Clifford I Stains, PhD

  • 801 Citations
  • 17 h-Index
20052020

Research output per year

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Research Output

  • 801 Citations
  • 17 h-Index
  • 32 Article
  • 4 Chapter
  • 3 Review article
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Article
2020

A luminescence-based assay for monitoring changes in alpha-synuclein aggregation in living cells

Nelson, T. J., Truong, T., Truong, B. L., Bilyeu, C. V., Zhao, J. & Stains, C. I., Apr 28 2020, In : RSC Advances. 10, 28, p. 16675-16678 4 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Imaging GPCR internalization using near-infrared Nebraska red-based reagents

Lesiak, L., Zhou, X., Fang, Y., Zhao, J., Beck, J. R. & Stains, C. I., Apr 7 2020, In : Organic and Biomolecular Chemistry. 18, 13, p. 2459-2467 9 p.

Research output: Contribution to journalArticle

2019

A Panel of Protein Kinase Chemosensors Distinguishes Different Types of Fatty Liver Disease

Beck, J. R., Cabral, F., Rasineni, K., Casey, C. A., Harris, E. N. & Stains, C. I., Sep 17 2019, In : Biochemistry. 58, 37, p. 3911-3917 7 p.

Research output: Contribution to journalArticle

1 Scopus citations

A Phosphinate-Containing Fluorophore Capable of Selectively Inducing Apoptosis in Cancer Cells

Zhou, X., Fang, Y., Lesiak, L. & Stains, C. I., Jul 1 2019, In : ChemBioChem. 20, 13, p. 1712-1716 5 p.

Research output: Contribution to journalArticle

1 Scopus citations

Phosphinate-containing rhodol and fluorescein scaffolds for the development of bioprobes

Fang, Y., Good, G. N., Zhou, X. & Stains, C. I., 2019, In : Chemical Communications. 55, 42, p. 5962-5965 4 p.

Research output: Contribution to journalArticle

5 Scopus citations
2017

Chemoselective Alteration of Fluorophore Scaffolds as a Strategy for the Development of Ratiometric Chemodosimeters

Zhou, X., Lesiak, L., Lai, R., Beck, J. R., Zhao, J., Elowsky, C. G., Li, H. & Stains, C. I., 2017, In : Angewandte Chemie - International Edition. 56, 15, p. 4197-4200 4 p.

Research output: Contribution to journalArticle

21 Scopus citations

Identification of a fragmented small GTPase capable of conditional effector binding

Zhao, J. & Stains, C. I., 2017, In : RSC Advances. 7, 20, p. 12265-12268 4 p.

Research output: Contribution to journalArticle

2016

An improved miniprotein host for fluorogenic supramolecular assembly on the surface of living cells

Xu, B., Zhou, X. & Stains, C. I., 2016, In : RSC Advances. 6, 24, p. 20381-20385 5 p.

Research output: Contribution to journalArticle

1 Scopus citations

Interrogating Endogenous Protein Phosphatase Activity with Rationally Designed Chemosensors

Beck, J. R., Lawrence, A., Tung, A. S., Harris, E. N. & Stains, C. I., Jan 15 2016, In : ACS chemical biology. 11, 1, p. 284-290 7 p.

Research output: Contribution to journalArticle

18 Scopus citations

Luminescent platforms for monitoring changes in the solubility of amylin and huntingtin in living cells

Zhao, J., Vu, Q. & Stains, C. I., 2016, In : Molecular BioSystems. 12, 10, p. 2984-2987 4 p.

Research output: Contribution to journalArticle

3 Scopus citations

Nebraska Red: A phosphinate-based near-infrared fluorophore scaffold for chemical biology applications

Zhou, X., Lai, R., Beck, J. R., Li, H. & Stains, C. I., 2016, In : Chemical Communications. 52, 83, p. 12290-12293 4 p.

Research output: Contribution to journalArticle

47 Scopus citations

Self-Assembling NanoLuc Luciferase Fragments as Probes for Protein Aggregation in Living Cells

Zhao, J., Nelson, T. J., Vu, Q., Truong, T. & Stains, C. I., Jan 15 2016, In : ACS chemical biology. 11, 1, p. 132-138 7 p.

Research output: Contribution to journalArticle

22 Scopus citations

Temporal Analysis of PP2A Phosphatase Activity During Insulin Stimulation Using a Direct Activity Probe

Beck, J. R., Truong, T. & Stains, C. I., Dec 16 2016, In : ACS chemical biology. 11, 12, p. 3284-3288 5 p.

Research output: Contribution to journalArticle

6 Scopus citations
2015

A real-time, fluorescence-based assay for Rho-associated protein kinase activity

Kelly, M. I., Bechtel, T. J., Reddy, D. R., Hankore, E. D., Beck, J. R. & Stains, C. I., Sep 3 2015, In : Analytica Chimica Acta. 891, p. 284-290 7 p.

Research output: Contribution to journalArticle

9 Scopus citations

Design and evaluation of a real-time activity probe for focal adhesion kinase

Beck, J. R., Zhou, X., Casey, G. R. & Stains, C. I., Oct 15 2015, In : Analytica Chimica Acta. 897, p. 62-68 7 p.

Research output: Contribution to journalArticle

8 Scopus citations

Supramolecular Assembly of an Evolved Miniprotein Host and Fluorogenic Guest Pair

Xu, B., Zhou, X. & Stains, C. I., Nov 2 2015, In : Journal of the American Chemical Society. 137, 45, p. 14252-14255 4 p.

Research output: Contribution to journalArticle

3 Scopus citations

The 8-silyloxyquinoline scaffold as a versatile platform for the sensitive detection of aqueous fluoride

Zhou, X., Lai, R., Li, H. & Stains, C. I., Apr 21 2015, In : Analytical chemistry. 87, 8, p. 4081-4086 6 p.

Research output: Contribution to journalArticle

27 Scopus citations
2014

Design, synthesis, and evaluation of a selective chemosensor for leucine-rich repeat kinase 2

Szalewski, D. A., Beck, J. R. & Stains, C. I., Dec 15 2014, In : Bioorganic and Medicinal Chemistry Letters. 24, 24, p. 5648-5651 4 p.

Research output: Contribution to journalArticle

7 Scopus citations

Quantification of protein kinase enzymatic activity in unfractionated cell lysates using CSox-based sensors

Beck, J. R., Peterson, L. B., Imperiali, B. & Stains, C. I., 2014, In : Current protocols in chemical biology. 6, 3, p. 135-156 22 p.

Research output: Contribution to journalArticle

9 Scopus citations
2012

Interrogating signaling nodes involved in cellular transformations using kinase activity probes

Stains, C. I., Tedford, N. C., Walkup, T. C., Luković, E., Goguen, B. N., Griffith, L. G., Lauffenburger, D. A. & Imperiali, B., Feb 24 2012, In : Chemistry and Biology. 19, 2, p. 210-217 8 p.

Research output: Contribution to journalArticle

27 Scopus citations
2011

A p38α-selective chemosensor for use in unfractionated cell lysates

Stains, C. I., Luković, E. & Imperiali, B., Jan 21 2011, In : ACS chemical biology. 6, 1, p. 101-105 5 p.

Research output: Contribution to journalArticle

23 Scopus citations

A turn-on split-luciferase sensor for the direct detection of poly(ADP-ribose) as a marker for DNA repair and cell death

Furman, J. L., Mok, P. W., Shen, S., Stains, C. I. & Ghosh, I., Dec 6 2011, In : Chemical Communications. 47, 1, p. 397-399 3 p.

Research output: Contribution to journalArticle

5 Scopus citations
2010

A general approach for receptor and antibody-targeted detection of native proteins utilizing split-luciferase reassembly

Stains, C. I., Furman, J. L., Porter, J. R., Rajagopal, S., Li, Y., Wyatt, R. T. & Ghosh, I., Oct 15 2010, In : ACS chemical biology. 5, 10, p. 943-952 10 p.

Research output: Contribution to journalArticle

23 Scopus citations

Toward a general approach for RNA-templated hierarchical assembly of split-proteins

Furman, J. L., Badran, A. H., Ajulo, O., Porter, J. R., Stains, C. I., Segal, D. J. & Ghosh, I., Aug 25 2010, In : Journal of the American Chemical Society. 132, 33, p. 11692-11701 10 p.

Research output: Contribution to journalArticle

27 Scopus citations
2009

Systematic evaluation of split-fluorescent proteins for the direct detection of native and methylated DNA

Furman, J. L., Badran, A. H., Shen, S., Stains, C. I., Hannallah, J., Segal, D. J. & Ghosh, I., Jul 15 2009, In : Bioorganic and Medicinal Chemistry Letters. 19, 14, p. 3748-3751 4 p.

Research output: Contribution to journalArticle

7 Scopus citations
2008
51 Scopus citations
2007

Split β-lactamase sensor for the sequence-specific detection of DNA methylation

Porter, J. R., Stains, C. I., Segal, D. J. & Ghosh, I., Sep 1 2007, In : Analytical chemistry. 79, 17, p. 6702-6708 7 p.

Research output: Contribution to journalArticle

44 Scopus citations

When conjugated polymers meet amyloid fibrils

Stains, C. I. & Ghosh, I., Aug 2007, In : ACS chemical biology. 2, 8, p. 525-528 4 p.

Research output: Contribution to journalArticle

4 Scopus citations
2006

Inhibition of β-amyloid fibrillization by directed evolution of a β-sheet presenting miniature protein

Smith, T. J., Stains, C. I., Meyer, S. C. & Ghosh, I., Nov 15 2006, In : Journal of the American Chemical Society. 128, 45, p. 14456-14457 2 p.

Research output: Contribution to journalArticle

40 Scopus citations

Sequence-enabled reassembly of β-lactamase (SEER-LAC): A sensitive method for the detection of double-stranded DNA

Ooi, A. T., Stains, C. I., Ghosh, I. & Segal, D. J., Mar 21 2006, In : Biochemistry. 45, 11, p. 3620-3625 6 p.

Research output: Contribution to journalArticle

46 Scopus citations

Site-specific detection of DNA methylation utilizing mCpG-SEER

Stains, C. I., Furman, J. L., Segal, D. J. & Ghosh, I., Aug 2 2006, In : Journal of the American Chemical Society. 128, 30, p. 9761-9765 5 p.

Research output: Contribution to journalArticle

68 Scopus citations
2005

DNA sequence-enabled reassembly of the green fluorescent protein

Stains, C. I., Porter, J. R., Ooi, A. T., Segal, D. J. & Ghosh, I., Aug 10 2005, In : Journal of the American Chemical Society. 127, 31, p. 10782-10783 2 p.

Research output: Contribution to journalArticle

69 Scopus citations