• 3017 Citations
  • 31 h-Index
19992020

Research output per year

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Research Output

2010

Chemical lead optimization of a pan Gq mAChR M1, M3, M5 positive allosteric modulator (PAM) lead. Part I: Development of the first highly selective M5 PAM

Bridges, T. M., Kennedy, J. P., Cho, H. P., Breininger, M. L., Gentry, P. R., Hopkins, C. R., Conn, P. J. & Lindsley, C. W., Jan 15 2010, In : Bioorganic and Medicinal Chemistry Letters. 20, 2, p. 558-562 5 p.

Research output: Contribution to journalArticle

35 Scopus citations

Heterobiaryl and heterobiaryl ether derived M5 positive allosteric modulators

Bridges, T. M., Kennedy, J. P., Hopkins, C. R., Conn, P. J. & Lindsley, C. W., Oct 1 2010, In : Bioorganic and Medicinal Chemistry Letters. 20, 19, p. 5617-5622 6 p.

Research output: Contribution to journalArticle

22 Scopus citations

In vivo structure - Activity relationship study of dorsomorphin analogues identifies selective VEGF and BMP inhibitors

Hao, J., Ho, J. N., Lewis, J. A., Karim, K. A., Daniels, R. N., Gentry, P. R., Hopkins, C. R., Lindsley, C. W. & Hong, C. C., Feb 19 2010, In : ACS chemical biology. 5, 2, p. 245-253 9 p.

Research output: Contribution to journalArticle

239 Scopus citations

Re-exploration of the PHCCC scaffold: Discovery of improved positive allosteric modulators of mGluR4

Williams, R., Zhou, Y., Niswender, C. M., Luo, Q., Conn, P. J., Lindsley, C. W. & Hopkins, C. R., Jun 16 2010, In : ACS Chemical Neuroscience. 1, 6, p. 411-419 9 p.

Research output: Contribution to journalArticle

40 Scopus citations

Synthesis and SAR of novel, 4-(phenylsulfamoyl)phenylacetamide mGlu 4 positive allosteric modulators (PAMs) identified by functional high-throughput screening (HTS)

Engers, D. W., Gentry, P. R., Williams, R., Bolinger, J. D., Weaver, C. D., Menon, U. N., Conn, P. J., Lindsley, C. W., Niswender, C. M. & Hopkins, C. R., Sep 1 2010, In : Bioorganic and Medicinal Chemistry Letters. 20, 17, p. 5175-5178 4 p.

Research output: Contribution to journalArticle

20 Scopus citations

Synthesis of 1,3-diarylsubstituted indazoles utilizing a Suzuki cross-coupling/deprotection/N-arylation sequence

Salovich, J. M., Lindsley, C. W. & Hopkins, C. R., Jul 21 2010, In : Tetrahedron Letters. 51, 29, p. 3796-3799 4 p.

Research output: Contribution to journalArticle

18 Scopus citations

The antipsychotic potential of muscarinic allosteric modulation

Bridges, T. M., LeBois, E. P., Hopkins, C. R., Wood, M. R., Jones, C. K., Conn, P. J. & Lindsley, C. W., May 2010, In : Drug News and Perspectives. 23, 4, p. 229-240 12 p.

Research output: Contribution to journalReview article

48 Scopus citations
2009

MGluR4-positive allosteric modulation as potential treatment for Parkinson's disease

Hopkins, C. R., Lindsley, C. W. & Niswender, C. M., Jun 2009, In : Future Medicinal Chemistry. 1, 3, p. 501-513 13 p.

Research output: Contribution to journalReview article

52 Scopus citations

Recent progress in the development of mGluR4 positive allosteric modulators for the treatment of Parkinson's disease

Lindsley, C. W., Niswender, C. M., Engers, D. W. & Hopkins, C. R., 2009, In : Current Topics in Medicinal Chemistry. 9, 10, p. 949-963 15 p.

Research output: Contribution to journalReview article

35 Scopus citations

Synthesis and evaluation of a series of heterobiarylamides that are centrally penetrant metabotropic glutamate receptor 4 (mGluR4) positive allosteric modulators (PAMs)

Engers, D. W., Niswender, C. M., Weaver, C. D., Jadhav, S., Menon, U. N., Zamorano, R., Conn, P. J., Lindsley, C. W. & Hopkins, C. R., Jul 23 2009, In : Journal of Medicinal Chemistry. 52, 14, p. 4115-4118 4 p.

Research output: Contribution to journalArticle

61 Scopus citations

Synthesis and SAR of a novel positive allosteric modulator (PAM) of the metabotropic glutamate receptor 4 (mGluR4)

Williams, R., Johnson, K. A., Gentry, P. R., Niswender, C. M., Weaver, C. D., Conn, P. J., Lindsley, C. W. & Hopkins, C. R., Sep 1 2009, In : Bioorganic and Medicinal Chemistry Letters. 19, 17, p. 4967-4970 4 p.

Research output: Contribution to journalArticle

25 Scopus citations
2008

Molecule of the month

Hopkins, C. R., 2008, In : Current Topics in Medicinal Chemistry. 8, 18, p. 1710-1711 2 p.

Research output: Contribution to journalReview article

2006

Design and synthesis of novel N-sulfonyl-2-indole carboxamides as potent PPAR-γ binding agents with potential application to the treatment of osteoporosis

Hopkins, C. R., O'Neil, S. V., Laufersweiler, M. C., Wang, Y., Pokross, M., Mekel, M., Evdokimov, A., Walter, R., Kontoyianni, M., Petrey, M. E., Sabatakos, G., Roesgen, J. T., Richardson, E. & Demuth, T. P., Nov 1 2006, In : Bioorganic and Medicinal Chemistry Letters. 16, 21, p. 5659-5663 5 p.

Research output: Contribution to journalArticle

37 Scopus citations

Development of N-4,6-pyrimidine-N-alkyl-N′-phenyl ureas as orally active inhibitors of lymphocyte specific tyrosine kinase

Maier, J. A., Brugel, T. A., Sabat, M., Golebiowski, A., Laufersweiler, M. J., VanRens, J. C., Hopkins, C. R., De, B., Hsieh, L. C., Brown, K. K., Easwaran, V. & Janusz, M. J., Jul 15 2006, In : Bioorganic and Medicinal Chemistry Letters. 16, 14, p. 3646-3650 5 p.

Research output: Contribution to journalArticle

20 Scopus citations
2005

Design, synthesis, and biological activity of potent and selective inhibitors of mast cell tryptase

Hopkins, C. R., Czekaj, M., Kaye, S. S., Gao, Z., Pribish, J., Pauls, H., Liang, G., Sides, K., Cramer, D., Cairns, J., Luo, Y., Lim, H. K., Vaz, R., Rebello, S., Maignan, S., Dupuy, A., Mathieu, M. & Levell, J., Jun 2 2005, In : Bioorganic and Medicinal Chemistry Letters. 15, 11, p. 2734-2737 4 p.

Research output: Contribution to journalArticle

29 Scopus citations

Synthesis of 6,7-disubstituted-5H-pyrrolo[2,3-b]pyrazines via palladium-catalyzed heteroannulation

Hopkins, C. R. & Collar, N., Mar 14 2005, In : Tetrahedron Letters. 46, 11, p. 1845-1848 4 p.

Research output: Contribution to journalArticle

12 Scopus citations
2004
30 Scopus citations
25 Scopus citations

Convenient synthesis of 4-amino-3,5-disubstituted pyrazoles in one step from the corresponding diketo oximes

Majid, T., Hopkins, C. R., Pedgrift, B. & Collar, N., Mar 1 2004, In : Tetrahedron Letters. 45, 10, p. 2137-2139 3 p.

Research output: Contribution to journalArticle

23 Scopus citations

Novel pyrazinone inhibitors of mast cell tryptase: Synthesis and SAR evaluation

Hopkins, C., Neuenschwander, K., Scotese, A., Jackson, S., Nieduzak, T., Pauls, H., Liang, G., Sides, K., Cramer, D., Cairns, J., Maignan, S. & Mathieu, M., Oct 4 2004, In : Bioorganic and Medicinal Chemistry Letters. 14, 19, p. 4819-4823 5 p.

Research output: Contribution to journalArticle

28 Scopus citations
2002

Separation of Cdc25 dual specificity phosphatase inhibition and DNA cleaving activities in a focused library of analogs of the antitumor antibiotic Dnacin

Wipf, P., Hopkins, C. R., Phillips, E. O. & Lazo, J. S., Aug 5 2002, In : Tetrahedron. 58, 32, p. 6367-6372 6 p.

Research output: Contribution to journalArticle

17 Scopus citations
2001

Enantioselective synthesis of the AB-ring system of the antitumor antibiotic tetrazomine

Wipf, P. & Hopkins, C. R., May 4 2001, In : Journal of Organic Chemistry. 66, 9, p. 3133-3139 7 p.

Research output: Contribution to journalArticle

24 Scopus citations
1999

Efficient synthesis of 1,4-dihydro-2H-isoquinoline-3,5,8-triones via cyclobutene ring expansion

Wipf, P. & Hopkins, C. R., Sep 3 1999, In : Journal of Organic Chemistry. 64, 18, p. 6881-6887 7 p.

Research output: Contribution to journalComment/debate

31 Scopus citations