• 3017 Citations
  • 31 h-Index
19992020

Research output per year

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Research Output

1999

Efficient synthesis of 1,4-dihydro-2H-isoquinoline-3,5,8-triones via cyclobutene ring expansion

Wipf, P. & Hopkins, C. R., Sep 3 1999, In : Journal of Organic Chemistry. 64, 18, p. 6881-6887 7 p.

Research output: Contribution to journalComment/debate

31 Scopus citations
2001

Enantioselective synthesis of the AB-ring system of the antitumor antibiotic tetrazomine

Wipf, P. & Hopkins, C. R., May 4 2001, In : Journal of Organic Chemistry. 66, 9, p. 3133-3139 7 p.

Research output: Contribution to journalArticle

24 Scopus citations
2002

Separation of Cdc25 dual specificity phosphatase inhibition and DNA cleaving activities in a focused library of analogs of the antitumor antibiotic Dnacin

Wipf, P., Hopkins, C. R., Phillips, E. O. & Lazo, J. S., Aug 5 2002, In : Tetrahedron. 58, 32, p. 6367-6372 6 p.

Research output: Contribution to journalArticle

17 Scopus citations
2004
30 Scopus citations
25 Scopus citations

Convenient synthesis of 4-amino-3,5-disubstituted pyrazoles in one step from the corresponding diketo oximes

Majid, T., Hopkins, C. R., Pedgrift, B. & Collar, N., Mar 1 2004, In : Tetrahedron Letters. 45, 10, p. 2137-2139 3 p.

Research output: Contribution to journalArticle

23 Scopus citations

Novel pyrazinone inhibitors of mast cell tryptase: Synthesis and SAR evaluation

Hopkins, C., Neuenschwander, K., Scotese, A., Jackson, S., Nieduzak, T., Pauls, H., Liang, G., Sides, K., Cramer, D., Cairns, J., Maignan, S. & Mathieu, M., Oct 4 2004, In : Bioorganic and Medicinal Chemistry Letters. 14, 19, p. 4819-4823 5 p.

Research output: Contribution to journalArticle

28 Scopus citations
2005

Design, synthesis, and biological activity of potent and selective inhibitors of mast cell tryptase

Hopkins, C. R., Czekaj, M., Kaye, S. S., Gao, Z., Pribish, J., Pauls, H., Liang, G., Sides, K., Cramer, D., Cairns, J., Luo, Y., Lim, H. K., Vaz, R., Rebello, S., Maignan, S., Dupuy, A., Mathieu, M. & Levell, J., Jun 2 2005, In : Bioorganic and Medicinal Chemistry Letters. 15, 11, p. 2734-2737 4 p.

Research output: Contribution to journalArticle

29 Scopus citations

Synthesis of 6,7-disubstituted-5H-pyrrolo[2,3-b]pyrazines via palladium-catalyzed heteroannulation

Hopkins, C. R. & Collar, N., Mar 14 2005, In : Tetrahedron Letters. 46, 11, p. 1845-1848 4 p.

Research output: Contribution to journalArticle

12 Scopus citations
2006

Design and synthesis of novel N-sulfonyl-2-indole carboxamides as potent PPAR-γ binding agents with potential application to the treatment of osteoporosis

Hopkins, C. R., O'Neil, S. V., Laufersweiler, M. C., Wang, Y., Pokross, M., Mekel, M., Evdokimov, A., Walter, R., Kontoyianni, M., Petrey, M. E., Sabatakos, G., Roesgen, J. T., Richardson, E. & Demuth, T. P., Nov 1 2006, In : Bioorganic and Medicinal Chemistry Letters. 16, 21, p. 5659-5663 5 p.

Research output: Contribution to journalArticle

37 Scopus citations

Development of N-4,6-pyrimidine-N-alkyl-N′-phenyl ureas as orally active inhibitors of lymphocyte specific tyrosine kinase

Maier, J. A., Brugel, T. A., Sabat, M., Golebiowski, A., Laufersweiler, M. J., VanRens, J. C., Hopkins, C. R., De, B., Hsieh, L. C., Brown, K. K., Easwaran, V. & Janusz, M. J., Jul 15 2006, In : Bioorganic and Medicinal Chemistry Letters. 16, 14, p. 3646-3650 5 p.

Research output: Contribution to journalArticle

20 Scopus citations
2008

Molecule of the month

Hopkins, C. R., 2008, In : Current Topics in Medicinal Chemistry. 8, 18, p. 1710-1711 2 p.

Research output: Contribution to journalReview article

2009

MGluR4-positive allosteric modulation as potential treatment for Parkinson's disease

Hopkins, C. R., Lindsley, C. W. & Niswender, C. M., Jun 2009, In : Future Medicinal Chemistry. 1, 3, p. 501-513 13 p.

Research output: Contribution to journalReview article

52 Scopus citations

Recent progress in the development of mGluR4 positive allosteric modulators for the treatment of Parkinson's disease

Lindsley, C. W., Niswender, C. M., Engers, D. W. & Hopkins, C. R., 2009, In : Current Topics in Medicinal Chemistry. 9, 10, p. 949-963 15 p.

Research output: Contribution to journalReview article

35 Scopus citations

Synthesis and evaluation of a series of heterobiarylamides that are centrally penetrant metabotropic glutamate receptor 4 (mGluR4) positive allosteric modulators (PAMs)

Engers, D. W., Niswender, C. M., Weaver, C. D., Jadhav, S., Menon, U. N., Zamorano, R., Conn, P. J., Lindsley, C. W. & Hopkins, C. R., Jul 23 2009, In : Journal of Medicinal Chemistry. 52, 14, p. 4115-4118 4 p.

Research output: Contribution to journalArticle

61 Scopus citations

Synthesis and SAR of a novel positive allosteric modulator (PAM) of the metabotropic glutamate receptor 4 (mGluR4)

Williams, R., Johnson, K. A., Gentry, P. R., Niswender, C. M., Weaver, C. D., Conn, P. J., Lindsley, C. W. & Hopkins, C. R., Sep 1 2009, In : Bioorganic and Medicinal Chemistry Letters. 19, 17, p. 4967-4970 4 p.

Research output: Contribution to journalArticle

25 Scopus citations
2010

ACS chemical neuroscience molecule spotlight on dimebon

Hopkins, C. R., Sep 15 2010, In : ACS Chemical Neuroscience. 1, 9, p. 587-588 2 p.

Research output: Contribution to journalShort survey

8 Scopus citations

ACS chemical neuroscience molecule spotlight on fanapt

Hopkins, C. R., Jun 16 2010, In : ACS Chemical Neuroscience. 1, 6, 1 p.

Research output: Contribution to journalShort survey

6 Scopus citations

ACS chemical neuroscience molecule spotlight on lorcaserin

Hopkins, C. R., Nov 17 2010, In : ACS Chemical Neuroscience. 1, 11, p. 718-719 2 p.

Research output: Contribution to journalShort survey

3 Scopus citations

ACS chemical neuroscience molecule spotlight on Sabril

Hopkins, C. R., Jul 21 2010, In : ACS Chemical Neuroscience. 1, 7, 1 p.

Research output: Contribution to journalShort survey

2 Scopus citations

ACS chemical neuroscience molecule spotlight on saphris

Hopkins, C. R., Apr 21 2010, In : ACS Chemical Neuroscience. 1, 4, p. 263-264 2 p.

Research output: Contribution to journalArticle

ACS chemical neuroscience molecule spotlight on saredutant

Hopkins, C. R., Oct 20 2010, In : ACS Chemical Neuroscience. 1, 10, p. 653-654 2 p.

Research output: Contribution to journalShort survey

ACS chemical neuroscience molecule spotlight on savella

Hopkins, C. R., May 19 2010, In : ACS Chemical Neuroscience. 1, 5, 1 p.

Research output: Contribution to journalShort survey

ACS chemical neuroscience molecule spotlight on semagacestat (ly450139)

Hopkins, C. R., Aug 18 2010, In : ACS Chemical Neuroscience. 1, 8, p. 533-534 2 p.

Research output: Contribution to journalShort survey

7 Scopus citations

ACS chemical neuroscience molecule spotlight on valdoxen

Hopkins, C. R., Dec 15 2010, In : ACS Chemical Neuroscience. 1, 12, p. 772-773 2 p.

Research output: Contribution to journalArticle

1 Scopus citations

Chemical lead optimization of a pan Gq mAChR M1, M3, M5 positive allosteric modulator (PAM) lead. Part I: Development of the first highly selective M5 PAM

Bridges, T. M., Kennedy, J. P., Cho, H. P., Breininger, M. L., Gentry, P. R., Hopkins, C. R., Conn, P. J. & Lindsley, C. W., Jan 15 2010, In : Bioorganic and Medicinal Chemistry Letters. 20, 2, p. 558-562 5 p.

Research output: Contribution to journalArticle

35 Scopus citations

Heterobiaryl and heterobiaryl ether derived M5 positive allosteric modulators

Bridges, T. M., Kennedy, J. P., Hopkins, C. R., Conn, P. J. & Lindsley, C. W., Oct 1 2010, In : Bioorganic and Medicinal Chemistry Letters. 20, 19, p. 5617-5622 6 p.

Research output: Contribution to journalArticle

22 Scopus citations

In vivo structure - Activity relationship study of dorsomorphin analogues identifies selective VEGF and BMP inhibitors

Hao, J., Ho, J. N., Lewis, J. A., Karim, K. A., Daniels, R. N., Gentry, P. R., Hopkins, C. R., Lindsley, C. W. & Hong, C. C., Feb 19 2010, In : ACS chemical biology. 5, 2, p. 245-253 9 p.

Research output: Contribution to journalArticle

239 Scopus citations

Re-exploration of the PHCCC scaffold: Discovery of improved positive allosteric modulators of mGluR4

Williams, R., Zhou, Y., Niswender, C. M., Luo, Q., Conn, P. J., Lindsley, C. W. & Hopkins, C. R., Jun 16 2010, In : ACS Chemical Neuroscience. 1, 6, p. 411-419 9 p.

Research output: Contribution to journalArticle

40 Scopus citations

Synthesis and SAR of novel, 4-(phenylsulfamoyl)phenylacetamide mGlu 4 positive allosteric modulators (PAMs) identified by functional high-throughput screening (HTS)

Engers, D. W., Gentry, P. R., Williams, R., Bolinger, J. D., Weaver, C. D., Menon, U. N., Conn, P. J., Lindsley, C. W., Niswender, C. M. & Hopkins, C. R., Sep 1 2010, In : Bioorganic and Medicinal Chemistry Letters. 20, 17, p. 5175-5178 4 p.

Research output: Contribution to journalArticle

20 Scopus citations

Synthesis of 1,3-diarylsubstituted indazoles utilizing a Suzuki cross-coupling/deprotection/N-arylation sequence

Salovich, J. M., Lindsley, C. W. & Hopkins, C. R., Jul 21 2010, In : Tetrahedron Letters. 51, 29, p. 3796-3799 4 p.

Research output: Contribution to journalArticle

18 Scopus citations

The antipsychotic potential of muscarinic allosteric modulation

Bridges, T. M., LeBois, E. P., Hopkins, C. R., Wood, M. R., Jones, C. K., Conn, P. J. & Lindsley, C. W., May 2010, In : Drug News and Perspectives. 23, 4, p. 229-240 12 p.

Research output: Contribution to journalReview article

48 Scopus citations
2011

ACS chemical neuroscience molecule spotlight on ELND006: Another γ-secretase inhibitor fails in the clinic

Hopkins, C. R., Jun 15 2011, In : ACS Chemical Neuroscience. 2, 6, p. 279-280 2 p.

Research output: Contribution to journalReview article

33 Scopus citations

ACS chemical neuroscience molecule spotlight on gilenya (fingolimod; FTY720)

Hopkins, C. R., Mar 16 2011, In : ACS Chemical Neuroscience. 2, 3, p. 116-117 2 p.

Research output: Contribution to journalArticle

3 Scopus citations

ACS chemical neuroscience molecule spotlight on Latuda (lurasidone; SM-13,496)

Hopkins, C. R., Feb 16 2011, In : ACS Chemical Neuroscience. 2, 2, p. 58-59 2 p.

Research output: Contribution to journalComment/debate

6 Scopus citations

ACS chemical neuroscience molecule spotlight on RG1678

Hopkins, C. R., Dec 21 2011, In : ACS Chemical Neuroscience. 2, 12, p. 685-686 2 p.

Research output: Contribution to journalArticle

11 Scopus citations

ACS chemical neuroscience molecule spotlight on STX209 (Arbaclofen)

Hopkins, C. R., Aug 17 2011, In : ACS Chemical Neuroscience. 2, 8, 1 p.

Research output: Contribution to journalReview article

3 Scopus citations

ACS chemical neuroscience molecule spotlight on telcagepant (MK-0974)

Hopkins, C. R., Jul 20 2011, In : ACS Chemical Neuroscience. 2, 7, p. 334-335 2 p.

Research output: Contribution to journalReview article

2 Scopus citations

ACS chemical neuroscience molecule spotlight on Viibryd (vilazodone)

Hopkins, C. R., Oct 19 2011, In : ACS Chemical Neuroscience. 2, 10, 1 p.

Research output: Contribution to journalArticle

9 Scopus citations

Application of small organic molecules reveals cooperative TGFβ and BMP regulation of mesothelial cell behaviors

Cross, E. E., Thomason, R. T., Martinez, M., Hopkins, C. R., Hong, C. C. & Bader, D. M., Sep 2 2011, In : ACS chemical biology. 6, 9, p. 952-961 10 p.

Research output: Contribution to journalArticle

15 Scopus citations

Biomimetic Synthesis of Lignans

Lindsley, C. W., Hopkins, C. R. & Sulikowski, G. A., Apr 21 2011, Biomimetic Organic Synthesis. Wiley-VCH, Vol. 2. p. 677-693 17 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Discovery, characterization, and structure-activity relationships of an inhibitor of inward rectifier potassium (Kir) channels with preference for Kir2.3, Kir3.X, and Kir7.1

Raphemot, R., Lonergan, D. F., Nguyen, T. T., Utley, T., Michelle Lewis, L., Kadakia, R., David Weaver, C., Gogliotti, R., Hopkins, C., Lindsley, C. W. & Denton, J. S., 2011, In : Frontiers in Pharmacology. 2 NOV, Article 75.

Research output: Contribution to journalArticle

28 Scopus citations

Discovery, synthesis, and structure-activity relationship development of a series of N-(4-acetamido)phenylpicolinamides as positive allosteric modulators of metabotropic glutamate receptor 4 (mGlu4) with CNS exposure in rats

Engers, D. W., Field, J. R., Le, U., Zhou, Y., Bolinger, J. D., Zamorano, R., Blobaum, A. L., Jones, C. K., Jadhav, S., Weaver, C. D., Conn, P. J., Lindsley, C. W., Niswender, C. M. & Hopkins, C. R., Feb 24 2011, In : Journal of Medicinal Chemistry. 54, 4, p. 1106-1110 5 p.

Research output: Contribution to journalArticle

33 Scopus citations

Discovery, synthesis, and structure-activity relationship development of a series of N -4-(2,5-dioxopyrrolidin-1-yl)phenylpicolinamides (VU0400195, ML182): Characterization of a novel positive allosteric modulator of the metabotropic glutamate receptor 4 (mGlu 4) with oral efficacy in an antiparkinsonian animal model

Jones, C. K., Engers, D. W., Thompson, A. D., Field, J. R., Blobaum, A. L., Lindsley, S. R., Zhou, Y., Gogliotti, R. D., Jadhav, S., Zamorano, R., Bogenpohl, J., Smith, Y., Morrison, R., Daniels, J. S., Weaver, C. D., Conn, P. J., Lindsley, C. W., Niswender, C. M. & Hopkins, C. R., Nov 10 2011, In : Journal of Medicinal Chemistry. 54, 21, p. 7639-7647 9 p.

Research output: Contribution to journalArticle

46 Scopus citations

Discovery, synthesis, and structure-activity relationship of a series of N -aryl-bicyclo[2.2.1]heptane-2-carboxamides: Characterization of ML213 as a novel KCNQ2 and KCNQ4 potassium channel opener

Yu, H., Wu, M., Townsend, S. D., Zou, B., Long, S., Daniels, J. S., McManus, O. B., Li, M., Lindsley, C. W. & Hopkins, C. R., Oct 19 2011, In : ACS Chemical Neuroscience. 2, 10, p. 572-577 6 p.

Research output: Contribution to journalArticle

37 Scopus citations

Identification of ML204, a novel potent antagonist that selectively modulates native TRPC4/C5 ion channels

Miller, M., Shi, J., Zhu, Y., Kustov, M., Tian, J. B., Stevens, A., Wu, M., Xu, J., Long, S., Yang, P., Zholos V, A., Salovich, J. M., Weaver, C. D., Hopkins, C. R., Lindsley, C. W., McManus, O., Li, M. & Zhu, M. X., Sep 23 2011, In : Journal of Biological Chemistry. 286, 38, p. 33436-33446 11 p.

Research output: Contribution to journalArticle

114 Scopus citations

"Molecular switches" on mGluR allosteric ligands that modulate modes of pharmacology

Wood, M. R., Hopkins, C. R., Brogan, J. T., Conn, P. J. & Lindsley, C. W., Apr 5 2011, In : Biochemistry. 50, 13, p. 2403-2410 8 p.

Research output: Contribution to journalArticle

124 Scopus citations

Recent progress on the identification of metabotropic glutamate 4 receptor ligands and their potential utility as CNS therapeutics

Robichaud, A. J., Engers, D. W., Lindsley, C. W. & Hopkins, C. R., Aug 17 2011, In : ACS Chemical Neuroscience. 2, 8, p. 433-449 17 p.

Research output: Contribution to journalReview article

31 Scopus citations

Selective inhibition of the K ir2 family of inward rectifier potassium channels by a small molecule probe: The discovery, SAR, and pharmacological characterization of ML133

Wang, H. R., Wu, M., Yu, H., Long, S., Stevens, A., Engers, D. W., Sackin, H., Daniels, J. S., Dawson, E. S., Hopkins, C. R., Lindsley, C. W., Li, M. & McManus, O. B., Aug 19 2011, In : ACS chemical biology. 6, 8, p. 845-856 12 p.

Research output: Contribution to journalArticle

48 Scopus citations