Channabasavaiah B Gurumurthy, DVM, PhD, MBA

  • 1136 Citations
  • 19 h-Index
20002020

Research output per year

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Research Output

2020

Slc26a9P2ACre: A new CRE driver to regulate gene expression in the otic placode lineage and other FGFR2b-dependent epithelia

Urness, L. D., Wang, X., Li, C., Quadros, R. M., Harms, D. W., Gurumurthy, C. B. & Mansour, S. L., Jul 2020, In : Development (Cambridge). 147, 13, 191015.

Research output: Contribution to journalArticle

Open Access
2019

Ca2+ sensor synaptotagmin-1 mediates exocytosis in mammalian photoreceptors

Grassmeyer, J. J., Cahill, A. L., Hays, C. L., Barta, C., Quadros, R. M., Gurumurthy, C. B. & Thoreson, W. B., Jun 2019, In : eLife. 8, e45946.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Creation of CRISPR-based germline-genome-engineered mice without ex vivo handling of zygotes by i-GONAD

Gurumurthy, C. B., Sato, M., Nakamura, A., Inui, M., Kawano, N., Islam, M. A., Ogiwara, S., Takabayashi, S., Matsuyama, M., Nakagawa, S., Miura, H. & Ohtsuka, M., Aug 1 2019, In : Nature protocols. 14, 8, p. 2452-2482 31 p.

Research output: Contribution to journalArticle

2 Scopus citations

CRISPR-cas technology as a tool to create animal models for biomedical research

Sundhari, A. K., Reddy, S. K., Walz, K., Gurumurthy, C. B. & Quadros, R. M., Jan 1 2019, Cellular and Animal Models in Human Genomics Research. Elsevier, p. 141-153 13 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Generating mouse models for biomedical research: Technological advances

Gurumurthy, C. B. & Kent Lloyd, K. C., Jan 2019, In : DMM Disease Models and Mechanisms. 12, 1, dmm.029462.

Research output: Contribution to journalArticle

14 Scopus citations

Human genome-edited hematopoietic stem cells phenotypically correct Mucopolysaccharidosis type I

Gomez-Ospina, N., Scharenberg, S. G., Mostrel, N., Bak, R. O., Mantri, S., Quadros, R. M., Gurumurthy, C. B., Lee, C., Bao, G., Suarez, C. J., Khan, S., Sawamoto, K., Tomatsu, S., Raj, N., Attardi, L. D., Aurelian, L. & Porteus, M. H., Dec 1 2019, In : Nature communications. 10, 1, 4045.

Research output: Contribution to journalArticle

Open Access
11 Scopus citations

Human-like NSG mouse glycoproteins sialylation pattern changes the phenotype of human lymphocytes and sensitivity to HIV-1 infection 11 Medical and Health Sciences 1107 Immunology

Dagur, R. S., Branch-Woods, A., Mathews, S., Joshi, P. S., Quadros, R. M., Harms, D. W., Cheng, Y., Miles, S. M., Pirruccello, S. J., Gurumurthy, C. B., Gorantla, S. & Poluektova, L. Y., Jan 7 2019, In : BMC Immunology. 20, 1, 2.

Research output: Contribution to journalArticle

1 Scopus citations

Isolation and analysis of a genome-edited single-hepatocyte from a Cas9 transgenic mouse line

Sakurai, T., Kamiyoshi, A., Ohtsuka, M., Gurumurthy, C. B., Sato, M. & Shindo, T., 2019, Methods in Molecular Biology. Humana Press Inc., p. 257-271 15 p. (Methods in Molecular Biology; vol. 1874).

Research output: Chapter in Book/Report/Conference proceedingChapter

Looking Forward: Cutting-Edge Technologies and Skills for Pathologists in the Future

Janardhan, K. S., Kohnken, R., Turner, O. C., Gurumurthy, C. B. & Kovi, R. C., Dec 1 2019, In : Toxicologic Pathology. 47, 8, p. 1082-1087 6 p.

Research output: Contribution to journalArticle

1 Scopus citations

Neuron-Type Specific Loss of CDKL5 Leads to Alterations in mTOR Signaling and Synaptic Markers

Schroeder, E., Yuan, L., Seong, E., Ligon, C., DeKorver, N., Gurumurthy, C. B. & Arikkath, J., Jun 1 2019, In : Molecular Neurobiology. 56, 6, p. 4151-4162 12 p.

Research output: Contribution to journalArticle

4 Scopus citations

Reproducibility of CRISPR-Cas9 methods for generation of conditional mouse alleles: A multi-center evaluation

Gurumurthy, C. B., O'Brien, A. R., Quadros, R. M., Adams, J., Alcaide, P., Ayabe, S., Ballard, J., Batra, S. K., Beauchamp, M. C., Becker, K. A., Bernas, G., Brough, D., Carrillo-Salinas, F., Chan, W., Chen, H., Dawson, R., Demambro, V., D'Hont, J., Dibb, K. M., Eudy, J. D. & 93 others, Gan, L., Gao, J., Gonzales, A., Guntur, A. R., Guo, H., Harms, D. W., Harrington, A., Hentges, K. E., Humphreys, N., Imai, S., Ishii, H., Iwama, M., Jonasch, E., Karolak, M., Keavney, B., Khin, N. C., Konno, M., Kotani, Y., Kunihiro, Y., Lakshmanan, I., Larochelle, C., Lawrence, C. B., Li, L., Lindner, V., Liu, X. D., Lopez-Castejon, G., Loudon, A., Lowe, J., Jerome-Majewska, L. A., Matsusaka, T., Miura, H., Miyasaka, Y., Morpurgo, B., Motyl, K., Nabeshima, Y. I., Nakade, K., Nakashiba, T., Nakashima, K., Obata, Y., Ogiwara, S., Ouellet, M., Oxburgh, L., Piltz, S., Pinz, I., Ponnusamy, M. P., Ray, D., Redder, R. J., Rosen, C. J., Ross, N., Ruhe, M. T., Ryzhova, L., Salvador, A. M., Alam, S. S., Sedlacek, R., Sharma, K., Smith, C., Staes, K., Starrs, L., Sugiyama, F., Takahashi, S., Tanaka, T., Trafford, A. W., Uno, Y., Vanhoutte, L., Vanrockeghem, F., Willis, B. J., Wright, C. S., Yamauchi, Y., Yi, X., Yoshimi, K., Zhang, X., Zhang, Y., Ohtsuka, M., Das, S., Garry, D. J., Hochepied, T., Thomas, P., Parker-Thornburg, J., Adamson, A. D., Yoshiki, A., Schmouth, J. F., Golovko, A., Thompson, W. R., Lloyd, K. C. K., Wood, J. A., Cowan, M., Mashimo, T., Mizuno, S., Zhu, H., Kasparek, P., Liaw, L., Miano, J. M. & Burgio, G., Aug 26 2019, In : Genome biology. 20, 1, 171.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Subcellular localization of sterol biosynthesis enzymes

Koczok, K., Gurumurthy, C. B., Balogh, I., Korade, Z. & Mirnics, K., Feb 15 2019, In : Journal of Molecular Histology. 50, 1, p. 63-73 11 p.

Research output: Contribution to journalArticle

2018

Antiretroviral drug metabolism in humanized PXR-CAR-CYP3A-NOG mice

McMillan, J. E. M., Cobb, D. A., Lin, Z., Banoub, M. G., Dagur, R. S., Branch Woods, A. A., Wang, W., Makarov, E., Kocher, T., Joshi, P. S., Quadros, R. M., Harms, D. W., Cohen, S. M., Gendelman, H. E., Gurumurthy, C. B., Gorantla, S. & Poluektova, L. Y., May 2018, In : Journal of Pharmacology and Experimental Therapeutics. 365, 2, p. 272-280 9 p.

Research output: Contribution to journalArticle

3 Scopus citations

Easi-CRISPR for creating knock-in and conditional knockout mouse models using long ssDNA donors

Miura, H., Quadros, R. M., Gurumurthy, C. B. & Ohtsuka, M., Jan 1 2018, In : Nature protocols. 13, 1, p. 195-215 21 p.

Research output: Contribution to journalArticle

36 Scopus citations

I-GONAD: A robust method for in situ germline genome engineering using CRISPR nucleases

Ohtsuka, M., Sato, M., Miura, H., Takabayashi, S., Matsuyama, M., Koyano, T., Arifin, N., Nakamura, S., Wada, K. & Gurumurthy, C. B., Feb 26 2018, In : Genome biology. 19, 1, 25.

Research output: Contribution to journalArticle

22 Scopus citations

In vivo genome editing targeted towards the female reproductive system

Sato, M., Ohtsuka, M., Nakamura, S., Sakurai, T., Watanabe, S. & Gurumurthy, C. B., Sep 1 2018, In : Archives of Pharmacal Research. 41, 9, p. 898-910 13 p.

Research output: Contribution to journalReview article

4 Scopus citations

Precise and efficient nucleotide substitution near genomic nick via noncanonical homology-directed repair

Nakajima, K., Zhou, Y., Tomita, A., Hirade, Y., Gurumurthy, C. B. & Nakada, S., Feb 2018, In : Genome Research. 28, 2, p. 223-230 8 p.

Research output: Contribution to journalArticle

9 Scopus citations

Reprogramming human T cell function and specificity with non-viral genome targeting

Roth, T. L., Puig-Saus, C., Yu, R., Shifrut, E., Carnevale, J., Li, P. J., Hiatt, J., Saco, J., Krystofinski, P., Li, H., Tobin, V., Nguyen, D. N., Lee, M. R., Putnam, A. L., Ferris, A. L., Chen, J. W., Schickel, J. N., Pellerin, L., Carmody, D., Alkorta-Aranburu, G. & 25 others, Del Gaudio, D., Matsumoto, H., Morell, M., Mao, Y., Cho, M., Quadros, R. M., Gurumurthy, C. B., Smith, B., Haugwitz, M., Hughes, S. H., Weissman, J. S., Schumann, K., Esensten, J. H., May, A. P., Ashworth, A., Kupfer, G. M., Greeley, S. A. W., Bacchetta, R., Meffre, E., Roncarolo, M. G., Romberg, N., Herold, K. C., Ribas, A., Leonetti, M. D. & Marson, A., Jul 19 2018, In : Nature. 559, 7714, p. 405-409 5 p.

Research output: Contribution to journalArticle

129 Scopus citations

Technological advances in integrating multi-kilobase DNA sequences into genomes

Gurumurthy, C. B. & Perez-Pinera, P., Sep 2018, In : Current Opinion in Biomedical Engineering. 7, p. 16-23 8 p.

Research output: Contribution to journalReview article

1 Scopus citations
2017

Arid1b haploinsufficiency disrupts cortical interneuron development and mouse behavior

Jung, E. M., Moffat, J. J., Liu, J., Dravid, S. M., Gurumurthy, C. B. & Kim, W. Y., Dec 1 2017, In : Nature Neuroscience. 20, 12, p. 1694-1707 14 p.

Research output: Contribution to journalArticle

29 Scopus citations

Easi-CRISPR: A robust method for one-step generation of mice carrying conditional and insertion alleles using long ssDNA donors and CRISPR ribonucleoproteins

Quadros, R. M., Miura, H., Harms, D. W., Akatsuka, H., Sato, T., Aida, T., Redder, R., Richardson, G. P., Inagaki, Y., Sakai, D., Buckley, S. M., Seshacharyulu, P., Batra, S. K., Behlke, M. A., Zeiner, S. A., Jacobi, A. M., Izu, Y., Thoreson, W. B., Urness, L. D., Mansour, S. L. & 2 others, Ohtsuka, M. & Gurumurthy, C. B., May 17 2017, In : Genome biology. 18, 1, 92.

Research output: Contribution to journalArticle

105 Scopus citations

Mammalian ECD protein is a novel negative regulator of the PERK arm of the unfolded protein response

Olou, A. A., Sarkar, A., Bele, A., Gurumurthy, C. B., Mir, R. A., Ammons, S. A., Mirza, S., Saleem, I., Urano, F., Band, H. & Band, V., Sep 1 2017, In : Molecular and cellular biology. 37, 18, e00030-17.

Research output: Contribution to journalArticle

1 Scopus citations

Simplified CRISPR tools for efficient genome editing and streamlined protocols for their delivery into mammalian cells and mouse zygotes

Jacobi, A. M., Rettig, G. R., Turk, R., Collingwood, M. A., Zeiner, S. A., Quadros, R. M., Harms, D. W., Bonthuis, P. J., Gregg, C., Ohtsuka, M., Gurumurthy, C. B. & Behlke, M. A., May 15 2017, In : Methods. 121-122, p. 16-28 13 p.

Research output: Contribution to journalArticle

45 Scopus citations

To cleave or not to cleave: Therapeutic gene editing with and without programmable nucleases

Woolf, T. M., Gurumurthy, C. B., Boyce, F. & Kmiec, E. B., Apr 1 2017, In : Nature Reviews Drug Discovery. 16, 4, p. 296 1 p.

Research output: Contribution to journalLetter

6 Scopus citations
2016

A novel interaction of Ecdysoneless (ECD) protein with R2TP complex component RUVBL1 is required for the functional role of ECD in cell cycle progression

Mir, R. A., Bele, A., Mirza, S., Srivastava, S., Olou, A. A., Ammons, S. A., Kim, J. H., Gurumurthy, C. B., Qiu, F., Band, H. & Band, V., 2016, In : Molecular and cellular biology. 36, 6, p. 886-899 14 p.

Research output: Contribution to journalArticle

12 Scopus citations

Cleavage by caspase 8 and mitochondrial membrane association activate the BH3-only protein bid during TRAIL-induced apoptosis

Huang, K., Zhang, J., O'Neill, K. L., Gurumurthy, C. B., Quadros, R. M., Tu, Y. & Luo, X., May 27 2016, In : Journal of Biological Chemistry. 291, 22, p. 11843-11851 9 p.

Research output: Contribution to journalArticle

42 Scopus citations

CRISPR: a versatile tool for both forward and reverse genetics research

Gurumurthy, C. B., Grati, M., Ohtsuka, M., Schilit, S. L. P., Quadros, R. M. & Liu, X. Z., Sep 1 2016, In : Human genetics. 135, 9, p. 971-976 6 p.

Research output: Contribution to journalArticle

14 Scopus citations

CRISPR/Cas9 and the paradigm shift in mouse genome manipulation technologies

Gurumurthy, C. B., Quadros, R. M., Sato, M., Mashimo, T., Lloyd, K. C. K. & Ohtsuka, M., Jan 1 2016, Genome Editing. Springer International Publishing, p. 65-77 13 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

5 Scopus citations

GONAD: A novel CRISPR/Cas9 genome editing method that does not require ex vivo handling of embryos

Gurumurthy, C. B., Takahashi, G., Wada, K., Miura, H., Sato, M. & Ohtsuka, M., 2016, In : Current Protocols in Human Genetics. 2016, p. 15.8.1-15.8.12

Research output: Contribution to journalArticle

10 Scopus citations

Mice deficient in Muc4 are resistant to experimental colitis and colitis-associated colorectal cancer

Das, S., Rachagani, S., Sheinin, Y., Smith, L. M., Gurumurthy, C. B., Roy, H. K. & Batra, S. K., May 19 2016, In : Oncogene. 35, 20, p. 2645-2654 10 p.

Research output: Contribution to journalArticle

25 Scopus citations

Nucleic acids delivery methods for genome editing in zygotes and embryos: The old, the new, and the old-new

Sato, M., Ohtsuka, M., Watanabe, S. & Gurumurthy, C. B., 2016, In : Biology direct. 11, 1, 16.

Research output: Contribution to journalReview article

17 Scopus citations

Pronuclear injection-based targeted transgenesis

Schilit, S. L. P., Ohtsuka, M., Quadros, R. M. & Gurumurthy, C. B., 2016, In : Current Protocols in Human Genetics. 2016, p. 15.10.1-15.10.28

Research output: Contribution to journalArticle

4 Scopus citations

Simple and reliable genotyping protocol for mouse PrkdcSCID mutation

Quadros, R. M., Poluektova, L. Y. & Gurumurthy, C. B., Apr 1 2016, In : Journal of Immunological Methods. 431, p. 60-62 3 p.

Research output: Contribution to journalArticle

1 Scopus citations
2015

Assessment of artificial miRNA architectures for higher knockdown efficiencies without the undesired effects in mice

Miura, H., Inoko, H., Tanaka, M., Nakaoka, H., Kimura, M., Gurumurthy, C. B., Sato, M. & Ohtsuka, M., Aug 18 2015, In : PloS one. 10, 8, e0135919.

Research output: Contribution to journalArticle

3 Scopus citations

CRISPR/Cas9-based generation of knockdown mice by intronic insertion of artificial microRNA using longer single-stranded DNA

Miura, H., Gurumurthy, C. B., Sato, T., Sato, M. & Ohtsuka, M., Aug 5 2015, In : Scientific reports. 5, 12799.

Research output: Contribution to journalArticle

56 Scopus citations

Generation of a retinoblastoma (Rb)1-inducible dominant-negative (DN) mouse model

Tarang, S., Doi, S. M. S. R., Gurumurthy, C. B., Harms, D., Quadros, R. & Rocha-Sanchez, S. M., Feb 23 2015, In : Frontiers in Cellular Neuroscience. 9, FEB

Research output: Contribution to journalArticle

6 Scopus citations

GONAD: Genome-editing via Oviductal Nucleic Acids Delivery system: A novel microinjection independent genome engineering method in mice

Takahashi, G., Gurumurthy, C. B., Wada, K., Miura, H., Sato, M. & Ohtsuka, M., Jun 22 2015, In : Scientific reports. 5, 11406.

Research output: Contribution to journalArticle

42 Scopus citations

Insertion of sequences at the original provirus integration site of mouse ROSA26 locus using the CRISPR/Cas9 system

Quadros, R. M., Harms, D. W., Ohtsuka, M. & Gurumurthy, C. B., Jan 1 2015, In : FEBS Open Bio. 5, p. 191-197 7 p.

Research output: Contribution to journalArticle

18 Scopus citations

One-step generation of multiple transgenic mouse lines using an improved Pronuclear Injection-based Targeted Transgenesis (i-PITT)

Ohtsuka, M., Miura, H., Mochida, K., Hirose, M., Hasegawa, A., Ogura, A., Mizutani, R., Kimura, M., Isotani, A., Ikawa, M., Sato, M. & Gurumurthy, C. B., Apr 9 2015, In : BMC genomics. 16, 1, 274.

Research output: Contribution to journalArticle

10 Scopus citations

TGFβ3 Regulates Periderm Removal Through ΔNp63 in the Developing Palate

Hu, L., Liu, J., Li, Z., Ozturk, F., Gurumurthy, C., Romano, R. A., Sinha, S. & Nawshad, A., Jun 1 2015, In : Journal of Cellular Physiology. 230, 6, p. 1212-1225 14 p.

Research output: Contribution to journalArticle

19 Scopus citations

The cell cycle regulator ecdysoneless cooperates with H-ras to promote oncogenic transformation of human mammary epithelial cells

Bele, A., Mirza, S., Zhang, Y., Mir, R. A., Lin, S., Kim, J. H., Gurumurthy, C. B., West, W., Qiu, F., Band, H. & Band, V., Apr 1 2015, In : Cell Cycle. 14, 7, p. 990-1000 11 p.

Research output: Contribution to journalArticle

5 Scopus citations

Validation of simple sequence length polymorphism regions of commonly used mouse strains for marker assisted speed congenics screening

Gurumurthy, C. B., Joshi, P. S., Kurz, S. G., Ohtsuka, M., Quadros, R. M., Harms, D. W. & Lloyd, K. C. K., Feb 28 2015, In : International Journal of Genomics. 2015, 735845.

Research output: Contribution to journalArticle

4 Scopus citations
2014

Generation of conditional knockout mice

Sakamoto, K., Gurumurthy, C. B. & Wagner, K. U., 2014, In : Methods in molecular biology (Clifton, N.J.). 1194, p. 21-35 15 p.

Research output: Contribution to journalArticle

6 Scopus citations

Mouse genome editing using the CRISPR/Cas system

Harms, D. W., Quadros, R. M., Seruggia, D., Ohtsuka, M., Takahashi, G., Montoliu, L. & Gurumurthy, C. B., 2014, In : Current Protocols in Human Genetics. 83, p. 15.7.1-15.7.27

Research output: Contribution to journalArticle

57 Scopus citations
2013

Cytoplasmic localization of alteration/deficiency in activation 3 (ADA3) predicts poor clinical outcome in breast cancer patients

Mirza, S., Rakha, E. A., Alshareeda, A., Mohibi, S., Zhao, X., Katafiasz, B. J., Wang, J., Gurumurthy, C. B., Bele, A., Ellis, I. O., Green, A. R., Band, H. & Band, V., Feb 2013, In : Breast Cancer Research and Treatment. 137, 3, p. 721-731 11 p.

Research output: Contribution to journalArticle

12 Scopus citations

Improvement of pronuclear injection-based targeted transgenesis (PITT) by iCre mRNA-mediated site-specific recombination

Ohtsuka, M., Miura, H., Hayashi, H., Nakaoka, H., Kimura, M., Sato, M., Gurumurthy, C. B. & Inoko, H., Aug 2013, In : Transgenic Research. 22, 4, p. 873-875 3 p.

Research output: Contribution to journalLetter

6 Scopus citations
2012

Alteration/deficiency in activation-3 (Ada3) plays a critical role in maintaining genomic stability

Mirza, S., Katafiasz, B. J., Kumar, R., Wang, J., Mohibi, S., Jain, S., Gurumurthy, C. B., Pandita, T. K., Dave, B. J., Band, H. & Band, V., Nov 15 2012, In : Cell Cycle. 11, 22, p. 4266-4274 9 p.

Research output: Contribution to journalArticle

14 Scopus citations

Fluorescent transgenic mice suitable for multi-color aggregation chimera studies

Ohtsuka, M., Miura, H., Gurumurthy, C. B., Kimura, M., Inoko, H., Yoshimura, S. & Sato, M., Nov 2012, In : Cell and Tissue Research. 350, 2, p. 251-260 10 p.

Research output: Contribution to journalArticle

12 Scopus citations

Mammalian alteration/deficiency in activation 3 (Ada3) is essential for embryonic development and cell cycle progression

Mohibi, S., Gurumurthy, C. B., Nag, A., Wang, J., Mirza, S., Mian, Y., Quinn, M., Katafiasz, B., Eudy, J. D., Pandey, S., Guda, C., Naramura, M., Band, H. & Band, V., Aug 24 2012, In : Journal of Biological Chemistry. 287, 35, p. 29442-29456 15 p.

Research output: Contribution to journalArticle

18 Scopus citations

Nucleic Acid and Non-Nucleic Acid-Based Reprogramming of Adult Limbal Progenitors to Pluripotency

Parameswaran, S., Balasubramanian, S., Babai, N., DelDebbio, C. B., Harms, D. W., Gurumurthy, C. B., Rao, M. S., Sharp, J. G. & Ahmad, I., Oct 8 2012, In : PloS one. 7, 10, e46734.

Research output: Contribution to journalArticle

8 Scopus citations