• 3017 Citations
  • 31 h-Index
19992020

Research output per year

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Research Output

30 Scopus citations

ACS chemical neuroscience molecule spotlight on begacestat (GSI-953)

Hopkins, C. R., Jan 18 2012, In : ACS Chemical Neuroscience. 3, 1, p. 3-4 2 p.

Research output: Contribution to journalReview article

25 Scopus citations

ACS chemical neuroscience molecule spotlight on BMS-708163

Hopkins, C. R., Mar 21 2012, In : ACS Chemical Neuroscience. 3, 3, p. 149-150 2 p.

Research output: Contribution to journalReview article

5 Scopus citations

ACS chemical neuroscience molecule spotlight on dimebon

Hopkins, C. R., Sep 15 2010, In : ACS Chemical Neuroscience. 1, 9, p. 587-588 2 p.

Research output: Contribution to journalShort survey

8 Scopus citations

ACS chemical neuroscience molecule spotlight on ELND006: Another γ-secretase inhibitor fails in the clinic

Hopkins, C. R., Jun 15 2011, In : ACS Chemical Neuroscience. 2, 6, p. 279-280 2 p.

Research output: Contribution to journalReview article

33 Scopus citations

ACS chemical neuroscience molecule spotlight on fanapt

Hopkins, C. R., Jun 16 2010, In : ACS Chemical Neuroscience. 1, 6, 1 p.

Research output: Contribution to journalShort survey

6 Scopus citations

ACS chemical neuroscience molecule spotlight on gilenya (fingolimod; FTY720)

Hopkins, C. R., Mar 16 2011, In : ACS Chemical Neuroscience. 2, 3, p. 116-117 2 p.

Research output: Contribution to journalArticle

3 Scopus citations

ACS chemical neuroscience molecule spotlight on Latuda (lurasidone; SM-13,496)

Hopkins, C. R., Feb 16 2011, In : ACS Chemical Neuroscience. 2, 2, p. 58-59 2 p.

Research output: Contribution to journalComment/debate

6 Scopus citations

ACS chemical neuroscience molecule spotlight on lorcaserin

Hopkins, C. R., Nov 17 2010, In : ACS Chemical Neuroscience. 1, 11, p. 718-719 2 p.

Research output: Contribution to journalShort survey

3 Scopus citations

ACS chemical neuroscience molecule spotlight on potiga (Ezogabine)

Hopkins, C. R., Aug 15 2012, In : ACS Chemical Neuroscience. 3, 8, 1 p.

Research output: Contribution to journalReview article

4 Scopus citations

ACS chemical neuroscience molecule spotlight on RG1678

Hopkins, C. R., Dec 21 2011, In : ACS Chemical Neuroscience. 2, 12, p. 685-686 2 p.

Research output: Contribution to journalArticle

11 Scopus citations

ACS chemical neuroscience molecule spotlight on Sabril

Hopkins, C. R., Jul 21 2010, In : ACS Chemical Neuroscience. 1, 7, 1 p.

Research output: Contribution to journalShort survey

2 Scopus citations

ACS chemical neuroscience molecule spotlight on saphris

Hopkins, C. R., Apr 21 2010, In : ACS Chemical Neuroscience. 1, 4, p. 263-264 2 p.

Research output: Contribution to journalArticle

ACS chemical neuroscience molecule spotlight on saredutant

Hopkins, C. R., Oct 20 2010, In : ACS Chemical Neuroscience. 1, 10, p. 653-654 2 p.

Research output: Contribution to journalShort survey

ACS chemical neuroscience molecule spotlight on savella

Hopkins, C. R., May 19 2010, In : ACS Chemical Neuroscience. 1, 5, 1 p.

Research output: Contribution to journalShort survey

ACS chemical neuroscience molecule spotlight on semagacestat (ly450139)

Hopkins, C. R., Aug 18 2010, In : ACS Chemical Neuroscience. 1, 8, p. 533-534 2 p.

Research output: Contribution to journalShort survey

7 Scopus citations

ACS chemical neuroscience molecule spotlight on STX209 (Arbaclofen)

Hopkins, C. R., Aug 17 2011, In : ACS Chemical Neuroscience. 2, 8, 1 p.

Research output: Contribution to journalReview article

3 Scopus citations

ACS chemical neuroscience molecule spotlight on suvorexant

Hopkins, C. R., Sep 19 2012, In : ACS Chemical Neuroscience. 3, 9, p. 647-648 2 p.

Research output: Contribution to journalReview article

10 Scopus citations

ACS chemical neuroscience molecule spotlight on telcagepant (MK-0974)

Hopkins, C. R., Jul 20 2011, In : ACS Chemical Neuroscience. 2, 7, p. 334-335 2 p.

Research output: Contribution to journalReview article

2 Scopus citations

ACS chemical neuroscience molecule spotlight on valdoxen

Hopkins, C. R., Dec 15 2010, In : ACS Chemical Neuroscience. 1, 12, p. 772-773 2 p.

Research output: Contribution to journalArticle

1 Scopus citations

ACS chemical neuroscience molecule spotlight on Viibryd (vilazodone)

Hopkins, C. R., Oct 19 2011, In : ACS Chemical Neuroscience. 2, 10, 1 p.

Research output: Contribution to journalArticle

9 Scopus citations

Activation of metabotropic glutamate receptor 7 is required for induction of long-term potentiation at SCCA1 synapses in the hippocampus

Klar, R., Walker, A. G., Ghose, D., Grueter, B. A., Engers, D. W., Hopkins, C. R., Lindsley, C. W., Xiang, Z., Conn, P. J. & Niswender, C. M., May 13 2015, In : Journal of Neuroscience. 35, 19, p. 7600-7615 16 p.

Research output: Contribution to journalArticle

21 Scopus citations

Advancing biological understanding and therapeutics discovery with small-molecule probes

Schreiber, S. L., Kotz, J. D., Li, M., Aubé, J., Austin, C. P., Reed, J. C., Rosen, H., White, E. L., Sklar, L. A., Lindsley, C. W., Alexander, B. R., Bittker, J. A., Clemons, P. A., De Souza, A., Foley, M. A., Palmer, M., Shamji, A. F., Wawer, M. J., McManus, O., Wu, M. & 26 others, Zou, B., Yu, H., Golden, J. E., Schoenen, F. J., Simeonov, A., Jadhav, A., Jackson, M. R., Pinkerton, A. B., Chung, T. D. Y., Griffin, P. R., Cravatt, B. F., Hodder, P. S., Roush, W. R., Roberts, E., Chung, D. H., Jonsson, C. B., Noah, J. W., Severson, W. E., Ananthan, S., Edwards, B., Oprea, T. I., Conn, P. J., Hopkins, C. R., Wood, M. R., Stauffer, S. R. & Emmitte, K. A., 2015, In : Cell. 161, 6, p. 1252-1265 14 p.

Research output: Contribution to journalReview article

78 Scopus citations

Allosteric modulation of seven transmembrane spanning receptors: Theory, practice, and opportunities for central nervous system drug discovery

Melancon, B. J., Hopkins, C. R., Wood, M. R., Emmitte, K. A., Niswender, C. M., Christopoulos, A., Conn, P. J. & Lindsley, C. W., Feb 23 2012, In : Journal of Medicinal Chemistry. 55, 4, p. 1445-1464 20 p.

Research output: Contribution to journalReview article

168 Scopus citations

Analgesic Effects of the GIRK Activator, VU0466551, Alone and in Combination with Morphine in Acute and Persistent Pain Models

Abney, K. K., Bubser, M., Du, Y., Kozek, K. A., Bridges, T. M., Linsdley, C. W., Daniels, J. S., Morrison, R. D., Wickman, K., Hopkins, C. R., Jones, C. K. & Weaver, C. D., Mar 20 2019, In : ACS Chemical Neuroscience. 10, 3, p. 1294-1299 6 p.

Research output: Contribution to journalArticle

2 Scopus citations
25 Scopus citations

An insecticide resistance-breaking mosquitocide targeting inward rectifier potassium channels in vectors of Zika virus and malaria

Swale, D. R., Engers, D. W., Bollinger, S. R., Gross, A., Inocente, E. A., Days, E., Kanga, F., Johnson, R. M., Yang, L., Bloomquist, J. R., Hopkins, C. R., Piermarini, P. M. & Denton, J. S., Nov 16 2016, In : Scientific reports. 6, 36954.

Research output: Contribution to journalArticle

31 Scopus citations

Application of small organic molecules reveals cooperative TGFβ and BMP regulation of mesothelial cell behaviors

Cross, E. E., Thomason, R. T., Martinez, M., Hopkins, C. R., Hong, C. C. & Bader, D. M., Sep 2 2011, In : ACS chemical biology. 6, 9, p. 952-961 10 p.

Research output: Contribution to journalArticle

15 Scopus citations

A small-molecule inhibitor of TRPC5 ion channels suppresses progressive kidney disease in animal models

Zhou, Y., Castonguay, P., Sidhom, E. H., Clark, A. R., Dvela-Levitt, M., Kim, S., Sieber, J., Wieder, N., Jung, J. Y., Andreeva, S., Reichardt, J., Dubois, F., Hoffmann, S. C., Basgen, J. M., Montesinos, M. S., Weins, A., Johnson, A. C., Lander, E. S., Garrett, M. R., Hopkins, C. R. & 1 others, Greka, A., Dec 8 2017, In : Science. 358, 6368, p. 1332-1336 5 p.

Research output: Contribution to journalArticle

42 Scopus citations

Biomimetic Synthesis of Lignans

Lindsley, C. W., Hopkins, C. R. & Sulikowski, G. A., Apr 21 2011, Biomimetic Organic Synthesis. Wiley-VCH, Vol. 2. p. 677-693 17 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Bone morphogenetic protein signaling promotes tumorigenesis in a murine model of high-grade glioma

Hover, L. D., Owens, P., Munden, A. L., Wang, J., Chambless, L. B., Hopkins, C. R., Hong, C. C., Moses, H. L. & Abel, T. W., Jul 1 2016, In : Neuro-Oncology. 18, 7, p. 928-938 11 p.

Research output: Contribution to journalArticle

13 Scopus citations

CHAPTER 8: Muscarinic Receptors Allosteric Modulation

Melancon, B. J. & Hopkins, C. R., 2017, Allosterism in Drug Discovery. Doller, D. (ed.). 56 ed. Royal Society of Chemistry, p. 175-193 19 p. (RSC Drug Discovery Series; vol. 2017-January, no. 56).

Research output: Chapter in Book/Report/Conference proceedingChapter

Chemical lead optimization of a pan Gq mAChR M1, M3, M5 positive allosteric modulator (PAM) lead. Part I: Development of the first highly selective M5 PAM

Bridges, T. M., Kennedy, J. P., Cho, H. P., Breininger, M. L., Gentry, P. R., Hopkins, C. R., Conn, P. J. & Lindsley, C. W., Jan 15 2010, In : Bioorganic and Medicinal Chemistry Letters. 20, 2, p. 558-562 5 p.

Research output: Contribution to journalArticle

35 Scopus citations

Chemical modulation of mutant mGlu1 receptors derived from deleterious GRM1 mutations found in schizophrenics

Cho, H. P., Garcia-Barrantes, P. M., Brogan, J. T., Hopkins, C. R., Niswender, C. M., Rodriguez, A. L., Venable, D. F., Morrison, R. D., Bubser, M., Daniels, J. S., Jones, C. K., Conn, P. J. & Lindsley, C. W., Oct 17 2014, In : ACS chemical biology. 9, 10, p. 2334-2346 13 p.

Research output: Contribution to journalArticle

30 Scopus citations

Convenient synthesis of 4-amino-3,5-disubstituted pyrazoles in one step from the corresponding diketo oximes

Majid, T., Hopkins, C. R., Pedgrift, B. & Collar, N., Mar 1 2004, In : Tetrahedron Letters. 45, 10, p. 2137-2139 3 p.

Research output: Contribution to journalArticle

23 Scopus citations

Correction to: Analgesic effects of the GIRK activator, VU0466551, Alone and in combination with morphine in acute and persistent pain models (ACS Chemical Neuroscience (2019) 10:3 (1294-1299) DOI: 10.1021/acschemneuro.8b00370)

Abney, K. K., Bubser, M., Du, Y., Kozek, K. A., Bridges, T. M., Lindsley, C. W., Daniels, J. S., Morrison, R. D., Wickman, K., Hopkins, C. R., Jones, C. K. & Weaver, C. D., May 15 2019, In : ACS Chemical Neuroscience. 10, 5, 1 p.

Research output: Contribution to journalComment/debate

Open Access

Design, synthesis, and biological activity of potent and selective inhibitors of mast cell tryptase

Hopkins, C. R., Czekaj, M., Kaye, S. S., Gao, Z., Pribish, J., Pauls, H., Liang, G., Sides, K., Cramer, D., Cairns, J., Luo, Y., Lim, H. K., Vaz, R., Rebello, S., Maignan, S., Dupuy, A., Mathieu, M. & Levell, J., Jun 2 2005, In : Bioorganic and Medicinal Chemistry Letters. 15, 11, p. 2734-2737 4 p.

Research output: Contribution to journalArticle

29 Scopus citations
8 Scopus citations

Design and synthesis of novel N-sulfonyl-2-indole carboxamides as potent PPAR-γ binding agents with potential application to the treatment of osteoporosis

Hopkins, C. R., O'Neil, S. V., Laufersweiler, M. C., Wang, Y., Pokross, M., Mekel, M., Evdokimov, A., Walter, R., Kontoyianni, M., Petrey, M. E., Sabatakos, G., Roesgen, J. T., Richardson, E. & Demuth, T. P., Nov 1 2006, In : Bioorganic and Medicinal Chemistry Letters. 16, 21, p. 5659-5663 5 p.

Research output: Contribution to journalArticle

37 Scopus citations

Development and Antiparkinsonian Activity of VU0418506, a Selective Positive Allosteric Modulator of Metabotropic Glutamate Receptor 4 Homomers without Activity at mGlu2/4 Heteromers

Niswender, C. M., Jones, C. K., Lin, X., Bubser, M., Thompson Gray, A., Blobaum, A. L., Engers, D. W., Rodriguez, A. L., Loch, M. T., Daniels, J. S., Lindsley, C. W., Hopkins, C. R., Javitch, J. A. & Conn, P. J., Sep 21 2016, In : ACS Chemical Neuroscience. 7, 9, p. 1201-1211 11 p.

Research output: Contribution to journalArticle

30 Scopus citations

Development of N-4,6-pyrimidine-N-alkyl-N′-phenyl ureas as orally active inhibitors of lymphocyte specific tyrosine kinase

Maier, J. A., Brugel, T. A., Sabat, M., Golebiowski, A., Laufersweiler, M. J., VanRens, J. C., Hopkins, C. R., De, B., Hsieh, L. C., Brown, K. K., Easwaran, V. & Janusz, M. J., Jul 15 2006, In : Bioorganic and Medicinal Chemistry Letters. 16, 14, p. 3646-3650 5 p.

Research output: Contribution to journalArticle

20 Scopus citations

Discovery, characterization, and effects on renal fluid and electrolyte excretion of the Kir4.1 potassium channel pore blocker, VU0134992

Kharade, S. V., Kurata, H., Bender, A. M., Blobaum, A. L., Figueroa, E. E., Duran, A., Kramer, M., Days, E., Vinson, P., Flores, D., Satlin, L. M., Meiler, J., Weaver, C. D., Lindsley, C. W., Hopkins, C. R. & Denton, J. S., Aug 2018, In : Molecular pharmacology. 94, 2, p. 926-937 12 p.

Research output: Contribution to journalArticle

9 Scopus citations

Discovery, characterization, and structure-activity relationships of an inhibitor of inward rectifier potassium (Kir) channels with preference for Kir2.3, Kir3.X, and Kir7.1

Raphemot, R., Lonergan, D. F., Nguyen, T. T., Utley, T., Michelle Lewis, L., Kadakia, R., David Weaver, C., Gogliotti, R., Hopkins, C., Lindsley, C. W. & Denton, J. S., 2011, In : Frontiers in Pharmacology. 2 NOV, Article 75.

Research output: Contribution to journalArticle

28 Scopus citations

Discovery, characterization and biological evaluation of a novel (R)-4,4-difluoropiperidine scaffold as dopamine receptor 4 (D4R) antagonists

Jeffries, D. E., Witt, J. O., McCollum, A. L., Temple, K. J., Hurtado, M. A., Harp, J. M., Blobaum, A. L., Lindsley, C. W. & Hopkins, C. R., 2016, In : Bioorganic and Medicinal Chemistry Letters. 26, 23, p. 5757-5764 8 p.

Research output: Contribution to journalArticle

2 Scopus citations

Discovery, Structure-Activity Relationship, and Biological Characterization of a Novel Series of 6-((1 H-Pyrazolo[4,3- b]pyridin-3-yl)amino)-benzo[ d]isothiazole-3-carboxamides as Positive Allosteric Modulators of the Metabotropic Glutamate Receptor 4 (mGlu 4 )

Bollinger, S. R., Engers, D. W., Panarese, J. D., West, M., Engers, J. L., Loch, M. T., Rodriguez, A. L., Blobaum, A. L., Jones, C. K., Thompson Gray, A., Conn, P. J., Lindsley, C. W., Niswender, C. M. & Hopkins, C. R., Oct 1 2019, In : Journal of Medicinal Chemistry. 62, 1, p. 342-358 17 p.

Research output: Contribution to journalArticle

6 Scopus citations

Discovery, Synthesis, and Preclinical Characterization of N-(3-Chloro-4-fluorophenyl)-1H-pyrazolo[4,3-b]pyridin-3-amine (VU0418506), a Novel Positive Allosteric Modulator of the Metabotropic Glutamate Receptor 4 (mGlu4)

Engers, D. W., Blobaum, A. L., Gogliotti, R. D., Cheung, Y. Y., Salovich, J. M., Garcia-Barrantes, P. M., Daniels, J. S., Morrison, R., Jones, C. K., Soars, M. G., Zhuo, X., Hurley, J., Macor, J. E., Bronson, J. J., Conn, P. J., Lindsley, C. W., Niswender, C. M. & Hopkins, C. R., Sep 21 2016, In : ACS Chemical Neuroscience. 7, 9, p. 1192-1200 9 p.

Research output: Contribution to journalArticle

23 Scopus citations

Discovery, synthesis, and structure-activity relationship development of a series of N-(4-acetamido)phenylpicolinamides as positive allosteric modulators of metabotropic glutamate receptor 4 (mGlu4) with CNS exposure in rats

Engers, D. W., Field, J. R., Le, U., Zhou, Y., Bolinger, J. D., Zamorano, R., Blobaum, A. L., Jones, C. K., Jadhav, S., Weaver, C. D., Conn, P. J., Lindsley, C. W., Niswender, C. M. & Hopkins, C. R., Feb 24 2011, In : Journal of Medicinal Chemistry. 54, 4, p. 1106-1110 5 p.

Research output: Contribution to journalArticle

33 Scopus citations

Discovery, synthesis, and structure-activity relationship development of a series of N -4-(2,5-dioxopyrrolidin-1-yl)phenylpicolinamides (VU0400195, ML182): Characterization of a novel positive allosteric modulator of the metabotropic glutamate receptor 4 (mGlu 4) with oral efficacy in an antiparkinsonian animal model

Jones, C. K., Engers, D. W., Thompson, A. D., Field, J. R., Blobaum, A. L., Lindsley, S. R., Zhou, Y., Gogliotti, R. D., Jadhav, S., Zamorano, R., Bogenpohl, J., Smith, Y., Morrison, R., Daniels, J. S., Weaver, C. D., Conn, P. J., Lindsley, C. W., Niswender, C. M. & Hopkins, C. R., Nov 10 2011, In : Journal of Medicinal Chemistry. 54, 21, p. 7639-7647 9 p.

Research output: Contribution to journalArticle

46 Scopus citations

Discovery, synthesis, and structure-activity relationship of a series of N -aryl-bicyclo[2.2.1]heptane-2-carboxamides: Characterization of ML213 as a novel KCNQ2 and KCNQ4 potassium channel opener

Yu, H., Wu, M., Townsend, S. D., Zou, B., Long, S., Daniels, J. S., McManus, O. B., Li, M., Lindsley, C. W. & Hopkins, C. R., Oct 19 2011, In : ACS Chemical Neuroscience. 2, 10, p. 572-577 6 p.

Research output: Contribution to journalArticle

37 Scopus citations

Discovery, synthesis and characterization of a series of (1-alkyl-3-methyl-1H-pyrazol-5-yl)-2-(5-aryl-2H-tetrazol-2-yl)acetamides as novel GIRK1/2 potassium channel activators

Sharma, S., Kozek, K. A., Abney, K. K., Kumar, S., Gautam, N., Alnouti, Y., David Weaver, C. & Hopkins, C. R., Mar 15 2019, In : Bioorganic and Medicinal Chemistry Letters. 29, 6, p. 791-796 6 p.

Research output: Contribution to journalArticle