Dario Ghersi, MD, PhD

  • 729 Citations
  • 14 h-Index
20042020

Research output per year

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Research Output

2020

Epstein-barr virus epitope-major histocompatibility complex interaction combined with convergent recombination drives selection of diverse T cell receptor α and β repertoires

Gil, A., Kamga, L., Chirravuri-Venkata, R., Aslan, N., Clark, F., Ghersi, D., Luzuriaga, K. & Selin, L. K., Mar 1 2020, In : mBio. 11, 2, e00250-20.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

MUCIN-4 (MUC4) is a novel tumor antigen in pancreatic cancer immunotherapy

Gautam, S. K., Kumar, S., Dam, V., Ghersi, D., Jain, M. & Batra, S. K., Feb 2020, In : Seminars in Immunology. 47, 101391.

Research output: Contribution to journalReview article

Presence and structure-activity relationship of intrinsically disordered regions across mucins

Carmicheal, J., Atri, P., Sharma, S., Kumar, S., Chirravuri Venkata, R., Kulkarni, P., Salgia, R., Ghersi, D., Kaur, S. & Batra, S. K., Feb 1 2020, In : FASEB Journal. 34, 2, p. 1939-1957 19 p.

Research output: Contribution to journalArticle

Open Access
2019

CDR3α drives selection of the immunodominant Epstein Barr virus (EBV) BRLF1-specific CD8 T cell receptor repertoire in primary infection

Kamga, L., Gil, A., Song, I., Brody, R., Ghersi, D., Aslan, N., Stern, L. J., Selin, L. K. & Luzuriaga, K., 2019, In : PLoS pathogens. 15, 11, e1008122.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Computer modeling of clonal dominance: Memory-anti-naïve and its curbing by attrition

Castiglione, F., Ghersi, D. & Celada, F., 2019, In : Frontiers in immunology. 10, JUL, 1513.

Research output: Contribution to journalArticle

Open Access
Open Access
4 Scopus citations

Identifying Structural Changes in Correlation Networks Models of Cancer Gene Expression by Stage

Li, Q., Ghersi, D., Thapa, I., Zhang, L., Ali, H. & Cooper, K., Nov 2019, Proceedings - 2019 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2019. Yoo, I., Bi, J. & Hu, X. T. (eds.). Institute of Electrical and Electronics Engineers Inc., p. 2075-2082 8 p. 8983069. (Proceedings - 2019 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2019).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Open Access
2018

Biological pathway analysis

Venkata, R. C. & Ghersi, D., Jan 1 2018, Encyclopedia of Bioinformatics and Computational Biology: ABC of Bioinformatics. Elsevier, Vol. 1-3. p. 1067-1070 4 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Biological pathway data formats and standards

Venkata, R. C. & Ghersi, D., Jan 1 2018, Encyclopedia of Bioinformatics and Computational Biology: ABC of Bioinformatics. Elsevier, Vol. 1-3. p. 1063-1066 4 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Cluster analysis of biological networks

Sharma, A., Ali, H. & Ghersi, D., Jan 1 2018, Encyclopedia of Bioinformatics and Computational Biology: ABC of Bioinformatics. Elsevier, Vol. 1-3. p. 1036-1046 11 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Two critical positions in zinc finger domains are heavily mutated in three human cancer types

Munro, D., Ghersi, D. & Singh, M., Jun 2018, In : PLoS computational biology. 14, 6, e1006290.

Research output: Contribution to journalArticle

4 Scopus citations
2017

Analyzing T cell receptor alpha/beta usage in binding to the pMHC

Ehrlich, R. & Ghersi, D., Dec 15 2017, Proceedings - 2017 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2017. Yoo, I., Zheng, J. H., Gong, Y., Hu, X. T., Shyu, C-R., Bromberg, Y., Gao, J. & Korkin, D. (eds.). Institute of Electrical and Electronics Engineers Inc., p. 83-87 5 p. (Proceedings - 2017 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2017; vol. 2017-January).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Broad TCR repertoire and diverse structural solutions for recognition of an immunodominant CD8+ T cell epitope

Song, I. Y., Gil, A., Mishra, R., Ghersi, D., Selin, L. K. & Stern, L. J., Apr 1 2017, In : Nature Structural and Molecular Biology. 24, 4, p. 395-406 12 p.

Research output: Contribution to journalArticle

22 Scopus citations
5 Scopus citations

In-silico analysis of the 'memory anti-Naïve' effect in anti-viral cross-reactive responses

Castiglione, F., Ghersi, D. & Celada, F., Dec 15 2017, Proceedings - 2017 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2017. Yoo, I., Zheng, J. H., Gong, Y., Hu, X. T., Shyu, C-R., Bromberg, Y., Gao, J. & Korkin, D. (eds.). Institute of Electrical and Electronics Engineers Inc., p. 1433-1437 5 p. (Proceedings - 2017 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2017; vol. 2017-January).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Severity of acute infectious mononucleosis correlates with cross-reactive influenza CD8 T-cell receptor repertoires

Aslan, N., Watkin, L. B., Gil, A., Mishra, R., Clark, F. G., Welsh, R. M., Ghersi, D., Luzuriaga, K. & Selina, L. K., Nov 1 2017, In : mBio. 8, 6, e01841-17.

Research output: Contribution to journalArticle

13 Scopus citations

Unique influenza A cross-reactive memory CD8 T-cell receptor repertoire has a potential to protect against EBV seroconversion

Watkin, L. B., Mishra, R., Gil, A., Aslan, N., Ghersi, D., Luzuriaga, K. & Selin, L. K., Oct 2017, In : Journal of Allergy and Clinical Immunology. 140, 4, p. 1206-1210 5 p.

Research output: Contribution to journalArticle

6 Scopus citations
2016

Building towards precision medicine: Empowering medical professionals for the next revolution

McGrath, S. & Ghersi, D., May 10 2016, In : BMC Medical Genomics. 9, 1, 23.

Research output: Contribution to journalReview article

30 Scopus citations
2 Scopus citations

Identifying enriched drug fragments as possible candidates for metabolic engineering

Sharma, S., Karri, K., Thapa, I., Bastola, D. & Ghersi, D., Oct 8 2016, In : BMC Medical Genomics. 9, 46.

Research output: Contribution to journalArticle

5 Scopus citations

Recovering bound forms of Protein structures using the Elastic Network Model and Molecular Interaction Fields

Ghersi, D. & Sanchez, R., Oct 2 2016, ACM-BCB 2016 - 7th ACM Conference on Bioinformatics, Computational Biology, and Health Informatics. Association for Computing Machinery, Inc, p. 50-57 8 p. (ACM-BCB 2016 - 7th ACM Conference on Bioinformatics, Computational Biology, and Health Informatics).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2015

A novel approach to identify shared fragments in drugs and natural products

Balasubramanya, A., Thapa, I., Bastola, D. & Ghersi, D., Dec 16 2015, Proceedings - 2015 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2015. Schapranow, L. M., Zhou, J., Hu, X. T., Ma, B., Rajasekaran, S., Miyano, S., Yoo, I., Pierce, B., Shehu, A., Gombar, V. K., Chen, B., Pai, V. & Huan, J. (eds.). Institute of Electrical and Electronics Engineers Inc., p. 575-580 6 p. 7359746. (Proceedings - 2015 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2015).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Genome-Wide Detection and Analysis of Multifunctional Genes

Pritykin, Y., Ghersi, D. & Singh, M., 2015, In : PLoS computational biology. 11, 10, e1004467.

Research output: Contribution to journalArticle

23 Scopus citations
2014

Interaction-based discovery of functionally important genes in cancers

Ghersi, D. & Singh, M., Feb 2014, In : Nucleic acids research. 42, 3, p. e18

Research output: Contribution to journalArticle

16 Scopus citations

MolBLOCKS: Decomposing small molecule sets and uncovering enriched fragments

Ghersi, D. & Singh, M., Jul 15 2014, In : Bioinformatics. 30, 14, p. 2081-2083 3 p.

Research output: Contribution to journalArticle

18 Scopus citations
2013

Disentangling function from topology to infer the network properties of disease genes

Ghersi, D. & Singh, M., Jan 16 2013, In : BMC systems biology. 7, 5.

Research output: Contribution to journalArticle

12 Scopus citations
2012

Automated identification of binding sites for phosphorylated ligands in protein structures

Ghersi, D. & Sanchez, R., Oct 2012, In : Proteins: Structure, Function and Bioinformatics. 80, 10, p. 2347-2358 12 p.

Research output: Contribution to journalArticle

2011
32 Scopus citations

Computer simulations of heterologous immunity: Highlights of an interdisciplinary cooperation

Calcagno, C., Puzone, R., Pearson, Y. E., Cheng, Y., Ghersi, D., Selin, L. K., Welsh, R. M. & Celada, F., Jun 2011, In : Autoimmunity. 44, 4, p. 304-314 11 p.

Research output: Contribution to journalArticle

2 Scopus citations

Systematic assessment of accuracy of comparative model of proteins belonging to different structural fold classes

Chakravarty, S., Ghersi, D. & Sanchez, R., Nov 2011, In : Journal of Molecular Modeling. 17, 11, p. 2831-2837 7 p.

Research output: Contribution to journalArticle

2 Scopus citations
2010

Biochemical profiling of histone binding selectivity of the yeast bromodomain family

Zhang, Q., Chakravarty, S., Ghersi, D., Zeng, L., Plotnikov, A. N., Sanchez, R. & Zhou, M. M., Jan 26 2010, In : PloS one. 5, 1, e8903.

Research output: Contribution to journalArticle

25 Scopus citations
2009

A discrete computer model of the immune system reveals competitive interactions between the humoral and cellular branch and between cross-reacting memory and naïve responses

Cheng, Y., Ghersi, D., Calcagno, C., Selin, L. K., Puzone, R. & Celada, F., Feb 5 2009, In : Vaccine. 27, 6, p. 833-845 13 p.

Research output: Contribution to journalArticle

15 Scopus citations

EasyMIFs and SiteHound: A toolkit for the identification of ligand-binding sites in protein structures

Ghersi, D. & Sanchez, R., Sep 29 2009, In : Bioinformatics. 25, 23, p. 3185-3186 2 p., btp562.

Research output: Contribution to journalArticle

47 Scopus citations
52 Scopus citations

SITEHOUND-web: A server for ligand binding site identification in protein structures

Hernandez, M., Ghersi, D. & Sanchez, R., 2009, In : Nucleic acids research. 37, SUPPL. 2, p. W413-W416

Research output: Contribution to journalArticle

121 Scopus citations
2007

Erratum: Narrowed TCR repertoire and viral escape as a consequence of heterologous immunity (Journal of Clinical Investigation (2006) 116, (1443-1456) DOI: 10.1172/JCI27804)

Cornberg, M., Chen, A. T., Wilkinson, L. A., Brehm, M. A., Kim, S. K., Calcagno, C., Ghersi, D., Puzone, R., Celada, F., Welsh, R. M. & Selin, L. K., May 1 2007, In : Journal of Clinical Investigation. 117, 5, 1 p.

Research output: Contribution to journalComment/debate

2006

IFN-induced attrition of CD8 T cells in the presence or absence of cognate antigen during the early stages of viral infections

Bahl, K., Kim, S. K., Calcagno, C., Ghersi, D., Puzone, R., Celada, F., Selin, L. K. & Welsh, R. M., Apr 1 2006, In : Journal of Immunology. 176, 7, p. 4284-4295 12 p.

Research output: Contribution to journalArticle

Open Access
85 Scopus citations

Narrowed TCR repertoire and viral escape as a consequence of heterologous immunity

Cornberg, M., Chen, A. T., Wilkinson, L. A., Brehm, M. A., Kim, S. K., Calcagno, C., Ghersi, D., Puzone, R., Celada, F., Welsh, R. M. & Selin, L. K., May 1 2006, In : Journal of Clinical Investigation. 116, 5, p. 1443-1456 14 p.

Research output: Contribution to journalArticle

102 Scopus citations
2004

CD8 memory T cells: Cross-reactivity and heterologous immunity

Selin, L. K., Cornberg, M., Brehm, M. A., Kim, S. K., Calcagno, C., Ghersi, D., Puzone, R., Celada, F. & Welsh, R. M., Oct 2004, In : Seminars in Immunology. 16, 5, p. 335-347 13 p.

Research output: Contribution to journalArticle

84 Scopus citations