• 8215 Citations
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1978 …2020

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2020

Brief Report: Sex Differences in Outcomes for Individuals Presenting for Third-Line Antiretroviral Therapy

Godfrey, C., Hughes, M. D., Ritz, J., Coelho, L., Gross, R., Salata, R., Mngqibisa, R., Wallis, C. L., Mumbi, M. E., Matoga, M., Poongulali, S., Van Schalkwyk, M., Hogg, E., Fletcher, C. V., Grinsztejn, B. & Collier, A. C., Jun 1 2020, In : Journal of acquired immune deficiency syndromes (1999). 84, 2, p. 203-207 5 p.

Research output: Contribution to journalArticle

1 Scopus citations

High-dose rifapentine with or without moxifloxacin for shortening treatment of pulmonary tuberculosis: Study protocol for TBTC study 31/ACTG A5349 phase 3 clinical trial

The AIDS Clinical Trials Group and the Tuberculosis Trials Consortium, Mar 2020, In : Contemporary Clinical Trials. 90, 105938.

Research output: Contribution to journalArticle

Pharmacokinetics of Coencapsulated Antiretrovirals with Ingestible Sensors

Liu, H., Daar, E., Wang, Y., Siqueiros, L., Campbell, K., Shen, J., Guerrero, M., Ko, M. W., Xiong, D., Dao, J., Young, T., Rosen, M. & Fletcher, C. V., Jan 2020, In : AIDS Research and Human Retroviruses. 36, 1, p. 65-74 10 p.

Research output: Contribution to journalArticle

1 Scopus citations

Plasma and intracellular pharmacokinetics of tenofovir disoproxil fumarate and emtricitabine in transgender women receiving feminizing hormone therapy

Cirrincione, L. R., Podany, A. T., Havens, J. P., Bares, S. H., Dyavar, S. R., Gwon, Y., Johnson, T. M., Amoura, N. J., Fletcher, C. V. & Scarsi, K. K., May 1 2020, In : Journal of Antimicrobial Chemotherapy. 75, 5, p. 1242-1249 8 p.

Research output: Contribution to journalArticle

2 Scopus citations

Real-Time and Wireless Assessment of Adherence to Antiretroviral Therapy With Co-Encapsulated Ingestion Sensor in HIV-Infected Patients: A Pilot Study

Daar, E. S., Rosen, M. I., Wang, Y., Siqueiros, L., Shen, J., Guerrero, M., Xiong, D., Dao, J., Young, T., Corado, K., Fletcher, C. V. & Liu, H., Jan 1 2020, In : Clinical and Translational Science. 13, 1, p. 189-194 6 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Semen Extracellular Vesicles from HIV-1-Infected Individuals Inhibit HIV-1 Replication in Vitro, and Extracellular Vesicles Carry Antiretroviral Drugs in Vivo

Welch, J. L., Kaddour, H., Winchester, L., Fletcher, C. V., Stapleton, J. T. & Okeoma, C. M., Jan 1 2020, In : Journal of Acquired Immune Deficiency Syndromes. 83, 1, p. 90-98 9 p.

Research output: Contribution to journalArticle

3 Scopus citations

The Lymphoid Tissue Pharmacokinetics of Tenofovir Disoproxil Fumarate and Tenofovir Alafenamide in HIV-Infected Persons

Fletcher, C. V., Podany, A. T., Thorkelson, A., Winchester, L. C., Mykris, T., Anderson, J., Jorstad, S., Baker, J. V. & Schacker, T. W., 2020, (Accepted/In press) In : Clinical Pharmacology and Therapeutics.

Research output: Contribution to journalArticle

1 Scopus citations

Treatment of advanced AIDS-associated Kaposi sarcoma in resource-limited settings: a three-arm, open-label, randomised, non-inferiority trial

A5263/AMC066 protocol team, Apr 11 2020, In : The Lancet. 395, 10231, p. 1195-1207 13 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2019

Assessing the lymphoid tissue bioavailability of antiretrovirals in human primary lymphoid endothelial cells and in mice

Dyavar, S. R., Gautam, N., Podany, A. T., Winchester, L. C., Weinhold, J. A., Mykris, T. M., Campbell, K. M., Alnouti, Y. & Fletcher, C. V., Oct 1 2019, In : The Journal of antimicrobial chemotherapy. 74, 10, p. 2974-2978 5 p.

Research output: Contribution to journalArticle

Impact of Integrase Inhibition Compared with Nonnucleoside Inhibition on HIV Reservoirs in Lymphoid Tissues

Rothenberger, M., Nganou-Makamdop, K., Kityo, C., Ssali, F., Chipman, J. G., Beilman, G. J., Hoskuldsson, T., Anderson, J., Jasurda, J., Schmidt, T. E., Calisto, S. P., Pearson, H., Reimann, T., David, C., Perkey, K., Southern, P., Wietgrefe, S., Helgeson, E., Reilly, C., Haase, A. T. & 3 others, Douek, D. C., Fletcher, C. V. & Schacker, T. W., Jul 1 2019, In : Journal of Acquired Immune Deficiency Syndromes. 81, 3, p. 355-360 6 p.

Research output: Contribution to journalArticle

7 Scopus citations

One month of rifapentine plus isoniazid to prevent HIV-related Tuberculosis

BRIEF TB/A5279 Study Team, Mar 14 2019, In : New England Journal of Medicine. 380, 11, p. 1001-1011 11 p.

Research output: Contribution to journalArticle

46 Scopus citations

Third-line antiretroviral therapy in low-income and middle-income countries (ACTG A5288): a prospective strategy study

A5288 Team, Sep 2019, In : The Lancet HIV. 6, 9, p. e588-e600

Research output: Contribution to journalArticle

4 Scopus citations
2018

Adipocytes impair efficacy of antiretroviral therapy

Couturier, J., Winchester, L. C., Suliburk, J. W., Wilkerson, G. K., Podany, A. T., Agarwal, N., Xuan Chua, C. Y., Nehete, P. N., Nehete, B. P., Grattoni, A., Sastry, K. J., Fletcher, C. V., Lake, J. E., Balasubramanyam, A. & Lewis, D. E., Jun 2018, In : Antiviral Research. 154, p. 140-148 9 p.

Research output: Contribution to journalArticle

11 Scopus citations
6 Scopus citations

Development, validation and utilization of a highly sensitive LC-MS/MS method for quantification of levonorgestrel released from a subdermal implant in human plasma

Cirrincione, L. R., Penchala, S. D., Scarsi, K. K., Podany, A. T., Winchester, L. C., Back, D. J., Khoo, S. H., Fletcher, C. V., Siccardi, M. & Else, L. J., May 1 2018, In : Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences. 1084, p. 106-112 7 p.

Research output: Contribution to journalArticle

4 Scopus citations

Normalization of cell associated antiretroviral drug concentrations with a novel RPP30 droplet digital PCR assay

Dyavar, S. R., Ye, Z., Byrareddy, S. N., Scarsi, K. K., Winchester, L. C., Weinhold, J. A., Fletcher, C. V. & Podany, A. T., Dec 1 2018, In : Scientific reports. 8, 1, 3626.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Physiologically based pharmacokinetic modelling prediction of the effects of dose adjustment in drug-drug interactions between levonorgestrel contraceptive implants and efavirenz-based art

Roberts, O., Rajoli, R. K. R., Back, D. J., Owen, A., Darin, K. M., Fletcher, C. V., Lamorde, M., Scarsi, K. K. & Siccardi, M., Apr 1 2018, In : Journal of Antimicrobial Chemotherapy. 73, 4, p. 1004-1012 9 p.

Research output: Contribution to journalArticle

6 Scopus citations

Plasma and intracellular pharmacokinetics of tenofovir in patients switched from tenofovir disoproxil fumarate to tenofovir alafenamide

Podany, A. T., Bares, S. H., Havens, J., Dyavar, S. R., O'Neill, J., Lee, S., Fletcher, C. V., Swindells, S. & Scarsi, K. K., Mar 27 2018, In : AIDS. 32, 6, p. 761-765 5 p.

Research output: Contribution to journalArticle

14 Scopus citations

Transplantation of CCR5∆32 homozygous umbilical cord blood in a child with acute lymphoblastic leukemia and perinatally acquired HIV infection

Rothenberger, M., Wagner, J. E., Haase, A., Richman, D., Grzywacz, B., Strain, M., Lada, S., Estes, J., Fletcher, C. V., Podany, A. T., Anderson, J., Schmidt, T., Wietgrefe, S., Schacker, T. & Verneris, M. R., 2018, In : Open Forum Infectious Diseases. 5, 5

Research output: Contribution to journalArticle

Open Access
5 Scopus citations
2017

Defining total-body AIDS-virus burden with implications for curative strategies

Estes, J. D., Kityo, C., Ssali, F., Swainson, L., Makamdop, K. N., Del Prete, G. Q., Deeks, S. G., Luciw, P. A., Chipman, J. G., Beilman, G. J., Hoskuldsson, T., Khoruts, A., Anderson, J., Deleage, C., Jasurda, J., Schmidt, T. E., Hafertepe, M., Callisto, S. P., Pearson, H., Reimann, T. & 12 others, Schuster, J., Schoephoerster, J., Southern, P., Perkey, K., Shang, L., Wietgrefe, S. W., Fletcher, C. V., Lifson, J. D., Douek, D. C., McCune, J. M., Haase, A. T. & Schacker, T. W., Nov 1 2017, In : Nature Medicine. 23, 11, p. 1271-1276 6 p.

Research output: Contribution to journalArticle

115 Scopus citations

Impact of efavirenz pharmacokinetics and pharmacogenomics on neuropsychological performance in older HIV-infected patients

Sandkovsky, U., Podany, A. T., Fletcher, C. V., Owen, A., Felton-Coleman, A., Winchester, L. C., Robertson, K. & Swindells, S., 2017, In : Journal of Antimicrobial Chemotherapy. 72, 1, p. 200-204 5 p.

Research output: Contribution to journalArticle

6 Scopus citations
2016

Alterations in P-Glycoprotein Expression and Function Between Macrophage Subsets

Cory, T. J., He, H., Winchester, L. C., Kumar, S. & Fletcher, C. V., Nov 1 2016, In : Pharmaceutical Research. 33, 11, p. 2713-2721 9 p.

Research output: Contribution to journalArticle

15 Scopus citations

Antiretroviral drug transporters and metabolic enzymes in human testicular tissue: Potential contribution to HIV-1 sanctuary site

Huang, Y., Hoque, M. T., Jenabian, M. A., Vyboh, K., Whyte, S. K., Sheehan, N. L., Brassard, P., Bélanger, M., Chomont, N., Fletcher, C. V., Routy, J. P. & Bendayan, R., 2016, In : Journal of Antimicrobial Chemotherapy. 71, 7, p. 1954-1965 12 p.

Research output: Contribution to journalArticle

24 Scopus citations

Etravirine pharmacokinetics in HIV-infected pregnant women

on behalf of the PANNA Network and the IMPAACT 1026s Study Teams, Aug 4 2016, In : Frontiers in Pharmacology. 7, AUG, 239.

Research output: Contribution to journalArticle

9 Scopus citations

Persistent HIV-1 replication maintains the tissue reservoir during therapy

Lorenzo-Redondo, R., Fryer, H. R., Bedford, T., Kim, E. Y., Archer, J., Kosakovsky Pond, S. L., Chung, Y. S., Penugonda, S., Chipman, J. G., Fletcher, C. V., Schacker, T. W., Malim, M. H., Rambaut, A., Haase, A. T., McLean, A. R. & Wolinsky, S. M., Feb 4 2016, In : Nature. 530, 7588, p. 51-56 6 p.

Research output: Contribution to journalArticle

309 Scopus citations

Pharmacogenetics of unboosted atazanavir in HIV-infected individuals in resource-limited settings: A sub-study of the AIDS Clinical Trials Group (ACTG) PEARLS study (NWCS 342)

Castillo-Mancilla, J. R., Aquilante, C. L., Wempe, M. F., Smeaton, L. M., Firnhaber, C., LaRosa, A. M., Kumarasamy, N., Andrade, A., Baheti, G., Fletcher, C. V., Campbell, T. B., Haas, D. W., MaWhinney, S. & Anderson, P. L., Jun 13 2016, In : Journal of Antimicrobial Chemotherapy. 71, 6, p. 1609-1618 10 p.

Research output: Contribution to journalArticle

6 Scopus citations

Topical tenofovir disoproxil fumarate nanoparticles prevent HIV-1 vaginal transmission in a humanized mouse model

Destache, C. J., Mandal, S., Yuan, Z., Kang, G., Date, A. A., Lu, W., Shibata, A., Pham, R., Bruck, P., Rezich, M., Zhou, Y., Vivekanandan, R., Fletcher, C. V. & Li, Q., Jun 2016, In : Antimicrobial Agents and Chemotherapy. 60, 6, p. 3633-3639 7 p.

Research output: Contribution to journalArticle

19 Scopus citations
2015

Antifibrotic therapy in simian immunodeficiency virus infection preserves CD4+ T-cell populations and improves immune reconstitution with antiretroviral therapy

Estes, J. D., Reilly, C., Trubey, C. M., Fletcher, C. V., Cory, T. J., Piatak, M., Russ, S., Anderson, J., Reimann, T. G., Star, R., Smith, A., Tracy, R. P., Berglund, A., Schmidt, T., Coalter, V., Chertova, E., Smedley, J., Haase, A. T., Lifson, J. D. & Schacker, T. W., 2015, In : Journal of Infectious Diseases. 211, 5, p. 744-754 11 p.

Research output: Contribution to journalArticle

34 Scopus citations

A rapid spin through oil results in higher cell-associated concentrations of antiretrovirals compared with conventional cell washing

Cory, T. J., Winchester, L. C., Robbins, B. L. & Fletcher, C. V., Jul 1 2015, In : Bioanalysis. 7, 12, p. 1447-1455 9 p.

Research output: Contribution to journalArticle

7 Scopus citations
10 Scopus citations

Efavirenz Pharmacokinetics and Pharmacodynamics in HIV-Infected Persons Receiving Rifapentine and Isoniazid for Tuberculosis Prevention

Podany, A. T., Bao, Y., Swindells, S., Chaisson, R. E., Andersen, J. W., Mwelase, T., Supparatpinyo, K., Mohapi, L., Gupta, A., Benson, C. A., Kim, P. & Fletcher, C. V., Oct 15 2015, In : Clinical Infectious Diseases. 61, 8, p. 1322-1327 6 p.

Research output: Contribution to journalArticle

31 Scopus citations

Large number of rebounding/founder HIV variants emerge from multifocal infection in lymphatic tissues after treatment interruption

Rothenberger, M. K., Keele, B. F., Wietgrefe, S. W., Fletcher, C. V., Beilman, G. J., Chipman, J. G., Khoruts, A., Estes, J. D., Anderson, J., Callisto, S. P., Schmidt, T. E., Thorkelson, A., Reilly, C., Perkey, K., Reimann, T. G., Utay, N. S., Makamdop, K. N., Stevenson, M., Douek, D. C., Haase, A. T. & 1 others, Schacker, T. W., Mar 10 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 10, p. E1126-E1134

Research output: Contribution to journalArticle

137 Scopus citations
10 Scopus citations

Pharmacokinetics of tenofovir during pregnancy and postpartum

for the International Maternal Pediatric and Adolescent AIDS Clinical Trials (IMPAACT) P1026s Team, Sep 1 2015, In : HIV Medicine. 16, 8, p. 502-511 10 p.

Research output: Contribution to journalArticle

27 Scopus citations

Plasma and Intracellular Pharmacokinetics of Tenofovir Disoproxil Fumarate 300 mg Every 48 Hours vs 150 mg Once Daily in HIV-Infected Adults with Moderate Renal Function Impairment

Cressey, T. R., Avihingsanon, A., Halue, G., Leenasirimakul, P., Sukrakanchana, P. O., Tawon, Y., Jaisieng, N., Jourdain, G., Podany, A. T., Fletcher, C. V., Klinbuayaem, V. & Bowonwatanuwong, C., Aug 15 2015, In : Clinical Infectious Diseases. 61, 4, p. 633-639 7 p.

Research output: Contribution to journalArticle

7 Scopus citations
2014

Correlation between plasma, intracellular, and cervical tissue levels of raltegravir at steady-state dosing in healthy women

Mitchell, C., Roemer, E., Nkwopara, E., Robbins, B., Cory, T., Rue, T., Fletcher, C. V. & Frenkel, L., Jun 2014, In : Antimicrobial Agents and Chemotherapy. 58, 6, p. 3360-3365 6 p.

Research output: Contribution to journalArticle

9 Scopus citations

Persistent HIV-1 replication is associated with lower antiretroviral drug concentrations in lymphatic tissues

Fletcher, C. V., Staskus, K., Wietgrefe, S. W., Rothenberger, M., Reilly, C., Chipman, J. G., Beilman, G. J., Khoruts, A., Thorkelson, A., Schmidt, T. E., Anderson, J., Perkey, K., Stevenson, M., Perelson, A. S., Douek, D. C., Haase, A. T. & Schacker, T. W., Feb 11 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 6, p. 2307-2312 6 p.

Research output: Contribution to journalArticle

348 Scopus citations

Pharmacometric characterization of efavirenz developmental pharmacokinetics and pharmacogenetics in HIV-Infected children

Salem, A. H., Fletcher, C. V. & Brundage, R. C., Jan 2014, In : Antimicrobial Agents and Chemotherapy. 58, 1, p. 136-143 8 p.

Research output: Contribution to journalArticle

20 Scopus citations
10 Scopus citations
2013

Age-related differences in plasma and intracellular tenofovir concentrations in HIV-1-infected children, adolescents and adults

Baheti, G., King, J. R., Acosta, E. P. & Fletcher, C. V., Jan 14 2013, In : AIDS. 27, 2, p. 221-225 5 p.

Research output: Contribution to journalArticle

13 Scopus citations
2012
19 Scopus citations

A novel ultrasensitive LC-MS/MS assay for quantification of intracellular raltegravir in human cell extracts

Robbins, B. L., Nelson, S. R. & Fletcher, C. V., Nov 2012, In : Journal of Pharmaceutical and Biomedical Analysis. 70, p. 378-387 10 p.

Research output: Contribution to journalArticle

16 Scopus citations

Isoniazid pharmacokinetics, pharmacodynamics, and dosing in South African infants

Kiser, J. J., Zhu, R., D'Argenio, D. Z., Cotton, M. F., Bobat, R., McSherry, G. D., Madhi, S. A., Carey, V. J., Seifart, H. I., Werely, C. J. & Fletcher, C. V., Aug 2012, In : Therapeutic Drug Monitoring. 34, 4, p. 446-451 6 p.

Research output: Contribution to journalArticle

16 Scopus citations

Measurement of plasma and intracellular concentrations of raltegravir in patients with HIV infection

Sandkovsky, U., Swindells, S., Robbins, B. L., Nelson, S. R., Acosta, E. P. & Fletcher, C. V., Nov 13 2012, In : AIDS. 26, 17, p. 2257-2259 3 p.

Research output: Contribution to journalArticle

8 Scopus citations

The pharmacogenetics of NAT2 enzyme maturation in perinatally HIV exposed infants receiving isoniazid

Zhu, R., Kiser, J. J., Seifart, H. I., Werely, C. J., Mitchell, C. D., D'Argenio, D. Z. & Fletcher, C. V., Apr 2012, In : Journal of Clinical Pharmacology. 52, 4, p. 511-519 9 p.

Research output: Contribution to journalArticle

17 Scopus citations
2011

Atazanavir and atazanavir/ritonavir pharmacokinetics in HIV-infected infants, children, and adolescents

Kiser, J. J., Rutstein, R. M., Samson, P., Graham, B., Aldrovandi, G., Mofenson, L. M., Smith, E., Schnittman, S., Fenton, T., Brundage, R. C. & Fletcher, C. V., Jul 31 2011, In : AIDS. 25, 12, p. 1489-1496 8 p.

Research output: Contribution to journalArticle

15 Scopus citations

Implications of HIV PrEP trials results

Veronese, F., Anton, P., Fletcher, C. V., DeGruttola, V., McGowan, I., Becker, S., Zwerski, S. & Burns, D., Jan 1 2011, In : AIDS Research and Human Retroviruses. 27, 1, p. 81-90 10 p.

Research output: Contribution to journalArticle

16 Scopus citations

Plasma and intracellular population pharmacokinetic analysis of tenofovir in HIV-1-infected patients

Baheti, G., Kiser, J. J., Havens, P. L. & Fletcher, C. V., Nov 2011, In : Antimicrobial Agents and Chemotherapy. 55, 11, p. 5294-5299 6 p.

Research output: Contribution to journalArticle

54 Scopus citations