Pharmacology, Toxicology and Pharmaceutical Science
Positive Allosteric Modulator
100%
Structure Activity Relationship
65%
Metabotropic Receptor 4
51%
Parkinson's Disease
36%
Disease
25%
Receptor
21%
Allosteric Modulator
21%
Dopamine 4 Receptor
20%
G Protein Coupled Receptor
19%
Picolinamide
18%
Transient Receptor Potential Channel 5
18%
Aedes aegypti
18%
Carboxamide
17%
G Protein Coupled Inwardly Rectifying Potassium Channel
16%
Metabotropic Receptor
15%
Pharmacokinetics
14%
Isotopes of Potassium
14%
Potassium Channel
13%
Mouse
13%
Clinical Trial
13%
High-Throughput Screening
13%
Guanine Nucleotide Binding Protein
12%
Pharmaceutical Chemistry
11%
IC50
10%
Colorectal Cancer
10%
Receptor Subtype
10%
Alzheimer's Disease
10%
Side Effect
9%
Colon Cancer
9%
Piperidine
9%
Phosphodiesterase
9%
Dorsomorphin
9%
Antiparkinson Agent
9%
Drug Discovery
9%
Secretase
9%
Claudin 1
9%
Malignant Neoplasm
8%
EC50
8%
Dopamine Receptor
8%
Glutamate Receptor
7%
Glutamic Acid
7%
Neurologic Disease
6%
Sulfonamide
6%
Receptor Antagonist
6%
Semagacestat
6%
Mosquito Vector
6%
Heart Arrhythmia
6%
Sulfonyl
6%
Haloperidol-Induced Catalepsy
5%
Benzimidazole
5%
Keyphrases
Positive Allosteric Modulator
46%
Metabotropic Glutamate Receptor Subtype 4 (mGlu4)
35%
Neuroscience
18%
Structure-activity Relationship
18%
Biological Evaluation
13%
Biological Characterization
13%
CNS Exposure
11%
Alzheimer's Disease
11%
Dopamine Receptor
10%
Potassium Channel Activators
9%
Ether
9%
Sulfonamides
9%
Piperidin
9%
GIRK1
9%
Pain Models
9%
Relationship Development
9%
MrgX1
9%
Lead Optimization
8%
Allosteric Modulator
6%
Chemical Optimization
6%
Muscarinic Acetylcholine Receptor
6%
MLPCN Probe
6%
Morpholine
6%
CNS Penetration
6%
DRD4
6%
GIRK Channel
6%
High-throughput Screening
5%
Heterobiaryls
5%
Brain Exposure
5%
MGlu
5%
Anti-Parkinson
5%
Biochemistry, Genetics and Molecular Biology
Small Molecule
31%
Mouse
16%
Agonist
16%
Structure Activity Relation
15%
Bone Morphogenetic Protein
13%
TRPC5
13%
Parallel Synthesis
9%
Metabotropic Glutamate Receptor 4
9%
G Protein-Coupled Inwardly-Rectifying Potassium Channel
9%
Claudin
9%
Metabotropic Glutamate Receptor
9%
Metabotropic Receptor
9%
Muscarinic Acetylcholine Receptor
9%
Podocyte
8%
Signaling Protein
7%
Cardiac Muscle Cell
6%
Cardiac Dysrhythmia
6%
Pharmacokinetic Properties
6%
Clinical Trial
5%
Colon
5%
Biological Activity
5%