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19992020

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30 Scopus citations

ACS chemical neuroscience molecule spotlight on gilenya (fingolimod; FTY720)

Hopkins, C. R., Mar 16 2011, In : ACS Chemical Neuroscience. 2, 3, p. 116-117 2 p.

Research output: Contribution to journalArticle

3 Scopus citations

ACS chemical neuroscience molecule spotlight on RG1678

Hopkins, C. R., Dec 21 2011, In : ACS Chemical Neuroscience. 2, 12, p. 685-686 2 p.

Research output: Contribution to journalArticle

11 Scopus citations

ACS chemical neuroscience molecule spotlight on saphris

Hopkins, C. R., Apr 21 2010, In : ACS Chemical Neuroscience. 1, 4, p. 263-264 2 p.

Research output: Contribution to journalArticle

ACS chemical neuroscience molecule spotlight on valdoxen

Hopkins, C. R., Dec 15 2010, In : ACS Chemical Neuroscience. 1, 12, p. 772-773 2 p.

Research output: Contribution to journalArticle

1 Scopus citations

ACS chemical neuroscience molecule spotlight on Viibryd (vilazodone)

Hopkins, C. R., Oct 19 2011, In : ACS Chemical Neuroscience. 2, 10, 1 p.

Research output: Contribution to journalArticle

9 Scopus citations

Activation of metabotropic glutamate receptor 7 is required for induction of long-term potentiation at SCCA1 synapses in the hippocampus

Klar, R., Walker, A. G., Ghose, D., Grueter, B. A., Engers, D. W., Hopkins, C. R., Lindsley, C. W., Xiang, Z., Conn, P. J. & Niswender, C. M., May 13 2015, In : Journal of Neuroscience. 35, 19, p. 7600-7615 16 p.

Research output: Contribution to journalArticle

21 Scopus citations

Analgesic Effects of the GIRK Activator, VU0466551, Alone and in Combination with Morphine in Acute and Persistent Pain Models

Abney, K. K., Bubser, M., Du, Y., Kozek, K. A., Bridges, T. M., Linsdley, C. W., Daniels, J. S., Morrison, R. D., Wickman, K., Hopkins, C. R., Jones, C. K. & Weaver, C. D., Mar 20 2019, In : ACS Chemical Neuroscience. 10, 3, p. 1294-1299 6 p.

Research output: Contribution to journalArticle

2 Scopus citations
25 Scopus citations

An insecticide resistance-breaking mosquitocide targeting inward rectifier potassium channels in vectors of Zika virus and malaria

Swale, D. R., Engers, D. W., Bollinger, S. R., Gross, A., Inocente, E. A., Days, E., Kanga, F., Johnson, R. M., Yang, L., Bloomquist, J. R., Hopkins, C. R., Piermarini, P. M. & Denton, J. S., Nov 16 2016, In : Scientific reports. 6, 36954.

Research output: Contribution to journalArticle

31 Scopus citations

Application of small organic molecules reveals cooperative TGFβ and BMP regulation of mesothelial cell behaviors

Cross, E. E., Thomason, R. T., Martinez, M., Hopkins, C. R., Hong, C. C. & Bader, D. M., Sep 2 2011, In : ACS chemical biology. 6, 9, p. 952-961 10 p.

Research output: Contribution to journalArticle

15 Scopus citations

A small-molecule inhibitor of TRPC5 ion channels suppresses progressive kidney disease in animal models

Zhou, Y., Castonguay, P., Sidhom, E. H., Clark, A. R., Dvela-Levitt, M., Kim, S., Sieber, J., Wieder, N., Jung, J. Y., Andreeva, S., Reichardt, J., Dubois, F., Hoffmann, S. C., Basgen, J. M., Montesinos, M. S., Weins, A., Johnson, A. C., Lander, E. S., Garrett, M. R., Hopkins, C. R. & 1 others, Greka, A., Dec 8 2017, In : Science. 358, 6368, p. 1332-1336 5 p.

Research output: Contribution to journalArticle

42 Scopus citations

Bone morphogenetic protein signaling promotes tumorigenesis in a murine model of high-grade glioma

Hover, L. D., Owens, P., Munden, A. L., Wang, J., Chambless, L. B., Hopkins, C. R., Hong, C. C., Moses, H. L. & Abel, T. W., Jul 1 2016, In : Neuro-Oncology. 18, 7, p. 928-938 11 p.

Research output: Contribution to journalArticle

13 Scopus citations

Chemical lead optimization of a pan Gq mAChR M1, M3, M5 positive allosteric modulator (PAM) lead. Part I: Development of the first highly selective M5 PAM

Bridges, T. M., Kennedy, J. P., Cho, H. P., Breininger, M. L., Gentry, P. R., Hopkins, C. R., Conn, P. J. & Lindsley, C. W., Jan 15 2010, In : Bioorganic and Medicinal Chemistry Letters. 20, 2, p. 558-562 5 p.

Research output: Contribution to journalArticle

35 Scopus citations

Chemical modulation of mutant mGlu1 receptors derived from deleterious GRM1 mutations found in schizophrenics

Cho, H. P., Garcia-Barrantes, P. M., Brogan, J. T., Hopkins, C. R., Niswender, C. M., Rodriguez, A. L., Venable, D. F., Morrison, R. D., Bubser, M., Daniels, J. S., Jones, C. K., Conn, P. J. & Lindsley, C. W., Oct 17 2014, In : ACS chemical biology. 9, 10, p. 2334-2346 13 p.

Research output: Contribution to journalArticle

30 Scopus citations

Convenient synthesis of 4-amino-3,5-disubstituted pyrazoles in one step from the corresponding diketo oximes

Majid, T., Hopkins, C. R., Pedgrift, B. & Collar, N., Mar 1 2004, In : Tetrahedron Letters. 45, 10, p. 2137-2139 3 p.

Research output: Contribution to journalArticle

23 Scopus citations

Design, synthesis, and biological activity of potent and selective inhibitors of mast cell tryptase

Hopkins, C. R., Czekaj, M., Kaye, S. S., Gao, Z., Pribish, J., Pauls, H., Liang, G., Sides, K., Cramer, D., Cairns, J., Luo, Y., Lim, H. K., Vaz, R., Rebello, S., Maignan, S., Dupuy, A., Mathieu, M. & Levell, J., Jun 2 2005, In : Bioorganic and Medicinal Chemistry Letters. 15, 11, p. 2734-2737 4 p.

Research output: Contribution to journalArticle

29 Scopus citations
8 Scopus citations

Design and synthesis of novel N-sulfonyl-2-indole carboxamides as potent PPAR-γ binding agents with potential application to the treatment of osteoporosis

Hopkins, C. R., O'Neil, S. V., Laufersweiler, M. C., Wang, Y., Pokross, M., Mekel, M., Evdokimov, A., Walter, R., Kontoyianni, M., Petrey, M. E., Sabatakos, G., Roesgen, J. T., Richardson, E. & Demuth, T. P., Nov 1 2006, In : Bioorganic and Medicinal Chemistry Letters. 16, 21, p. 5659-5663 5 p.

Research output: Contribution to journalArticle

37 Scopus citations

Development and Antiparkinsonian Activity of VU0418506, a Selective Positive Allosteric Modulator of Metabotropic Glutamate Receptor 4 Homomers without Activity at mGlu2/4 Heteromers

Niswender, C. M., Jones, C. K., Lin, X., Bubser, M., Thompson Gray, A., Blobaum, A. L., Engers, D. W., Rodriguez, A. L., Loch, M. T., Daniels, J. S., Lindsley, C. W., Hopkins, C. R., Javitch, J. A. & Conn, P. J., Sep 21 2016, In : ACS Chemical Neuroscience. 7, 9, p. 1201-1211 11 p.

Research output: Contribution to journalArticle

30 Scopus citations

Development of N-4,6-pyrimidine-N-alkyl-N′-phenyl ureas as orally active inhibitors of lymphocyte specific tyrosine kinase

Maier, J. A., Brugel, T. A., Sabat, M., Golebiowski, A., Laufersweiler, M. J., VanRens, J. C., Hopkins, C. R., De, B., Hsieh, L. C., Brown, K. K., Easwaran, V. & Janusz, M. J., Jul 15 2006, In : Bioorganic and Medicinal Chemistry Letters. 16, 14, p. 3646-3650 5 p.

Research output: Contribution to journalArticle

20 Scopus citations

Discovery, characterization, and effects on renal fluid and electrolyte excretion of the Kir4.1 potassium channel pore blocker, VU0134992

Kharade, S. V., Kurata, H., Bender, A. M., Blobaum, A. L., Figueroa, E. E., Duran, A., Kramer, M., Days, E., Vinson, P., Flores, D., Satlin, L. M., Meiler, J., Weaver, C. D., Lindsley, C. W., Hopkins, C. R. & Denton, J. S., Aug 2018, In : Molecular pharmacology. 94, 2, p. 926-937 12 p.

Research output: Contribution to journalArticle

9 Scopus citations

Discovery, characterization, and structure-activity relationships of an inhibitor of inward rectifier potassium (Kir) channels with preference for Kir2.3, Kir3.X, and Kir7.1

Raphemot, R., Lonergan, D. F., Nguyen, T. T., Utley, T., Michelle Lewis, L., Kadakia, R., David Weaver, C., Gogliotti, R., Hopkins, C., Lindsley, C. W. & Denton, J. S., 2011, In : Frontiers in Pharmacology. 2 NOV, Article 75.

Research output: Contribution to journalArticle

28 Scopus citations

Discovery, characterization and biological evaluation of a novel (R)-4,4-difluoropiperidine scaffold as dopamine receptor 4 (D4R) antagonists

Jeffries, D. E., Witt, J. O., McCollum, A. L., Temple, K. J., Hurtado, M. A., Harp, J. M., Blobaum, A. L., Lindsley, C. W. & Hopkins, C. R., 2016, In : Bioorganic and Medicinal Chemistry Letters. 26, 23, p. 5757-5764 8 p.

Research output: Contribution to journalArticle

2 Scopus citations

Discovery, Structure-Activity Relationship, and Biological Characterization of a Novel Series of 6-((1 H-Pyrazolo[4,3- b]pyridin-3-yl)amino)-benzo[ d]isothiazole-3-carboxamides as Positive Allosteric Modulators of the Metabotropic Glutamate Receptor 4 (mGlu 4 )

Bollinger, S. R., Engers, D. W., Panarese, J. D., West, M., Engers, J. L., Loch, M. T., Rodriguez, A. L., Blobaum, A. L., Jones, C. K., Thompson Gray, A., Conn, P. J., Lindsley, C. W., Niswender, C. M. & Hopkins, C. R., Oct 1 2019, In : Journal of Medicinal Chemistry. 62, 1, p. 342-358 17 p.

Research output: Contribution to journalArticle

6 Scopus citations

Discovery, Synthesis, and Preclinical Characterization of N-(3-Chloro-4-fluorophenyl)-1H-pyrazolo[4,3-b]pyridin-3-amine (VU0418506), a Novel Positive Allosteric Modulator of the Metabotropic Glutamate Receptor 4 (mGlu4)

Engers, D. W., Blobaum, A. L., Gogliotti, R. D., Cheung, Y. Y., Salovich, J. M., Garcia-Barrantes, P. M., Daniels, J. S., Morrison, R., Jones, C. K., Soars, M. G., Zhuo, X., Hurley, J., Macor, J. E., Bronson, J. J., Conn, P. J., Lindsley, C. W., Niswender, C. M. & Hopkins, C. R., Sep 21 2016, In : ACS Chemical Neuroscience. 7, 9, p. 1192-1200 9 p.

Research output: Contribution to journalArticle

23 Scopus citations

Discovery, synthesis, and structure-activity relationship development of a series of N-(4-acetamido)phenylpicolinamides as positive allosteric modulators of metabotropic glutamate receptor 4 (mGlu4) with CNS exposure in rats

Engers, D. W., Field, J. R., Le, U., Zhou, Y., Bolinger, J. D., Zamorano, R., Blobaum, A. L., Jones, C. K., Jadhav, S., Weaver, C. D., Conn, P. J., Lindsley, C. W., Niswender, C. M. & Hopkins, C. R., Feb 24 2011, In : Journal of Medicinal Chemistry. 54, 4, p. 1106-1110 5 p.

Research output: Contribution to journalArticle

33 Scopus citations

Discovery, synthesis, and structure-activity relationship development of a series of N -4-(2,5-dioxopyrrolidin-1-yl)phenylpicolinamides (VU0400195, ML182): Characterization of a novel positive allosteric modulator of the metabotropic glutamate receptor 4 (mGlu 4) with oral efficacy in an antiparkinsonian animal model

Jones, C. K., Engers, D. W., Thompson, A. D., Field, J. R., Blobaum, A. L., Lindsley, S. R., Zhou, Y., Gogliotti, R. D., Jadhav, S., Zamorano, R., Bogenpohl, J., Smith, Y., Morrison, R., Daniels, J. S., Weaver, C. D., Conn, P. J., Lindsley, C. W., Niswender, C. M. & Hopkins, C. R., Nov 10 2011, In : Journal of Medicinal Chemistry. 54, 21, p. 7639-7647 9 p.

Research output: Contribution to journalArticle

46 Scopus citations

Discovery, synthesis, and structure-activity relationship of a series of N -aryl-bicyclo[2.2.1]heptane-2-carboxamides: Characterization of ML213 as a novel KCNQ2 and KCNQ4 potassium channel opener

Yu, H., Wu, M., Townsend, S. D., Zou, B., Long, S., Daniels, J. S., McManus, O. B., Li, M., Lindsley, C. W. & Hopkins, C. R., Oct 19 2011, In : ACS Chemical Neuroscience. 2, 10, p. 572-577 6 p.

Research output: Contribution to journalArticle

37 Scopus citations

Discovery, synthesis and characterization of a series of (1-alkyl-3-methyl-1H-pyrazol-5-yl)-2-(5-aryl-2H-tetrazol-2-yl)acetamides as novel GIRK1/2 potassium channel activators

Sharma, S., Kozek, K. A., Abney, K. K., Kumar, S., Gautam, N., Alnouti, Y., David Weaver, C. & Hopkins, C. R., Mar 15 2019, In : Bioorganic and Medicinal Chemistry Letters. 29, 6, p. 791-796 6 p.

Research output: Contribution to journalArticle

Discovery and Characterization of 1H-Pyrazol-5-yl-2-phenylacetamides as Novel, Non-Urea-Containing GIRK1/2 Potassium Channel Activators

Wieting, J. M., Vadukoot, A. K., Sharma, S., Abney, K. K., Bridges, T. M., Daniels, J. S., Morrison, R. D., Wickman, K., Weaver, C. D. & Hopkins, C. R., Sep 20 2017, In : ACS Chemical Neuroscience. 8, 9, p. 1873-1879 7 p.

Research output: Contribution to journalArticle

2 Scopus citations

Discovery and characterization of 2-(cyclopropanesulfonamido)-n-(2-ethoxyphenyl)benzamide, ML382: A potent and selective positive allosteric modulator of MrgX1

Wen, W., Wang, Y., Li, Z., Tseng, P. Y., McManus, O. B., Wu, M., Li, M., Lindsley, C. W., Dong, X. & Hopkins, C. R., Jan 2015, In : ChemMedChem. 10, 1, p. 57-61 5 p.

Research output: Contribution to journalArticle

2 Scopus citations

Discovery and Characterization of 2-Nitro-5-(4-(phenylsulfonyl)piperazin-1-yl)- N-(pyridin-4-ylmethyl)anilines as Novel Inhibitors of the Aedes aegypti Kir1 (AeKir1) Channel

Aretz, C. D., Morwitzer, M. J., Sanford, A. G., Hogan, A. M., Portillo, M. V., Kharade, S. V., Kramer, M., McCarthey, J. B., Trigueros, R. R., Piermarini, P. M., Denton, J. S. & Hopkins, C. R., Jun 14 2019, In : ACS infectious diseases. 5, 6, p. 917-931 15 p.

Research output: Contribution to journalArticle

Discovery and characterization of a novel series of N-phenylsulfonyl-1H-pyrrole picolinamides as positive allosteric modulators of the metabotropic glutamate receptor 4 (mGlu4)

Gogliotti, R. D., Blobaum, A. L., Morrison, R. M., Daniels, J. S., Salovich, J. M., Cheung, Y. Y., Rodriguez, A. L., Loch, M. T., Conn, P. J., Lindsley, C. W., Niswender, C. M. & Hopkins, C. R., Jul 1 2016, In : Bioorganic and Medicinal Chemistry Letters. 26, 13, p. 2984-2987 4 p.

Research output: Contribution to journalArticle

5 Scopus citations

Discovery and characterization of a potent and selective inhibitor of Aedes aegypti inward rectifier potassium channels

Raphemot, R., Rouhier, M. F., Swale, D. R., Days, E., Weaver, C. D., Lovell, K. M., Konkel, L. C., Engers, D. W., Bollinger, S. F., Hopkins, C., Piermarini, P. M. & Denton, J. S., Nov 6 2014, In : PloS one. 9, 11, 110772.

Research output: Contribution to journalArticle

26 Scopus citations

Discovery and characterization of ML398, a potent and selective antagonist of the D4 receptor with in vivo activity

Berry, C. B., Bubser, M., Jones, C. K., Hayes, J. P., Wepy, J. A., Locuson, C. W., Daniels, J. S., Lindsley, C. W. & Hopkins, C. R., Sep 11 2014, In : ACS Medicinal Chemistry Letters. 5, 9, p. 1060-1064 5 p.

Research output: Contribution to journalArticle

9 Scopus citations

Discovery and characterization of N-(1,3-dialkyl-1H-indazol-6-yl)-1H-pyrazolo[4,3-b]pyridin-3-amine scaffold as mGlu4 positive allosteric modulators that mitigate CYP1A2 induction liability

Engers, D. W., Bollinger, S. R., Engers, J. L., Panarese, J. D., Breiner, M. M., Gregro, A., Blobaum, A. L., Bronson, J. J., Wu, Y. J., Macor, J. E., Rodriguez, A. L., Zamorano, R., Conn, P. J., Lindsley, C. W., Niswender, C. M. & Hopkins, C. R., Aug 15 2018, In : Bioorganic and Medicinal Chemistry Letters. 28, 15, p. 2641-2646 6 p.

Research output: Contribution to journalArticle

3 Scopus citations

Discovery and Characterization of VU0529331, a Synthetic Small-Molecule Activator of Homomeric G Protein-Gated, Inwardly Rectifying, Potassium (GIRK) Channels

Kozek, K. A., Du, Y., Sharma, S., Prael, F. J., Spitznagel, B. D., Kharade, S. V., Denton, J. S., Hopkins, C. R. & Weaver, C. D., Jan 16 2019, In : ACS Chemical Neuroscience. 10, 1, p. 358-370 13 p.

Research output: Contribution to journalArticle

3 Scopus citations

Discovery and optimization of a novel series of highly CNS penetrant M4 PAMs based on a 5,6-dimethyl-4-(piperidin-1-yl)thieno[2,3-d]pyrimidine core

Wood, M. R., Noetzel, M. J., Engers, J. L., Bollinger, K. A., Melancon, B. J., Tarr, J. C., Han, C., West, M., Gregro, A. R., Lamsal, A., Chang, S., Ajmera, S., Smith, E., Chase, P., Hodder, P. S., Bubser, M., Jones, C. K., Hopkins, C. R., Emmitte, K. A., Niswender, C. M. & 5 others, Wood, M. W., Duggan, M. E., Conn, P. J., Bridges, T. M. & Lindsley, C. W., Jul 1 2016, In : Bioorganic and Medicinal Chemistry Letters. 26, 13, p. 3029-3033 5 p.

Research output: Contribution to journalArticle

17 Scopus citations

Discovery of 3-aminopicolinamides as metabotropic glutamate receptor subtype 4 (mGlu4) positive allosteric modulator warheads engendering CNS exposure and in vivo efficacy

Gogliotti, R. D., Engers, D. W., Garcia-Barrantes, P. M., Panarese, J. D., Gentry, P. R., Blobaum, A. L., Morrison, R. D., Daniels, J. S., Thompson, A. D., Jones, C. K., Conn, P. J., Niswender, C. M., Lindsley, C. W. & Hopkins, C. R., Jun 15 2016, In : Bioorganic and Medicinal Chemistry Letters. 26, 12, p. 2915-2919 5 p.

Research output: Contribution to journalArticle

1 Scopus citations

Discovery of a selective M4 positive allosteric modulator based on the 3-amino-thieno[2,3-b]pyridine-2-carboxamide scaffold: Development of ML253, a potent and brain penetrant compound that is active in a preclinical model of schizophrenia

Le, U., Melancon, B. J., Bridges, T. M., Vinson, P. N., Utley, T. J., Lamsal, A., Rodriguez, A. L., Venable, D., Sheffler, D. J., Jones, C. K., Blobaum, A. L., Wood, M. R., Daniels, J. S., Conn, P. J., Niswender, C. M., Lindsley, C. W. & Hopkins, C. R., Jan 1 2013, In : Bioorganic and Medicinal Chemistry Letters. 23, 1, p. 346-350 5 p.

Research output: Contribution to journalArticle

24 Scopus citations
15 Scopus citations

Discovery of N-(4-methoxy-7-methylbenzo[d]thiazol-2-yl)isonicatinamide, ML293, as a novel, selective and brain penetrant positive allosteric modulator of the muscarinic 4 (M4) receptor

Salovich, J. M., Vinson, P. N., Sheffler, D. J., Lamsal, A., Utley, T. J., Blobaum, A. L., Bridges, T. M., Le, U., Jones, C. K., Wood, M. R., Scott Daniels, J., Jeffrey Conn, P., Niswender, C. M., Lindsley, C. W. & Hopkins, C. R., Aug 1 2012, In : Bioorganic and Medicinal Chemistry Letters. 22, 15, p. 5084-5088 5 p.

Research output: Contribution to journalArticle

29 Scopus citations
1 Scopus citations

Discovery of VU2957 (Valiglurax): An mGlu 4 Positive Allosteric Modulator Evaluated as a Preclinical Candidate for the Treatment of Parkinson's Disease

Panarese, J. D., Engers, D. W., Wu, Y. J., Bronson, J. J., Macor, J. E., Chun, A., Rodriguez, A. L., Felts, A. S., Engers, J. L., Loch, M. T., Emmitte, K. A., Castelhano, A. L., Kates, M. J., Nader, M. A., Jones, C. K., Blobaum, A. L., Conn, P. J., Niswender, C. M., Hopkins, C. R. & Lindsley, C. W., Mar 14 2019, In : ACS Medicinal Chemistry Letters. 10, 3, p. 255-260 6 p.

Research output: Contribution to journalArticle

5 Scopus citations

DMH1, a highly selective small molecule BMP inhibitor promotes neurogenesis of hiPSCs: Comparison of PAX6 and SOX1 expression during neural induction

Neely, M. D., Litt, M. J., Tidball, A. M., Li, G. G., Aboud, A. A., Hopkins, C. R., Chamberlin, R., Hong, C. C., Ess, K. C. & Bowman, A. B., Jun 20 2012, In : ACS Chemical Neuroscience. 3, 6, p. 482-491 10 p.

Research output: Contribution to journalArticle

57 Scopus citations

DMH1, a novel BMP small molecule inhibitor, increases cardiomyocyte progenitors and promotes cardiac differentiation in mouse embryonic stem cells

Ao, A., Hao, J., Hopkins, C. R. & Hong, C. C., Jul 27 2012, In : PloS one. 7, 7, e41627.

Research output: Contribution to journalArticle

35 Scopus citations

Dynamic subunit stoichiometry confers a progressive continuum of pharmacological sensitivity by KCNQ potassium channels

Yu, H., Lin, Z., Mattmann, M. E., Zou, B., Terrenoire, C., Zhang, H., Wu, M., McManus, O. B., Kass, R. S., Lindsley, C. W., Hopkins, C. R. & Li, M., May 21 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 21, p. 8732-8737 6 p.

Research output: Contribution to journalArticle

38 Scopus citations

Eliciting Renal Failure in Mosquitoes with a Small-Molecule Inhibitor of Inward-Rectifying Potassium Channels

Raphemot, R., Rouhier, M. F., Hopkins, C. R., Gogliotti, R. D., Lovell, K. M., Hine, R. M., Ghosalkar, D., Longo, A., Beyenbach, K. W., Denton, J. S. & Piermarini, P. M., May 29 2013, In : PloS one. 8, 5, e64905.

Research output: Contribution to journalArticle

41 Scopus citations

Enantioselective synthesis of the AB-ring system of the antitumor antibiotic tetrazomine

Wipf, P. & Hopkins, C. R., May 4 2001, In : Journal of Organic Chemistry. 66, 9, p. 3133-3139 7 p.

Research output: Contribution to journalArticle

24 Scopus citations