Daniel T Monaghan, PhD

  • 10680 Citations
  • 47 h-Index
1981 …2020

Research output per year

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Research Output

  • 10680 Citations
  • 47 h-Index
  • 95 Article
  • 7 Chapter
  • 5 Review article
2020

NMDA receptors containing GluN2C and GluN2D subunits have opposing roles in modulating neuronal oscillations; potential mechanism for bidirectional feedback

Mao, Z., He, S., Mesnard, C., Synowicki, P., Zhang, Y., Chung, L., Wiesman, A. I., Wilson, T. W. & Monaghan, D. T., Jan 15 2020, In : Brain Research. 1727, 146571.

Research output: Contribution to journalArticle

Structural basis of subtype-selective competitive antagonism for GluN2C/2D-containing NMDA receptors

Wang, J. X., Irvine, M. W., Burnell, E. S., Sapkota, K., Thatcher, R. J., Li, M., Simorowski, N., Volianskis, A., Collingridge, G. L., Monaghan, D. T., Jane, D. E. & Furukawa, H., Dec 1 2020, In : Nature communications. 11, 1, 423.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2019

In the Telencephalon, GluN2C NMDA Receptor Subunit mRNA is Predominately Expressed in Glial Cells and GluN2D mRNA in Interneurons

A. Alsaad, H., W. DeKorver, N., Mao, Z., M. Dravid, S., Arikkath, J. & T. Monaghan, D., Jan 15 2019, In : Neurochemical Research. 44, 1, p. 61-77 17 p.

Research output: Contribution to journalArticle

8 Scopus citations

Investigation of the structural requirements for N-methyl-D-aspartate receptor positive and negative allosteric modulators based on 2-naphthoic acid

Irvine, M. W., Fang, G., Sapkota, K., Burnell, E. S., Volianskis, A., Costa, B. M., Culley, G., Collingridge, G. L., Monaghan, D. T. & Jane, D. E., Feb 15 2019, In : European Journal of Medicinal Chemistry. 164, p. 471-498 28 p.

Research output: Contribution to journalArticle

3 Scopus citations

Positive and Negative Allosteric Modulators of N-Methyl- d -aspartate (NMDA) Receptors: Structure-Activity Relationships and Mechanisms of Action

Burnell, E. S., Irvine, M., Fang, G., Sapkota, K., Jane, D. E. & Monaghan, D. T., Oct 1 2019, In : Journal of Medicinal Chemistry. 62, 1, p. 3-23 21 p.

Research output: Contribution to journalArticle

13 Scopus citations

The NMDA receptor intracellular C-terminal domains reciprocally interact with allosteric modulators

Sapkota, K., Dore, K., Tang, K., Irvine, M., Fang, G., Burnell, E. S., Malinow, R., Jane, D. E. & Monaghan, D. T., Jan 2019, In : Biochemical Pharmacology. 159, p. 140-153 14 p.

Research output: Contribution to journalArticle

1 Scopus citations
2017

A single-channel mechanism for pharmacological potentiation of GluN1/GluN2A NMDA receptors

Chopra, DI. A., Sapkota, K., Irvine, M. W., Fang, G., Jane, D. E., Monaghan, D. T. & Dravid, S. M., Dec 1 2017, In : Scientific reports. 7, 1, 6933.

Research output: Contribution to journalArticle

6 Scopus citations

Mechanism and properties of positive allosteric modulation of N-methyl-D-aspartate receptors by 6-alkyl 2-naphthoic acid derivatives

Sapkota, K., Irvine, M. W., Fang, G., Burnell, E. S., Bannister, N., Volianskis, A., Culley, G. R., Dravid, S. M., Collingridge, G. L., Jane, D. E. & Monaghan, D. T., Oct 2017, In : Neuropharmacology. 125, p. 64-79 16 p.

Research output: Contribution to journalArticle

7 Scopus citations

Multiple roles of GluN2B-containing NMDA receptors in synaptic plasticity in juvenile hippocampus

France, G., Fernández-Fernández, D., Burnell, E. S., Irvine, M. W., Monaghan, D. T., Jane, D. E., Bortolotto, Z. A., Collingridge, G. L. & Volianskis, A., Jan 1 2017, In : Neuropharmacology. 112, p. 76-83 8 p.

Research output: Contribution to journalArticle

18 Scopus citations
2016

GluN2D N-methyl-D-aspartate receptor subunit contribution to the stimulation of brain activity and gamma oscillations by ketamine: Implications for schizophrenia

Sapkota, K., Mao, Z., Synowicki, P., Lieber, D., Liu, M., Ikezu, T., Gautam, V. & Monaghan, D. T., Mar 1 2016, In : Journal of Pharmacology and Experimental Therapeutics. 356, 3, p. 702-711 10 p.

Research output: Contribution to journalArticle

32 Scopus citations

The NMDA receptor GluN2C subunit controls cortical excitatory-inhibitory balance, neuronal oscillations and cognitive function

Gupta, S. C., Ravikrishnan, A., Liu, J., Mao, Z., Pavuluri, R., Hillman, B. G., Gandhi, P. J., Stairs, D. J., Li, M., Ugale, R. R., Monaghan, D. T. & Dravid, S. M., Dec 6 2016, In : Scientific reports. 6, 38321.

Research output: Contribution to journalArticle

19 Scopus citations
2015
7 Scopus citations

Synthesis of a series of novel 3,9-disubstituted phenanthrenes as analogues of known N-methyl-D-aspartate receptor allosteric modulators

Irvine, M. W., Fang, G., Eaves, R., Mayo-Martin, M. B., Burnell, E. S., Costa, B. M., Culley, G. R., Volianskis, A., Collingridge, G. L., Monaghan, D. T. & Jane, D. E., Dec 22 2015, In : Synthesis (Germany). 47, 11, p. 1593-1610 18 p., ss-2014-t0697-op.

Research output: Contribution to journalArticle

5 Scopus citations
2013

Different NMDA receptor subtypes mediate induction of long-term potentiation and two forms of short-term potentiation at CA1 synapses in rat hippocampus in vitro

Volianskis, A., Bannister, N., Collett, V. J., Irvine, M. W., Monaghan, D. T., Fitzjohn, S. M., Jensen, M. S., Jane, D. E. & Collingridge, G. L., Feb 2013, In : Journal of Physiology. 591, 4, p. 955-972 18 p.

Research output: Contribution to journalArticle

46 Scopus citations

Nedd4 is a specific E3 ubiquitin ligase for the NMDA receptor subunit GluN2D

Gautam, V., Trinidad, J. C., Rimerman, R. A., Costa, B. M., Burlingame, A. L. & Monaghan, D. T., 2013, In : Neuropharmacology. 74, p. 96-107 12 p.

Research output: Contribution to journalArticle

19 Scopus citations

The NMDA receptor as a target for cognitive enhancement

Collingridge, G. L., Volianskis, A., Bannister, N., France, G., Hanna, L., Mercier, M., Tidball, P., Fang, G., Irvine, M. W., Costa, B. M., Monaghan, D. T., Bortolotto, Z. A., Molnár, E., Lodge, D. & Jane, D. E., Jan 2013, In : Neuropharmacology. 64, p. 13-26 14 p.

Research output: Contribution to journalReview article

154 Scopus citations
2012

Anatomical, pharmacological, and molecular diversity of native NMDA receptor subtypes

Monaghan, D. T. & Buller, A. L., Mar 22 2012, The NMDA Receptor. Oxford University Press

Research output: Chapter in Book/Report/Conference proceedingChapter

Coumarin-3-carboxylic acid derivatives as potentiators and inhibitors of recombinant and native N-methyl-d-aspartate receptors

Irvine, M. W., Costa, B. M., Volianskis, A., Fang, G., Ceolin, L., Collingridge, G. L., Monaghan, D. T. & Jane, D. E., Sep 2012, In : Neurochemistry International. 61, 4, p. 593-600 8 p.

Research output: Contribution to journalArticle

20 Scopus citations

Pharmacological modulation of NMDA receptor activity and the advent of negative and positive allosteric modulators

Monaghan, D. T., Irvine, M. W., Costa, B. M., Fang, G. & Jane, D. E., Sep 2012, In : Neurochemistry International. 61, 4, p. 581-592 12 p.

Research output: Contribution to journalArticle

64 Scopus citations

Piperazine-2,3-dicarboxylic acid derivatives as dual antagonists of NMDA and GluK1-containing kainate receptors

Irvine, M. W., Costa, B. M., Dlaboga, D., Culley, G. R., Hulse, R., Scholefield, C. L., Atlason, P., Fang, G., Eaves, R., Morley, R., Mayo-Martin, M. B., Amici, M., Bortolotto, Z. A., Donaldson, L., Collingridge, G. L., Molnár, E., Monaghan, D. T. & Jane, D. E., Jan 12 2012, In : Journal of Medicinal Chemistry. 55, 1, p. 327-341 15 p.

Research output: Contribution to journalArticle

13 Scopus citations

Structure-activity relationships for allosteric NMDA receptor inhibitors based on 2-naphthoic acid

Costa, B. M., Irvine, M. W., Fang, G., Eaves, R. J., Mayo-Martin, M. B., Laube, B., Jane, D. E. & Monaghan, D. T., Mar 2012, In : Neuropharmacology. 62, 4, p. 1730-1736 7 p.

Research output: Contribution to journalArticle

28 Scopus citations
2011

Selective inhibition of GluN2D-containing N-methyl-D-aspartate receptors prevents tissue plasminogen activator-promoted neurotoxicity both in vitro and in vivo

Jullienne, A., Montagne, A., Orset, C., Lesept, F., Jane, D. E., Monaghan, D. T., Maubert, E., Vivien, D. & Ali, C., 2011, In : Molecular neurodegeneration. 6, 1, 68.

Research output: Contribution to journalArticle

20 Scopus citations
2010

A novel family of negative and positive allosteric modulators of NMDA receptors

Costa, B. M., Irvine, M. W., Fang, G., Eaves, R. J., Mayo-Martin, M. B., Skifter, D. A., Jane, D. E. & Monaghan, D. T., Dec 2010, In : Journal of Pharmacology and Experimental Therapeutics. 335, 3, p. 614-621 8 p.

Research output: Contribution to journalArticle

60 Scopus citations

Functional heterogeneity of NMDA receptors in rat substantia nigra pars compacta and reticulata neurones

Suárez, F., Zhao, Q., Monaghan, D. T., Jane, D. E., Jones, S. & Gibb, A. J., Aug 2010, In : European Journal of Neuroscience. 32, 3, p. 359-367 9 p.

Research output: Contribution to journalArticle

29 Scopus citations
2009

N-methyl-D-aspartate (NMDA) receptor NR2 subunit selectivity of a series of novel piperazine-2,3-dicarboxylate derivatives: Preferential blockade of extrasynaptic NMDA receptors in the rat hippocampal CA3-CA1 synapse

Costa, B. M., Feng, B., Tsintsadze, T. S., Morley, R. M., Irvine, M. W., Tsintsadze, V., Lozovaya, N. A., Jane, D. E. & Monaghan, D. T., Nov 2009, In : Journal of Pharmacology and Experimental Therapeutics. 331, 2, p. 618-626 9 p.

Research output: Contribution to journalArticle

40 Scopus citations

Regulation of mu opioid receptor internalization by the scaffold protein RanBPM

Talbot, J. N., Skifter, D. A., Bianchi, E., Monaghan, D. T., Toews, M. L. & Murrin, L. C., Dec 11 2009, In : Neuroscience Letters. 466, 3, p. 154-158 5 p.

Research output: Contribution to journalArticle

16 Scopus citations
2008

Calcium-permeable AMPA receptors containing Q/R-unedited GluR2 direct human neural progenitor cell differentiation to neurons

Whitney, N. P., Peng, H., Erdmann, N. B., Tian, C., Monaghan, D. T. & Zheng, J. C., Aug 2008, In : FASEB Journal. 22, 8, p. 2888-2900 13 p.

Research output: Contribution to journalArticle

68 Scopus citations

NR2B- and NR2D-containing synaptic NMDA receptors in developing rat substantia nigra pars compacta dopaminergic neurones

Brothwell, S. L. C., Barber, J. L., Monaghan, D. T., Jane, D. E., Gibb, A. J. & Jones, S., Feb 1 2008, In : Journal of Physiology. 586, 3, p. 739-750 12 p.

Research output: Contribution to journalArticle

78 Scopus citations

Pharmacology of NMDA receptors

Monaghan, D. T. & Jane, D. E., Jan 1 2008, Biology of the NMDA Receptor. CRC Press, p. 257-281 25 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

7 Scopus citations
2007

AP5

Monaghan, D., 2007, xPharm: The Comprehensive Pharmacology Reference. Elsevier Inc., p. 1-3 3 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

CPP

Monaghan, D., 2007, xPharm: The Comprehensive Pharmacology Reference. Elsevier Inc., p. 1-6 6 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Dizocilpine

Monaghan, D., 2007, xPharm: The Comprehensive Pharmacology Reference. Elsevier Inc., p. 1-4 4 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

NMDA

Monaghan, D., 2007, xPharm: The Comprehensive Pharmacology Reference. Elsevier Inc., p. 1-3 3 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2006

Interaction with σ1 protein, but not N-Methyl-D-aspartate receptor, is involved in the pharmacological activity of donepezil

Maurice, T., Meunier, J., Feng, B., Ieni, J. & Monaghan, D. T., May 2006, In : Journal of Pharmacology and Experimental Therapeutics. 317, 2, p. 606-614 9 p.

Research output: Contribution to journalArticle

59 Scopus citations

Regional variations in NMDA receptor downregulation in streptozotocin-diabetic rat brain

Bean, L. D., Zheng, H., Patel, K. P. & Monaghan, D. T., Oct 18 2006, In : Brain Research. 1115, 1, p. 217-222 6 p.

Research output: Contribution to journalArticle

7 Scopus citations
2005

An antisense oligonucleotide to the N-methyl-D-aspartate (NMDA) subunit NMDAR1 attenuates NMDA-induced nociception, hyperalgesia, and morphine tolerance

Shimoyama, N., Shimoyama, M., Davis, A. M., Monaghan, D. T. & Inturrisi, C. E., Feb 2005, In : Journal of Pharmacology and Experimental Therapeutics. 312, 2, p. 834-840 7 p.

Research output: Contribution to journalArticle

44 Scopus citations

Glutamate receptors ionotropic

Monaghan, D. T., More, J. C. A., Feng, B. & Jane, D. E., 2005, Dopamine and Glutamate in Psychiatric Disorders. Humana Press, p. 79-116 38 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Identification of subunit- and antagonist-specific amino acid residues in the N-methyl-D-aspartate receptor glutamate-binding pocket

Kinarsky, L., Feng, B., Skifter, D. A., Morley, R. M., Sherman, S., Jane, D. E. & Monaghan, D. T., Jun 2005, In : Journal of Pharmacology and Experimental Therapeutics. 313, 3, p. 1066-1074 9 p.

Research output: Contribution to journalArticle

34 Scopus citations

Synthesis and pharmacology of N1-substituted piperazine-2,3-dicarboxylic acid derivatives acting as NMDA receptor antagonists

Morley, R. M., Tse, H. W., Feng, B., Miller, J. C., Monaghan, D. T. & Jane, D. E., Apr 7 2005, In : Journal of Medicinal Chemistry. 48, 7, p. 2627-2637 11 p.

Research output: Contribution to journalArticle

45 Scopus citations

The effect of competitive antagonist chain length on NMDA receptor subunit selectivity

Feng, B., Morley, R. M., Jane, D. E. & Monaghan, D. T., Mar 2005, In : Neuropharmacology. 48, 3, p. 354-359 6 p.

Research output: Contribution to journalArticle

43 Scopus citations
2004

Extrasynaptic NR2B and NR2D subunits of NMDA receptors shape 'superslow' afterburst EPSC in rat hippocampus

Lozovaya, N. A., Grebenyuk, S. E., Tsintsadze, T. S., Feng, B., Monaghan, D. T. & Krishtal, O. A., Jul 15 2004, In : Journal of Physiology. 558, 2, p. 451-463 13 p.

Research output: Contribution to journalArticle

120 Scopus citations

Structure - Activity analysis of a novel NR2C/NR2D-preferring NMDA receptor antagonist: 1-(phenanthrene-2-carbonyl) piperazine-2,3-dicarboxylic acid

Feng, B., Tse, H. W., Skifter, D. A., Morley, R., Jane, D. E. & Monaghan, D. T., Feb 2004, In : British Journal of Pharmacology. 141, 3, p. 508-516 9 p.

Research output: Contribution to journalArticle

117 Scopus citations
2003
16 Scopus citations
2000

Distinct NMDA receptor subpopulations contribute to long-term potentiation and long-term depression induction.

Hrabetova, S., Serrano, P., Blace, N., Tse, H. W., Skifter, D. A., Jane, D. E., Monaghan, D. T. & Sacktor, T. C., Jun 15 2000, In : The Journal of neuroscience : the official journal of the Society for Neuroscience. 20, 12, p. RC81

Research output: Contribution to journalArticle

Open Access
93 Scopus citations

Interaction of the N-methyl-D-aspartic acid receptor NR2D subunit with the c-Abl tyrosine kinase

Glover, R. T., Angiolieri, M., Kelly, S., Monaghan, D. T., Wang, J. Y. J., Smithgall, T. E. & Buller, A. L., Apr 28 2000, In : Journal of Biological Chemistry. 275, 17, p. 12725-12729 5 p.

Research output: Contribution to journalArticle

18 Scopus citations
43 Scopus citations
1999

Insulin causes a transient tyrosine phosphorylation of NR2A and NR2B NMDA receptor subunits in rat hippocampus

Christie, J. M., Wenthold, R. J. & Monaghan, D. T., 1999, In : Journal of Neurochemistry. 72, 4, p. 1523-1528 6 p.

Research output: Contribution to journalArticle

74 Scopus citations

N-methyl-D-aspartate receptor agonists modulate homocysteine-induced developmental abnormalities

Rosenquist, T. H., Schneider, A. M. & Monaghan, D. T., 1999, In : FASEB Journal. 13, 12, p. 1523-1531 9 p.

Research output: Contribution to journalArticle

50 Scopus citations
1998

[3H]Homoquinolinate binds to a subpopulation of NMDA receptors and to a novel binding site

Brown, J. C., Tse, H. W., Skifter, D. A., Christie, J. M., Andaloro, V. J., Kemp, M. C., Watkins, J. C., Jane, D. E. & Monaghan, D. T., Oct 1998, In : Journal of Neurochemistry. 71, 4, p. 1464-1470 7 p.

Research output: Contribution to journalArticle

27 Scopus citations

Dextromethorphan and other N-methyl-D-aspartate receptor antagonists are teratogenic in the avian embryo model

Andaloro, V. J., Monaghan, D. T. & Rosenquist, T. H., Jan 1998, In : Pediatric Research. 43, 1, p. 1-7 7 p.

Research output: Contribution to journalArticle

Open Access
45 Scopus citations