Dahn L Clemens, PhD

  • 1903 Citations
  • 22 h-Index
1989 …2020

Research output per year

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Research Output

  • 1903 Citations
  • 22 h-Index
  • 57 Article
  • 4 Review article
  • 1 Chapter
  • 1 Comment/debate
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Article
2020

High omega arachidonic acid/docosahexaenoic acid ratio induces mitochondrial dysfunction and altered lipid metabolism in human hepatoma cells

Ghazali, R., Mehta, K. J., Bligh, S. W. A., Tewfik, I., Clemens, D. & Patel, V. B., Mar 27 2020, In : World Journal of Hepatology. 12, 3, p. 84-98 15 p.

Research output: Contribution to journalArticle

Open Access
2019

Mucin-1 is required for Coxsackie Virus B3-induced inflammation in pancreatitis

Liu, X., Clemens, D. L., Grunkemeyer, J. A., Price, J. D., O’Connell, K., Chapman, N. M., Storz, P., Wen, H., Cox, J. L., Reid, W. L., Hollingsworth, M. A. & Thayer, S., Dec 1 2019, In : Scientific reports. 9, 1, 10656.

Research output: Contribution to journalArticle

Open Access
2018

Novel antioxidant properties of doxycycline

Clemens, D. L., Duryee, M. J., Sarmiento, C., Chiou, A., McGowan, J. D., Hunter, C. D., Schlichte, S. L., Tian, J., Klassen, L. W., O'Dell, J. R., Thiele, G. M., Mikuls, T. R., Zimmerman, M. C. & Anderson, D. R., Jan 1 2018, In : International journal of molecular sciences. 19, 12, 4078.

Research output: Contribution to journalArticle

6 Scopus citations
2017
2 Scopus citations
15 Scopus citations

The effects of changes in glutathione levels through exogenous agents on intracellular cysteine content and protein adduct formation in chronic alcohol-treated VL17A cells

Kumar, S. M., Haridoss, M., Swaminathan, K., Gopal, R. K., Clemens, D. & Dey, A., Feb 12 2017, In : Toxicology Mechanisms and Methods. 27, 2, p. 128-135 8 p.

Research output: Contribution to journalArticle

3 Scopus citations
2016

Retinoid regulation of antiviral innate immunity in hepatocytes

Cho, N. E., Bang, B. R., Gurung, P., Li, M., Clemens, D. L., Underhill, T. M., James, L. P., Chase, J. R. & Saito, T., Jan 1 2016, In : Hepatology. 63, 6, p. 1783-1795 13 p.

Research output: Contribution to journalArticle

11 Scopus citations

The involvement of acetaldehyde in ethanol-induced cell cycle impairment

Scheer, M. A., Schneider, K. J., Finnigan, R. L., Maloney, E. P., Wells, M. A. & Clemens, D. L., Mar 31 2016, In : Biomolecules. 6, 2

Research output: Contribution to journalArticle

3 Scopus citations
2015
9 Scopus citations

Free fatty acids enhance the oxidative damage induced by ethanol metabolism in an in vitro model

Hernández, I., Domínguez-Pérez, M., Bucio, L., Souza, V., Miranda, R. U., Clemens, D. L., Gomez-Quiroz, L. E. & Gutiérrez-Ruiz, M. C., Feb 1 2015, In : Food and Chemical Toxicology. 76, p. 109-115 7 p.

Research output: Contribution to journalArticle

14 Scopus citations

GSH protects against oxidative stress and toxicity in VL-17A cells exposed to high glucose

Kumar, S. M., Swaminathan, K., Clemens, D. L. & Dey, A., Jan 1 2015, In : European Journal of Nutrition. 54, 2, p. 223-234 12 p.

Research output: Contribution to journalArticle

9 Scopus citations
2014

Modulation of GSH with exogenous agents leads to changes in glyoxalase 1 enzyme activity in VL-17A cells exposed to chronic alcohol plus high glucose

Kumar, S. M., Swaminathan, K., Clemens, D. L. & Dey, A., Feb 1 2014, In : Food and Function. 5, 2, p. 345-358 14 p.

Research output: Contribution to journalArticle

2 Scopus citations
2013
1 Scopus citations

Inhibition of CYP2E1 leads to decreased advanced glycated end product formation in high glucose treated ADH and CYP2E1 over-expressing VL-17A cells

Swaminathan, K., Kumar, S. M., Clemens, D. L. & Dey, A., Jul 3 2013, In : Biochimica et Biophysica Acta - General Subjects. 1830, 10, p. 4407-4416 10 p.

Research output: Contribution to journalArticle

7 Scopus citations

Inhibition of CYP2E1 leads to decreased malondialdehyde-acetaldehyde adduct formation in VL-17A cells under chronic alcohol exposure

Swaminathan, K., Clemens, D. L. & Dey, A., Mar 14 2013, In : Life Sciences. 92, 6-7, p. 325-336 12 p.

Research output: Contribution to journalArticle

14 Scopus citations

Multilevel regulation of autophagosome content by ethanol oxidation in HepG2 cells

Thomes, P. G., Ehlers, R. A., Trambly, C. S., Clemens, D. L., Fox, H. S., Tuma, D. J. & Donohue, T. M., Jan 2013, In : Autophagy. 9, 1, p. 63-73 11 p.

Research output: Contribution to journalArticle

47 Scopus citations
2012

Ethanol administration impairs pancreatic repair after injury

Schneider, K. J. M., Scheer, M., Suhr, M. & Clemens, D. L., Nov 1 2012, In : Pancreas. 41, 8, p. 1272-1279 8 p.

Research output: Contribution to journalArticle

9 Scopus citations

Hepatic mitochondrial dysfunction induced by fatty acids and ethanol

Gyamfi, D., Everitt, H. E., Tewfik, I., Clemens, D. L. & Patel, V. B., Dec 1 2012, In : Free Radical Biology and Medicine. 53, 11, p. 2131-2145 15 p.

Research output: Contribution to journalArticle

18 Scopus citations

In Vitro Evidence for Chronic Alcohol and High Glucose Mediated Increased Oxidative Stress and Hepatotoxicity

Chandrasekaran, K., Swaminathan, K., Mathan Kumar, S., Clemens, D. L. & Dey, A., Jun 2012, In : Alcoholism: Clinical and Experimental Research. 36, 6, p. 1004-1012 9 p.

Research output: Contribution to journalArticle

10 Scopus citations

Mitochondrial morphology and dynamics in hepatocytes from normal and ethanol-fed rats

Das, S., Hajnóczky, N., Antony, A. N., Csordás, G., Gaspers, L. D., Clemens, D. L., Hoek, J. B. & Hajnóczky, G., Jul 1 2012, In : Pflugers Archiv European Journal of Physiology. 464, 1, p. 101-109 9 p.

Research output: Contribution to journalArticle

29 Scopus citations
2011
8 Scopus citations

Ethanol metabolism activates cell cycle checkpoint kinase, Chk2

Clemens, D. L., Mahan Schneider, K. J. & Nuss, R. F., Dec 1 2011, In : Alcohol. 45, 8, p. 785-793 9 p.

Research output: Contribution to journalArticle

6 Scopus citations

Knock down of GCN5 histone acetyltransferase by siRNA decreases ethanol-induced histone acetylation and affects differential expression of genes in human hepatoma cells

Choudhury, M., Pandey, R. S., Clemens, D. L., Davis, J. W., Lim, R. W. & Shukla, S. D., Jun 1 2011, In : Alcohol. 45, 4, p. 311-324 14 p.

Research output: Contribution to journalArticle

18 Scopus citations

Zinc deprivation mediates alcohol-induced hepatocyte IL-8 analog expression in rodents via an epigenetic mechanism

Zhao, Y., Zhong, W., Sun, X., Song, Z., Clemens, D. L., Kang, Y. J., McClain, C. J. & Zhou, Z., Aug 1 2011, In : American Journal of Pathology. 179, 2, p. 693-702 10 p.

Research output: Contribution to journalArticle

13 Scopus citations
2010

Alcoholic pancreatitis: Lessons from the liver

Clemens, D. L. & Mahan, K. J., Mar 21 2010, In : World Journal of Gastroenterology. 16, 11, p. 1314-1320 7 p.

Research output: Contribution to journalArticle

19 Scopus citations

Autophagy reduces acute ethanol-induced hepatotoxicity and steatosis in mice

Ding, W., Li, M., Chen, X., Ni, H., Lin, C., Gao, W., Lu, B., Stolz, D. B., Clemens, D. L. & Yin, X., Nov 2010, In : Gastroenterology. 139, 5, p. 1740-1752 13 p.

Research output: Contribution to journalArticle

308 Scopus citations
2009

A novel small molecule, LAS-0811, inhibits alcohol-induced apoptosis in VL-17A cells

Kim, T. H., Venugopal, S. K., Zhu, M., Wang, S. S., Lau, D., Lam, K. S., Clemens, D. L. & Zern, M. A., Feb 20 2009, In : Biochemical and Biophysical Research Communications. 379, 4, p. 876-881 6 p.

Research output: Contribution to journalArticle

4 Scopus citations

Hepatocyte growth factor protects hepatocytes against oxidative injury induced by ethanol metabolism

Valdés-Arzate, A., Luna, A., Bucio, L., Licona, C., Clemens, D. L., Souza, V., Hernandez, E., Kershenobich, D., Gutiérrez-Ruiz, M. C. & Gómez-Quiroz, L. E., Aug 15 2009, In : Free Radical Biology and Medicine. 47, 4, p. 424-430 7 p.

Research output: Contribution to journalArticle

39 Scopus citations
2007

Ethanol-induced oxidative stress suppresses generation of peptides for antigen presentation by hepatoma cells

Osna, N. A., White, R. L., Todero, S., Mc Vicker, B. L., Thiele, G. M., Clemens, D. L., Tuma, D. J. & Donohue, T. M., Jan 1 2007, In : Hepatology. 45, 1, p. 53-61 9 p.

Research output: Contribution to journalArticle

39 Scopus citations

Role of MAPK phosphatase-1 in sustained activation of JNK during ethanol-induced apoptosis in hepatocyte-like VL-17A cells

Venugopal, S. K., Chen, J., Zhang, Y., Clemens, D., Follenzi, A. & Zern, M. A., Nov 2 2007, In : Journal of Biological Chemistry. 282, 44, p. 31900-31908 9 p.

Research output: Contribution to journalArticle

48 Scopus citations
2006

Alcohol metabolism-mediated oxidative stress down-regulates hepcidin transcription and leads to increased duodenal iron transporter expression

Harrison-Findik, D. D., Schafer, D., Klein, E., Timchenko, N. A., Kulaksiz, H., Clemens, D., Fein, E., Andriopoulos, B., Pantopoulos, K. & Gollan, J., Aug 11 2006, In : Journal of Biological Chemistry. 281, 32, p. 22974-22982 9 p.

Research output: Contribution to journalArticle

202 Scopus citations

Metabolic basis of ethanol-induced cytotoxicity in recombinant HepG2 cells: Role of nonoxidative metabolism

Wu, H., Cai, P., Clemens, D. L., Jerrells, T. R., Ansari, G. A. S. & Kaphalia, B. S., Oct 15 2006, In : Toxicology and Applied Pharmacology. 216, 2, p. 238-247 10 p.

Research output: Contribution to journalArticle

40 Scopus citations
91 Scopus citations
2005

Ethanol metabolism alters interferon gamma signaling in recombinant HepG2 cells

Osna, N. A., Clemens, D. L. & Donohue, T. M., Nov 1 2005, In : Hepatology. 42, 5, p. 1109-1117 9 p.

Research output: Contribution to journalArticle

44 Scopus citations
2004

Ethanol consumption potentiates viral pancreatitis and may inhibit pancreas regeneration: Preliminary findings

Clemens, D. L. & Jerrells, T. R., Jan 1 2004, In : Alcohol. 33, 3, p. 183-189 7 p.

Research output: Contribution to journalArticle

31 Scopus citations

Suicide gene therapy: Conversion of ethanol to acetaldehyde mediated by human beta 2 alcohol dehydrogenase

Savage, P., Cowburn, P., Clemens, D., Hurley, T., Laguda, B., Martin-Duque, P., Vassaux, G. & Lemoine, N. R., Dec 1 2004, In : Cancer Gene Therapy. 11, 12, p. 774-781 8 p.

Research output: Contribution to journalArticle

6 Scopus citations
2003

Animal Model of Alcoholic Pancreatitis: Role of Viral Infections

Jerrells, T. R., Chapman, N. & Clemens, D. L., Nov 1 2003, In : Pancreas. 27, 4, p. 301-304 4 p.

Research output: Contribution to journalArticle

31 Scopus citations

Ethanol metabolism results in a G2/M cell-cycle arrest in recombinant Hep G2 cells

Clemens, D. L., Calisto, L. E., Sorrell, M. F. & Tuma, D. J., Aug 1 2003, In : Hepatology. 38, 2, p. 385-393 9 p.

Research output: Contribution to journalArticle

24 Scopus citations
48 Scopus citations
2002

AKT proto-oncogene overexpression is an early event during sporadic colon carcinogenesis

Roy, H. K., Olusola, B. F., Clemens, D. L., Karolski, W. J., Ratashak, A., Lynch, H. T. & Smyrk, T. C., Jan 1 2002, In : Carcinogenesis. 23, 1, p. 201-205 5 p.

Research output: Contribution to journalArticle

Open Access
275 Scopus citations

Relationship between acetaldehyde levels and cell survival in ethanol-metabolizing hepatoma cells

Clemens, D. L., Forman, A., Jerrells, T. R., Sorrell, M. F. & Tuma, D. J., Jan 1 2002, In : Hepatology. 35, 5, p. 1196-1204 9 p.

Research output: Contribution to journalArticle

60 Scopus citations
2001

Characterization of human liver thermostable phenol sulfotransferase (SULT1A1) allozymes with 3,3′,5-triiodothyronine as the substrate

Li, X., Clemens, D. L., Cole, J. R. & Anderson, R. J., Dec 1 2001, In : Journal of Endocrinology. 171, 3, p. 525-532 8 p.

Research output: Contribution to journalArticle

27 Scopus citations
27 Scopus citations

Use of cultured cells in assessing ethanol toxicity and ethanol-related metabolism

Donohue, J., Clemens, D. L., Galli, A., Crabb, D., Nieto, N., Kato, J. & Barve, S. S., Jun 27 2001, In : Alcoholism: Clinical and Experimental Research. 25, 5 SUPPL., p. 87S-93S

Research output: Contribution to journalArticle

15 Scopus citations
2000

Sulfation of iodothyronines by human sulfotransferase 1C1 (SULT1C1)

Li, X., Clemens, D. L. & Anderson, R. J., Dec 1 2000, In : Biochemical Pharmacology. 60, 11, p. 1713-1716 4 p.

Research output: Contribution to journalArticle

30 Scopus citations
1998

Ethanol oxidation mediates impaired hepatic receptor-mediated enocytosis

Clemens, D. L., Casey, C. A., Sorrell, M. F. & Tuma, D. J., Jul 8 1998, In : Alcoholism: Clinical and Experimental Research. 22, 4, p. 778-779 2 p.

Research output: Contribution to journalArticle

11 Scopus citations

Sulfation of minoxidil by multiple human cytosolic sulfotransferases

Anderson, R. J., Kudlacek, P. E. & Clemens, D. L., Feb 20 1998, In : Chemico-Biological Interactions. 109, 1-3, p. 53-67 15 p.

Research output: Contribution to journalArticle

52 Scopus citations
1997

Characterization of recombinant human liver dehydroepiandrosterone sulfotransferase with minoxidil as the substrate

Kudlacek, P. E., Clemens, D. L., Halgard, C. M. & Anderson, R. J., Jan 24 1997, In : Biochemical Pharmacology. 53, 2, p. 215-221 7 p.

Research output: Contribution to journalArticle

11 Scopus citations
1996

Characterization of recombinant human liver dehydroepiandrosterone sulfotransferase (DHEA ST) with minoxidil as the substrate

Kudlacek, P., Clemens, D., Halgard, C. & Anderson, R., Dec 1 1996, In : FASEB Journal. 10, 3, p. A456

Research output: Contribution to journalArticle

Human liver thermostable phenol sulfotransferase its PST: CDNA cloning, bacterial expression and characterization

Clemens, D., Cole, J., Kudlacek, P., Halgard, C. & Andersen, R., Dec 1 1996, In : FASEB Journal. 10, 3, p. A284

Research output: Contribution to journalArticle

3 Scopus citations