Carol B Toris, PhD

  • 3910 Citations
  • 34 h-Index
1984 …2019

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2019

A Highly Effective and Ultra-Long-Acting Anti-Glaucoma Drug, with a Novel Periorbital Delivery Method

Woodward, D. F., Wang, J. W., Coleman, R. A., Woodrooffe, A. J., Clark, K. L., Stamer, W. D., Tao, G., Fan, S. & Toris, C. B., Jun 2019, In : Journal of Ocular Pharmacology and Therapeutics. 35, 5, p. 265-277 13 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Differences in ocular biometrics and aqueous humour dynamics between Chinese and Caucasian adults

Fan, S., Guo, T., Chen, B., Xiong, J., Havens, S., Gulati, V. & Toris, C. B., Dec 1 2019, In : British Journal of Ophthalmology. 103, 12, p. 1845-1849 5 p.

Research output: Contribution to journalArticle

1 Scopus citations

Effect of Timolol on Aqueous Humor Outflow Facility in Healthy Human Eyes

Kazemi, A., McLaren, J. W., Trese, M. G. J., Toris, C. B., Gulati, V., Fan, S., Reed, D. M., Kristoff, T., Gilbert, J., Moroi, S. E. & Sit, A. J., Jun 2019, In : American journal of ophthalmology. 202, p. 126-132 7 p.

Research output: Contribution to journalArticle

2 Scopus citations

The affinity, intrinsic activity and selectivity of a structurally novel EP 2 receptor agonist at human prostanoid receptors

Coleman, R. A., Woodrooffe, A. J., Clark, K. L., Toris, C. B., Fan, S., Wang, J. W. & Woodward, D. F., Mar 2019, In : British Journal of Pharmacology. 176, 5, p. 687-698 12 p.

Research output: Contribution to journalArticle

2 Scopus citations

The future of canine glaucoma therapy

Komáromy, A. M., Bras, D., Esson, D. W., Fellman, R. L., Grozdanic, S. D., Kagemann, L., Miller, P. E., Moroi, S. E., Plummer, C. E., Sapienza, J. S., Storey, E. S., Teixeira, L. B., Toris, C. B. & Webb, T. R., Sep 1 2019, In : Veterinary Ophthalmology. 22, 5, p. 726-740 15 p.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations
2018

Consequences of puberty on efficacy of intraocular pressure-lowering drugs in male Dutch-belted rabbits

Hays, C. L., Okafor, K. C., Fan, S., High, R., Singh, D. P. & Toris, C. B., Jan 1 2018, In : Journal of Ocular Pharmacology and Therapeutics. 34, 1-2, p. 76-84 9 p.

Research output: Contribution to journalArticle

1 Scopus citations

Effects of a Novel Selective EP2 Receptor Agonist, Omidenepag Isopropyl, on Aqueous Humor Dynamics in Laser-Induced Ocular Hypertensive Monkeys

Fuwa, M., Toris, C. B., Fan, S., Taniguchi, T., Ichikawa, M., Odani-Kawabata, N., Iwamura, R., Yoneda, K., Matsugi, T., Shams, N. K. & Zhang, J. Z., Sep 2018, In : Journal of Ocular Pharmacology and Therapeutics. 34, 7, p. 531-537 7 p.

Research output: Contribution to journalArticle

9 Scopus citations
2017

Aqueous humour dynamics and biometrics in the ageing Chinese eye

Guo, T., Sampathkumar, S., Fan, S., Morris, N., Wang, F. & Toris, C. B., Sep 2017, In : British Journal of Ophthalmology. 101, 9, p. 1290-1296 7 p.

Research output: Contribution to journalArticle

3 Scopus citations

Comparison of aqueous outflow facility measurement by pneumatonography and digital schiøtz tonography

Kazemi, A., McLaren, J. W., Lin, S. C., Toris, C. B., Gulati, V., Moroi, S. E. & Sit, A. J., Jan 1 2017, In : Investigative Ophthalmology and Visual Science. 58, 1, p. 204-210 7 p.

Research output: Contribution to journalArticle

6 Scopus citations

Mechanism of action of selective laser trabeculoplasty and predictors of response

Gulati, V., Fan, S., Gardner, B. J., Havens, S. J., Schaaf, M. T., Neely, D. G. & Toris, C. B., Mar 2017, In : Investigative Ophthalmology and Visual Science. 58, 3, p. 1462-1468 7 p.

Research output: Contribution to journalArticle

13 Scopus citations
2016

Aqueous flow measured by fluorophotometry in the mouse

Toris, C. B., Fan, S., Johnson, T. V., Camras, L. J., Hays, C. L., Liu, H. & Ishimoto, B. M., Jul 2016, In : Investigative Ophthalmology and Visual Science. 57, 8, p. 3844-3852 9 p.

Research output: Contribution to journalArticle

6 Scopus citations

Effects of rho kinase inhibitors on intraocular pressure and aqueous humor dynamics in nonhuman primates and rabbits

Toris, C. B., McLaughlin, M. A., Dworak, D. P., Fan, S., Havens, S., Zhan, G. L., Horan, N. & Prasanna, G., Jul 1 2016, In : Journal of Ocular Pharmacology and Therapeutics. 32, 6, p. 355-364 10 p.

Research output: Contribution to journalArticle

12 Scopus citations

Prostanoid Receptor Antagonist Effects on Intraocular Pressure, Supported by Ocular Biodisposition Experiments

Woodward, D. F., Wenthur, S. L., Rudebush, T. L., Fan, S. & Toris, C. B., Nov 1 2016, In : Journal of Ocular Pharmacology and Therapeutics. 32, 9, p. 606-622 17 p.

Research output: Contribution to journalArticle

5 Scopus citations
9 Scopus citations
2015

Continuous non-cell autonomous reprogramming to generate retinal ganglion cells for glaucomatous neuropathy

Parameswaran, S., Dravid, S. M., Teotia, P., Krishnamoorthy, R. R., Qiu, F., Toris, C., Morrison, J. & Ahmad, I., Jun 1 2015, In : STEM CELLS. 33, 6, p. 1743-1758 16 p.

Research output: Contribution to journalArticle

9 Scopus citations

Intraocular pressure–lowering activity of NCX 470, a novel nitric oxide–donating bimatoprost in preclinical models

Impagnatiello, F., Toris, C. B., Batugo, M., Prasanna, G., Borghi, V., Bastia, E., Ongini, E. & Krauss, A. H. P., 2015, In : Investigative Ophthalmology and Visual Science. 56, 11, p. 6558-6564 7 p.

Research output: Contribution to journalArticle

9 Scopus citations
2014

Daytime and nighttime effects of brimonidine on IOP and aqueous humor dynamics in participants with ocular hypertension

Fan, S., Agrawal, A., Gulati, V., Neely, D. G. & Toris, C. B., 2014, In : Journal of Glaucoma. 23, 5, p. 276-281 6 p.

Research output: Contribution to journalArticle

11 Scopus citations

Effects of a Schlemm canal scaffold on collector channel ostia in human anterior segments

Johnstone, M. A., Saheb, H., Ahmed, I. I. K., Samuelson, T. W., Schieber, A. T. & Toris, C. B., Feb 2014, In : Experimental Eye Research. 119, p. 70-76 7 p.

Research output: Contribution to journalArticle

16 Scopus citations

FR-190997, a nonpeptide bradykinin B2-receptor partial agonist, is a potent and efficacious intraocular pressure lowering agent in ocular hypertensive cynomolgus monkeys

Sharif, N. A., Katoli, P., Scott, D., Li, L., Kelly, C., Xu, S., Husain, S., Toris, C. & Crosson, C., Jun 2014, In : Drug Development Research. 75, 4, p. 211-223 13 p.

Research output: Contribution to journalArticle

4 Scopus citations

Improvement in outflow facility by two novel microinvasive glaucoma surgery implants

Hays, C. L., Gulati, V., Fan, S., Samuelson, T. W., Ahmed, I. I. K. & Toris, C. B., 2014, In : Investigative Ophthalmology and Visual Science. 55, 3, p. 1893-1900 8 p.

Research output: Contribution to journalArticle

17 Scopus citations
2013
2 Scopus citations

A novel 8-mm Schlemm's canal scaffold reduces outflow resistance in a human anterior segment perfusion model

Gulati, V., Fan, S., Hays, C. L., Samuelson, T. W., Ahmed, I. I. K. & Toris, C. B., 2013, In : Investigative Ophthalmology and Visual Science. 54, 3, p. 1698-1704 7 p.

Research output: Contribution to journalArticle

24 Scopus citations

Molecular biomarkers in glaucoma

Seventh ARVO/Pfizer Ophthalmics Research Institute Conference Working Group, Jan 1 2013, In : Investigative Ophthalmology and Visual Science. 54, 1, p. 121-131 11 p.

Research output: Contribution to journalArticle

24 Scopus citations
2012

A novel schlemm's canal scaffold increases outflow facility in a human anterior segment perfusion model

Camras, L. J., Yuan, F., Fan, S., Samuelson, T. W., Ahmed, I. K., Schieber, A. T. & Toris, C. B., Sep 2012, In : Investigative Ophthalmology and Visual Science. 53, 10, p. 6115-6121 7 p.

Research output: Contribution to journalArticle

39 Scopus citations

Diurnal and nocturnal variations in aqueous humor dynamics of patients with ocular hypertension undergoing medical therapy

Gulati, V., Fan, S., Zhao, M., Maslonka, M. A., Gangahar, C. & Toris, C. B., Jun 2012, In : Archives of Ophthalmology. 130, 6, p. 677-684 8 p.

Research output: Contribution to journalArticle

30 Scopus citations
2011

Aqueous humor dynamics during the day and night in healthy mature volunteers

Liu, H., Fan, S., Gulati, V., Camras, L. J., Zhan, G., Ghate, D., Camras, C. B. & Toris, C. B., Mar 2011, In : Archives of Ophthalmology. 129, 3, p. 269-275 7 p.

Research output: Contribution to journalArticle

30 Scopus citations

Aqueous humor dynamics during the day and night in volunteers with ocular hypertension

Fan, S., Hejkal, J. J., Gulati, V., Galata, S., Camras, C. B. & Toris, C. B., Sep 2011, In : Archives of Ophthalmology. 129, 9, p. 1162-1166 5 p.

Research output: Contribution to journalArticle

11 Scopus citations
4 Scopus citations

Effect of PF-04217329 a prodrug of a selective prostaglandin EP 2 agonist on intraocular pressure in preclinical models of glaucoma

Prasanna, G., Carreiro, S., Anderson, S., Gukasyan, H., Sartnurak, S., Younis, H., Gale, D., Xiang, C., Wells, P., Dinh, D., Almaden, C., Fortner, J., Toris, C., Niesman, M., Lafontaine, J. & Krauss, A., Sep 2011, In : Experimental Eye Research. 93, 3, p. 256-264 9 p.

Research output: Contribution to journalArticle

29 Scopus citations

Ocular hypotensive activity of BOL-303259-X, a nitric oxide donating Prostaglandin F2α agonist, in preclinical models

Krauss, A. H. P., Impagnatiello, F., Toris, C. B., Gale, D. C., Prasanna, G., Borghi, V., Chiroli, V., Chong, W. K. M., Carreiro, S. T. & Ongini, E., Sep 2011, In : Experimental Eye Research. 93, 3, p. 250-255 6 p.

Research output: Contribution to journalArticle

66 Scopus citations

Regulation of ocular angiogenesis by notch signaling: Implications in neovascular age-related macular degeneration

Ahmad, I., Balasubramanian, S., del Debbio, C. B., Parameswaran, S., Katz, A. R., Toris, C. & Fariss, R. N., May 2011, In : Investigative Ophthalmology and Visual Science. 52, 6, p. 2868-2878 11 p.

Research output: Contribution to journalArticle

34 Scopus citations
2010

A novel nitric oxide releasing prostaglandin analog, NCX 125, reduces intraocular pressure in rabbit, dog, and primate models of glaucoma

Borghi, V., Bastia, E., Guzzetta, M., Chiroli, V., Toris, C. B., Batugo, M. R., Carreiro, S. T., Chong, W. K. M., Gale, D. C., Kucera, D. J., Jia, L., Prasanna, G., Ongini, E., Krauss, A. H. P. & Impagnatiello, F., Apr 1 2010, In : Journal of Ocular Pharmacology and Therapeutics. 26, 2, p. 125-131 7 p.

Research output: Contribution to journalArticle

53 Scopus citations

Aqueous humor dynamics during the day and night in juvenile and adult rabbits

Zhao, M., Hejkal, J. J., Camras, C. B. & Toris, C. B., Jun 2010, In : Investigative Ophthalmology and Visual Science. 51, 6, p. 3145-3151 7 p.

Research output: Contribution to journalArticle

16 Scopus citations

Aqueous humor dynamics in inbred rhesus monkeys with naturally occurring ocular hypertension

Toris, C. B., Risma, J. M., Gonzales-Martinez, J., McLaughlin, M. A. & Dawson, W. W., Dec 2010, In : Experimental Eye Research. 91, 6, p. 860-865 6 p.

Research output: Contribution to journalArticle

5 Scopus citations

Aqueous humor dynamics in pigment dispersion syndrome

Toris, C. B., Haecker, N. R., Teasley, L. A., Zhan, G., Gulati, V. & Camras, C. B., Sep 2010, In : Archives of Ophthalmology. 128, 9, p. 1115-1118 4 p.

Research output: Contribution to journalArticle

5 Scopus citations

Duration of anesthesia affects intraocular pressure, but not outflow facility in mice

Camras, L. J., Sufficool, K. E., Camras, C. B., Fan, S., Liu, H. & Toris, C. B., Sep 2010, In : Current Eye Research. 35, 9, p. 819-827 9 p.

Research output: Contribution to journalArticle

23 Scopus citations
12 Scopus citations

Intraocular pressure and aqueous humor flow during a euglycemic- hyperinsulinemic clamp in patients with type 1 diabetes and microvascular complications

Lane, J. T., Larson, L. A., Fan, S., Stoner, J. A., Margalit, E. & Toris, C. B., 2010, In : BMC Ophthalmology. 10, 1, 19.

Research output: Contribution to journalArticle

2 Scopus citations

Pharmacotherapies for glaucoma

Toris, C. B., 2010, In : Current Molecular Medicine. 10, 9, p. 824-840 17 p.

Research output: Contribution to journalArticle

46 Scopus citations
2009

Cabergoline: Pharmacology, ocular hypotensive studies in multiple species, and aqueous humor dynamic modulation in the Cynomolgus monkey eyes

Sharif, N. A., McLaughlin, M. A., Kelly, C. R., Katoli, P., Drace, C., Husain, S., Crosson, C., Toris, C., Zhan, G. L. & Camras, C., Mar 2009, In : Experimental Eye Research. 88, 3, p. 386-397 12 p.

Research output: Contribution to journalArticle

27 Scopus citations

Morphological and hydrodynamic correlates in monkey eyes with laser induced glaucoma

Zhang, Y., Toris, C. B., Liu, Y., Ye, W. & Gong, H., Nov 2009, In : Experimental Eye Research. 89, 5, p. 748-756 9 p.

Research output: Contribution to journalArticle

23 Scopus citations

PRDX6 attenuates oxidative stress-and TGF-induced abnormalities of human trabecular meshwork cells

Fatma, N., Kubo, E., Toris, C. B., Stamer, W. D., Camras, C. B. & Singh, D. P., 2009, In : Free Radical Research. 43, 9, p. 783-795 13 p.

Research output: Contribution to journalArticle

36 Scopus citations

Prostanoid EP4 receptor stimulation produces ocular hypotension by a mechanism that does not appear to involve uveoscleral outflow

Woodward, D. F., Nilsson, S. F. E., Toris, C. B., Kharlamb, A. B., Nieves, A. L. & Krauss, A. H. P., 2009, In : Investigative Ophthalmology and Visual Science. 50, 7, p. 3320-3328 9 p.

Research output: Contribution to journalArticle

30 Scopus citations
2008

Aqueous humor dynamics in exfoliation syndrome

Johnson, T. V., Fan, S., Camras, C. B. & Toris, C. B., Jul 2008, In : Archives of Ophthalmology. 126, 7, p. 914-920 7 p.

Research output: Contribution to journalArticle

39 Scopus citations

Chapter 7 Aqueous Humor Dynamics I. Measurement Methods and Animal Studies

Toris, C. B., 2008, In : Current Topics in Membranes. 62, p. 193-229 37 p.

Research output: Contribution to journalArticle

9 Scopus citations

Chapter 8 Aqueous Humor Dynamics II. Clinical Studies

Toris, C. B. & Camras, C. B., 2008, In : Current Topics in Membranes. 62, p. 231-272 42 p.

Research output: Contribution to journalArticle

8 Scopus citations

Effects of central corneal thickness on the efficacy of topical ocular hypotensive medications

Johnson, T. V., Toris, C. B., Fan, S. & Camras, C. B., Mar 2008, In : Journal of Glaucoma. 17, 2, p. 89-99 11 p.

Research output: Contribution to journalArticle

17 Scopus citations

Mechanism of Action of Bimatoprost, Latanoprost, and Travoprost in Healthy Subjects. A Crossover Study

Lim, K. S., Nau, C. B., O'Byrne, M. M., Hodge, D. O., Toris, C. B., McLaren, J. W. & Johnson, D. H., May 2008, In : Ophthalmology. 115, 5, p. 790-795.e4

Research output: Contribution to journalArticle

112 Scopus citations
34 Scopus citations

Update on the Mechanism of Action of Topical Prostaglandins for Intraocular Pressure Reduction

Toris, C. B., Gabelt, BA. T. & Kaufman, P. L., Nov 2008, In : Survey of Ophthalmology. 53, 6 SUPPL., p. S107-S120

Research output: Contribution to journalArticle

180 Scopus citations