• 3017 Citations
  • 31 h-Index
19992020

Research output per year

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Research Output

2013

Dynamic subunit stoichiometry confers a progressive continuum of pharmacological sensitivity by KCNQ potassium channels

Yu, H., Lin, Z., Mattmann, M. E., Zou, B., Terrenoire, C., Zhang, H., Wu, M., McManus, O. B., Kass, R. S., Lindsley, C. W., Hopkins, C. R. & Li, M., May 21 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 21, p. 8732-8737 6 p.

Research output: Contribution to journalArticle

38 Scopus citations

Eliciting Renal Failure in Mosquitoes with a Small-Molecule Inhibitor of Inward-Rectifying Potassium Channels

Raphemot, R., Rouhier, M. F., Hopkins, C. R., Gogliotti, R. D., Lovell, K. M., Hine, R. M., Ghosalkar, D., Longo, A., Beyenbach, K. W., Denton, J. S. & Piermarini, P. M., May 29 2013, In : PloS one. 8, 5, e64905.

Research output: Contribution to journalArticle

41 Scopus citations

Further exploration of M1 allosteric agonists: Subtle structural changes abolish M1 allosteric agonism and result in pan-mAChR orthosteric antagonism

Sheffler, D. J., Sevel, C., Le, U., Lovell, K. M., Tarr, J. C., Carrington, S. J. S., Cho, H. P., Digby, G. J., Niswender, C. M., Conn, P. J., Hopkins, C. R., Wood, M. R. & Lindsley, C. W., Jan 1 2013, In : Bioorganic and Medicinal Chemistry Letters. 23, 1, p. 223-227 5 p.

Research output: Contribution to journalArticle

10 Scopus citations

Inhibition of the TRPC5 ion channel protects the kidney filter

Schaldecker, T., Kim, S., Tarabanis, C., Tian, D., Hakroush, S., Castonguay, P., Ahn, W., Wallentin, H., Heid, H., Hopkins, C. R., Lindsley, C. W., Riccio, A., Buvall, L., Weins, A. & Greka, A., Dec 2 2013, In : Journal of Clinical Investigation. 123, 12, p. 5298-5309 12 p.

Research output: Contribution to journalArticle

94 Scopus citations

Is there a path forward for mGlu2 positive allosteric modulators for the treatment of schizophrenia?

Hopkins, C. R., Feb 20 2013, In : ACS Chemical Neuroscience. 4, 2, p. 211-213 3 p.

Research output: Contribution to journalArticle

27 Scopus citations

Reversible inhibitors of regulators of G-protein signaling identified in a high-throughput cell-based calcium signaling assay

Storaska, A. J., Mei, J. P., Wu, M., Li, M., Wade, S. M., Blazer, L. L., Sjögren, B., Hopkins, C. R., Lindsley, C. W., Lin, Z., Babcock, J. J., McManus, O. B. & Neubig, R. R., Dec 2013, In : Cellular Signalling. 25, 12, p. 2848-2855 8 p.

Research output: Contribution to journalArticle

17 Scopus citations
46 Scopus citations
2012

ACS chemical neuroscience molecule spotlight on begacestat (GSI-953)

Hopkins, C. R., Jan 18 2012, In : ACS Chemical Neuroscience. 3, 1, p. 3-4 2 p.

Research output: Contribution to journalReview article

25 Scopus citations

ACS chemical neuroscience molecule spotlight on BMS-708163

Hopkins, C. R., Mar 21 2012, In : ACS Chemical Neuroscience. 3, 3, p. 149-150 2 p.

Research output: Contribution to journalReview article

5 Scopus citations

ACS chemical neuroscience molecule spotlight on potiga (Ezogabine)

Hopkins, C. R., Aug 15 2012, In : ACS Chemical Neuroscience. 3, 8, 1 p.

Research output: Contribution to journalReview article

4 Scopus citations

ACS chemical neuroscience molecule spotlight on suvorexant

Hopkins, C. R., Sep 19 2012, In : ACS Chemical Neuroscience. 3, 9, p. 647-648 2 p.

Research output: Contribution to journalReview article

10 Scopus citations

Allosteric modulation of seven transmembrane spanning receptors: Theory, practice, and opportunities for central nervous system drug discovery

Melancon, B. J., Hopkins, C. R., Wood, M. R., Emmitte, K. A., Niswender, C. M., Christopoulos, A., Conn, P. J. & Lindsley, C. W., Feb 23 2012, In : Journal of Medicinal Chemistry. 55, 4, p. 1445-1464 20 p.

Research output: Contribution to journalReview article

168 Scopus citations
15 Scopus citations

Discovery of N-(4-methoxy-7-methylbenzo[d]thiazol-2-yl)isonicatinamide, ML293, as a novel, selective and brain penetrant positive allosteric modulator of the muscarinic 4 (M4) receptor

Salovich, J. M., Vinson, P. N., Sheffler, D. J., Lamsal, A., Utley, T. J., Blobaum, A. L., Bridges, T. M., Le, U., Jones, C. K., Wood, M. R., Scott Daniels, J., Jeffrey Conn, P., Niswender, C. M., Lindsley, C. W. & Hopkins, C. R., Aug 1 2012, In : Bioorganic and Medicinal Chemistry Letters. 22, 15, p. 5084-5088 5 p.

Research output: Contribution to journalArticle

29 Scopus citations

DMH1, a highly selective small molecule BMP inhibitor promotes neurogenesis of hiPSCs: Comparison of PAX6 and SOX1 expression during neural induction

Neely, M. D., Litt, M. J., Tidball, A. M., Li, G. G., Aboud, A. A., Hopkins, C. R., Chamberlin, R., Hong, C. C., Ess, K. C. & Bowman, A. B., Jun 20 2012, In : ACS Chemical Neuroscience. 3, 6, p. 482-491 10 p.

Research output: Contribution to journalArticle

57 Scopus citations

DMH1, a novel BMP small molecule inhibitor, increases cardiomyocyte progenitors and promotes cardiac differentiation in mouse embryonic stem cells

Ao, A., Hao, J., Hopkins, C. R. & Hong, C. C., Jul 27 2012, In : PloS one. 7, 7, e41627.

Research output: Contribution to journalArticle

35 Scopus citations

Identification and characterization of a compound that protects cardiac tissue from human Ether-à-go-go-related gene (hERG)-related drug-induced arrhythmias

Potet, F., Lorinc, A. N., Chaigne, S., Hopkins, C. R., Venkataraman, R., Stepanovic, S. Z., Lewis, L. M., Days, E., Sidorov, V. Y., Engers, D. W., Zou, B., Afshartous, D., George, A. L., Campbell, C. M., Balser, J. R., Li, M., Baudenbacher, F. J., Lindsley, C. W., Weaver, C. D. & Kupershmidt, S., Nov 16 2012, In : Journal of Biological Chemistry. 287, 47, p. 39613-39625 13 p.

Research output: Contribution to journalArticle

11 Scopus citations

Identification of (R)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-1- tosylpiperidine-2-carboxamide, ML277, as a novel, potent and selective K v7.1 (KCNQ1) potassium channel activator

Mattmann, M. E., Yu, H., Lin, Z., Xu, K., Huang, X., Long, S., Wu, M., McManus, O. B., Engers, D. W., Le, U. M., Li, M., Lindsley, C. W. & Hopkins, C. R., Sep 15 2012, In : Bioorganic and Medicinal Chemistry Letters. 22, 18, p. 5936-5941 6 p.

Research output: Contribution to journalArticle

28 Scopus citations

Iterative experimental and virtual high-throughput screening identifies metabotropic glutamate receptor subtype 4 positive allosteric modulators

Mueller, R., Dawson, E. S., Niswender, C. M., Butkiewicz, M., Hopkins, C. R., Weaver, C. D., Lindsley, C. W., Conn, P. J. & Meiler, J., Sep 2012, In : Journal of Molecular Modeling. 18, 9, p. 4437-4446 10 p.

Research output: Contribution to journalArticle

9 Scopus citations
27 Scopus citations

The metabotropic glutamate receptor 4-positive allosteric modulator VU0364770 produces efficacy alone and in combination with L-DOPA or an adenosine 2A antagonist in preclinical rodent models of Parkinson's disease

Jones, C. K., Bubser, M., Thompson, A. D., Dickerson, J. W., Turle-Lorenzo, N., Amalric, M., Blobaum, A. L., Bridges, T. M., Morrison, R. D., Jadhav, S., Engers, D. W., Italiano, K., Bode, J., Daniels, J. S., Lindsley, C. W., Hopkins, C. R., Conn, P. J. & Niswender, C. M., Feb 2012, In : Journal of Pharmacology and Experimental Therapeutics. 340, 2, p. 404-421 18 p.

Research output: Contribution to journalArticle

71 Scopus citations
2011

ACS chemical neuroscience molecule spotlight on ELND006: Another γ-secretase inhibitor fails in the clinic

Hopkins, C. R., Jun 15 2011, In : ACS Chemical Neuroscience. 2, 6, p. 279-280 2 p.

Research output: Contribution to journalReview article

33 Scopus citations

ACS chemical neuroscience molecule spotlight on gilenya (fingolimod; FTY720)

Hopkins, C. R., Mar 16 2011, In : ACS Chemical Neuroscience. 2, 3, p. 116-117 2 p.

Research output: Contribution to journalArticle

3 Scopus citations

ACS chemical neuroscience molecule spotlight on Latuda (lurasidone; SM-13,496)

Hopkins, C. R., Feb 16 2011, In : ACS Chemical Neuroscience. 2, 2, p. 58-59 2 p.

Research output: Contribution to journalComment/debate

6 Scopus citations

ACS chemical neuroscience molecule spotlight on RG1678

Hopkins, C. R., Dec 21 2011, In : ACS Chemical Neuroscience. 2, 12, p. 685-686 2 p.

Research output: Contribution to journalArticle

11 Scopus citations

ACS chemical neuroscience molecule spotlight on STX209 (Arbaclofen)

Hopkins, C. R., Aug 17 2011, In : ACS Chemical Neuroscience. 2, 8, 1 p.

Research output: Contribution to journalReview article

3 Scopus citations

ACS chemical neuroscience molecule spotlight on telcagepant (MK-0974)

Hopkins, C. R., Jul 20 2011, In : ACS Chemical Neuroscience. 2, 7, p. 334-335 2 p.

Research output: Contribution to journalReview article

2 Scopus citations

ACS chemical neuroscience molecule spotlight on Viibryd (vilazodone)

Hopkins, C. R., Oct 19 2011, In : ACS Chemical Neuroscience. 2, 10, 1 p.

Research output: Contribution to journalArticle

9 Scopus citations

Application of small organic molecules reveals cooperative TGFβ and BMP regulation of mesothelial cell behaviors

Cross, E. E., Thomason, R. T., Martinez, M., Hopkins, C. R., Hong, C. C. & Bader, D. M., Sep 2 2011, In : ACS chemical biology. 6, 9, p. 952-961 10 p.

Research output: Contribution to journalArticle

15 Scopus citations

Biomimetic Synthesis of Lignans

Lindsley, C. W., Hopkins, C. R. & Sulikowski, G. A., Apr 21 2011, Biomimetic Organic Synthesis. Wiley-VCH, Vol. 2. p. 677-693 17 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Discovery, characterization, and structure-activity relationships of an inhibitor of inward rectifier potassium (Kir) channels with preference for Kir2.3, Kir3.X, and Kir7.1

Raphemot, R., Lonergan, D. F., Nguyen, T. T., Utley, T., Michelle Lewis, L., Kadakia, R., David Weaver, C., Gogliotti, R., Hopkins, C., Lindsley, C. W. & Denton, J. S., 2011, In : Frontiers in Pharmacology. 2 NOV, Article 75.

Research output: Contribution to journalArticle

28 Scopus citations

Discovery, synthesis, and structure-activity relationship development of a series of N-(4-acetamido)phenylpicolinamides as positive allosteric modulators of metabotropic glutamate receptor 4 (mGlu4) with CNS exposure in rats

Engers, D. W., Field, J. R., Le, U., Zhou, Y., Bolinger, J. D., Zamorano, R., Blobaum, A. L., Jones, C. K., Jadhav, S., Weaver, C. D., Conn, P. J., Lindsley, C. W., Niswender, C. M. & Hopkins, C. R., Feb 24 2011, In : Journal of Medicinal Chemistry. 54, 4, p. 1106-1110 5 p.

Research output: Contribution to journalArticle

33 Scopus citations

Discovery, synthesis, and structure-activity relationship development of a series of N -4-(2,5-dioxopyrrolidin-1-yl)phenylpicolinamides (VU0400195, ML182): Characterization of a novel positive allosteric modulator of the metabotropic glutamate receptor 4 (mGlu 4) with oral efficacy in an antiparkinsonian animal model

Jones, C. K., Engers, D. W., Thompson, A. D., Field, J. R., Blobaum, A. L., Lindsley, S. R., Zhou, Y., Gogliotti, R. D., Jadhav, S., Zamorano, R., Bogenpohl, J., Smith, Y., Morrison, R., Daniels, J. S., Weaver, C. D., Conn, P. J., Lindsley, C. W., Niswender, C. M. & Hopkins, C. R., Nov 10 2011, In : Journal of Medicinal Chemistry. 54, 21, p. 7639-7647 9 p.

Research output: Contribution to journalArticle

46 Scopus citations

Discovery, synthesis, and structure-activity relationship of a series of N -aryl-bicyclo[2.2.1]heptane-2-carboxamides: Characterization of ML213 as a novel KCNQ2 and KCNQ4 potassium channel opener

Yu, H., Wu, M., Townsend, S. D., Zou, B., Long, S., Daniels, J. S., McManus, O. B., Li, M., Lindsley, C. W. & Hopkins, C. R., Oct 19 2011, In : ACS Chemical Neuroscience. 2, 10, p. 572-577 6 p.

Research output: Contribution to journalArticle

37 Scopus citations

Identification of ML204, a novel potent antagonist that selectively modulates native TRPC4/C5 ion channels

Miller, M., Shi, J., Zhu, Y., Kustov, M., Tian, J. B., Stevens, A., Wu, M., Xu, J., Long, S., Yang, P., Zholos V, A., Salovich, J. M., Weaver, C. D., Hopkins, C. R., Lindsley, C. W., McManus, O., Li, M. & Zhu, M. X., Sep 23 2011, In : Journal of Biological Chemistry. 286, 38, p. 33436-33446 11 p.

Research output: Contribution to journalArticle

114 Scopus citations

"Molecular switches" on mGluR allosteric ligands that modulate modes of pharmacology

Wood, M. R., Hopkins, C. R., Brogan, J. T., Conn, P. J. & Lindsley, C. W., Apr 5 2011, In : Biochemistry. 50, 13, p. 2403-2410 8 p.

Research output: Contribution to journalArticle

124 Scopus citations

Recent progress on the identification of metabotropic glutamate 4 receptor ligands and their potential utility as CNS therapeutics

Robichaud, A. J., Engers, D. W., Lindsley, C. W. & Hopkins, C. R., Aug 17 2011, In : ACS Chemical Neuroscience. 2, 8, p. 433-449 17 p.

Research output: Contribution to journalReview article

31 Scopus citations

Selective inhibition of the K ir2 family of inward rectifier potassium channels by a small molecule probe: The discovery, SAR, and pharmacological characterization of ML133

Wang, H. R., Wu, M., Yu, H., Long, S., Stevens, A., Engers, D. W., Sackin, H., Daniels, J. S., Dawson, E. S., Hopkins, C. R., Lindsley, C. W., Li, M. & McManus, O. B., Aug 19 2011, In : ACS chemical biology. 6, 8, p. 845-856 12 p.

Research output: Contribution to journalArticle

48 Scopus citations

Solution-phase parallel synthesis and SAR of homopiperazinyl analogs as positive allosteric modulators of mGlu4

Cheung, Y. Y., Zamorano, R., Blobaum, A. L., Weaver, C. D., Conn, P. J., Lindsley, C. W., Niswender, C. M. & Hopkins, C. R., Mar 14 2011, In : ACS Combinatorial Science. 13, 2, p. 159-165 7 p.

Research output: Contribution to journalArticle

4 Scopus citations

Synthesis and SAR of a novel metabotropic glutamate receptor 4 (mGlu 4) antagonist: Unexpected 'molecular switch' from a closely related mGlu 4 positive allosteric modulator

Utley, T., Haddenham, D., Salovich, J. M., Zamorano, R., Vinson, P. N., Lindsley, C. W., Hopkins, C. R. & Niswender, C. M., Dec 1 2011, In : Bioorganic and Medicinal Chemistry Letters. 21, 23, p. 6955-6959 5 p.

Research output: Contribution to journalArticle

15 Scopus citations

The discovery and characterization of ML218: A novel, centrally active T-Type calcium channel inhibitor with robust effects in STN neurons and in a rodent model of Parkinson's disease

Xiang, Z., Thompson, A. D., Brogan, J. T., Schulte, M. L., Melancon, B. J., Mi, D., Lewis, L. M., Zou, B., Yang, L., Morrison, R., Santomango, T., Byers, F., Brewer, K., Aldrich, J. S., Yu, H., Dawson, E. S., Li, M., McManus, O., Jones, C. K., Daniels, J. S. & 5 others, Hopkins, C. R., Xie, X. S., Conn, P. J., Weaver, C. D. & Lindsley, C. W., Dec 21 2011, In : ACS Chemical Neuroscience. 2, 12, p. 730-742 13 p.

Research output: Contribution to journalArticle

47 Scopus citations
2010

ACS chemical neuroscience molecule spotlight on dimebon

Hopkins, C. R., Sep 15 2010, In : ACS Chemical Neuroscience. 1, 9, p. 587-588 2 p.

Research output: Contribution to journalShort survey

8 Scopus citations

ACS chemical neuroscience molecule spotlight on fanapt

Hopkins, C. R., Jun 16 2010, In : ACS Chemical Neuroscience. 1, 6, 1 p.

Research output: Contribution to journalShort survey

6 Scopus citations

ACS chemical neuroscience molecule spotlight on lorcaserin

Hopkins, C. R., Nov 17 2010, In : ACS Chemical Neuroscience. 1, 11, p. 718-719 2 p.

Research output: Contribution to journalShort survey

3 Scopus citations

ACS chemical neuroscience molecule spotlight on Sabril

Hopkins, C. R., Jul 21 2010, In : ACS Chemical Neuroscience. 1, 7, 1 p.

Research output: Contribution to journalShort survey

2 Scopus citations

ACS chemical neuroscience molecule spotlight on saphris

Hopkins, C. R., Apr 21 2010, In : ACS Chemical Neuroscience. 1, 4, p. 263-264 2 p.

Research output: Contribution to journalArticle

ACS chemical neuroscience molecule spotlight on saredutant

Hopkins, C. R., Oct 20 2010, In : ACS Chemical Neuroscience. 1, 10, p. 653-654 2 p.

Research output: Contribution to journalShort survey

ACS chemical neuroscience molecule spotlight on savella

Hopkins, C. R., May 19 2010, In : ACS Chemical Neuroscience. 1, 5, 1 p.

Research output: Contribution to journalShort survey

ACS chemical neuroscience molecule spotlight on semagacestat (ly450139)

Hopkins, C. R., Aug 18 2010, In : ACS Chemical Neuroscience. 1, 8, p. 533-534 2 p.

Research output: Contribution to journalShort survey

7 Scopus citations

ACS chemical neuroscience molecule spotlight on valdoxen

Hopkins, C. R., Dec 15 2010, In : ACS Chemical Neuroscience. 1, 12, p. 772-773 2 p.

Research output: Contribution to journalArticle

1 Scopus citations