• 2998 Citations
  • 31 h-Index
19992020

Research output per year

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Research Output

2020

Selective α7 nicotinic receptor agonists and positive allosteric modulators for the treatment of schizophrenia–a review

Antonio-Tolentino, K. & Hopkins, C. R., Jan 1 2020, (Accepted/In press) In : Expert Opinion on Investigational Drugs.

Research output: Contribution to journalReview article

U000328, a novel ALK2/3 kinase inhibitor, represses hepcidin and significantly improves the phenotype of IRIDA

Belot, A., Gourbeyre, O., Fay, A., Palin, A., Besson-Fournier, C., Latour, C., Hopkins, C. R., Tidmarsh, G. F., Coppin, H., Roth, M. P., Ritter, M. R., Hong, C. C. & Meynard, D., Mar 1 2020, In : Haematologica. 105, 3

Research output: Contribution to journalArticle

Open Access
2019

Analgesic Effects of the GIRK Activator, VU0466551, Alone and in Combination with Morphine in Acute and Persistent Pain Models

Abney, K. K., Bubser, M., Du, Y., Kozek, K. A., Bridges, T. M., Linsdley, C. W., Daniels, J. S., Morrison, R. D., Wickman, K., Hopkins, C. R., Jones, C. K. & Weaver, C. D., Mar 20 2019, In : ACS Chemical Neuroscience. 10, 3, p. 1294-1299 6 p.

Research output: Contribution to journalArticle

2 Scopus citations

Correction to: Analgesic effects of the GIRK activator, VU0466551, Alone and in combination with morphine in acute and persistent pain models (ACS Chemical Neuroscience (2019) 10:3 (1294-1299) DOI: 10.1021/acschemneuro.8b00370)

Abney, K. K., Bubser, M., Du, Y., Kozek, K. A., Bridges, T. M., Lindsley, C. W., Daniels, J. S., Morrison, R. D., Wickman, K., Hopkins, C. R., Jones, C. K. & Weaver, C. D., May 15 2019, In : ACS Chemical Neuroscience. 10, 5, 1 p.

Research output: Contribution to journalComment/debate

Open Access
8 Scopus citations

Discovery, Structure-Activity Relationship, and Biological Characterization of a Novel Series of 6-((1 H-Pyrazolo[4,3- b]pyridin-3-yl)amino)-benzo[ d]isothiazole-3-carboxamides as Positive Allosteric Modulators of the Metabotropic Glutamate Receptor 4 (mGlu 4 )

Bollinger, S. R., Engers, D. W., Panarese, J. D., West, M., Engers, J. L., Loch, M. T., Rodriguez, A. L., Blobaum, A. L., Jones, C. K., Thompson Gray, A., Conn, P. J., Lindsley, C. W., Niswender, C. M. & Hopkins, C. R., Oct 1 2019, In : Journal of Medicinal Chemistry. 62, 1, p. 342-358 17 p.

Research output: Contribution to journalArticle

6 Scopus citations

Discovery, synthesis and characterization of a series of (1-alkyl-3-methyl-1H-pyrazol-5-yl)-2-(5-aryl-2H-tetrazol-2-yl)acetamides as novel GIRK1/2 potassium channel activators

Sharma, S., Kozek, K. A., Abney, K. K., Kumar, S., Gautam, N., Alnouti, Y., David Weaver, C. & Hopkins, C. R., Mar 15 2019, In : Bioorganic and Medicinal Chemistry Letters. 29, 6, p. 791-796 6 p.

Research output: Contribution to journalArticle

Discovery and Characterization of 2-Nitro-5-(4-(phenylsulfonyl)piperazin-1-yl)- N-(pyridin-4-ylmethyl)anilines as Novel Inhibitors of the Aedes aegypti Kir1 (AeKir1) Channel

Aretz, C. D., Morwitzer, M. J., Sanford, A. G., Hogan, A. M., Portillo, M. V., Kharade, S. V., Kramer, M., McCarthey, J. B., Trigueros, R. R., Piermarini, P. M., Denton, J. S. & Hopkins, C. R., Jun 14 2019, In : ACS infectious diseases. 5, 6, p. 917-931 15 p.

Research output: Contribution to journalArticle

Discovery and Characterization of VU0529331, a Synthetic Small-Molecule Activator of Homomeric G Protein-Gated, Inwardly Rectifying, Potassium (GIRK) Channels

Kozek, K. A., Du, Y., Sharma, S., Prael, F. J., Spitznagel, B. D., Kharade, S. V., Denton, J. S., Hopkins, C. R. & Weaver, C. D., Jan 16 2019, In : ACS Chemical Neuroscience. 10, 1, p. 358-370 13 p.

Research output: Contribution to journalArticle

3 Scopus citations
1 Scopus citations

Discovery of VU2957 (Valiglurax): An mGlu 4 Positive Allosteric Modulator Evaluated as a Preclinical Candidate for the Treatment of Parkinson's Disease

Panarese, J. D., Engers, D. W., Wu, Y. J., Bronson, J. J., Macor, J. E., Chun, A., Rodriguez, A. L., Felts, A. S., Engers, J. L., Loch, M. T., Emmitte, K. A., Castelhano, A. L., Kates, M. J., Nader, M. A., Jones, C. K., Blobaum, A. L., Conn, P. J., Niswender, C. M., Hopkins, C. R. & Lindsley, C. W., Mar 14 2019, In : ACS Medicinal Chemistry Letters. 10, 3, p. 255-260 6 p.

Research output: Contribution to journalArticle

5 Scopus citations

Review of Transient Receptor Potential Canonical (TRPC5) Channel Modulators and Diseases

Sharma, S. & Hopkins, C. R., Sep 12 2019, In : Journal of Medicinal Chemistry. 62, 17, p. 7589-7602 14 p.

Research output: Contribution to journalReview article

2 Scopus citations

The discovery of VU0652957 (VU2957, Valiglurax): SAR and DMPK challenges en route to an mGlu4 PAM development candidate

Panarese, J. D., Engers, D. W., Wu, Y. J., Guernon, J. M., Chun, A., Gregro, A. R., Bender, A. M., Capstick, R. A., Wieting, J. M., Bronson, J. J., Macor, J. E., Westphal, R., Soars, M., Engers, J. E., Felts, A. S., Rodriguez, A. L., Emmitte, K. A., Jones, C. K., Blobaum, A. L., Jeffrey Conn, P. & 3 others, Niswender, C. M., Hopkins, C. R. & Lindsley, C. W., Jan 15 2019, In : Bioorganic and Medicinal Chemistry Letters. 29, 2, p. 342-346 5 p.

Research output: Contribution to journalArticle

2 Scopus citations

VU0810464, a non-urea G protein-gated inwardly rectifying K+ (Kir3/GIRK) channel activator, exhibits enhanced selectivity for neuronal Kir3 channels and reduces stress-induced hyperthermia in mice

Vo, B. N., Abney, K. K., Anderson, A., Marron Fernandez de Velasco, E., Benneyworth, M. A., Daniels, J. S., Morrison, R. D., Hopkins, C. R., Weaver, C. D. & Wickman, K., Jul 2019, In : British Journal of Pharmacology. 176, 13, p. 2238-2249 12 p.

Research output: Contribution to journalArticle

1 Scopus citations
2018

Discovery, characterization, and effects on renal fluid and electrolyte excretion of the Kir4.1 potassium channel pore blocker, VU0134992

Kharade, S. V., Kurata, H., Bender, A. M., Blobaum, A. L., Figueroa, E. E., Duran, A., Kramer, M., Days, E., Vinson, P., Flores, D., Satlin, L. M., Meiler, J., Weaver, C. D., Lindsley, C. W., Hopkins, C. R. & Denton, J. S., Aug 2018, In : Molecular pharmacology. 94, 2, p. 926-937 12 p.

Research output: Contribution to journalArticle

9 Scopus citations

Discovery and characterization of N-(1,3-dialkyl-1H-indazol-6-yl)-1H-pyrazolo[4,3-b]pyridin-3-amine scaffold as mGlu4 positive allosteric modulators that mitigate CYP1A2 induction liability

Engers, D. W., Bollinger, S. R., Engers, J. L., Panarese, J. D., Breiner, M. M., Gregro, A., Blobaum, A. L., Bronson, J. J., Wu, Y. J., Macor, J. E., Rodriguez, A. L., Zamorano, R., Conn, P. J., Lindsley, C. W., Niswender, C. M. & Hopkins, C. R., Aug 15 2018, In : Bioorganic and Medicinal Chemistry Letters. 28, 15, p. 2641-2646 6 p.

Research output: Contribution to journalArticle

3 Scopus citations

Inward rectifier potassium (Kir) channels in the soybean aphid Aphis glycines: Functional characterization, pharmacology, and toxicology

Piermarini, P. M., Inocente, E. A., Acosta, N., Hopkins, C. R., Denton, J. S. & Michel, A. P., Oct 2018, In : Journal of Insect Physiology. 110, p. 57-65 9 p.

Research output: Contribution to journalArticle

2 Scopus citations

Pharmacological inhibition of inward rectifier potassium channels induces lethality in larval Aedes aegypti

Trigueros, R. R., Hopkins, C. R., Denton, J. S. & Piermarini, P. M., Jan 1 2018, In : Insects. 9, 4, 163.

Research output: Contribution to journalArticle

1 Scopus citations
2017

A small-molecule inhibitor of TRPC5 ion channels suppresses progressive kidney disease in animal models

Zhou, Y., Castonguay, P., Sidhom, E. H., Clark, A. R., Dvela-Levitt, M., Kim, S., Sieber, J., Wieder, N., Jung, J. Y., Andreeva, S., Reichardt, J., Dubois, F., Hoffmann, S. C., Basgen, J. M., Montesinos, M. S., Weins, A., Johnson, A. C., Lander, E. S., Garrett, M. R., Hopkins, C. R. & 1 others, Greka, A., Dec 8 2017, In : Science. 358, 6368, p. 1332-1336 5 p.

Research output: Contribution to journalArticle

42 Scopus citations

CHAPTER 8: Muscarinic Receptors Allosteric Modulation

Melancon, B. J. & Hopkins, C. R., Jan 1 2017, Allosterism in Drug Discovery. Doller, D. (ed.). 56 ed. Royal Society of Chemistry, p. 175-193 19 p. (RSC Drug Discovery Series; vol. 2017-January, no. 56).

Research output: Chapter in Book/Report/Conference proceedingChapter

Discovery and Characterization of 1H-Pyrazol-5-yl-2-phenylacetamides as Novel, Non-Urea-Containing GIRK1/2 Potassium Channel Activators

Wieting, J. M., Vadukoot, A. K., Sharma, S., Abney, K. K., Bridges, T. M., Daniels, J. S., Morrison, R. D., Wickman, K., Weaver, C. D. & Hopkins, C. R., Sep 20 2017, In : ACS Chemical Neuroscience. 8, 9, p. 1873-1879 7 p.

Research output: Contribution to journalArticle

2 Scopus citations

MGlu7 potentiation rescues cognitive, social, and respiratory phenotypes in a mouse model of Rett syndrome

Gogliotti, R. G., Senter, R. K., Fisher, N. M., Adams, J., Zamorano, R., Walker, A. G., Blobaum, A. L., Engers, D. W., Hopkins, C. R., Daniels, J. S., Jones, C. K., Lindsley, C. W., Xiang, Z., Conn, P. J. & Niswender, C. M., Aug 16 2017, In : Science translational medicine. 9, 403, eaai7459.

Research output: Contribution to journalArticle

Open Access
25 Scopus citations

Return of D4 Dopamine Receptor Antagonists in Drug Discovery

Lindsley, C. W. & Hopkins, C. R., Jan 1 2017, In : Journal of Medicinal Chemistry. 60, 17, p. 7233-7243 11 p.

Research output: Contribution to journalReview article

16 Scopus citations
2016

An insecticide resistance-breaking mosquitocide targeting inward rectifier potassium channels in vectors of Zika virus and malaria

Swale, D. R., Engers, D. W., Bollinger, S. R., Gross, A., Inocente, E. A., Days, E., Kanga, F., Johnson, R. M., Yang, L., Bloomquist, J. R., Hopkins, C. R., Piermarini, P. M. & Denton, J. S., Nov 16 2016, In : Scientific reports. 6, 36954.

Research output: Contribution to journalArticle

31 Scopus citations

Bone morphogenetic protein signaling promotes tumorigenesis in a murine model of high-grade glioma

Hover, L. D., Owens, P., Munden, A. L., Wang, J., Chambless, L. B., Hopkins, C. R., Hong, C. C., Moses, H. L. & Abel, T. W., Jul 1 2016, In : Neuro-Oncology. 18, 7, p. 928-938 11 p.

Research output: Contribution to journalArticle

13 Scopus citations

Development and Antiparkinsonian Activity of VU0418506, a Selective Positive Allosteric Modulator of Metabotropic Glutamate Receptor 4 Homomers without Activity at mGlu2/4 Heteromers

Niswender, C. M., Jones, C. K., Lin, X., Bubser, M., Thompson Gray, A., Blobaum, A. L., Engers, D. W., Rodriguez, A. L., Loch, M. T., Daniels, J. S., Lindsley, C. W., Hopkins, C. R., Javitch, J. A. & Conn, P. J., Sep 21 2016, In : ACS Chemical Neuroscience. 7, 9, p. 1201-1211 11 p.

Research output: Contribution to journalArticle

30 Scopus citations

Discovery, characterization and biological evaluation of a novel (R)-4,4-difluoropiperidine scaffold as dopamine receptor 4 (D4R) antagonists

Jeffries, D. E., Witt, J. O., McCollum, A. L., Temple, K. J., Hurtado, M. A., Harp, J. M., Blobaum, A. L., Lindsley, C. W. & Hopkins, C. R., Jan 1 2016, In : Bioorganic and Medicinal Chemistry Letters. 26, 23, p. 5757-5764 8 p.

Research output: Contribution to journalArticle

2 Scopus citations

Discovery, Synthesis, and Preclinical Characterization of N-(3-Chloro-4-fluorophenyl)-1H-pyrazolo[4,3-b]pyridin-3-amine (VU0418506), a Novel Positive Allosteric Modulator of the Metabotropic Glutamate Receptor 4 (mGlu4)

Engers, D. W., Blobaum, A. L., Gogliotti, R. D., Cheung, Y. Y., Salovich, J. M., Garcia-Barrantes, P. M., Daniels, J. S., Morrison, R., Jones, C. K., Soars, M. G., Zhuo, X., Hurley, J., Macor, J. E., Bronson, J. J., Conn, P. J., Lindsley, C. W., Niswender, C. M. & Hopkins, C. R., Sep 21 2016, In : ACS Chemical Neuroscience. 7, 9, p. 1192-1200 9 p.

Research output: Contribution to journalArticle

23 Scopus citations

Discovery and characterization of a novel series of N-phenylsulfonyl-1H-pyrrole picolinamides as positive allosteric modulators of the metabotropic glutamate receptor 4 (mGlu4)

Gogliotti, R. D., Blobaum, A. L., Morrison, R. M., Daniels, J. S., Salovich, J. M., Cheung, Y. Y., Rodriguez, A. L., Loch, M. T., Conn, P. J., Lindsley, C. W., Niswender, C. M. & Hopkins, C. R., Jul 1 2016, In : Bioorganic and Medicinal Chemistry Letters. 26, 13, p. 2984-2987 4 p.

Research output: Contribution to journalArticle

5 Scopus citations

Discovery and optimization of a novel series of highly CNS penetrant M4 PAMs based on a 5,6-dimethyl-4-(piperidin-1-yl)thieno[2,3-d]pyrimidine core

Wood, M. R., Noetzel, M. J., Engers, J. L., Bollinger, K. A., Melancon, B. J., Tarr, J. C., Han, C., West, M., Gregro, A. R., Lamsal, A., Chang, S., Ajmera, S., Smith, E., Chase, P., Hodder, P. S., Bubser, M., Jones, C. K., Hopkins, C. R., Emmitte, K. A., Niswender, C. M. & 5 others, Wood, M. W., Duggan, M. E., Conn, P. J., Bridges, T. M. & Lindsley, C. W., Jul 1 2016, In : Bioorganic and Medicinal Chemistry Letters. 26, 13, p. 3029-3033 5 p.

Research output: Contribution to journalArticle

17 Scopus citations

Discovery of 3-aminopicolinamides as metabotropic glutamate receptor subtype 4 (mGlu4) positive allosteric modulator warheads engendering CNS exposure and in vivo efficacy

Gogliotti, R. D., Engers, D. W., Garcia-Barrantes, P. M., Panarese, J. D., Gentry, P. R., Blobaum, A. L., Morrison, R. D., Daniels, J. S., Thompson, A. D., Jones, C. K., Conn, P. J., Niswender, C. M., Lindsley, C. W. & Hopkins, C. R., Jun 15 2016, In : Bioorganic and Medicinal Chemistry Letters. 26, 12, p. 2915-2919 5 p.

Research output: Contribution to journalArticle

1 Scopus citations

Inhibitors of the bone morphogenetic protein (BMP) signaling pathway: a patent review (2008-2015)

Hopkins, C. R., Oct 2 2016, In : Expert Opinion on Therapeutic Patents. 26, 10, p. 1115-1128 14 p.

Research output: Contribution to journalReview article

10 Scopus citations

ML418: The First Selective, Sub-Micromolar Pore Blocker of Kir7.1 Potassium Channels

Swale, D. R., Kurata, H., Kharade, S. V., Sheehan, J., Raphemot, R., Voigtritter, K. R., Figueroa, E. E., Meiler, J., Blobaum, A. L., Lindsley, C. W., Hopkins, C. R. & Denton, J. S., Jul 20 2016, In : ACS Chemical Neuroscience. 7, 7, p. 1013-1023 11 p.

Research output: Contribution to journalArticle

8 Scopus citations

Practical Strategies and Concepts in GPCR Allosteric Modulator Discovery: Recent Advances with Metabotropic Glutamate Receptors

Lindsley, C. W., Emmitte, K. A., Hopkins, C. R., Bridges, T. M., Gregory, K. J., Niswender, C. M. & Conn, P. J., Jun 8 2016, In : Chemical Reviews. 116, 11, p. 6707-6741 35 p.

Research output: Contribution to journalReview article

91 Scopus citations

Synthesis and characterization of a series of chiral alkoxymethyl morpholine analogs as dopamine receptor 4 (D4R) antagonists

Witt, J. O., McCollum, A. L., Hurtado, M. A., Huseman, E. D., Jeffries, D. E., Temple, K. J., Plumley, H. C., Blobaum, A. L., Lindsley, C. W. & Hopkins, C. R., May 1 2016, In : Bioorganic and Medicinal Chemistry Letters. 26, 10, p. 2481-2488 8 p.

Research output: Contribution to journalArticle

10 Scopus citations

Validation of an improved scale for rating L-DOPA-induced dyskinesia in the mouse and effects of specific dopamine receptor antagonists

Sebastianutto, I., Maslava, N., Hopkins, C. R. & Cenci, M. A., Dec 1 2016, In : Neurobiology of Disease. 96, p. 156-170 15 p.

Research output: Contribution to journalArticle

19 Scopus citations
2015

Activation of metabotropic glutamate receptor 7 is required for induction of long-term potentiation at SCCA1 synapses in the hippocampus

Klar, R., Walker, A. G., Ghose, D., Grueter, B. A., Engers, D. W., Hopkins, C. R., Lindsley, C. W., Xiang, Z., Conn, P. J. & Niswender, C. M., May 13 2015, In : Journal of Neuroscience. 35, 19, p. 7600-7615 16 p.

Research output: Contribution to journalArticle

21 Scopus citations

Advancing biological understanding and therapeutics discovery with small-molecule probes

Schreiber, S. L., Kotz, J. D., Li, M., Aubé, J., Austin, C. P., Reed, J. C., Rosen, H., White, E. L., Sklar, L. A., Lindsley, C. W., Alexander, B. R., Bittker, J. A., Clemons, P. A., De Souza, A., Foley, M. A., Palmer, M., Shamji, A. F., Wawer, M. J., McManus, O., Wu, M. & 26 others, Zou, B., Yu, H., Golden, J. E., Schoenen, F. J., Simeonov, A., Jadhav, A., Jackson, M. R., Pinkerton, A. B., Chung, T. D. Y., Griffin, P. R., Cravatt, B. F., Hodder, P. S., Roush, W. R., Roberts, E., Chung, D. H., Jonsson, C. B., Noah, J. W., Severson, W. E., Ananthan, S., Edwards, B., Oprea, T. I., Conn, P. J., Hopkins, C. R., Wood, M. R., Stauffer, S. R. & Emmitte, K. A., Jan 1 2015, In : Cell. 161, 6, p. 1252-1265 14 p.

Research output: Contribution to journalReview article

77 Scopus citations

Discovery and characterization of 2-(cyclopropanesulfonamido)-n-(2-ethoxyphenyl)benzamide, ML382: A potent and selective positive allosteric modulator of MrgX1

Wen, W., Wang, Y., Li, Z., Tseng, P. Y., McManus, O. B., Wu, M., Li, M., Lindsley, C. W., Dong, X. & Hopkins, C. R., Jan 2015, In : ChemMedChem. 10, 1, p. 57-61 5 p.

Research output: Contribution to journalArticle

2 Scopus citations

Identification and characterization of ml352: A novel, noncompetitive inhibitor of the presynaptic choline transporter

Ennis, E. A., Wright, J., Retzlaff, C. L., McManus, O. B., Lin, Z., Huang, X., Wu, M., Li, M., Daniels, J. S., Lindsley, C. W., Hopkins, C. R. & Blakely, R. D., Mar 18 2015, In : ACS Chemical Neuroscience. 6, 3, p. 417-427 11 p.

Research output: Contribution to journalArticle

10 Scopus citations

Inhibition of BMP signaling suppresses metastasis in mammary cancer

Owens, P., Pickup, M. W., Novitskiy, S. V., Giltnane, J. M., Gorska, A. E., Hopkins, C. R., Hong, C. C. & Moses, H. L., May 7 2015, In : Oncogene. 34, 19, p. 2437-2449 13 p.

Research output: Contribution to journalArticle

55 Scopus citations

Pharmacological stimulation of metabotropic glutamate receptor type 4 in a rat model of Parkinson's disease and l-DOPA-induced dyskinesia: Comparison between a positive allosteric modulator and an orthosteric agonist

Iderberg, H., Maslava, N., Thompson, A. D., Bubser, M., Niswender, C. M., Hopkins, C. R., Lindsley, C. W., Conn, P. J., Jones, C. K. & Cenci, M. A., Aug 2015, In : Neuropharmacology. 95, p. 121-129 9 p., 5768.

Research output: Contribution to journalArticle

23 Scopus citations

Synthesis and structure-activity relationships of a series of 4-methoxy-3-(piperidin-4-yl)oxy benzamides as novel inhibitors of the presynaptic choline transporter

Bollinger, S. R., Engers, D. W., Ennis, E. A., Wright, J., Locuson, C. W., Lindsley, C. W., Blakely, R. D. & Hopkins, C. R., Apr 15 2015, In : Bioorganic and Medicinal Chemistry Letters. 25, 8, p. 1757-1760 4 p.

Research output: Contribution to journalArticle

3 Scopus citations
2014

Chemical modulation of mutant mGlu1 receptors derived from deleterious GRM1 mutations found in schizophrenics

Cho, H. P., Garcia-Barrantes, P. M., Brogan, J. T., Hopkins, C. R., Niswender, C. M., Rodriguez, A. L., Venable, D. F., Morrison, R. D., Bubser, M., Daniels, J. S., Jones, C. K., Conn, P. J. & Lindsley, C. W., Oct 17 2014, In : ACS chemical biology. 9, 10, p. 2334-2346 13 p.

Research output: Contribution to journalArticle

30 Scopus citations

Discovery and characterization of a potent and selective inhibitor of Aedes aegypti inward rectifier potassium channels

Raphemot, R., Rouhier, M. F., Swale, D. R., Days, E., Weaver, C. D., Lovell, K. M., Konkel, L. C., Engers, D. W., Bollinger, S. F., Hopkins, C., Piermarini, P. M. & Denton, J. S., Nov 6 2014, In : PloS one. 9, 11, 110772.

Research output: Contribution to journalArticle

26 Scopus citations

Discovery and characterization of ML398, a potent and selective antagonist of the D4 receptor with in vivo activity

Berry, C. B., Bubser, M., Jones, C. K., Hayes, J. P., Wepy, J. A., Locuson, C. W., Daniels, J. S., Lindsley, C. W. & Hopkins, C. R., Sep 11 2014, In : ACS Medicinal Chemistry Letters. 5, 9, p. 1060-1064 5 p.

Research output: Contribution to journalArticle

9 Scopus citations

Identification of positive allosteric modulators VU0155094 (ML397) and VU0422288 (ML396) reveals new insights into the biology of metabotropic glutamate receptor 7

Jalan-Sakrikar, N., Field, J. R., Klar, R., Mattmann, M. E., Gregory, K. J., Zamorano, R., Engers, D. W., Bollinger, S. R., Weaver, C. D., Days, E. L., Lewis, L. M., Utley, T. J., Hurtado, M., Rigault, D., Acher, F., Walker, A. G., Melancon, B. J., Wood, M. R., Lindsley, C. W., Conn, P. J. & 3 others, Xiang, Z., Hopkins, C. R. & Niswender, C. M., Dec 17 2014, In : ACS Chemical Neuroscience. 5, 12, p. 1221-1237 17 p.

Research output: Contribution to journalArticle

32 Scopus citations

Specific activin receptor-like kinase 3 inhibitors enhance liver regeneration

Tsugawa, D., Oya, Y., Masuzaki, R., Ray, K., Engers, D. W., Dib, M., Do, N., Kuramitsu, K., Ho, K., Frist, A., Yu, P. B., Bloch, K. D., Lindsley, C. W., Hopkins, C. R., Hong, C. C. & Karp, S. J., Dec 1 2014, In : Journal of Pharmacology and Experimental Therapeutics. 351, 3, p. 549-558 10 p.

Research output: Contribution to journalArticle

17 Scopus citations
2013

Discovery of a selective M4 positive allosteric modulator based on the 3-amino-thieno[2,3-b]pyridine-2-carboxamide scaffold: Development of ML253, a potent and brain penetrant compound that is active in a preclinical model of schizophrenia

Le, U., Melancon, B. J., Bridges, T. M., Vinson, P. N., Utley, T. J., Lamsal, A., Rodriguez, A. L., Venable, D., Sheffler, D. J., Jones, C. K., Blobaum, A. L., Wood, M. R., Daniels, J. S., Conn, P. J., Niswender, C. M., Lindsley, C. W. & Hopkins, C. R., Jan 1 2013, In : Bioorganic and Medicinal Chemistry Letters. 23, 1, p. 346-350 5 p.

Research output: Contribution to journalArticle

23 Scopus citations

Dynamic subunit stoichiometry confers a progressive continuum of pharmacological sensitivity by KCNQ potassium channels

Yu, H., Lin, Z., Mattmann, M. E., Zou, B., Terrenoire, C., Zhang, H., Wu, M., McManus, O. B., Kass, R. S., Lindsley, C. W., Hopkins, C. R. & Li, M., May 21 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 21, p. 8732-8737 6 p.

Research output: Contribution to journalArticle

37 Scopus citations