• 3050 Citations
  • 31 h-Index
19992020

Research output per year

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Research Output

Short survey

ACS chemical neuroscience molecule spotlight on dimebon

Hopkins, C. R., Sep 15 2010, In : ACS Chemical Neuroscience. 1, 9, p. 587-588 2 p.

Research output: Contribution to journalShort survey

8 Scopus citations

ACS chemical neuroscience molecule spotlight on fanapt

Hopkins, C. R., Jun 16 2010, In : ACS Chemical Neuroscience. 1, 6, p. 410 1 p.

Research output: Contribution to journalShort survey

6 Scopus citations

ACS chemical neuroscience molecule spotlight on lorcaserin

Hopkins, C. R., Nov 17 2010, In : ACS Chemical Neuroscience. 1, 11, p. 718-719 2 p.

Research output: Contribution to journalShort survey

3 Scopus citations

ACS chemical neuroscience molecule spotlight on Sabril

Hopkins, C. R., Jul 21 2010, In : ACS Chemical Neuroscience. 1, 7, p. 475 1 p.

Research output: Contribution to journalShort survey

2 Scopus citations

ACS chemical neuroscience molecule spotlight on saredutant

Hopkins, C. R., Oct 20 2010, In : ACS Chemical Neuroscience. 1, 10, p. 653-654 2 p.

Research output: Contribution to journalShort survey

ACS chemical neuroscience molecule spotlight on savella

Hopkins, C. R., May 19 2010, In : ACS Chemical Neuroscience. 1, 5, p. 345 1 p.

Research output: Contribution to journalShort survey

ACS chemical neuroscience molecule spotlight on semagacestat (ly450139)

Hopkins, C. R., Aug 18 2010, In : ACS Chemical Neuroscience. 1, 8, p. 533-534 2 p.

Research output: Contribution to journalShort survey

7 Scopus citations
Review article

ACS chemical neuroscience molecule spotlight on begacestat (GSI-953)

Hopkins, C. R., Jan 18 2012, In : ACS Chemical Neuroscience. 3, 1, p. 3-4 2 p.

Research output: Contribution to journalReview article

25 Scopus citations

ACS chemical neuroscience molecule spotlight on BMS-708163

Hopkins, C. R., Mar 21 2012, In : ACS Chemical Neuroscience. 3, 3, p. 149-150 2 p.

Research output: Contribution to journalReview article

5 Scopus citations

ACS chemical neuroscience molecule spotlight on ELND006: Another γ-secretase inhibitor fails in the clinic

Hopkins, C. R., Jun 15 2011, In : ACS Chemical Neuroscience. 2, 6, p. 279-280 2 p.

Research output: Contribution to journalReview article

33 Scopus citations

ACS chemical neuroscience molecule spotlight on potiga (Ezogabine)

Hopkins, C. R., Aug 15 2012, In : ACS Chemical Neuroscience. 3, 8, p. 632 1 p.

Research output: Contribution to journalReview article

4 Scopus citations

ACS chemical neuroscience molecule spotlight on STX209 (Arbaclofen)

Hopkins, C. R., Aug 17 2011, In : ACS Chemical Neuroscience. 2, 8, p. 381 1 p.

Research output: Contribution to journalReview article

3 Scopus citations

ACS chemical neuroscience molecule spotlight on suvorexant

Hopkins, C. R., Sep 19 2012, In : ACS Chemical Neuroscience. 3, 9, p. 647-648 2 p.

Research output: Contribution to journalReview article

10 Scopus citations

ACS chemical neuroscience molecule spotlight on telcagepant (MK-0974)

Hopkins, C. R., Jul 20 2011, In : ACS Chemical Neuroscience. 2, 7, p. 334-335 2 p.

Research output: Contribution to journalReview article

2 Scopus citations

Advancing biological understanding and therapeutics discovery with small-molecule probes

Schreiber, S. L., Kotz, J. D., Li, M., Aubé, J., Austin, C. P., Reed, J. C., Rosen, H., White, E. L., Sklar, L. A., Lindsley, C. W., Alexander, B. R., Bittker, J. A., Clemons, P. A., De Souza, A., Foley, M. A., Palmer, M., Shamji, A. F., Wawer, M. J., McManus, O., Wu, M. & 26 others, Zou, B., Yu, H., Golden, J. E., Schoenen, F. J., Simeonov, A., Jadhav, A., Jackson, M. R., Pinkerton, A. B., Chung, T. D. Y., Griffin, P. R., Cravatt, B. F., Hodder, P. S., Roush, W. R., Roberts, E., Chung, D. H., Jonsson, C. B., Noah, J. W., Severson, W. E., Ananthan, S., Edwards, B., Oprea, T. I., Conn, P. J., Hopkins, C. R., Wood, M. R., Stauffer, S. R. & Emmitte, K. A., 2015, In : Cell. 161, 6, p. 1252-1265 14 p.

Research output: Contribution to journalReview article

79 Scopus citations

Allosteric modulation of seven transmembrane spanning receptors: Theory, practice, and opportunities for central nervous system drug discovery

Melancon, B. J., Hopkins, C. R., Wood, M. R., Emmitte, K. A., Niswender, C. M., Christopoulos, A., Conn, P. J. & Lindsley, C. W., Feb 23 2012, In : Journal of Medicinal Chemistry. 55, 4, p. 1445-1464 20 p.

Research output: Contribution to journalReview article

168 Scopus citations

Inhibitors of the bone morphogenetic protein (BMP) signaling pathway: a patent review (2008-2015)

Hopkins, C. R., Oct 2 2016, In : Expert Opinion on Therapeutic Patents. 26, 10, p. 1115-1128 14 p.

Research output: Contribution to journalReview article

11 Scopus citations
27 Scopus citations

MGluR4-positive allosteric modulation as potential treatment for Parkinson's disease

Hopkins, C. R., Lindsley, C. W. & Niswender, C. M., Jun 2009, In : Future Medicinal Chemistry. 1, 3, p. 501-513 13 p.

Research output: Contribution to journalReview article

52 Scopus citations

Molecule of the month

Hopkins, C. R., 2008, In : Current Topics in Medicinal Chemistry. 8, 18, p. 1710-1711 2 p.

Research output: Contribution to journalReview article

Practical Strategies and Concepts in GPCR Allosteric Modulator Discovery: Recent Advances with Metabotropic Glutamate Receptors

Lindsley, C. W., Emmitte, K. A., Hopkins, C. R., Bridges, T. M., Gregory, K. J., Niswender, C. M. & Conn, P. J., Jun 8 2016, In : Chemical Reviews. 116, 11, p. 6707-6741 35 p.

Research output: Contribution to journalReview article

95 Scopus citations

Recent progress in the development of mGluR4 positive allosteric modulators for the treatment of Parkinson's disease

Lindsley, C. W., Niswender, C. M., Engers, D. W. & Hopkins, C. R., 2009, In : Current Topics in Medicinal Chemistry. 9, 10, p. 949-963 15 p.

Research output: Contribution to journalReview article

35 Scopus citations

Recent progress on the identification of metabotropic glutamate 4 receptor ligands and their potential utility as CNS therapeutics

Robichaud, A. J., Engers, D. W., Lindsley, C. W. & Hopkins, C. R., Aug 17 2011, In : ACS Chemical Neuroscience. 2, 8, p. 433-449 17 p.

Research output: Contribution to journalReview article

31 Scopus citations

Return of D4 Dopamine Receptor Antagonists in Drug Discovery

Lindsley, C. W. & Hopkins, C. R., 2017, In : Journal of Medicinal Chemistry. 60, 17, p. 7233-7243 11 p.

Research output: Contribution to journalReview article

17 Scopus citations

Review of Transient Receptor Potential Canonical (TRPC5) Channel Modulators and Diseases

Sharma, S. & Hopkins, C. R., Sep 12 2019, In : Journal of Medicinal Chemistry. 62, 17, p. 7589-7602 14 p.

Research output: Contribution to journalReview article

3 Scopus citations

Selective α7 nicotinic receptor agonists and positive allosteric modulators for the treatment of schizophrenia–a review

Antonio-Tolentino, K. & Hopkins, C. R., Jun 2 2020, In : Expert Opinion on Investigational Drugs. 29, 6, p. 603-610 8 p.

Research output: Contribution to journalReview article

The antipsychotic potential of muscarinic allosteric modulation

Bridges, T. M., LeBois, E. P., Hopkins, C. R., Wood, M. R., Jones, C. K., Conn, P. J. & Lindsley, C. W., May 2010, In : Drug News and Perspectives. 23, 4, p. 229-240 12 p.

Research output: Contribution to journalReview article

48 Scopus citations
Comment/debate

ACS chemical neuroscience molecule spotlight on Latuda (lurasidone; SM-13,496)

Hopkins, C. R., Feb 16 2011, In : ACS Chemical Neuroscience. 2, 2, p. 58-59 2 p.

Research output: Contribution to journalComment/debate

6 Scopus citations

Correction to: Analgesic effects of the GIRK activator, VU0466551, Alone and in combination with morphine in acute and persistent pain models (ACS Chemical Neuroscience (2019) 10:3 (1294-1299) DOI: 10.1021/acschemneuro.8b00370)

Abney, K. K., Bubser, M., Du, Y., Kozek, K. A., Bridges, T. M., Lindsley, C. W., Daniels, J. S., Morrison, R. D., Wickman, K., Hopkins, C. R., Jones, C. K. & Weaver, C. D., May 15 2019, In : ACS Chemical Neuroscience. 10, 5, p. 2621 1 p.

Research output: Contribution to journalComment/debate

Open Access

Efficient synthesis of 1,4-dihydro-2H-isoquinoline-3,5,8-triones via cyclobutene ring expansion

Wipf, P. & Hopkins, C. R., Sep 3 1999, In : Journal of Organic Chemistry. 64, 18, p. 6881-6887 7 p.

Research output: Contribution to journalComment/debate

31 Scopus citations
Chapter

Biomimetic Synthesis of Lignans

Lindsley, C. W., Hopkins, C. R. & Sulikowski, G. A., Apr 21 2011, Biomimetic Organic Synthesis. Wiley-VCH, Vol. 2. p. 677-693 17 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

CHAPTER 8: Muscarinic Receptors Allosteric Modulation

Melancon, B. J. & Hopkins, C. R., 2017, Allosterism in Drug Discovery. Doller, D. (ed.). 56 ed. Royal Society of Chemistry, p. 175-193 19 p. (RSC Drug Discovery Series; vol. 2017-January, no. 56).

Research output: Chapter in Book/Report/Conference proceedingChapter

Article
30 Scopus citations

ACS chemical neuroscience molecule spotlight on gilenya (fingolimod; FTY720)

Hopkins, C. R., Mar 16 2011, In : ACS Chemical Neuroscience. 2, 3, p. 116-117 2 p.

Research output: Contribution to journalArticle

3 Scopus citations

ACS chemical neuroscience molecule spotlight on RG1678

Hopkins, C. R., Dec 21 2011, In : ACS Chemical Neuroscience. 2, 12, p. 685-686 2 p.

Research output: Contribution to journalArticle

11 Scopus citations

ACS chemical neuroscience molecule spotlight on saphris

Hopkins, C. R., Apr 21 2010, In : ACS Chemical Neuroscience. 1, 4, p. 263-264 2 p.

Research output: Contribution to journalArticle

ACS chemical neuroscience molecule spotlight on valdoxen

Hopkins, C. R., Dec 15 2010, In : ACS Chemical Neuroscience. 1, 12, p. 772-773 2 p.

Research output: Contribution to journalArticle

1 Scopus citations

ACS chemical neuroscience molecule spotlight on Viibryd (vilazodone)

Hopkins, C. R., Oct 19 2011, In : ACS Chemical Neuroscience. 2, 10, p. 554 1 p.

Research output: Contribution to journalArticle

9 Scopus citations

Activation of metabotropic glutamate receptor 7 is required for induction of long-term potentiation at SCCA1 synapses in the hippocampus

Klar, R., Walker, A. G., Ghose, D., Grueter, B. A., Engers, D. W., Hopkins, C. R., Lindsley, C. W., Xiang, Z., Conn, P. J. & Niswender, C. M., May 13 2015, In : Journal of Neuroscience. 35, 19, p. 7600-7615 16 p.

Research output: Contribution to journalArticle

21 Scopus citations

Analgesic Effects of the GIRK Activator, VU0466551, Alone and in Combination with Morphine in Acute and Persistent Pain Models

Abney, K. K., Bubser, M., Du, Y., Kozek, K. A., Bridges, T. M., Linsdley, C. W., Daniels, J. S., Morrison, R. D., Wickman, K., Hopkins, C. R., Jones, C. K. & Weaver, C. D., Mar 20 2019, In : ACS Chemical Neuroscience. 10, 3, p. 1294-1299 6 p.

Research output: Contribution to journalArticle

2 Scopus citations
25 Scopus citations

An insecticide resistance-breaking mosquitocide targeting inward rectifier potassium channels in vectors of Zika virus and malaria

Swale, D. R., Engers, D. W., Bollinger, S. R., Gross, A., Inocente, E. A., Days, E., Kanga, F., Johnson, R. M., Yang, L., Bloomquist, J. R., Hopkins, C. R., Piermarini, P. M. & Denton, J. S., Nov 16 2016, In : Scientific reports. 6, 36954.

Research output: Contribution to journalArticle

31 Scopus citations

Application of small organic molecules reveals cooperative TGFβ and BMP regulation of mesothelial cell behaviors

Cross, E. E., Thomason, R. T., Martinez, M., Hopkins, C. R., Hong, C. C. & Bader, D. M., Sep 2 2011, In : ACS chemical biology. 6, 9, p. 952-961 10 p.

Research output: Contribution to journalArticle

15 Scopus citations

A small-molecule inhibitor of TRPC5 ion channels suppresses progressive kidney disease in animal models

Zhou, Y., Castonguay, P., Sidhom, E. H., Clark, A. R., Dvela-Levitt, M., Kim, S., Sieber, J., Wieder, N., Jung, J. Y., Andreeva, S., Reichardt, J., Dubois, F., Hoffmann, S. C., Basgen, J. M., Montesinos, M. S., Weins, A., Johnson, A. C., Lander, E. S., Garrett, M. R., Hopkins, C. R. & 1 others, Greka, A., Dec 8 2017, In : Science. 358, 6368, p. 1332-1336 5 p.

Research output: Contribution to journalArticle

44 Scopus citations

Bone morphogenetic protein signaling promotes tumorigenesis in a murine model of high-grade glioma

Hover, L. D., Owens, P., Munden, A. L., Wang, J., Chambless, L. B., Hopkins, C. R., Hong, C. C., Moses, H. L. & Abel, T. W., Jul 1 2016, In : Neuro-Oncology. 18, 7, p. 928-938 11 p.

Research output: Contribution to journalArticle

14 Scopus citations

Chemical lead optimization of a pan Gq mAChR M1, M3, M5 positive allosteric modulator (PAM) lead. Part I: Development of the first highly selective M5 PAM

Bridges, T. M., Kennedy, J. P., Cho, H. P., Breininger, M. L., Gentry, P. R., Hopkins, C. R., Conn, P. J. & Lindsley, C. W., Jan 15 2010, In : Bioorganic and Medicinal Chemistry Letters. 20, 2, p. 558-562 5 p.

Research output: Contribution to journalArticle

35 Scopus citations

Chemical modulation of mutant mGlu1 receptors derived from deleterious GRM1 mutations found in schizophrenics

Cho, H. P., Garcia-Barrantes, P. M., Brogan, J. T., Hopkins, C. R., Niswender, C. M., Rodriguez, A. L., Venable, D. F., Morrison, R. D., Bubser, M., Daniels, J. S., Jones, C. K., Conn, P. J. & Lindsley, C. W., Oct 17 2014, In : ACS chemical biology. 9, 10, p. 2334-2346 13 p.

Research output: Contribution to journalArticle

30 Scopus citations

Convenient synthesis of 4-amino-3,5-disubstituted pyrazoles in one step from the corresponding diketo oximes

Majid, T., Hopkins, C. R., Pedgrift, B. & Collar, N., Mar 1 2004, In : Tetrahedron Letters. 45, 10, p. 2137-2139 3 p.

Research output: Contribution to journalArticle

23 Scopus citations

Design, synthesis, and biological activity of potent and selective inhibitors of mast cell tryptase

Hopkins, C. R., Czekaj, M., Kaye, S. S., Gao, Z., Pribish, J., Pauls, H., Liang, G., Sides, K., Cramer, D., Cairns, J., Luo, Y., Lim, H. K., Vaz, R., Rebello, S., Maignan, S., Dupuy, A., Mathieu, M. & Levell, J., Jun 2 2005, In : Bioorganic and Medicinal Chemistry Letters. 15, 11, p. 2734-2737 4 p.

Research output: Contribution to journalArticle

29 Scopus citations