, J. A., Minobe, W. A., Rodriguez, E. M., Altman, N. L., Lowes, B. D., Gilbert, E. M., Buttrick, P. M., Kao, D. P. & Bristow, M. R., 2019, In : PloS one. 14, 10, e0224389.

Research output: Contribution to journalComment/debate

Open Access

Left Ventricular Assist Devices in Pulmonary Hypertension Group 2 With Significantly Elevated Pulmonary Vascular Resistance: A Bridge to Cure

Selim, A. M., Wadhwani, L., Burdorf, A., Raichlin, E., Lowes, B. & Zolty, R., Jun 2019, In : Heart Lung and Circulation. 28, 6, p. 946-952 7 p.

Research output: Contribution to journalArticle

4 Scopus citations

Sequential analysis of myocardial gene expression with phenotypic change: Use of cross-platform concordance to strengthen biologic relevance

Toni, L. S., Carroll, I. A., Jones, K. L., Schwisow, J. A., Minobe, W. A., Rodriguez, E. M., Altman, N. L., Lowes, B. D., Gilbert, E. M., Buttrick, P. M., Kao, D. P. & Bristow, M. R., 2019, In : PloS one. 14, 8, e0221519.

Research output: Contribution to journalArticle

Open Access

Sirolimus for Recurrent Giant Cell Myocarditis After Heart Transplantation: A Unique Therapeutic Strategy

Patel, A. D., Lowes, B., Chamsi-Pasha, M. A., Radio, S. J., Hyden, M. & Zolty, R., Sep 1 2019, In : American journal of therapeutics. 26, 5, p. 600-603 4 p.

Research output: Contribution to journalArticle

TGF-β induces a heart failure phenotype via fibroblasts exosome signaling

Basma, H., Johanson, A. N., Dhar, K., Anderson, D., Qiu, F., Rennard, S. & Lowes, B. D., Oct 2019, In : Heliyon. 5, 10, e02633.

Research output: Contribution to journalArticle

Open Access

The effect of donor alcohol abuse on outcomes following heart transplantation

Newman, J., Liebo, M., Lowes, B. D., Ilias Basha, H., Peled, Y., Cendrowski, E., Zolty, R., Douglas, D., Um, J. Y., McGee, E., Heroux, A. & Raichlin, E., Feb 1 2019, In : Clinical Transplantation. 33, 2, e13461.

Research output: Contribution to journalArticle

2018

Depression and anxiety in patients undergoing left ventricular assist device implantation

Lundgren, S., Poon, C. Y. M., Selim, A., Lowes, B. D., Zolty, R., Burdorf, A., Potashnik-Peled, Y., Moulton, M. J., Um, J. Y. & Raichlin, E., Nov 1 2018, In : International Journal of Artificial Organs. 41, 2, p. 76-83 8 p.

Research output: Contribution to journalArticle

5 Scopus citations

Do Psychosocial Factors Have Any Impact on Outcomes After Left Ventricular Assist Device Implantation?

Lundgren, S., Lowes, B. D., Zolty, R., Burdorf, A., Raichlin, E., Um, J. Y. & Poon, C., Jul 1 2018, In : ASAIO journal (American Society for Artificial Internal Organs : 1992). 64, 4, p. e43-e47

Research output: Contribution to journalArticle

8 Scopus citations

Risk Factors for In-Hospital Mortality in Heart Failure Patients: Does Rurality, Payer or Admission Source Matter?

Nayar, P., Yu, F., Chandak, A., Kan, G. L., Lowes, B. & Apenteng, B. A., Dec 1 2018, In : Journal of Rural Health. 34, 1, p. 103-108 6 p.

Research output: Contribution to journalArticle

3 Scopus citations
2017

Effect of diltiazem on exercise capacity after heart transplantation

Varnado, S., Peled-Potashnik, Y., Huntsberry, A., Lowes, B. D., Zolty, R., Burdorf, A., Lyden, E. R., Moulton, M. J., Um, J. Y. & Raichlin, E., Aug 2017, In : Clinical Transplantation. 31, 8, e12997.

Research output: Contribution to journalArticle

1 Scopus citations

Sinus tachycardia is associated with impaired exercise tolerance following heart transplantation

Peled, Y., Varnado, S., Lowes, B. D., Zolty, R., Lyden, E. R., Moulton, M. J., Um, J. Y. & Raichlin, E., May 2017, In : Clinical Transplantation. 31, 5, e12946.

Research output: Contribution to journalArticle

3 Scopus citations

Structural and Functional Phenotyping of the Failing Heart: Is the Left Ventricular Ejection Fraction Obsolete?

Bristow, M. R., Kao, D. P., Breathett, K. K., Altman, N. L., Gorcsan, J., Gill, E. A., Lowes, B. D., Gilbert, E. M., Quaife, R. A. & Mann, D. L., Nov 2017, In : JACC: Heart Failure. 5, 11, p. 772-781 10 p.

Research output: Contribution to journalReview article

18 Scopus citations
2016

Corrigendum: Inhaled Milrinone after Left Ventricular Assist Device Implantation (Journal of Cardiac Failure (2015) 21:10 (792-797) doi:10.1016/j.cardfail.2015.04.011)

Haglund, N. A., Burdorf, A., Jones, T., Shostrom, V., Um, J., Ryan, T., Shillcutt, S., Fischer, P., Cox, Z. L., Raichlin, E., Anderson, D. R., Lowes, B. D. & Dumitru, I., Mar 1 2016, In : Journal of Cardiac Failure. 22, 3, 1 p.

Research output: Contribution to journalComment/debate

Outcomes in patients with severe preexisting renal dysfunction after continuous-flow left ventricular assist device implantation

Raichlin, E., Baibhav, B., Lowes, B. D., Zolty, R., Lyden, E. R., Vongooru, H. R., Siddique, A., Moulton, M. J. & Um, J. Y., 2016, In : ASAIO Journal. 62, 3, p. 261-267 7 p.

Research output: Contribution to journalArticle

16 Scopus citations

Targeted myocardial gene expression in failing hearts by RNA sequencing

Dhar, K., Moulton, A. M., Rome, E., Qiu, F., Kittrell, J., Raichlin, E., Zolty, R., Um, J. Y., Moulton, M. J., Basma, H., Anderson, D. R., Eudy, J. D. & Lowes, B. D., Nov 25 2016, In : Journal of Translational Medicine. 14, 1, 327.

Research output: Contribution to journalArticle

6 Scopus citations
2 Scopus citations
2015

Inhaled milrinone after left ventricular assist device implantation

Haglund, N. A., Burdorf, A., Jones, T., Shostrom, V., Um, J. Y., Ryan, T., Shillcutt, S. K., Fischer, P., Cox, Z. L., Raichlin, E., Lowes, B. D. & Dumitru, I., Oct 1 2015, In : Journal of Cardiac Failure. 21, 10, p. 792-797 6 p.

Research output: Contribution to journalArticle

16 Scopus citations

Therapeutic molecular phenotype of β-blocker-associated reverse-remodeling in nonischemic dilated cardiomyopathy

Kao, D. P., Lowes, B. D., Gilbert, E. M., Minobe, W., Epperson, L. E., Meyer, L. K., Ferguson, D. A., Volkman, A. K., Zolty, R., Borg, C. D., Quaife, R. A. & Bristow, M. R., Apr 4 2015, In : Circulation: Cardiovascular Genetics. 8, 2, p. 270-283 14 p.

Research output: Contribution to journalArticle

22 Scopus citations
2014

Combined heart and liver transplantation against positive cross-match for patient with hypoplastic left heart syndrome

Raichlin, E., Um, J. Y., F. Duncan, K., Dumitru, I., Lowes, B. D., Moulton, M., Gebhart, C. L., Grant, W. J. & Hammel, J. M., 2014, In : Transplantation. 98, 12, p. e100-e102

Research output: Contribution to journalLetter

6 Scopus citations

Risk of death in heart disease is associated with elevated urinary globotriaosylceramide.

Schiffmann, R., Forni, S., Swift, C., Brignol, N., Wu, X., Lockhart, D. J., Blankenship, D., Wang, X., Grayburn, P. A., Taylor, M. R. G., Lowes, B. D., Fuller, M., Benjamin, E. R. & Sweetman, L., 2014, In : Journal of the American Heart Association. 3, 1, p. e000394

Research output: Contribution to journalArticle

18 Scopus citations

Timed response to inhaled nitric oxide in pulmonary hypertension

Hunt, J. M., Risbano, M. G., Messenger, J. C., Carroll, J., Badesch, D., Lowes, B. D., Casserly, I. P., Kay, J. & Bull, T. M., Mar 1 2014, In : Pulmonary Circulation. 4, 1, p. 103-109 7 p.

Research output: Contribution to journalArticle

1 Scopus citations

Worsening renal function in patients with acute decompensated heart failure treated with ultrafiltration: Predictors and outcomes

Raichlin, E., Haglund, N. A., Dumitru, I., Lyden, E. R., Johnston, M. D., Mack, J. M., Windle, J. R. & Lowes, B. D., May 2014, In : Journal of Cardiac Failure. 20, 5, p. 376.e25-376.e32

Research output: Contribution to journalArticle

6 Scopus citations
2013

Association of DJ-1/PTEN/AKT- and ASK1/p38-mediated cell signalling with ischaemic cardiomyopathy

Klawitter, J., Klawitter, J., Agardi, E., Corby, K., Leibfritz, D., Lowes, B. D., Christians, U. & Seres, T., Jan 1 2013, In : Cardiovascular research. 97, 1, p. 66-76 11 p.

Research output: Contribution to journalArticle

36 Scopus citations

Cytomegalovirus reactivation and colitis after left ventricular assist device placement

Sandkovsky, U., Florescu, D. F., Um, J. Y., Raichlin, E., Lowes, B. D., Kapalis, M., Hewlett, A., Duncan, K. F., Ryan, T., DiMaio, D., Wedel, W. & Kalil, A. C., May 2013, In : International Journal of Infectious Diseases. 17, 5, p. e348-e351

Research output: Contribution to journalArticle

2 Scopus citations

Left Ventricular Assist Device Effects on Metabolic Substrates in the Failing Heart

Weitzel, L. B., Ambardekar, A. V., Brieke, A., Cleveland, J. C., Serkova, N. J., Wischmeyer, P. E. & Lowes, B. D., Apr 1 2013, In : PloS one. 8, 4, e60292.

Research output: Contribution to journalArticle

12 Scopus citations

Worsening renal function in patients with acute decompensated heart failure treated with ultrafiltration: Predictors and outcomes

Raichlin, E., Haglund, N. A., Dumitru, I., Lyden, E. R., Johnston, M. D., Mack, J. M., Windle, J. R. & Lowes, B. D., Jul 2013, In : Journal of Cardiac Failure. 19, 7, p. 787-794 8 p.

Research output: Contribution to journalArticle

Worsening renal function in patients with acute decompensated heart failure treated with ultrafiltration: Predictors and outcomes

Raichlin, E., Haglund, N. A., Dumitru, I., Lyden, E. R., Johnston, M. D., Mack, J. M., Windle, J. R. & Lowes, B. D., Dec 2013, In : Journal of Cardiac Failure. 19, 12, p. 787-794 8 p.

Research output: Contribution to journalArticle

3 Scopus citations
2012

Adora2b-elicited Per2 stabilization promotes a HIF-dependent metabolic switch crucial for myocardial adaptation to ischemia

Eckle, T., Hartmann, K., Bonney, S., Reithel, S., Mittelbronn, M., Walker, L. A., Lowes, B. D., Han, J., Borchers, C. H., Buttrick, P. M., Kominsky, D. J., Colgan, S. P. & Eltzschig, H. K., May 2012, In : Nature Medicine. 18, 5, p. 774-782 9 p.

Research output: Contribution to journalArticle

172 Scopus citations

A Personalized BEST: Characterization of Latent Clinical Classes of Nonischemic Heart Failure That Predict Outcomes and Response to Bucindolol

Kao, D. P., Wagner, B. D., Robertson, A. D., Bristow, M. R. & Lowes, B. D., Nov 7 2012, In : PloS one. 7, 11, e48184.

Research output: Contribution to journalArticle

15 Scopus citations
2011

Incomplete recovery of myocyte contractile function despite improvement of myocardial architecture with left ventricular assist device support

Ambardekar, A. V., Walker, J. S., Walker, L. A., Cleveland, J. C., Lowes, B. D. & Buttrick, P. M., Jul 2011, In : Circulation: Heart Failure. 4, 4, p. 425-432 8 p.

Research output: Contribution to journalArticle

38 Scopus citations
2010

An α2C-adrenergic receptor polymorphism alters the norepinephrine-lowering effects and therapeutic response of the β-Blocker Bucindolol in chronic heart failure

Bristow, M. R., Murphy, G. A., Krause-Steinrauf, H., Anderson, J. L., Carlquist, J. F., Thaneemit-Chen, S., Krishnan, V., Abraham, W. T., Lowes, B. D., Port, J. D., Davis, G. W., Lazzeroni, L. C., Robertson, A. D., Lavori, P. W. & Liggett, S. B., Jan 2010, In : Circulation: Heart Failure. 3, 1, p. 21-28 8 p.

Research output: Contribution to journalArticle

89 Scopus citations

Rationale and design of the treatment of hyponatremia based on Lixivaptan in NYHA class III/IV cardiac patient evaluation (THE BALANCE) study

Abraham, W. T., Aranda, J. M., Boehmer, J. P., Elkayam, U., Gilbert, E. M., Gottlieb, S. S., Hasenfub, G., Kukin, M., Lowes, B. D., O'Connell, J. B., Tavazzi, L., Feldman, A. M., Ticho, B. & Orlandi, C., Oct 2010, In : Clinical and Translational Science. 3, 5, p. 249-253 5 p.

Research output: Contribution to journalArticle

19 Scopus citations
2009

Myocardial FFA metabolism during rest and atrial pacing in humans

Bergman, B. C., Tsvetkova, T., Lowes, B. & Wolfel, E. E., Feb 2009, In : American Journal of Physiology - Endocrinology and Metabolism. 296, 2, p. E358-E366

Research output: Contribution to journalArticle

11 Scopus citations

Myocardial glucose and lactate metabolism during rest and atrial pacing in humans

Bergman, B. C., Tsvetkova, T., Lowes, B. & Wolfel, E. E., 2009, In : Journal of Physiology. 587, 9, p. 2087-2099 13 p.

Research output: Contribution to journalArticle

29 Scopus citations

Overdrive pacing suppresses ectopy and minimizes left ventricular assist device suction events

Ambardekar, A. V., Lowes, B., Cleveland, J. C. & Brieke, A., Sep 2009, In : Circulation: Heart Failure. 2, 5, p. 516-517 2 p.

Research output: Contribution to journalArticle

2 Scopus citations
2008

Genetic determinants of drug response in heart failure

Lowes, B. D. & Buttrick, P. M., 2008, In : Current Cardiovascular Risk Reports. 2, 6, p. 485-490 6 p.

Research output: Contribution to journalArticle

Genetic determinants of drug response in heart failure

Lowes, B. D. & Buttrick, P. M., 2008, In : Current Cardiology Reports. 10, 3, p. 176-181 6 p.

Research output: Contribution to journalReview article

4 Scopus citations

Impact of Cardiac Resynchronization Therapy on Exercise Performance, Functional Capacity, and Quality of Life in Systolic Heart Failure With QRS Prolongation: COMPANION Trial Sub-Study

De Marco, T., Wolfel, E., Feldman, A. M., Lowes, B., Higginbotham, M. B., Ghali, J. K., Wagoner, L., Kirlin, P. C., Kennett, J. D., Goel, S., Saxon, L. A., Boehmer, J. P., Mann, D., Galle, E., Ecklund, F., Yong, P. & Bristow, M. R., Feb 2008, In : Journal of Cardiac Failure. 14, 1, p. 9-18 10 p.

Research output: Contribution to journalArticle

53 Scopus citations

Left ventricular assist device as bridge to transplantation does not adversely affect one-year heart transplantation survival

Cleveland, J. C., Grover, F. L., Fullerton, D. A., Campbell, D. N., Mitchell, M. B., Lindenfeld, J. A., Wolfel, E. E., Lowes, B. D., Shakar, S. F., Brieke, A., Cannon, A. & Robertson, A. D., Sep 2008, In : Journal of Thoracic and Cardiovascular Surgery. 136, 3, p. 774-777 4 p.

Research output: Contribution to journalArticle

35 Scopus citations

Myocardial protection in sepsis

Shakar, S. & Lowes, B. D., Sep 3 2008, In : Critical Care. 12, 5, 177.

Research output: Contribution to journalArticle

2 Scopus citations