Caroline L Ng, PhD

  • 451 Citations
  • 11 h-Index

Research output per year

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Research Output

  • 451 Citations
  • 11 h-Index
  • 15 Article
  • 1 Chapter
  • 1 Editorial
  • 1 Review article

Covalent plasmodium falciparum-selective proteasome inhibitors exhibit a low propensity for generating resistance in vitro and synergize with multiple antimalarial agents

Stokes, B. H., Yoo, E., Murithi, J. M., Luth, M. R., Afanasyev, P., da Fonseca, P. C. A., Winzeler, E. A., Ng, C. L., Bogyo, M. & Fidock, D. A., Jun 2019, In : PLoS pathogens. 15, 6, e1007722.

Research output: Contribution to journalArticle

Open Access
  • 6 Scopus citations

    Identification and Mechanistic Understanding of Dihydroorotate Dehydrogenase Point Mutations in Plasmodium falciparum that Confer in Vitro Resistance to the Clinical Candidate DSM265

    White, J., Dhingra, S. K., Deng, X., El Mazouni, F., Lee, M. C. S., Afanador, G. A., Lawong, A., Tomchick, D. R., Ng, C. L., Bath, J., Rathod, P. K., Fidock, D. A. & Phillips, M. A., Nov 1 2019, In : ACS infectious diseases. 5, 1, p. 90-101 12 p.

    Research output: Contribution to journalArticle

  • 6 Scopus citations

    Plasmodium falciparum in vitro drug resistance selections and gene editing

    Ng, C. L. & Fidock, D. A., Jan 1 2019, Methods in Molecular Biology. Humana Press Inc., p. 123-140 18 p. (Methods in Molecular Biology; vol. 2013).

    Research output: Chapter in Book/Report/Conference proceedingChapter

  • 1 Scopus citations

    Antimalarial activity of single-dose DSM265, a novel plasmodium dihydroorotate dehydrogenase inhibitor, in patients with uncomplicated Plasmodium falciparum or Plasmodium vivax malaria infection: a proof-of-concept, open-label, phase 2a study

    Llanos-Cuentas, A., Casapia, M., Chuquiyauri, R., Hinojosa, J. C., Kerr, N., Rosario, M., Toovey, S., Arch, R. H., Phillips, M. A., Rozenberg, F. D., Bath, J., Ng, C. L., Cowell, A. N., Winzeler, E. A., Fidock, D. A., Baker, M., Möhrle, J. J., Hooft van Huijsduijnen, R., Gobeau, N., Araeipour, N. & 3 others, Andenmatten, N., Rückle, T. & Duparc, S., Aug 2018, In : The Lancet Infectious Diseases. 18, 8, p. 874-883 10 p.

    Research output: Contribution to journalArticle

  • 23 Scopus citations

    Defining the Determinants of Specificity of Plasmodium Proteasome Inhibitors

    Yoo, E., Stokes, B. H., De Jong, H., Vanaerschot, M., Kumar, T. R. S., Lawrence, N., Njoroge, M., Garcia, A., Van Der Westhuyzen, R., Momper, J. D., Ng, C. L., Fidock, D. A. & Bogyo, M., Sep 12 2018, In : Journal of the American Chemical Society. 140, 36, p. 11424-11437 14 p.

    Research output: Contribution to journalArticle

  • 13 Scopus citations